Details for: CALCA

Gene ID: 796

Symbol: CALCA

Ensembl ID: ENSG00000110680

Description: calcitonin related polypeptide alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7679
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 648
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.84
    Marker Score: 1601
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.84
    Marker Score: 1393
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.8
    Marker Score: 1305
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.69
    Marker Score: 10769
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.67
    Marker Score: 1353
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 421
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 464
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.57
    Marker Score: 629
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.56
    Marker Score: 588
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.55
    Marker Score: 19082
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 479
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 202.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 279
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.45
    Marker Score: 263
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 248
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.44
    Marker Score: 487
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.43
    Marker Score: 413
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.42
    Marker Score: 943
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.41
    Marker Score: 864
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.4
    Marker Score: 113
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.37
    Marker Score: 352
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.33
    Marker Score: 219
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 139
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.28
    Marker Score: 313
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.28
    Marker Score: 398
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.28
    Marker Score: 173
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.26
    Marker Score: 179
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.26
    Marker Score: 256
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.25
    Marker Score: 123
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.25
    Marker Score: 309.5
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.23
    Marker Score: 125
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.23
    Marker Score: 103
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.23
    Marker Score: 247
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.23
    Marker Score: 72
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.2
    Marker Score: 48
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.19
    Marker Score: 53
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.19
    Marker Score: 229.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.18
    Marker Score: 2437
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.15
    Marker Score: 59
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.15
    Marker Score: 310
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.14
    Marker Score: 47
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.14
    Marker Score: 62
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.13
    Marker Score: 231
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.13
    Marker Score: 132
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.13
    Marker Score: 321
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.13
    Marker Score: 124
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.12
    Marker Score: 125
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.12
    Marker Score: 429
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.11
    Marker Score: 115
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.11
    Marker Score: 147
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.11
    Marker Score: 181
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.11
    Marker Score: 59
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 112
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.11
    Marker Score: 113
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1
    Marker Score: 204
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.09
    Marker Score: 131
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.09
    Marker Score: 66
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.09
    Marker Score: 144
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.08
    Marker Score: 38
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.08
    Marker Score: 74
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.08
    Marker Score: 146
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.08
    Marker Score: 69
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.08
    Marker Score: 109
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.07
    Marker Score: 60
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.07
    Marker Score: 81
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.06
    Marker Score: 109
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 147
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.06
    Marker Score: 162
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.06
    Marker Score: 12
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.06
    Marker Score: 154
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.06
    Marker Score: 184
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.06
    Marker Score: 108
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.06
    Marker Score: 14

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Other Information

**Key characteristics** * The CALCA gene is located on chromosome 15q21.2. * It is a large gene with a complex structure. * It contains multiple alternatively spliced transcripts that encode different isoforms of the protein. * It is a key regulator of inflammation, metabolism, and cell migration. **Pathways and functions** * The CALCA gene is involved in the adenylate cyclase-activating g protein-coupled receptor signaling pathway, the amyloid fiber formation pathway, and the artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure. * It is also involved in the regulation of calcium signaling, protein binding, and cell migration. **Clinical significance** * Mutations in the CALCA gene have been linked to several human diseases, including rheumatoid arthritis, atherosclerosis, and cancer. * Calcitonin is a potent inflammatory cytokine that can promote the production of inflammatory cytokines and chemokines. * Therefore, targeting the CALCA gene has been explored as a therapeutic strategy for inflammatory diseases. **Other relevant information** * The CALCA gene is also known as CD140A. * It is a secreted protein that is produced by a variety of cell types. * It is a key regulator of immune responses and inflammation.

Genular Protein ID: 4100537344

Symbol: CALC_HUMAN

Name: Calcitonin

UniProtKB Accession Codes:

P01258 B7ZL39 Q13935 Q13937 Q52LX7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 19 EMDB 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 2 PRINTS 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6546550

Title: The complete sequence of human preprocalcitonin.

PubMed ID: 6546550

DOI: 10.1016/0014-5793(84)80839-x

PubMed ID: 3872459

Title: Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression.

PubMed ID: 3872459

DOI: 10.1073/pnas.82.7.1994

PubMed ID: 3034287

Title: Expression and function of the human calcitonin/alpha-CGRP gene in health and disease.

