Details for: CACNB2

Gene ID: 783

Symbol: CACNB2

Ensembl ID: ENSG00000165995

Description: calcium voltage-gated channel auxiliary subunit beta 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 419.7493
    Cell Significance Index: -65.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 258.7885
    Cell Significance Index: -65.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 133.6093
    Cell Significance Index: -63.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.0433
    Cell Significance Index: -65.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.0854
    Cell Significance Index: -41.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.7332
    Cell Significance Index: -66.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 10.4507
    Cell Significance Index: 280.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 8.2615
    Cell Significance Index: 633.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 7.5194
    Cell Significance Index: 332.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 6.9039
    Cell Significance Index: 261.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 6.7451
    Cell Significance Index: 192.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.8004
    Cell Significance Index: 390.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.6185
    Cell Significance Index: 291.0900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 4.2364
    Cell Significance Index: 59.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.7722
    Cell Significance Index: 1353.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.3407
    Cell Significance Index: 670.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.7432
    Cell Significance Index: 1897.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.6146
    Cell Significance Index: 1660.5600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.3468
    Cell Significance Index: 18.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.1730
    Cell Significance Index: 54.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.7676
    Cell Significance Index: 3328.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.6943
    Cell Significance Index: 176.4100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.6432
    Cell Significance Index: 24.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.3078
    Cell Significance Index: 15.5900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.2096
    Cell Significance Index: 25.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.0202
    Cell Significance Index: 463.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9766
    Cell Significance Index: 60.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.9331
    Cell Significance Index: 15.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7809
    Cell Significance Index: 43.8200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.6424
    Cell Significance Index: 8.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5245
    Cell Significance Index: 12.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4674
    Cell Significance Index: 76.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4506
    Cell Significance Index: 44.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3559
    Cell Significance Index: 10.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3543
    Cell Significance Index: 319.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2567
    Cell Significance Index: 50.9500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2435
    Cell Significance Index: 3.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2276
    Cell Significance Index: 24.7600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1627
    Cell Significance Index: 2.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1594
    Cell Significance Index: 5.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0672
    Cell Significance Index: 123.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0613
    Cell Significance Index: 94.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0266
    Cell Significance Index: 5.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0016
    Cell Significance Index: 2.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0024
    Cell Significance Index: -0.3600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0338
    Cell Significance Index: -0.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0419
    Cell Significance Index: -7.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0491
    Cell Significance Index: -36.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0656
    Cell Significance Index: -48.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0861
    Cell Significance Index: -48.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0921
    Cell Significance Index: -11.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0981
    Cell Significance Index: -43.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1097
    Cell Significance Index: -7.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1107
    Cell Significance Index: -69.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1111
    Cell Significance Index: -60.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1354
    Cell Significance Index: -8.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1464
    Cell Significance Index: -25.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1551
    Cell Significance Index: -3.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1579
    Cell Significance Index: -21.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1772
    Cell Significance Index: -50.9900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2195
    Cell Significance Index: -4.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2404
    Cell Significance Index: -7.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2881
    Cell Significance Index: -60.6800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2943
