Details for: CACNB3

Gene ID: 784

Symbol: CACNB3

Ensembl ID: ENSG00000167535

Description: calcium voltage-gated channel auxiliary subunit beta 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.59
    Marker Score: 4338
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.15
    Marker Score: 2344
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.1
    Marker Score: 1230
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.01
    Marker Score: 10120
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71804
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48028
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.97
    Marker Score: 1694
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.96
    Marker Score: 324
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.96
    Marker Score: 1023
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5138
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.88
    Marker Score: 9071
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5277
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.79
    Marker Score: 48602
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.79
    Marker Score: 12307
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.77
    Marker Score: 3318
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1249
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3112.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.74
    Marker Score: 1137
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.73
    Marker Score: 1725
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 555
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 290
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.71
    Marker Score: 6777
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.71
    Marker Score: 204
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.71
    Marker Score: 1436
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7
    Marker Score: 7930
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 639
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.68
    Marker Score: 5857
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.66
    Marker Score: 1127
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.66
    Marker Score: 2749
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.66
    Marker Score: 4262
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 430
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.64
    Marker Score: 1337
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.64
    Marker Score: 2594
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.61
    Marker Score: 769.5
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.61
    Marker Score: 364
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.6
    Marker Score: 286
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.57
    Marker Score: 271.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.55
    Marker Score: 592
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 434
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.53
    Marker Score: 328
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.53
    Marker Score: 425
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.52
    Marker Score: 1804
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.51
    Marker Score: 4816
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.51
    Marker Score: 427
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.5
    Marker Score: 701
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.49
    Marker Score: 4300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.48
    Marker Score: 6395
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.46
    Marker Score: 867
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.46
    Marker Score: 432
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 272
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.44
    Marker Score: 5849
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.43
    Marker Score: 212
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.41
    Marker Score: 157
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.41
    Marker Score: 1598
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.4
    Marker Score: 139
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.37
    Marker Score: 7446
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.37
    Marker Score: 3270
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.37
    Marker Score: 198
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.37
    Marker Score: 540
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.36
    Marker Score: 3131
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.36
    Marker Score: 358
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.35
    Marker Score: 462
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.35
    Marker Score: 113
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.35
    Marker Score: 251
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.35
    Marker Score: 68
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.34
    Marker Score: 611
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.34
    Marker Score: 319
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.34
    Marker Score: 640
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.34
    Marker Score: 1761
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.33
    Marker Score: 85
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.33
    Marker Score: 124
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.33
    Marker Score: 776
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.32
    Marker Score: 216
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.32
    Marker Score: 103
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.32
    Marker Score: 277
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.32
    Marker Score: 151
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.32
    Marker Score: 99
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.32
    Marker Score: 174
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 83
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.31
    Marker Score: 3120
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.31
    Marker Score: 118
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.29
    Marker Score: 134
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.29
    Marker Score: 353
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.29
    Marker Score: 68
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.29
    Marker Score: 2207
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.28
    Marker Score: 192
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.28
    Marker Score: 666
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.28
    Marker Score: 2179
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.28
    Marker Score: 268
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.28
    Marker Score: 325
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.28
    Marker Score: 342

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Other Information

**Key characteristics:** - CACB3 is a transmembrane protein with a molecular weight of approximately 150 kDa. - It is expressed in a variety of cell types, including ovarian surface epithelial cells, GABAergic amacrine cells, peripheral nervous system neurons, and brain cells. - It is a key regulator of insulin secretion, and its expression is upregulated in cells that secrete insulin. - It is also involved in axon guidance, calcium channel regulation, and other cellular processes. **Pathways and functions:** - CACB3 is involved in regulating insulin secretion by interacting with the insulin receptor. - It is also involved in axon guidance by interacting with the axonal guidance molecule Ncam1. - It is involved in calcium channel regulation by interacting with the calcium channel opener Ncam1. - It is involved in other cellular processes, such as developmental biology, metabolism, and neuronal development. **Clinical significance:** - Mutations in the CACB3 gene have been linked to a number of human diseases, including diabetes, obesity, and cardiovascular disease. - Targeting CACB3 has been investigated as a therapeutic strategy for these diseases. - The development of drugs that target CACB3 is an active area of research.

Genular Protein ID: 4212876236

Symbol: CACB3_HUMAN

Name: Voltage-dependent L-type calcium channel subunit beta-3

UniProtKB Accession Codes:

P54284 A8K0Z4 B7Z4Q1 B7Z973 B7ZAK8 F5GZW7 F5H2P6 F8VSG3 Q13913

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 30 EMBL 12 EMDB 8 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 8 PIR 3 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7557998

Title: The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes.

PubMed ID: 7557998

DOI: 10.1006/geno.1995.1048

PubMed ID: 8119293

Title: Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit.

PubMed ID: 8119293

DOI: 10.1111/j.1432-1033.1994.tb18621.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12181424

Title: Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.

PubMed ID: 12181424

DOI: 10.1124/mol.62.3.485

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 29742403

Title: Alternative Splicing at N Terminus and Domain I Modulates CaV1.2 Inactivation and Surface Expression.

PubMed ID: 29742403

DOI: 10.1016/j.bpj.2018.03.029

PubMed ID: 34234349

Title: Structure of human Cav2.2 channel blocked by the painkiller ziconotide.

PubMed ID: 34234349

DOI: 10.1038/s41586-021-03699-6

Sequence Information:

  • Length: 484
  • Mass: 54532
  • Checksum: 19CD3549F5A8E17A
  • Sequence:
    • MYDDSYVPGF EDSEAGSADS YTSRPSLDSD VSLEEDRESA RREVESQAQQ QLERAKHKPV 
AFAVRTNVSY CGVLDEECPV QGSGVNFEAK DFLHIKEKYS NDWWIGRLVK EGGDIAFIPS 
PQRLESIRLK QEQKARRSGN PSSLSDIGNR RSPPPSLAKQ KQKQAEHVPP YDVVPSMRPV 
VLVGPSLKGY EVTDMMQKAL FDFLKHRFDG RISITRVTAD LSLAKRSVLN NPGKRTIIER 
SSARSSIAEV QSEIERIFEL AKSLQLVVLD ADTINHPAQL AKTSLAPIIV FVKVSSPKVL 
QRLIRSRGKS QMKHLTVQMM AYDKLVQCPP ESFDVILDEN QLEDACEHLA EYLEVYWRAT 
HHPAPGPGLL GPPSAIPGLQ NQQLLGERGE EHSPLERDSL MPSDEASESS RQAWTGSSQR 
SSRHLEEDYA DAYQDLYQPH RQHTSGLPSA NGHDPQDRLL AQDSEHNHSD RNWQRNRPWP 
KDSY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.