Details for: CALB1

Gene ID: 793

Symbol: CALB1

Ensembl ID: ENSG00000104327

Description: calbindin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 16.0799
    Cell Significance Index: 61.5700
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 14.7860
    Cell Significance Index: 50.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.7397
    Cell Significance Index: 125.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.1453
    Cell Significance Index: 165.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.1732
    Cell Significance Index: 96.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.7981
    Cell Significance Index: 68.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0868
    Cell Significance Index: 73.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9367
    Cell Significance Index: 511.5500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8279
    Cell Significance Index: 20.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0902
    Cell Significance Index: 18.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0416
    Cell Significance Index: 2.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0156
    Cell Significance Index: 10.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0008
    Cell Significance Index: -0.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0016
    Cell Significance Index: -1.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0030
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0038
    Cell Significance Index: -7.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0041
    Cell Significance Index: -6.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0047
    Cell Significance Index: -8.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -3.9800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0074
    Cell Significance Index: -0.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0080
    Cell Significance Index: -1.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0091
    Cell Significance Index: -5.1300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0097
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0113
    Cell Significance Index: -2.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0123
    Cell Significance Index: -4.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0158
    Cell Significance Index: -10.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0178
    Cell Significance Index: -3.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0219
    Cell Significance Index: -6.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0237
    Cell Significance Index: -10.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0418
    Cell Significance Index: -4.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0496
    Cell Significance Index: -8.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0546
    Cell Significance Index: -6.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0559
    Cell Significance Index: -11.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0646
    Cell Significance Index: -0.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0661
    Cell Significance Index: -9.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0662
    Cell Significance Index: -9.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0678
    Cell Significance Index: -7.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0691
    Cell Significance Index: -0.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0695
    Cell Significance Index: -8.5400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0797
    Cell Significance Index: -2.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0855
    Cell Significance Index: -2.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0898
    Cell Significance Index: -10.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1011
    Cell Significance Index: -10.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1015
    Cell Significance Index: -10.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1022
    Cell Significance Index: -7.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1045
    Cell Significance Index: -1.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1114
    Cell Significance Index: -2.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1191
    Cell Significance Index: -9.4400
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.1238
    Cell Significance Index: -1.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1239
    Cell Significance Index: -3.1900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1260
    Cell Significance Index: -1.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1336
    Cell Significance Index: -8.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1404
    Cell Significance Index: -7.8800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1414
    Cell Significance Index: -1.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1461
    Cell Significance Index: -3.1000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1582
    Cell Significance Index: -2.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1608
    Cell Significance Index: -6.5900
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.1791
    Cell Significance Index: -1.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1861
    Cell Significance Index: -4.0200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1880
    Cell Significance Index: -4.0200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1911
    Cell Significance Index: -2.3700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1918
    Cell Significance Index: -2.2300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1943
    Cell Significance Index: -2.5900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1945
    Cell Significance Index: -4.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1986
    Cell Significance Index: -5.8500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1990
    Cell Significance Index: -3.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2016
    Cell Significance Index: -4.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2116
    Cell Significance Index: -9.5900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2155
    Cell Significance Index: -2.0500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2190
    Cell Significance Index: -6.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2233
    Cell Significance Index: -11.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2260
    Cell Significance Index: -10.6200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2293
    Cell Significance Index: -2.8800
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.2329
    Cell Significance Index: -2.4700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2446
    Cell Significance Index: -3.3500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2501
    Cell Significance Index: -7.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2507
    Cell Significance Index: -11.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2521
    Cell Significance Index: -8.8300
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.2699
    Cell Significance Index: -2.4600
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2764
    Cell Significance Index: -2.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2846
    Cell Significance Index: -9.8900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2880
    Cell Significance Index: -3.3600
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.2938
    Cell Significance Index: -3.4000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2967
    Cell Significance Index: -4.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2969
    Cell Significance Index: -9.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2989
    Cell Significance Index: -9.5200
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.3024
    Cell Significance Index: -3.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3039
    Cell Significance Index: -10.6800
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.3076
    Cell Significance Index: -3.3600
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.3236
    Cell Significance Index: -3.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3261
    Cell Significance Index: -9.4000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.3284
    Cell Significance Index: -4.1000
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.3287
    Cell Significance Index: -3.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3296
    Cell Significance Index: -12.1000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3336
    Cell Significance Index: -4.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3436
    Cell Significance Index: -5.7500
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.3535
    Cell Significance Index: -3.4600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3586
    Cell Significance Index: -2.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3616
    Cell Significance Index: -10.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CALB1 is a calcium-binding protein that belongs to the calreticulin family. Its molecular structure consists of a calcium-binding domain, which is essential for its function. CALB1 is highly expressed in the kidney, where it regulates calcium ion transport and homeostasis. In the nervous system, CALB1 is involved in the regulation of synaptic transmission and plasticity. Its expression is also significant in immune cells, where it modulates immune responses and inflammation. **Pathways and Functions** CALB1 is involved in various signaling pathways, including: 1. **Calcium ion binding**: CALB1 binds to calcium ions, regulating their concentration in the cytosol and influencing cellular processes such as muscle contraction, neurotransmitter release, and protein folding. 2. **Regulation of postsynaptic and presynaptic cytosolic calcium ion concentration**: CALB1 modulates calcium ion concentration in the postsynaptic and presynaptic compartments, influencing synaptic transmission and plasticity. 3. **Protein binding**: CALB1 interacts with various proteins, including calcium channels, pumps, and receptors, to regulate their activity and function. 4. **Regulation of long-term synaptic potentiation**: CALB1 is involved in the regulation of long-term synaptic potentiation, a process that underlies learning and memory. **Clinical Significance** CALB1 has significant implications in various clinical conditions, including: 1. **Kidney disease**: Alterations in CALB1 expression are associated with kidney disease, including chronic kidney disease and kidney failure. 2. **Neurological disorders**: CALB1 is implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Immune system disorders**: CALB1 plays a crucial role in immune system disorders, including autoimmune diseases and inflammatory conditions. 4. **Cancer**: CALB1 is overexpressed in certain types of cancer, including breast cancer and lung cancer. In conclusion, CALB1 is a multifunctional protein that plays a critical role in various physiological and pathological processes. Its expression and function are influenced by various factors, including calcium and vitamin D. Understanding the molecular mechanisms and clinical implications of CALB1 is essential for developing novel therapeutic strategies for various diseases. **Recommendations for Future Research** 1. Investigate the role of CALB1 in kidney disease and its potential as a biomarker for kidney function. 2. Explore the relationship between CALB1 expression and neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. Investigate the potential of CALB1 as a therapeutic target for immune system disorders and cancer. 4. Elucidate the molecular mechanisms underlying CALB1's role in regulating calcium ion concentration and synaptic transmission. By further exploring the molecular mechanisms and clinical significance of CALB1, we can uncover new insights into the regulation of calcium ion homeostasis, synaptic transmission, and immune system function, ultimately leading to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 3024895088