    Cell Significance Index: -3.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3470
    Cell Significance Index: -15.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3546
    Cell Significance Index: -7.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3847
    Cell Significance Index: -49.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3984
    Cell Significance Index: -4.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4239
    Cell Significance Index: -43.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4669
    Cell Significance Index: -60.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5239
    Cell Significance Index: -60.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5344
    Cell Significance Index: -17.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5364
    Cell Significance Index: -63.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5998
    Cell Significance Index: -69.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6296
    Cell Significance Index: -13.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6395
    Cell Significance Index: -39.2100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6901
    Cell Significance Index: -8.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6968
    Cell Significance Index: -55.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7094
    Cell Significance Index: -50.1700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.7120
    Cell Significance Index: -9.1300
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.7442
    Cell Significance Index: -8.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7919
    Cell Significance Index: -11.3400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.7963
    Cell Significance Index: -12.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7971
    Cell Significance Index: -41.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8126
    Cell Significance Index: -60.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8141
    Cell Significance Index: -42.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8507
    Cell Significance Index: -18.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8988
    Cell Significance Index: -42.2500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.9124
    Cell Significance Index: -11.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9133
    Cell Significance Index: -58.9200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.9201
    Cell Significance Index: -10.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9381
    Cell Significance Index: -43.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9386
    Cell Significance Index: -48.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.9515
    Cell Significance Index: -26.5900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.0355
    Cell Significance Index: -12.0800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.0447
    Cell Significance Index: -9.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0522
    Cell Significance Index: -33.7000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0771
    Cell Significance Index: -22.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0816
    Cell Significance Index: -37.8900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.1903
    Cell Significance Index: -15.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CACNB2 gene is a member of the calcium voltage-gated channel auxiliary subunit family, which consists of six subunits (β1-β4 and α1). The β2 subunit is specifically expressed in various cell types, including cortical neurons, sympathetic neurons, and cardiac myocytes. The CACNB2 gene has a single coding exon and a short intron, resulting in a 170-amino acid protein with a characteristic β-barrel structure. The β2 subunit interacts with the α1 subunit to form functional L-type calcium channels, which have a high affinity for calcium ions and a rapid activation time. **Pathways and Functions:** The CACNB2 gene is involved in various cellular pathways, including: 1. **Cardiac Conduction:** The β2 subunit is expressed in cardiac myocytes and plays a crucial role in regulating cardiac conduction, particularly in the atrial and ventricular repolarization phases. 2. **Neurotransmission:** The β2 subunit is expressed in sympathetic neurons and is involved in regulating neurotransmitter release, particularly in the regulation of presynaptic cytosolic calcium ion concentration. 3. **Muscle Contraction:** The β2 subunit is expressed in skeletal and cardiac muscle cells and plays a crucial role in regulating muscle contraction, particularly in the regulation of calcium ion transport. 4. **Metabolism:** The β2 subunit is involved in regulating energy metabolism, particularly in the regulation of insulin secretion and glucose uptake in pancreatic β cells. **Clinical Significance:** Dysregulation of the CACNB2 gene has been implicated in various clinical conditions, including: 1. **Cardiovascular Disease:** Mutations in the CACNB2 gene have been associated with arrhythmias, cardiac conduction disorders, and hypertension. 2. **Neurological Disorders:** The β2 subunit has been implicated in regulating neurotransmitter release and synaptic plasticity, and mutations in the CACNB2 gene have been associated with neurological disorders such as Parkinson's disease and Alzheimer's disease. 3. **Metabolic Disorders:** The β2 subunit plays a crucial role in regulating insulin secretion and glucose uptake, and mutations in the CACNB2 gene have been associated with metabolic disorders such as type 2 diabetes and obesity. In conclusion, the CACNB2 gene plays a critical role in regulating calcium ion transport and cellular function, and its dysregulation has been implicated in various clinical conditions. Further research is needed to fully understand the mechanisms underlying the CACNB2 gene's role in human disease and to develop therapeutic strategies for the treatment of related disorders.

