Details for: CACNG1

Gene ID: 786

Symbol: CACNG1

Ensembl ID: ENSG00000108878

Description: calcium voltage-gated channel auxiliary subunit gamma 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 3.4422
    Cell Significance Index: 55.5400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.0857
    Cell Significance Index: 50.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.8958
    Cell Significance Index: 48.7300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.5233
    Cell Significance Index: 8.9500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.5030
    Cell Significance Index: 4.0200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3090
    Cell Significance Index: 4.4300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.1214
    Cell Significance Index: 1.5900
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: 0.0627
    Cell Significance Index: 0.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0608
    Cell Significance Index: 1.6300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0241
    Cell Significance Index: 0.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0138
    Cell Significance Index: 4.9500
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.0031
    Cell Significance Index: 0.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0020
    Cell Significance Index: 0.0900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0012
    Cell Significance Index: 0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0008
    Cell Significance Index: 0.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0008
    Cell Significance Index: -0.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0010
    Cell Significance Index: -1.4000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0021
    Cell Significance Index: -1.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0022
    Cell Significance Index: -1.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0029
    Cell Significance Index: -1.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0030
    Cell Significance Index: -0.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0030
    Cell Significance Index: -0.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0058
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0065
    Cell Significance Index: -1.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0073
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0080
    Cell Significance Index: -1.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0086
    Cell Significance Index: -1.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0087
    Cell Significance Index: -0.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0090
    Cell Significance Index: -0.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0094
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0095
    Cell Significance Index: -1.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0101
    Cell Significance Index: -1.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0117
    Cell Significance Index: -0.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0129
    Cell Significance Index: -1.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0141
    Cell Significance Index: -0.7900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0153
    Cell Significance Index: -0.3900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0179
    Cell Significance Index: -0.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0187
    Cell Significance Index: -1.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0217
    Cell Significance Index: -1.0200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0231
    Cell Significance Index: -0.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0239
    Cell Significance Index: -0.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0240
    Cell Significance Index: -1.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0263
    Cell Significance Index: -1.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0268
    Cell Significance Index: -0.6500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0273
    Cell Significance Index: -0.3500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0296
    Cell Significance Index: -0.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0297
    Cell Significance Index: -1.0400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0305
    Cell Significance Index: -0.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0306
    Cell Significance Index: -0.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0325
    Cell Significance Index: -0.7800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0328
    Cell Significance Index: -0.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0342
    Cell Significance Index: -1.1200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0349
    Cell Significance Index: -0.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0356
    Cell Significance Index: -0.9700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0364
    Cell Significance Index: -0.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0371
    Cell Significance Index: -1.1800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0376
    Cell Significance Index: -1.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0382
    Cell Significance Index: -1.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0401
    Cell Significance Index: -1.0700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0403
    Cell Significance Index: -1.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0413
    Cell Significance Index: -0.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0421
    Cell Significance Index: -0.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0433
    Cell Significance Index: -1.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0454
    Cell Significance Index: -1.3000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0460
    Cell Significance Index: -1.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0481
    Cell Significance Index: -0.8100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0484
    Cell Significance Index: -1.0100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0485
    Cell Significance Index: -0.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0488
    Cell Significance Index: -0.7200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0489
    Cell Significance Index: -1.2200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0495
    Cell Significance Index: -0.6500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0533
    Cell Significance Index: -1.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0540
    Cell Significance Index: -1.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0540
    Cell Significance Index: -1.5100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0551
    Cell Significance Index: -0.7200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0560
    Cell Significance Index: -0.5800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0584
    Cell Significance Index: -1.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0594
    Cell Significance Index: -0.8100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0598
    Cell Significance Index: -1.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0600
    Cell Significance Index: -1.5000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0606
    Cell Significance Index: -0.8400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0611
    Cell Significance Index: -0.8900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0616
    Cell Significance Index: -0.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0617
    Cell Significance Index: -1.2800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0626
    Cell Significance Index: -0.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0645
    Cell Significance Index: -1.4900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0654
    Cell Significance Index: -0.6200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0654
    Cell Significance Index: -1.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0657
    Cell Significance Index: -2.6900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0680
    Cell Significance Index: -0.7100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0689
    Cell Significance Index: -0.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CACNG1 is a member of the auxiliary subunit family of voltage-gated calcium channels, which are crucial for regulating calcium ion influx into cells. The gamma 1 subunit, encoded by CACNG1, is specifically associated with L-type voltage-gated calcium channels, which are involved in the regulation of muscle contraction, cell signaling, and neurotransmission. The gamma 1 subunit enhances the activity of the high voltage-gated calcium channel complex, thereby modulating calcium ion transmembrane transport. **Pathways and Functions:** The CACNG1 gene is involved in several key pathways, including: 1. **Calcium ion transmembrane transport**: CACNG1 regulates the influx of calcium ions into cells, which is essential for muscle contraction, neuronal signaling, and cell proliferation. 2. **Muscle contraction**: The gamma 1 subunit is specifically associated with L-type voltage-gated calcium channels, which are responsible for regulating muscle contraction in skeletal and cardiac muscles. 3. **Cell signaling**: CACNG1 modulates calcium-dependent signaling pathways, including those involved in neuronal excitability, cell growth, and differentiation. 4. **Neurotransmission**: The gamma 1 subunit is expressed in neurons, where it regulates calcium-dependent neurotransmitter release and synaptic plasticity. **Clinical Significance:** Dysregulation of CACNG1 has been implicated in various diseases, including: 1. **Muscular dystrophy**: Mutations in the CACNG1 gene have been associated with certain forms of muscular dystrophy, highlighting the importance of calcium ion regulation in muscle function. 2. **Cardiac arrhythmias**: Abnormalities in L-type voltage-gated calcium channels, which are regulated by CACNG1, have been linked to cardiac arrhythmias and other cardiovascular disorders. 3. **Neurological disorders**: CACNG1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where calcium ion dysregulation is thought to contribute to disease pathology. In conclusion, the CACNG1 gene plays a critical role in regulating calcium ion transmembrane transport, muscle contraction, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and physiological function. Further research into the mechanisms of CACNG1 function and its role in disease will provide valuable insights into the development of novel therapeutic strategies.

Genular Protein ID: 3821115444

Symbol: CCG1_HUMAN

Name: Voltage-dependent calcium channel gamma-1 subunit

UniProtKB Accession Codes:

Q06432 B2R9N3 Q14D59

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ComplexPortal 16 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 12 DrugCentral 1 EMBL 8 Ensembl 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8387489

Title: Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location.

PubMed ID: 8387489

DOI: 10.1016/s0021-9258(18)98346-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8404045

Title: Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene (CACNLG) to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus.

PubMed ID: 8404045

DOI: 10.1159/000133583

Sequence Information:

  • Length: 222
  • Mass: 25028
  • Checksum: EFEC34266CFC47CB
  • Sequence:
    • MSQTKMLKVR VTLFCILAGI VLAMTAVVTD HWAVLSPHME HHNTTCEAAH FGLWRICTKR 
IPMDDSKTCG PITLPGEKNC SYFRHFNPGE SSEIFEFTTQ KEYSISAAAI AIFSLGFIIL 
GSLCVLLSLG KKRDYLLRPA SMFYAFAGLC ILVSVEVMRQ SVKRMIDSED TVWIEYYYSW 
SFACACAAFI LLFLGGLALL LFSLPRMPRN PWESCMDAEP EH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.