Symbol: CALB1_HUMAN

Name: Calbindin

UniProtKB Accession Codes:

P05937 B2R696 B7Z9J4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 19 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 14 Ensembl 2 ExpressionAtlas 1 GO 34 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SASBDB 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3691519

Title: Human 27-kDa calbindin complementary DNA sequence. Evolutionary and functional implications.

PubMed ID: 3691519

DOI: 10.1111/j.1432-1033.1987.tb13688.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2565876

Title: The human calbindin 27-kDa gene: structural organization of the 5' and 3' regions, chromosomal assignment, and restriction fragment length polymorphism.

PubMed ID: 2565876

DOI: 10.1016/0888-7543(89)90335-2

PubMed ID: 12684061

Title: Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy.

PubMed ID: 12684061

DOI: 10.1016/s0006-291x(03)00499-6

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 30289411

Title: The X-ray structure of human calbindin-D28K: an improved model.

PubMed ID: 30289411

DOI: 10.1107/s2059798318011610

Sequence Information:

  • Length: 261
  • Mass: 30025
  • Checksum: 8ED7A09BCC5FE5E4
  • Sequence:
    • MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA GLELSPEMKT 
FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC EEFMKTWRKY DTDHSGFIET 
EELKNFLKDL LEKANKTVDD TKLAEYTDLM LKLFDSNNDG KLELTEMARL LPVQENFLLK 
FQGIKMCGKE FNKAFELYDQ DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA 
LSDGGKLYRT DLALILCAGD N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.