Details for: CALB2

Gene ID: 794

Symbol: CALB2

Ensembl ID: ENSG00000172137

Description: calbindin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 13.9775
    Cell Significance Index: 67.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 8.5641
    Cell Significance Index: 449.6500
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.2039
    Cell Significance Index: 11.0000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.8815
    Cell Significance Index: 20.5800
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.9953
    Cell Significance Index: 4.2800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.8238
    Cell Significance Index: 9.2100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7730
    Cell Significance Index: 18.7300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5692
    Cell Significance Index: 7.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4139
    Cell Significance Index: 148.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3886
    Cell Significance Index: 18.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3666
    Cell Significance Index: 253.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2883
    Cell Significance Index: 4.4600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.2236
    Cell Significance Index: 4.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1089
    Cell Significance Index: 14.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1027
    Cell Significance Index: 2.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0082
    Cell Significance Index: -15.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0120
    Cell Significance Index: -22.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0141
    Cell Significance Index: -21.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0166
    Cell Significance Index: -22.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0179
    Cell Significance Index: -13.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0190
    Cell Significance Index: -14.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0213
    Cell Significance Index: -12.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0216
    Cell Significance Index: -0.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0217
    Cell Significance Index: -13.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0217
    Cell Significance Index: -4.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0219
    Cell Significance Index: -9.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0282
    Cell Significance Index: -15.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0291
    Cell Significance Index: -4.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0316
    Cell Significance Index: -3.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0355
    Cell Significance Index: -16.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0371
    Cell Significance Index: -10.6800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0545
    Cell Significance Index: -0.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0610
    Cell Significance Index: -2.8700
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.0712
    Cell Significance Index: -0.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0739
    Cell Significance Index: -13.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0791
    Cell Significance Index: -15.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0794
    Cell Significance Index: -16.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0942
    Cell Significance Index: -13.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1121
    Cell Significance Index: -13.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1248
    Cell Significance Index: -21.3100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1267
    Cell Significance Index: -1.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1346
    Cell Significance Index: -13.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1547
    Cell Significance Index: -16.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1555
    Cell Significance Index: -6.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1617
    Cell Significance Index: -18.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1726
    Cell Significance Index: -10.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1742
    Cell Significance Index: -12.9800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1873
    Cell Significance Index: -1.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1875
    Cell Significance Index: -8.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2198
    Cell Significance Index: -16.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2257
    Cell Significance Index: -12.6700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2378
    Cell Significance Index: -4.6800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2395
    Cell Significance Index: -2.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2491
    Cell Significance Index: -15.2700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2726
    Cell Significance Index: -2.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2804
    Cell Significance Index: -14.5700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2805
    Cell Significance Index: -3.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3005
    Cell Significance Index: -6.5800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3141
    Cell Significance Index: -5.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3180
    Cell Significance Index: -10.4100
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.3209
    Cell Significance Index: -3.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3588
    Cell Significance Index: -12.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3597
    Cell Significance Index: -15.9100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3621
    Cell Significance Index: -4.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3806
    Cell Significance Index: -13.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4032
    Cell Significance Index: -12.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4204
    Cell Significance Index: -14.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4208
    Cell Significance Index: -10.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4217
    Cell Significance Index: -15.9700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4343
    Cell Significance Index: -8.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4411
    Cell Significance Index: -15.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4421