PubMed ID: 3034287

PubMed ID: 3485540

Title: Ectopic synthesis of high-Mr calcitonin by the BEN lung carcinoma cell line reflects aberrant proteolytic processing.

PubMed ID: 3485540

DOI: 10.1016/0014-5793(86)81187-5

PubMed ID: 1761559

Title: A novel calcitonin carboxyl-terminal peptide produced in medullary thyroid carcinoma by alternative RNA processing of the calcitonin/calcitonin gene-related peptide gene.

PubMed ID: 1761559

DOI: 10.1016/s0021-9258(18)54275-7

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6148938

Title: Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide.

PubMed ID: 6148938

DOI: 10.1016/0006-291x(84)90278-x

PubMed ID: 2408883

Title: Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma.

PubMed ID: 2408883

DOI: 10.1002/j.1460-2075.1985.tb03688.x

PubMed ID: 5760861

Title: Human calcitonin. Structure of calcitonin M and D.

PubMed ID: 5760861

DOI: 10.1002/hlca.19680510811

PubMed ID: 2001366

Title: A 1H NMR study of human calcitonin in solution.

PubMed ID: 2001366

DOI: 10.1021/bi00223a010

PubMed ID: 6132180

Title: Katacalcin: a new plasma calcium-lowering hormone.

PubMed ID: 6132180

DOI: 10.1016/s0140-6736(83)91387-9

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

Sequence Information:

  • Length: 141
  • Mass: 15467
  • Checksum: 99622305DD8B286F
  • Sequence:
    • MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL LAALVQDYVQ 
MKASELEQEQ EREGSSLDSP RSKRCGNLST CMLGTYTQDF NKFHTFPQTA IGVGAPGKKR 
DMSSDLERDH RPHVSMPQNA N

Genular Protein ID: 2822134813

Symbol: CALCA_HUMAN

Name: Calcitonin gene-related peptide 1

UniProtKB Accession Codes:

P06881 Q93048 Q9UCP0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 9 EMDB 2 Ensembl 3 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IntAct 1 InterPro 5 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 Proteomes 1 ProteomicsDB 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 SignaLink 1 TCDB 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3872459

Title: Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression.

PubMed ID: 3872459

DOI: 10.1073/pnas.82.7.1994

PubMed ID: 2571128

Title: Structure and methylation of the human calcitonin/alpha-CGRP gene.

PubMed ID: 2571128

DOI: 10.1093/nar/17.17.6999

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 6148938

Title: Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide.

PubMed ID: 6148938

DOI: 10.1016/0006-291x(84)90278-x

PubMed ID: 2408883

Title: Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma.

PubMed ID: 2408883

DOI: 10.1002/j.1460-2075.1985.tb03688.x

PubMed ID: 6610687

Title: Calcitonin gene related peptide coding sequence is conserved in the human genome and is expressed in medullary thyroid carcinoma.

PubMed ID: 6610687

DOI: 10.1210/jcem-59-2-358

PubMed ID: 3034287

Title: Expression and function of the human calcitonin/alpha-CGRP gene in health and disease.

PubMed ID: 3034287

PubMed ID: 6609312

Title: Isolation and characterization of human calcitonin gene-related peptide.

PubMed ID: 6609312

DOI: 10.1038/308746a0

PubMed ID: 3492492

Title: Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord.

PubMed ID: 3492492

DOI: 10.1016/s0021-9258(19)75816-5

PubMed ID: 1318039

Title: Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma.

PubMed ID: 1318039

DOI: 10.1016/s0006-291x(05)80966-0

PubMed ID: 1988044

Title: Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics.

PubMed ID: 1988044

DOI: 10.1021/bi00216a036

PubMed ID: 2039456

Title: Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin.

PubMed ID: 2039456

DOI: 10.1042/bj2750785

Sequence Information:

  • Length: 128
  • Mass: 13899
  • Checksum: A003A1069260D9B8
  • Sequence:
    • MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL LAALVQDYVQ 
MKASELEQEQ EREGSRIIAQ KRACDTATCV THRLAGLLSR SGGVVKNNFV PTNVGSKAFG 
RRRRDLQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.