Details for: CACNB3

Gene ID: 784

Symbol: CACNB3

Ensembl ID: ENSG00000167535

Description: calcium voltage-gated channel auxiliary subunit beta 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 84.0592
    Cell Significance Index: -13.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.3902
    Cell Significance Index: -12.5300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 26.7833
    Cell Significance Index: -12.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.4365
    Cell Significance Index: -10.7400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 26.1198
    Cell Significance Index: -10.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.1863
    Cell Significance Index: -10.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.6208
    Cell Significance Index: -13.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3198
    Cell Significance Index: -13.1000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.3656
    Cell Significance Index: 11.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9199
    Cell Significance Index: 91.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6952
    Cell Significance Index: 31.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6461
    Cell Significance Index: 22.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6012
    Cell Significance Index: 82.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5981
    Cell Significance Index: 540.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5871
    Cell Significance Index: 117.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5461
    Cell Significance Index: 28.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4624
    Cell Significance Index: 75.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4472
    Cell Significance Index: 12.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4365
    Cell Significance Index: 47.4800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4209
    Cell Significance Index: 5.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3698
    Cell Significance Index: 22.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2912
    Cell Significance Index: 6.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2825
    Cell Significance Index: 195.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2784
    Cell Significance Index: 7.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2715
    Cell Significance Index: 51.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2697
    Cell Significance Index: 14.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2589
    Cell Significance Index: 5.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2434
    Cell Significance Index: 6.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2161
    Cell Significance Index: 1.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2160
    Cell Significance Index: 4.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2052
    Cell Significance Index: 14.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1641
    Cell Significance Index: 29.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1570
    Cell Significance Index: 56.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1537
    Cell Significance Index: 9.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1130
    Cell Significance Index: 2.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0978
    Cell Significance Index: 6.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0921
    Cell Significance Index: 2.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0883
    Cell Significance Index: 5.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0742
    Cell Significance Index: 32.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0694
    Cell Significance Index: 37.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0576
    Cell Significance Index: 1.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0494
    Cell Significance Index: 0.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0478
    Cell Significance Index: 1.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0466
    Cell Significance Index: 5.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0455
    Cell Significance Index: 5.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0426
    Cell Significance Index: 0.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0415
    Cell Significance Index: 2.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0301
    Cell Significance Index: 0.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0045
    Cell Significance Index: 0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0053
    Cell Significance Index: -10.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0058
    Cell Significance Index: -0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0059
    Cell Significance Index: -10.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0070
    Cell Significance Index: -0.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0075
    Cell Significance Index: -0.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0075
    Cell Significance Index: -0.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0090
    Cell Significance Index: -13.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0119
    Cell Significance Index: -16.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0141
    Cell Significance Index: -8.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0150
    Cell Significance Index: -11.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0153
    Cell Significance Index: -11.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0172
    Cell Significance Index: -12.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0202
    Cell Significance Index: -0.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0217
    Cell Significance Index: -9.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0232
    Cell Significance Index: -13.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0256
    Cell Significance Index: -5.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0261
    Cell Significance Index: -16.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0304
    Cell Significance Index: -0.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0347
    Cell Significance Index: -4.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0366
    Cell Significance Index: -10.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0367
    Cell Significance Index: -2.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0368
    Cell Significance Index: -4.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0441
    Cell Significance Index: -3.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0536
    Cell Significance Index: -5.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0610
    Cell Significance Index: -8.8600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0633
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0656
    Cell Significance Index: -11.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0688
    Cell Significance Index: -14.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0731
    Cell Significance Index: -5.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0892
    Cell Significance Index: -10.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0921
    Cell Significance Index: -4.3300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1027
    Cell Significance Index: -1.3700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1038
    Cell Significance Index: -1.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1041
    Cell Significance Index: -12.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1214
    Cell Significance Index: -3.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1246
    Cell Significance Index: -12.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1468
    Cell Significance Index: -9.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1588
    Cell Significance Index: -1.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1740
    Cell Significance Index: -13.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1941
    Cell Significance Index: -12.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1943
    Cell Significance Index: -6.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2019
    Cell Significance Index: -6.6100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2199
    Cell Significance Index: -3.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2228
    Cell Significance Index: -3.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2355
    Cell Significance Index: -5.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2400
    Cell Significance Index: -6.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2530
    Cell Significance Index: -2.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2606
    Cell Significance Index: -9.1300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2620
    Cell Significance Index: -5.4400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2621
    Cell Significance Index: -1.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2623
    Cell Significance Index: -2.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Auxiliary Subunit of VGCCs:** CACNB3 is a beta subunit of VGCCs, which are essential for the modulation of calcium influx into cells. The beta subunit influences the biophysical properties of VGCCs, including their voltage dependence, calcium channel density, and interaction with other proteins. 2. **Modulation of Calcium Signaling:** CACNB3 plays a critical role in regulating calcium signaling pathways, which are essential for neuronal excitability, neurotransmitter release, and hormone secretion. 3. **Expression in Neurons and Endocrine Cells:** CACNB3 is expressed in various cell types, including neurons, glial cells, and hormone-producing cells (e.g., granulosa cells, ovarian surface epithelial cells). Its expression patterns suggest a wide range of physiological and pathological roles. 4. **Regulation of Insulin Secretion:** CACNB3 has been implicated in the regulation of insulin secretion, particularly in pancreatic beta cells. **Pathways and Functions:** 1. **Calcium Channel Regulator Activity:** CACNB3 modulates the activity of VGCCs, influencing calcium influx into cells and subsequent signaling pathways. 2. **Neurotransmitter Release and Synaptic Transmission:** CACNB3 is involved in the regulation of neurotransmitter release and synaptic transmission, particularly in the nervous system. 3. **Insulin Secretion and Glucose Metabolism:** CACNB3 regulates insulin secretion and glucose metabolism, highlighting its potential role in the pathogenesis of diabetes and metabolic disorders. 4. **Neuronal Excitability and Development:** CACNB3 influences neuronal excitability and development, particularly in the context of axon guidance and neuronal migration. **Clinical Significance:** 1. **Diabetes and Metabolic Disorders:** Dysregulation of CACNB3 has been implicated in the pathogenesis of diabetes and metabolic disorders, such as insulin resistance and impaired glucose metabolism. 2. **Neurological Disorders:** CACNB3 mutations have been associated with neurological disorders, including epilepsy, migraines, and neuropathic pain. 3. **Cancer and Hormone-Producing Tumors:** CACNB3 has been found to be overexpressed in various types of cancer, including breast, lung, and ovarian cancer. Its role in hormone-producing tumors, such as prostate cancer, is also being investigated. 4. **Therapeutic Applications:** Targeting CACNB3 has been proposed as a potential therapeutic strategy for the treatment of various diseases, including diabetes, neurological disorders, and cancer.

