Details for: CALB2

Gene ID: 794

Symbol: CALB2

Ensembl ID: ENSG00000172137

Description: calbindin 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.79
    Marker Score: 3375
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.41
    Marker Score: 2275
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.32
    Marker Score: 1101
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.31
    Marker Score: 6288
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.22
    Marker Score: 1169
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.14
    Marker Score: 81175
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.9
    Marker Score: 610
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.9
    Marker Score: 3853
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.58
    Marker Score: 12123
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.38
    Marker Score: 5736
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.16
    Marker Score: 465
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7690
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.15
    Marker Score: 284
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.1
    Marker Score: 1188
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.08
    Marker Score: 485
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.07
    Marker Score: 338
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.02
    Marker Score: 4165
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.87
    Marker Score: 8963
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.87
    Marker Score: 663
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.78
    Marker Score: 3027
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.78
    Marker Score: 938
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 504
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.67
    Marker Score: 386
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.65
    Marker Score: 1135
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.64
    Marker Score: 235
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 489
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.57
    Marker Score: 474
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.56
    Marker Score: 5624
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.54
    Marker Score: 225
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.44
    Marker Score: 427
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.41
    Marker Score: 227
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.4
    Marker Score: 232
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.37
    Marker Score: 350
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.35
    Marker Score: 4732
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.35
    Marker Score: 181
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.33
    Marker Score: 2866
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.32
    Marker Score: 78
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.3
    Marker Score: 147
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3
    Marker Score: 683
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.25
    Marker Score: 700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.24
    Marker Score: 698
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.24
    Marker Score: 2069
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.24
    Marker Score: 497
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.23
    Marker Score: 293
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 69
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 137
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.22
    Marker Score: 1458
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.22
    Marker Score: 311
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.21
    Marker Score: 68
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.21
    Marker Score: 359
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.21
    Marker Score: 108
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.2
    Marker Score: 249.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.2
    Marker Score: 70
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.2
    Marker Score: 471
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.2
    Marker Score: 1175
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.19
    Marker Score: 59
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 109
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.16
    Marker Score: 391
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.16
    Marker Score: 74
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.16
    Marker Score: 499
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.15
    Marker Score: 591
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.15
    Marker Score: 947
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.14
    Marker Score: 79
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.13
    Marker Score: 244
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.13
    Marker Score: 115
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.13
    Marker Score: 1024
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.13
    Marker Score: 133
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.13
    Marker Score: 121
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.12
    Marker Score: 46
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 138
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.12
    Marker Score: 25
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.12
    Marker Score: 47
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.11
    Marker Score: 44
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.11
    Marker Score: 1596
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1
    Marker Score: 52

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Other Information

**Key characteristics:** - Type: Membrane protein - Ensembl ID: ENSG00000172137 - Protein length: 124 amino acids - Subcellular location: Cytosol - Cellular function: Calcium-binding, regulation of presynaptic cytosolic calcium ion concentration, synaptic transmission **Pathways and functions:** - Calcium ion binding: CALB2 is a calcium-binding protein that is primarily expressed in neurons and oligodendrocytes. It is a key regulator of presynaptic calcium signaling, which is essential for synaptic transmission. - Regulation of presynaptic cytosolic calcium ion concentration: CALB2 helps to maintain a relatively low concentration of calcium ions in the presynaptic terminal, which is important for the proper functioning of neurotransmitter release. - Synapse: CALB2 is expressed in the presynaptic terminal of neurons and is a key regulator of presynaptic calcium signaling. It helps to ensure that neurotransmitter release is triggered when the presynaptic terminal is stimulated. - Long-term synaptic potentiation: CALB2 is involved in the regulation of long-term synaptic potentiation (LTP), a form of synaptic plasticity that is essential for learning and memory. - Synaptic transmission: CALB2 is also involved in synaptic transmission, where it helps to regulate the release of neurotransmitters from the presynaptic terminal. **Clinical significance:** Mutations in CALB2 have been linked to a number of neurological disorders, including epilepsy, schizophrenia, and autism. These disorders are characterized by abnormal calcium signaling, which is thought to be caused by mutations in genes that regulate calcium ion concentration and signaling.

Genular Protein ID: 4139275331

Symbol: CALB2_HUMAN

Name: Calretinin

UniProtKB Accession Codes:

P22676 A8K4Y1 Q53HD2 Q96BK4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 25 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2618861

Title: The human calbindins: cDNA and gene cloning.

PubMed ID: 2618861

DOI: 10.1007/978-1-4684-5679-0_25

PubMed ID: 2001709

Title: Structure of the human brain calcium-binding protein calretinin and its expression in bacteria.

PubMed ID: 2001709

DOI: 10.1111/j.1432-1033.1991.tb15788.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 271
  • Mass: 31540
  • Checksum: 98116AD706079DB9
  • Sequence:
    • MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK 
SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSSA EFMEAWRKYD 
TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL 
PVQENFLLKF QGMKLTSEEF NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL 
TNYRKSVMSL AEAGKLYRKD LEIVLCSEPP M

Genular Protein ID: 877355345

Symbol: A6NER6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6NER6

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 5 EPD 1 Ensembl 4 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 Pfam 1 PharmGKB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 192
  • Mass: 22155
  • Checksum: 7A69EA37E7D3D246
  • Sequence:
    • MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK 
SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSSA EFMEAWRKYD 
TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRIE 
AATLTSMSWM PF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.