Genular Protein ID: 4114303328

Symbol: CACB2_HUMAN

Name: Voltage-dependent L-type calcium channel subunit beta-2

UniProtKB Accession Codes:

Q08289 A6PVM5 A6PVM7 A6PVM8 O00304 Q5QJ99 Q5QJA0 Q5VVG9 Q5VVH0 Q5VWV6 Q6TME1 Q6TME2 Q6TME3 Q8WX81 Q96NZ3 Q96NZ4 Q96NZ5 Q9BWU2 Q9HD32 Q9Y340 Q9Y341

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 8 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 34 EMBL 30 EMDB 3 Ensembl 8 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 RNAct 1 Reactome 7 RefSeq 10 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8494331

Title: Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen.

PubMed ID: 8494331

DOI: 10.1002/ana.410330126

PubMed ID: 9254841

Title: Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23.

PubMed ID: 9254841

DOI: 10.1007/pl00008704

PubMed ID: 12042350

Title: Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells.

PubMed ID: 12042350

DOI: 10.1113/jphysiol.2002.018515

PubMed ID: 14762176

Title: Molecular heterogeneity of calcium channel beta-subunits in canine and human heart: evidence for differential subcellular localization.

PubMed ID: 14762176

DOI: 10.1152/physiolgenomics.00207.2003

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17525370

Title: Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart.

PubMed ID: 17525370

DOI: 10.1161/circresaha.106.146399

PubMed ID: 22419821

Title: Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis.

PubMed ID: 22419821

DOI: 10.1091/mbc.e11-11-0934

PubMed ID: 28130356

Title: Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.

PubMed ID: 28130356

DOI: 10.1523/jneurosci.2068-16.2017

PubMed ID: 36424916

Title: Rad regulation of CaV1.2 channels controls cardiac fight-or-flight response.

PubMed ID: 36424916

DOI: 10.1038/s44161-022-00157-y

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17224476

Title: Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death.

PubMed ID: 17224476

DOI: 10.1161/circulationaha.106.668392

Sequence Information:

  • Length: 660
  • Mass: 73581
  • Checksum: 4A08B141EE66404E
  • Sequence:
    • MVQRDMSKSP PTAAAAVAQE IQMELLENVA PAGALGAAAQ SYGKGARRKN RFKGSDGSTS 
SDTTSNSFVR QGSADSYTSR PSDSDVSLEE DREAVRREAE RQAQAQLEKA KTKPVAFAVR 
TNVSYSAAHE DDVPVPGMAI SFEAKDFLHV KEKFNNDWWI GRLVKEGCEI GFIPSPVKLE 
NMRLQHEQRA KQGKFYSSKS GGNSSSSLGD IVPSSRKSTP PSSAIDIDAT GLDAEENDIP 
ANHRSPKPSA NSVTSPHSKE KRMPFFKKTE HTPPYDVVPS MRPVVLVGPS LKGYEVTDMM 
QKALFDFLKH RFEGRISITR VTADISLAKR SVLNNPSKHA IIERSNTRSS LAEVQSEIER 
IFELARTLQL VVLDADTINH PAQLSKTSLA PIIVYVKISS PKVLQRLIKS RGKSQAKHLN 
VQMVAADKLA QCPPELFDVI LDENQLEDAC EHLADYLEAY WKATHPPSSS LPNPLLSRTL 
ATSSLPLSPT LASNSQGSQG DQRTDRSAPI RSASQAEEEP SVEPVKKSQH RSSSSAPHHN 
HRSGTSRGLS RQETFDSETQ ESRDSAYVEP KEDYSHDHVD HYASHRDHNH RDETHGSSDH 
RHRESRHRSR DVDREQDHNE CNKQRSRHKS KDRYCEKDGE VISKKRNEAG EWNRDVYIRQ

Genular Protein ID: 3254471522

Symbol: Q5VVH1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5VVH1

Database IDs:

ARBA 15 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 2 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PROSITE-ProRule 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Sequence Information:

  • Length: 612
  • Mass: 68838
  • Checksum: 1D60077179676927
  • Sequence:
    • MKATWIRLLK RAKGGRLKNS DICGSADSYT SRPSDSDVSL EEDREAVRRE AERQAQAQLE 
KAKTKPVAFA VRTNVSYSAA HEDDVPVPGM AISFEAKDFL HVKEKFNNDW WIGRLVKEGC 
EIGFIPSPVK LENMRLQHEQ RAKQGKFYSS KSGGNSSSSL GDIVPSSRKS TPPSSAIDID 
ATGLDAEEND IPANHRSPKP SANSVTSPHS KEKRMPFFKK TEHTPPYDVV PSMRPVVLVG 
PSLKGYEVTD MMQKALFDFL KHRFEGRISI TRVTADISLA KRSVLNNPSK HAIIERSNTR 
SSLAEVQSEI ERIFELARTL QLVVLDADTI NHPAQLSKTS LAPIIVYVKI SSPKVLQRLI 
KSRGKSQAKH LNVQMVAADK LAQCPPELFD VILDENQLED ACEHLADYLE AYWKATHPPS 
SSLPNPLLSR TLATSSLPLS PTLASNSQGS QGDQRTDRSA PIRSASQAEE EPSVEPVKKS 
QHRSSSSAPH HNHRSGTSRG LSRQETFDSE TQESRDSAYV EPKEDYSHDH VDHYASHRDH 
NHRDETHGSS DHRHRESRHR SRDVDREQDH NECNKQRSRH KSKDRYCEKD GEVISKKRNE 
AGEWNRDVYI RQ

