Details for: CALCB

Gene ID: 797

Symbol: CALCB

Ensembl ID: ENSG00000175868

Description: calcitonin related polypeptide beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.6769
    Cell Significance Index: 243.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.9220
    Cell Significance Index: 15.8000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.7914
    Cell Significance Index: 13.3100
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.4901
    Cell Significance Index: 4.9100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.4455
    Cell Significance Index: 14.0900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3723
    Cell Significance Index: 5.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2907
    Cell Significance Index: 57.7000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.2474
    Cell Significance Index: 3.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2448
    Cell Significance Index: 9.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2402
    Cell Significance Index: 10.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1370
    Cell Significance Index: 3.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1266
    Cell Significance Index: 3.7300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1186
    Cell Significance Index: 1.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0812
    Cell Significance Index: 50.6900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0722
    Cell Significance Index: 1.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0702
    Cell Significance Index: 11.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0543
    Cell Significance Index: 29.6600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0421
    Cell Significance Index: 0.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0382
    Cell Significance Index: 2.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0326
    Cell Significance Index: 3.7200
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.0304
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0154
    Cell Significance Index: 11.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0136
    Cell Significance Index: 25.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0135
    Cell Significance Index: 4.8600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0113
    Cell Significance Index: 0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0081
    Cell Significance Index: 5.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0036
    Cell Significance Index: 0.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0035
    Cell Significance Index: 1.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0030
    Cell Significance Index: 4.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0018
    Cell Significance Index: 3.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0010
    Cell Significance Index: 0.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0002
    Cell Significance Index: 0.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0012
    Cell Significance Index: -0.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0020
    Cell Significance Index: -0.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0024
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0027
    Cell Significance Index: -0.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0049
    Cell Significance Index: -1.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0081
    Cell Significance Index: -1.6200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0095
    Cell Significance Index: -0.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0095
    Cell Significance Index: -1.1200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0120
    Cell Significance Index: -0.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0187
    Cell Significance Index: -1.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0189
    Cell Significance Index: -2.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0242
    Cell Significance Index: -2.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0255
    Cell Significance Index: -3.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0302
    Cell Significance Index: -3.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0312
    Cell Significance Index: -1.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0328
    Cell Significance Index: -4.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0414
    Cell Significance Index: -4.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0433
    Cell Significance Index: -4.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0480
    Cell Significance Index: -2.9500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0543
    Cell Significance Index: -0.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0543
    Cell Significance Index: -1.5500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0553
    Cell Significance Index: -0.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0564
    Cell Significance Index: -1.5100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0598
    Cell Significance Index: -0.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0604
    Cell Significance Index: -1.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0611
    Cell Significance Index: -2.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0629
    Cell Significance Index: -4.6900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0630
    Cell Significance Index: -0.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0646
    Cell Significance Index: -1.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0647
    Cell Significance Index: -1.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0681
    Cell Significance Index: -3.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0727
    Cell Significance Index: -1.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0754
    Cell Significance Index: -3.9300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0764
    Cell Significance Index: -0.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0764
    Cell Significance Index: -4.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0781
    Cell Significance Index: -1.7100
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0827
    Cell Significance Index: -0.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0848
    Cell Significance Index: -2.9800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0855
    Cell Significance Index: -2.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0862
    Cell Significance Index: -2.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0935
    Cell Significance Index: -4.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0965
    Cell Significance Index: -2.0200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1002
    Cell Significance Index: -1.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1012
    Cell Significance Index: -2.1000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1062
    Cell Significance Index: -2.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1099
    Cell Significance Index: -2.8900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1177
    Cell Significance Index: -0.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1210
    Cell Significance Index: -4.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1216
    Cell Significance Index: -3.9800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.1282
    Cell Significance Index: -1.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1291
    Cell Significance Index: -4.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1328
    Cell Significance Index: -3.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1338
    Cell Significance Index: -4.2600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1353
    Cell Significance Index: -2.2300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1365
    Cell Significance Index: -2.3600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1365
    Cell Significance Index: -1.8400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1463
    Cell Significance Index: -2.0300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1508
    Cell Significance Index: -1.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1543
    Cell Significance Index: -3.7000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1581
    Cell Significance Index: -2.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1592
    Cell Significance Index: -4.2500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1594
    Cell Significance Index: -3.9800
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1596
    Cell Significance Index: -2.2700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1599
    Cell Significance Index: -2.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1608
    Cell Significance Index: -4.0100
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1629
    Cell Significance Index: -1.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** CALCB is expressed in a wide range of cell types, including hematopoietic stem cells, migratory enteric neural crest cells, cardiac endothelial cells, and neural crest cells. 2. **Signal Transduction:** CALCB is involved in signaling pathways, including adenylate cyclase-activating G protein-coupled receptor signaling, calcitonin receptor binding, and regulation of cytosolic calcium ion concentration. 3. **Protein Binding:** CALCB interacts with various proteins, including calcitonin receptors, G-proteins, and other signaling molecules, to modulate cellular responses. 4. **Cellular Functions:** CALCB plays a role in regulating cellular processes, such as intracellular calcium ion homeostasis, neuropeptide hormone activity, and protein binding. **Pathways and Functions:** 1. **Adenylate Cyclase-Activating G Protein-Coupled Receptor Signaling Pathway:** CALCB's involvement in this pathway highlights its capacity to modulate cellular responses to G protein-coupled receptor ligands. 2. **Calcitonin Receptor Binding:** CALCB's interaction with calcitonin receptors suggests its potential role in regulating calcium homeostasis and bone metabolism. 3. **Class b/2 (Secretin Family Receptors) Signaling:** CALCB's expression in secretin family receptors indicates its involvement in regulating cellular responses to secretin-like ligands. 4. **Intracellular Calcium Ion Homeostasis:** CALCB's role in regulating cytosolic calcium ion concentration is crucial for maintaining cellular homeostasis and regulating various physiological processes. 5. **Neuropeptide Hormone Activity:** CALCB's involvement in neuropeptide hormone activity suggests its potential role in regulating neural signaling and behavior. **Clinical Significance:** 1. **Bone Metabolism:** CALCB's interaction with calcitonin receptors suggests its potential role in regulating bone metabolism and density. 2. **Cardiovascular Disease:** CALCB's involvement in intracellular calcium ion homeostasis and cardiac endothelial cell function highlights its potential role in cardiovascular disease. 3. **Neurological Disorders:** CALCB's expression in neural crest cells and cerebral cortex GABAergic interneurons suggests its potential role in regulating neural signaling and behavior in neurological disorders. 4. **Cancer:** CALCB's involvement in immune cell function and cancer research highlights its potential role in cancer development and progression. In conclusion, the CALCB gene plays a multifaceted role in human physiology, influencing various cellular processes and signaling pathways. Further research is necessary to fully elucidate the significance of CALCB in human health and disease, and its potential as a therapeutic target for various conditions.

