Details for: S100G

Gene ID: 795

Symbol: S100G

Ensembl ID: ENSG00000169906

Description: S100 calcium binding protein G

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.87
    Marker Score: 1881
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.28
    Marker Score: 1278.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48061
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.82
    Marker Score: 1266
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.77
    Marker Score: 1068
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.75
    Marker Score: 417
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3135
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1274
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6
    Marker Score: 9323
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.55
    Marker Score: 1121
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.37
    Marker Score: 221
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.32
    Marker Score: 305.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.23
    Marker Score: 101
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.22
    Marker Score: 1063
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.22
    Marker Score: 53
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 90
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.15
    Marker Score: 1246
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.15
    Marker Score: 372
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.13
    Marker Score: 182
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.13
    Marker Score: 111
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.11
    Marker Score: 59
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.11
    Marker Score: 45
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.11
    Marker Score: 316.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.09
    Marker Score: 151
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 168
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 45
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 30.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.05
    Marker Score: 13
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.05
    Marker Score: 65
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.05
    Marker Score: 56
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.04
    Marker Score: 598
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.04
    Marker Score: 49
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.04
    Marker Score: 111
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.04
    Marker Score: 48
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.04
    Marker Score: 119.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.04
    Marker Score: 57
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.04
    Marker Score: 103.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.03
    Marker Score: 209
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.03
    Marker Score: 1129
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.03
    Marker Score: 184
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.03
    Marker Score: 12
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.03
    Marker Score: 110.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.02
    Marker Score: 42
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.02
    Marker Score: 35
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.02
    Marker Score: 17

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Other Information

**Key characteristics:** - S100G is a large protein with a molecular weight of approximately 120 kDa. - It belongs to the S100 family of calcium-binding proteins. - S100G is a calcium-dependent protein that undergoes conformational changes upon calcium binding. - It is a key regulator of cell migration, adhesion, and signaling. **Pathways and functions:** - S100G is involved in the apical-basal plasma membrane pathway, where it regulates the transport of molecules between the two plasma membranes. - It also plays a role in the calcium-dependent protein binding pathway, which is involved in cell signaling and adhesion. - S100G is also involved in the cytoplasm, extracellular space, and transition metal ion binding pathways. - It is important for the regulation of cell migration, proliferation, and differentiation. **Clinical significance:** - Mutations in the S100G gene have been linked to several human diseases, including cancer, cardiovascular disease, and osteoporosis. - S100G is a potential therapeutic target for diseases characterized by calcium dysregulation, such as cancer and cardiovascular disease. - Targeting S100G signaling can inhibit cancer cell growth and migration. **Additional information:** - S100G is a highly conserved protein with similar sequences found in other organisms. - It is expressed in high levels in various tissues, including blood vessels, skin, and brain. - S100G is a regulated protein that undergoes changes in its expression levels and subcellular localization in response to various stimuli.

Genular Protein ID: 2105028603

Symbol: S100G_HUMAN

Name: Protein S100-G

UniProtKB Accession Codes:

P29377 Q5JS49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 5 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1610358

Title: Molecular cloning and chromosomal assignment of human calbindin-D9k.

PubMed ID: 1610358

DOI: 10.1016/0006-291x(92)91676-h

PubMed ID: 1379540

Title: Molecular cloning of the full-length cDNA encoding the human calbindin-D9k.

PubMed ID: 1379540

DOI: 10.1016/0014-5793(92)80772-9

PubMed ID: 8308886

Title: The human calbindin-D9k gene. Complete structure and implications on steroid hormone regulation.

PubMed ID: 8308886

DOI: 10.1006/jmbi.1994.1076

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 79
  • Mass: 9016
  • Checksum: 30416A681485B690
  • Sequence:
    • MSTKKSPEEL KRIFEKYAAK EGDPDQLSKD ELKLLIQAEF PSLLKGPNTL DDLFQELDKN 
GDGEVSFEEF QVLVKKISQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.