Genular Protein ID: 3242227102

Symbol: A0A494C184_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A494C184

Database IDs:

ARBA 15 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneTree 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 600
  • Mass: 67541
  • Checksum: 142AB87921F82275
  • Sequence:
    • MYYDDDEPSE VGSADSYTSR PSDSDVSLEE DREAVRREAE RQAQAQLEKA KTKPVAFAVR 
TNVSYSAAHE DDVPVPGMAI SFEAKDFLHV KEKFNNDWWI GRLVKEGCEI GFIPSPVKLE 
NMRLQHEQRA KQGKFYSSKS GGNSSSSLGD IVPSSRKSTP PSSAIDIDAT GLDAEENDIP 
ANHRSPKPSA NSVTSPHSKE KRMPFFKKTE HTPPYDVVPS MRPVVLVGPS LKGYEVTDMM 
QKALFDFLKH RFEGRISITR VTADISLAKR SVLNNPSKHA IIERSNTRSS LAEVQSEIER 
IFELARTLQL VVLDADTINH PAQLSKTSLA PIIVYVKISS PKVLQRLIKS RGKSQAKHLN 
VQMVAADKLA QCPPELFDVI LDENQLEDAC EHLADYLEAY WKATHPPSSS LPNPLLSRTL 
ATSSLPLSPT LASNSQGSQG DQRTDRSAPI RSASQAEEEP SVEPVKKSQH RSSSSAPHHN 
HRSGTSRGLS RQETFDSETQ ESRDSAYVEP KEDYSHDHVD HYASHRDHNH RDETHGSSDH 
RHRESRHRSR DVDREQDHNE CNKQRSRHKS KDRYCEKDGE VISKKRNEAG EWNRDVYIRQ

Genular Protein ID: 3999467436

Symbol: Q59H42_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59H42

Database IDs:

ARBA 15 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 616
  • Mass: 69360
  • Checksum: 372E8F373F7015FB
  • Sequence:
    • SHTLTAFCPL FMQCCGLVHR RRVRVSYGSA DSYTSRPSDS DVSLEEDREA VRREAERQAQ 
AQLEKAKTKP VAFAVRTNVS YSAAHEDDVP VPGMAISFEA KDFLHVKEKF NNDWWIGRLV 
KEGCEIGFIP SPVKLENMRL QHEQRAKQGK FYSSKSGGNS SSSLGDIVPS SRKSTPPSSA 
IDIDATGLDA EENDIPANHR SPKPSANSVT SPHSKEKRMP FFKKTEHTPP YDVVPSMRPV 
VLVGPSLKGY EVTDMMQKAL FDFLKHRFEG RISITRVTAD ISLAKRSVLN NPSKHAIIER 
SNTRSSLAEV QSEIERIFEL ARTLQLVVLD ADTINHPAQL SKTSLAPIIV YVKISSPKVL 
QRLIKSRGKS QAKHLNVQMV AADKLAQCPP ELFDVILDEN QLEDACEHLA DYLEAYWKAT 
HPPSSSLPNP LLSRTLATSS LPLSPTLASN SQGSQGDQRT DRSAPIRSAS QAEEEPSVEP 
VKKSQHRSSS SAPHHNHRSG TSRGLSRQET FDSETQESRD SAYVEPKEDY SHDHVDHYAS 
HRDHNHRDET HGSSDHRHRE SRHRSRDVDR EQDHNECNKQ RSRHKSKDRY CEKDGEVISK 
KRNEAGEWNR DVYIRQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.