Details for: CALCB

Gene ID: 797

Symbol: CALCB

Ensembl ID: ENSG00000175868

Description: calcitonin related polypeptide beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.22
    Marker Score: 645
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.21
    Marker Score: 1140
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2
    Marker Score: 2279
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.17
    Marker Score: 732
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.08
    Marker Score: 2192
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251806
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.04
    Marker Score: 1109
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.03
    Marker Score: 6828
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2419
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13988
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.8
    Marker Score: 787
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.8
    Marker Score: 481
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577.5
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.75
    Marker Score: 716
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.75
    Marker Score: 240
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.68
    Marker Score: 1598
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.66
    Marker Score: 6808
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.66
    Marker Score: 144
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.62
    Marker Score: 618
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.61
    Marker Score: 530
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.55
    Marker Score: 602
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.53
    Marker Score: 221
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.51
    Marker Score: 3072
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.51
    Marker Score: 173
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5
    Marker Score: 331
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.49
    Marker Score: 260
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.46
    Marker Score: 208
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.44
    Marker Score: 9452
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.44
    Marker Score: 138
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.43
    Marker Score: 209
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 203
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 177
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4
    Marker Score: 706
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.4
    Marker Score: 1434
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 156
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.35
    Marker Score: 93
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.35
    Marker Score: 176.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.34
    Marker Score: 195
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.34
    Marker Score: 124
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.33
    Marker Score: 4391
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.32
    Marker Score: 108
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.32
    Marker Score: 458
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.3
    Marker Score: 318
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.29
    Marker Score: 162
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.28
    Marker Score: 177
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.28
    Marker Score: 134
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.28
    Marker Score: 188
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.27
    Marker Score: 111
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.27
    Marker Score: 127
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.26
    Marker Score: 235
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.26
    Marker Score: 370
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.26
    Marker Score: 104
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.25
    Marker Score: 260
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.23
    Marker Score: 374.5
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.22
    Marker Score: 145
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.21
    Marker Score: 432
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.21
    Marker Score: 94
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.2
    Marker Score: 229
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.2
    Marker Score: 204
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 121
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.2
    Marker Score: 366
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.19
    Marker Score: 46
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.18
    Marker Score: 230
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.18
    Marker Score: 121
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.18
    Marker Score: 601
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.18
    Marker Score: 112
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.17
    Marker Score: 222
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.17
    Marker Score: 45
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.17
    Marker Score: 114
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.17
    Marker Score: 179
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.17
    Marker Score: 87
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.16
    Marker Score: 675
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.16
    Marker Score: 108
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.16
    Marker Score: 194
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.15
    Marker Score: 55
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.14
    Marker Score: 513
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.14
    Marker Score: 160
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.14
    Marker Score: 297.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.14
    Marker Score: 80
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.14
    Marker Score: 96
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.13
    Marker Score: 257
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.13
    Marker Score: 97

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Other Information

**Key characteristics:** - The CALCB gene is located on chromosome 17q21.1. - It is a large gene, encoding a protein of 1,115 amino acids. - The protein is a transmembrane protein that is expressed in the cytoplasm. - It is a member of the G protein-coupled receptor (GPCR) family. **Pathways and functions:** - The CALCB gene is involved in the adenylate cyclase-activating g protein-coupled receptor signaling pathway. - It is also involved in the Calcitonin-like ligand receptors, Calcitonin receptor binding, Class b/2 (secretin family receptors), Extracellular region, Extracellular space, G alpha (s) signalling events, Gpcr downstream signalling, Gpcr ligand binding, Intracellular calcium ion homeostasis, Neuropeptide hormone activity. **Clinical significance:** - Mutations in the CALCB gene have been linked to several human diseases, including hypercalcemia, hypocalcemia, and chronic kidney disease. - CALCB is a potential therapeutic target for these diseases.

Genular Protein ID: 3759267725

Symbol: CALCB_HUMAN

Name: Calcitonin gene-related peptide 2

UniProtKB Accession Codes:

P10092 A8K573 D3DQX4 Q569I0 Q9UCN9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3492393

Title: Structure and expression of the human calcitonin/CGRP genes.

PubMed ID: 3492393

DOI: 10.1016/0014-5793(86)81091-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2985435

Title: A second human calcitonin/CGRP gene.

PubMed ID: 2985435

DOI: 10.1016/0014-5793(85)80820-6

PubMed ID: 3492492

Title: Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord.

PubMed ID: 3492492

DOI: 10.1016/s0021-9258(19)75816-5

PubMed ID: 2322288

Title: Isolation, purification and characterization of beta-hCGRP from human spinal cord.

PubMed ID: 2322288

DOI: 10.1016/0006-291x(90)90621-s

PubMed ID: 1318039

Title: Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma.

PubMed ID: 1318039

DOI: 10.1016/s0006-291x(05)80966-0

Sequence Information:

  • Length: 127
  • Mass: 13706
  • Checksum: B0A71A063CD5ACE7
  • Sequence:
    • MGFRKFSPFL ALSILVLYQA GSLQAAPFRS ALESSPDPAT LSKEDARLLL AALVQDYVQM 
KASELKQEQE TQGSSSAAQK RACNTATCVT HRLAGLLSRS GGMVKSNFVP TNVGSKAFGR 
RRRDLQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.