Genular Protein ID: 4212876236

Symbol: CACB3_HUMAN

Name: Voltage-dependent L-type calcium channel subunit beta-3

UniProtKB Accession Codes:

P54284 A8K0Z4 B7Z4Q1 B7Z973 B7ZAK8 F5GZW7 F5H2P6 F8VSG3 Q13913

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 8 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 30 EMBL 12 EMDB 16 Ensembl 4 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PIR 3 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7557998

Title: The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes.

PubMed ID: 7557998

DOI: 10.1006/geno.1995.1048

PubMed ID: 8119293

Title: Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit.

PubMed ID: 8119293

DOI: 10.1111/j.1432-1033.1994.tb18621.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12181424

Title: Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.

PubMed ID: 12181424

DOI: 10.1124/mol.62.3.485

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 29742403

Title: Alternative Splicing at N Terminus and Domain I Modulates CaV1.2 Inactivation and Surface Expression.

PubMed ID: 29742403

DOI: 10.1016/j.bpj.2018.03.029

PubMed ID: 34234349

Title: Structure of human Cav2.2 channel blocked by the painkiller ziconotide.

PubMed ID: 34234349

DOI: 10.1038/s41586-021-03699-6

Sequence Information:

  • Length: 484
  • Mass: 54532
  • Checksum: 19CD3549F5A8E17A
  • Sequence:
    • MYDDSYVPGF EDSEAGSADS YTSRPSLDSD VSLEEDRESA RREVESQAQQ QLERAKHKPV 
AFAVRTNVSY CGVLDEECPV QGSGVNFEAK DFLHIKEKYS NDWWIGRLVK EGGDIAFIPS 
PQRLESIRLK QEQKARRSGN PSSLSDIGNR RSPPPSLAKQ KQKQAEHVPP YDVVPSMRPV 
VLVGPSLKGY EVTDMMQKAL FDFLKHRFDG RISITRVTAD LSLAKRSVLN NPGKRTIIER 
SSARSSIAEV QSEIERIFEL AKSLQLVVLD ADTINHPAQL AKTSLAPIIV FVKVSSPKVL 
QRLIRSRGKS QMKHLTVQMM AYDKLVQCPP ESFDVILDEN QLEDACEHLA EYLEVYWRAT 
HHPAPGPGLL GPPSAIPGLQ NQQLLGERGE EHSPLERDSL MPSDEASESS RQAWTGSSQR 
SSRHLEEDYA DAYQDLYQPH RQHTSGLPSA NGHDPQDRLL AQDSEHNHSD RNWQRNRPWP 
KDSY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.