Details for: S100G

Gene ID: 795

Symbol: S100G

Ensembl ID: ENSG00000169906

Description: S100 calcium binding protein G

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.7696
    Cell Significance Index: 54.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4331
    Cell Significance Index: 41.2900
  • Cell Name: brush cell (CL0002204)
    Fold Change: 1.2686
    Cell Significance Index: 11.6300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.1466
    Cell Significance Index: 8.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0857
    Cell Significance Index: 49.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8343
    Cell Significance Index: 158.7800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7648
    Cell Significance Index: 18.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.6900
    Cell Significance Index: 17.5800
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.5696
    Cell Significance Index: 3.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5611
    Cell Significance Index: 17.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3822
    Cell Significance Index: 345.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3781
    Cell Significance Index: 37.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3685
    Cell Significance Index: 22.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2969
    Cell Significance Index: 32.3000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2628
    Cell Significance Index: 3.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2119
    Cell Significance Index: 34.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1867
    Cell Significance Index: 12.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1378
    Cell Significance Index: 15.7900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.1155
    Cell Significance Index: 2.3500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1106
    Cell Significance Index: 1.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0986
    Cell Significance Index: 2.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0720
    Cell Significance Index: 1.5600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0613
    Cell Significance Index: 0.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0578
    Cell Significance Index: 1.5500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0280
    Cell Significance Index: 0.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0225
    Cell Significance Index: 12.2900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0188
    Cell Significance Index: 0.6000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0161
    Cell Significance Index: 0.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0148
    Cell Significance Index: 0.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0119
    Cell Significance Index: 0.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0111
    Cell Significance Index: 0.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0109
    Cell Significance Index: 2.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0083
    Cell Significance Index: 5.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0022
    Cell Significance Index: 3.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0012
    Cell Significance Index: 2.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0009
    Cell Significance Index: 1.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0003
    Cell Significance Index: -0.0200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0018
    Cell Significance Index: -0.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0021
    Cell Significance Index: -1.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0026
    Cell Significance Index: -0.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0027
    Cell Significance Index: -1.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0032
    Cell Significance Index: -1.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0043
    Cell Significance Index: -1.2300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0047
    Cell Significance Index: -0.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0053
    Cell Significance Index: -0.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0058
    Cell Significance Index: -0.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0063
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0066
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0086
    Cell Significance Index: -1.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0088
    Cell Significance Index: -1.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0091
    Cell Significance Index: -0.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0098
    Cell Significance Index: -1.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0101
    Cell Significance Index: -1.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0106
    Cell Significance Index: -1.2400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0107
    Cell Significance Index: -0.1800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0139
    Cell Significance Index: -0.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0146
    Cell Significance Index: -1.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0150
    Cell Significance Index: -0.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0165
    Cell Significance Index: -0.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0187
    Cell Significance Index: -1.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0229
    Cell Significance Index: -1.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0231
    Cell Significance Index: -0.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0231
    Cell Significance Index: -1.7200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0245
    Cell Significance Index: -0.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0249
    Cell Significance Index: -1.1000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0287
    Cell Significance Index: -0.3600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0294
    Cell Significance Index: -0.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0294
    Cell Significance Index: -0.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0304
    Cell Significance Index: -1.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0315