    Cell Significance Index: -22.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4570
    Cell Significance Index: -12.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4685
    Cell Significance Index: -13.4300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4897
    Cell Significance Index: -12.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4899
    Cell Significance Index: -14.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5126
    Cell Significance Index: -14.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5256
    Cell Significance Index: -13.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5279
    Cell Significance Index: -11.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5281
    Cell Significance Index: -14.1000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.5332
    Cell Significance Index: -6.9000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.5352
    Cell Significance Index: -7.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5579
    Cell Significance Index: -14.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5647
    Cell Significance Index: -11.8200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5847
    Cell Significance Index: -7.3800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5920
    Cell Significance Index: -9.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5981
    Cell Significance Index: -7.1300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.6164
    Cell Significance Index: -12.5400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6234
    Cell Significance Index: -13.0100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6284
    Cell Significance Index: -16.0100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.6284
    Cell Significance Index: -7.8700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6369
    Cell Significance Index: -13.7600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.6463
    Cell Significance Index: -9.4200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.6464
    Cell Significance Index: -8.1400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.6543
    Cell Significance Index: -8.3800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6556
    Cell Significance Index: -26.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6625
    Cell Significance Index: -14.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6908
    Cell Significance Index: -13.6600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.7007
    Cell Significance Index: -13.7000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.7055
    Cell Significance Index: -7.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium-binding protein:** CALB2 is a calcium-binding protein that can bind to four calcium ions, which is essential for its function in regulating calcium homeostasis. 2. **Presynaptic localization:** CALB2 is primarily localized to the presynaptic terminals of neurons, where it plays a critical role in regulating the concentration of calcium ions within the synaptic cleft. 3. **Regulation of calcium ion concentration:** CALB2 helps to regulate the concentration of calcium ions within the synaptic cleft by modulating the influx and efflux of calcium ions across the presynaptic membrane. 4. **Involvement in synaptic plasticity:** CALB2 is involved in regulating synaptic plasticity, including long-term synaptic potentiation (LTP) and depression (LTD), which are critical for learning and memory. **Pathways and Functions:** 1. **Calcium ion signaling pathways:** CALB2 is involved in various calcium ion signaling pathways, including the regulation of the voltage-gated calcium channels (VGCCs) and the calcium-dependent protein kinase (CaMK) pathway. 2. **Presynaptic calcium regulation:** CALB2 helps to regulate the concentration of calcium ions within the synaptic cleft by modulating the influx of calcium ions through VGCCs and the efflux of calcium ions through the calcium-ATPase (Ca2+/Mn2+-ATPase) pump. 3. **Regulation of neurotransmitter release:** CALB2 helps to regulate the release of neurotransmitters, including GABA and glycine, by modulating the concentration of calcium ions within the synaptic cleft. 4. **Involvement in synaptic transmission:** CALB2 is involved in regulating synaptic transmission, including the regulation of the amplitude and duration of synaptic potentials. **Clinical Significance:** 1. **Neurological disorders:** CALB2 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. 2. **Neuromuscular junction dysfunction:** CALB2 has been shown to be involved in the regulation of neuromuscular junction function, which is critical for muscle contraction and relaxation. 3. **Cancer development:** CALB2 has been implicated in the development of certain types of cancer, including ovarian cancer and leukemia. 4. **Neurodevelopmental disorders:** CALB2 has been implicated in the development of neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, CALB2 is a critical protein that plays a vital role in maintaining calcium homeostasis and regulating synaptic plasticity. Its dysregulation has been implicated in various neurological disorders, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 4139275331

Symbol: CALB2_HUMAN

Name: Calretinin

UniProtKB Accession Codes:

P22676 A8K4Y1 Q53HD2 Q96BK4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 25 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2618861

Title: The human calbindins: cDNA and gene cloning.

PubMed ID: 2618861

DOI: 10.1007/978-1-4684-5679-0_25

PubMed ID: 2001709

Title: Structure of the human brain calcium-binding protein calretinin and its expression in bacteria.

PubMed ID: 2001709

DOI: 10.1111/j.1432-1033.1991.tb15788.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 271
  • Mass: 31540
  • Checksum: 98116AD706079DB9
  • Sequence:
    • MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK 
SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSSA EFMEAWRKYD 
TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL 
PVQENFLLKF QGMKLTSEEF NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL 
TNYRKSVMSL AEAGKLYRKD LEIVLCSEPP M

Genular Protein ID: 877355345

Symbol: A6NER6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6NER6

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 192
  • Mass: 22155
  • Checksum: 7A69EA37E7D3D246
  • Sequence:
    • MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK 
SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSSA EFMEAWRKYD 
TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRIE 
AATLTSMSWM PF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.