Details for: SLC25A20

Gene ID: 788

Symbol: SLC25A20

Ensembl ID: ENSG00000178537

Description: solute carrier family 25 member 20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 57.6038
    Cell Significance Index: -8.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.1424
    Cell Significance Index: -8.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.3288
    Cell Significance Index: -10.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 23.2355
    Cell Significance Index: -10.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.1998
    Cell Significance Index: -10.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0705
    Cell Significance Index: -6.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.9975
    Cell Significance Index: -8.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.8032
    Cell Significance Index: -8.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6457
    Cell Significance Index: -10.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6743
    Cell Significance Index: 272.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.6173
    Cell Significance Index: 43.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1413
    Cell Significance Index: 68.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1260
    Cell Significance Index: 122.4800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0593
    Cell Significance Index: 31.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0160
    Cell Significance Index: 917.3500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9984
    Cell Significance Index: 21.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8583
    Cell Significance Index: 65.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6309
    Cell Significance Index: 43.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5990
    Cell Significance Index: 9.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5774
    Cell Significance Index: 16.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5670
    Cell Significance Index: 392.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4853
    Cell Significance Index: 96.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3877
    Cell Significance Index: 8.4000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3832
    Cell Significance Index: 6.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2571
    Cell Significance Index: 48.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2536
    Cell Significance Index: 6.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2475
    Cell Significance Index: 11.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2159
    Cell Significance Index: 5.5500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1917
    Cell Significance Index: 2.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1765
    Cell Significance Index: 3.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1759
    Cell Significance Index: 20.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1538
    Cell Significance Index: 15.2100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1467
    Cell Significance Index: 3.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1069
    Cell Significance Index: 12.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0961
    Cell Significance Index: 19.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0871
    Cell Significance Index: 4.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0569
    Cell Significance Index: 7.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0536
    Cell Significance Index: 3.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0472
    Cell Significance Index: 20.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0353
    Cell Significance Index: 6.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0353
    Cell Significance Index: 0.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0348
    Cell Significance Index: 12.5000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0207
    Cell Significance Index: 0.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0204
    Cell Significance Index: 11.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0128
    Cell Significance Index: 0.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0095
    Cell Significance Index: 0.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0082
    Cell Significance Index: 0.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0074
    Cell Significance Index: 0.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0061
    Cell Significance Index: 11.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0035
    Cell Significance Index: 0.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0018
    Cell Significance Index: 0.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0040
    Cell Significance Index: -5.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0044
    Cell Significance Index: -2.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0057
    Cell Significance Index: -4.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0084
    Cell Significance Index: -6.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0112
    Cell Significance Index: -8.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0120
    Cell Significance Index: -5.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0155
    Cell Significance Index: -8.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0186
    Cell Significance Index: -11.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0219
    Cell Significance Index: -2.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0277
    Cell Significance Index: -1.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0294
    Cell Significance Index: -8.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0302
    Cell Significance Index: -1.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0331
    Cell Significance Index: -1.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0350
    Cell Significance Index: -5.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0388
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0410
    Cell Significance Index: -4.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0499
    Cell Significance Index: -6.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0562
    Cell Significance Index: -11.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0685
    Cell Significance Index: -3.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0709
    Cell Significance Index: -4.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0729
    Cell Significance Index: -1.2500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0810
    Cell Significance Index: -1.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0871
    Cell Significance Index: -2.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0872
    Cell Significance Index: -6.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0891
    Cell Significance Index: -9.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1154
    Cell Significance Index: -7.0800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1177
    Cell Significance Index: -0.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1192
    Cell Significance Index: -6.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1209
    Cell Significance Index: -6.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1260
    Cell Significance Index: -5.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1317
    Cell Significance Index: -10.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1428
    Cell Significance Index: -8.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1493
    Cell Significance Index: -2.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1539
    Cell Significance Index: -10.3500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1611
    Cell Significance Index: -2.7100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1809
    Cell Significance Index: -2.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1817
    Cell Significance Index: -9.5400
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.1884
    Cell Significance Index: -0.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2027
    Cell Significance Index: -5.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2103
    Cell Significance Index: -9.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2159
    Cell Significance Index: -2.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2238
    Cell Significance Index: -4.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2355
    Cell Significance Index: -8.2500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2363
    Cell Significance Index: -3.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2384
    Cell Significance Index: -6.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2461
    Cell Significance Index: -9.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2482
    Cell Significance Index: -9.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Carnitine Shuttle System:** SLC25A20 is a key player in the carnitine shuttle system, which facilitates the transport of long-chain fatty acids into mitochondria for beta-oxidation. This process is essential for energy production and lipid metabolism. 2. **Mitochondrial Transport:** The gene is responsible for transporting carnitine across the mitochondrial inner membrane, enabling the uptake of fatty acids by the mitochondria. 3. **Expression in Various Cell Types:** SLC25A20 is expressed in a wide range of cell types, including cardiac myocytes, hepatocytes, and neural cells, highlighting its importance in various physiological processes. 4. **Protein Binding:** The gene product, MCAT_HUMAN, exhibits high affinity for carnitine, facilitating its transport across cell membranes. **Pathways and Functions:** 1. **Acyl Carnitine Transmembrane Transport:** SLC25A20 mediates the transport of acyl carnitine across the mitochondrial inner membrane, a critical step in fatty acid metabolism. 2. **Carnitine Metabolism:** The gene plays a central role in the regulation of carnitine levels, which is essential for maintaining energy homeostasis and lipid metabolism. 3. **Fatty Acid Metabolism:** SLC25A20 is involved in the transport of long-chain fatty acids into mitochondria, where they are oxidized to produce energy. 4. **Mitochondrial Function:** The gene contributes to the maintenance of mitochondrial function, particularly in the context of energy metabolism and lipid synthesis. **Clinical Significance:** 1. **Cardiovascular Disease:** Alterations in SLC25A20 expression have been linked to cardiovascular disease, highlighting the gene's importance in heart health. 2. **Neurological Disorders:** The gene's involvement in neurological disorders, such as epilepsy and cognitive dysfunction, underscores its role in brain development and function. 3. **Cancer:** SLC25A20 has been implicated in cancer development, particularly in the context of fatty acid metabolism and energy homeostasis. 4. **Embryonic Development:** The gene's role in embryonic development highlights its importance in early life stages and its potential as a therapeutic target for developmental disorders. In conclusion, the SLC25A20 gene is a crucial component of the carnitine shuttle system, playing a pivotal role in fatty acid metabolism and mitochondrial function. Its expression in various cell types and its involvement in multiple physiological processes underscore its importance in human health and disease. Further research is needed to fully elucidate the gene's mechanisms and its potential as a therapeutic target for various diseases.