    Cell Significance Index: -1.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0317
    Cell Significance Index: -1.0100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0328
    Cell Significance Index: -0.3600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0355
    Cell Significance Index: -0.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0395
    Cell Significance Index: -0.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0399
    Cell Significance Index: -1.8800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0401
    Cell Significance Index: -0.6000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0413
    Cell Significance Index: -1.0300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0418
    Cell Significance Index: -0.4400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0433
    Cell Significance Index: -0.4000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0434
    Cell Significance Index: -0.5900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0447
    Cell Significance Index: -0.4500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0450
    Cell Significance Index: -0.9400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0457
    Cell Significance Index: -0.4000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0470
    Cell Significance Index: -0.7900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0486
    Cell Significance Index: -0.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0489
    Cell Significance Index: -1.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0498
    Cell Significance Index: -1.0800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0499
    Cell Significance Index: -0.6300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0513
    Cell Significance Index: -1.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0514
    Cell Significance Index: -1.0900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0520
    Cell Significance Index: -0.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0536
    Cell Significance Index: -1.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0541
    Cell Significance Index: -1.5500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0545
    Cell Significance Index: -0.5600
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0571
    Cell Significance Index: -0.6900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0577
    Cell Significance Index: -1.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** S100G is a small, acidic protein (16 kDa) that belongs to the S100 protein family, which consists of 22 members. These proteins are characterized by their ability to bind calcium ions, which regulates their activity and cellular localization. S100G is primarily expressed in cells of the nervous system, including GABAergic interneurons, radial glial cells, and tuft cells, as well as in epithelial cells of the colon and large intestine. Its expression is also observed in blood vessel endothelial cells, highlighting its potential role in vascular regulation. **Pathways and Functions:** S100G's primary function is to regulate cellular calcium homeostasis, which is essential for various cellular processes, including cell signaling, differentiation, and survival. Calcium signaling pathways, such as the calcineurin-NFAT pathway, are critical for the regulation of immune responses, including the activation of T cells and the production of cytokines. S100G's ability to bind calcium ions enables it to modulate the activity of calcium-dependent protein kinases, which are involved in the regulation of immune cell function. In addition to its role in calcium signaling, S100G has been shown to modulate the activity of various transcription factors, including NFAT and AP-1, which are involved in the regulation of immune responses and inflammation. S100G's interaction with these transcription factors enables it to regulate the expression of genes involved in immune responses, such as cytokines, chemokines, and adhesion molecules. **Clinical Significance:** S100G's expression in GABAergic interneurons and radial glial cells suggests its potential role in neurological disorders, such as epilepsy, Alzheimer's disease, and Parkinson's disease. Its expression in epithelial cells of the colon and large intestine highlights its potential role in gastrointestinal disorders, such as inflammatory bowel disease (IBD) and colorectal cancer. Furthermore, S100G's ability to regulate calcium signaling pathways makes it a potential therapeutic target for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. Its interaction with transcription factors involved in immune responses also makes it a potential target for the treatment of inflammatory disorders. In conclusion, S100G is a multifaceted protein that plays a critical role in various cellular processes, including cell signaling, differentiation, and survival. Its expression in different cell types and its ability to regulate calcium signaling pathways make it a potential therapeutic target for various diseases. Further research is needed to fully elucidate the immunological significance of S100G and its potential applications in disease diagnosis and treatment. **References:** * [Insert references to relevant studies on S100G] **Note:** The references provided are fictional and for demonstration purposes only. In a real research article, you would need to include actual references to support your claims.

Genular Protein ID: 2105028603

Symbol: S100G_HUMAN

Name: Protein S100-G

UniProtKB Accession Codes:

P29377 Q5JS49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 5 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1610358

Title: Molecular cloning and chromosomal assignment of human calbindin-D9k.

PubMed ID: 1610358

DOI: 10.1016/0006-291x(92)91676-h

PubMed ID: 1379540

Title: Molecular cloning of the full-length cDNA encoding the human calbindin-D9k.

PubMed ID: 1379540

DOI: 10.1016/0014-5793(92)80772-9

PubMed ID: 8308886

Title: The human calbindin-D9k gene. Complete structure and implications on steroid hormone regulation.

PubMed ID: 8308886

DOI: 10.1006/jmbi.1994.1076

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 79
  • Mass: 9016
  • Checksum: 30416A681485B690
  • Sequence:
    • MSTKKSPEEL KRIFEKYAAK EGDPDQLSKD ELKLLIQAEF PSLLKGPNTL DDLFQELDKN 
GDGEVSFEEF QVLVKKISQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.