Genular Protein ID: 3759267725

Symbol: CALCB_HUMAN

Name: Calcitonin gene-related peptide 2

UniProtKB Accession Codes:

P10092 A8K573 D3DQX4 Q569I0 Q9UCN9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3492393

Title: Structure and expression of the human calcitonin/CGRP genes.

PubMed ID: 3492393

DOI: 10.1016/0014-5793(86)81091-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2985435

Title: A second human calcitonin/CGRP gene.

PubMed ID: 2985435

DOI: 10.1016/0014-5793(85)80820-6

PubMed ID: 3492492

Title: Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord.

PubMed ID: 3492492

DOI: 10.1016/s0021-9258(19)75816-5

PubMed ID: 2322288

Title: Isolation, purification and characterization of beta-hCGRP from human spinal cord.

PubMed ID: 2322288

DOI: 10.1016/0006-291x(90)90621-s

PubMed ID: 1318039

Title: Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma.

PubMed ID: 1318039

DOI: 10.1016/s0006-291x(05)80966-0

Sequence Information:

  • Length: 127
  • Mass: 13706
  • Checksum: B0A71A063CD5ACE7
  • Sequence:
    • MGFRKFSPFL ALSILVLYQA GSLQAAPFRS ALESSPDPAT LSKEDARLLL AALVQDYVQM 
KASELKQEQE TQGSSSAAQK RACNTATCVT HRLAGLLSRS GGMVKSNFVP TNVGSKAFGR 
RRRDLQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.