Genular Protein ID: 229073912

Symbol: MCAT_HUMAN

Name: Solute carrier family 25 member 20

UniProtKB Accession Codes:

O43772 B2R7F4 Q9UIQ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9399886

Title: Cloning of the human carnitine-acylcarnitine carrier cDNA and identification of the molecular defect in a patient.

PubMed ID: 9399886

DOI: 10.1086/301628

PubMed ID: 9837782

Title: The structure and organization of the human carnitine/acylcarnitine translocase (CACT) gene.

PubMed ID: 9837782

DOI: 10.1006/bbrc.1998.9738

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12892634

Title: Functional analysis of mutations in the human carnitine/acylcarnitine translocase in Aspergillus nidulans.

PubMed ID: 12892634

DOI: 10.1016/s1087-1845(03)00049-5

PubMed ID: 18307102

Title: Functional characterization of residues within the carnitine/acylcarnitine translocase RX2PANAAXF distinct motif.

PubMed ID: 18307102

DOI: 10.1080/09687680701697476

PubMed ID: 20347717

Title: Site-directed mutagenesis of charged amino acids of the human mitochondrial carnitine/acylcarnitine carrier: insight into the molecular mechanism of transport.

PubMed ID: 20347717

DOI: 10.1016/j.bbabio.2010.03.017

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 12859414

Title: A novel molecular defect of the carnitine acylcarnitine translocase gene in a Saudi patient.

PubMed ID: 12859414

DOI: 10.1034/j.1399-0004.2003.00117.x

PubMed ID: 15057979

Title: Response to therapy in carnitine/acylcarnitine translocase (CACT) deficiency due to a novel missense mutation.

PubMed ID: 15057979

DOI: 10.1002/ajmg.a.20573

PubMed ID: 15365988

Title: Molecular and functional analysis of SLC25A20 mutations causing carnitine-acylcarnitine translocase deficiency.

PubMed ID: 15365988

DOI: 10.1002/humu.20085

Sequence Information:

  • Length: 301
  • Mass: 32944
  • Checksum: AEB34E4E335102B0
  • Sequence:
    • MADQPKPISP LKNLLAGGFG GVCLVFVGHP LDTVKVRLQT QPPSLPGQPP MYSGTFDCFR 
KTLFREGITG LYRGMAAPII GVTPMFAVCF FGFGLGKKLQ QKHPEDVLSY PQLFAAGMLS 
GVFTTGIMTP GERIKCLLQI QASSGESKYT GTLDCAKKLY QEFGIRGIYK GTVLTLMRDV 
PASGMYFMTY EWLKNIFTPE GKRVSELSAP RILVAGGIAG IFNWAVAIPP DVLKSRFQTA 
PPGKYPNGFR DVLRELIRDE GVTSLYKGFN AVMIRAFPAN AACFLGFEVA MKFLNWATPN 
L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.