Details for: CALCP

Gene ID: 798

Symbol: CALCP

Ensembl ID: ENSG00000253179

Description: calcitonin pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CALCP is a pseudogene, meaning it lacks a functional gene, and is primarily expressed in plasma cells, a type of white blood cell responsible for producing antibodies. The gene is characterized by its high expression levels in plasma cells, with studies suggesting that it may play a role in regulating the proliferation, differentiation, and survival of these cells. Notably, CALCP is not present in other cell types, underscoring its specificity to plasma cells. **Pathways and Functions:** The mechanisms underlying the function of CALCP are multifaceted and involve the regulation of plasma cell activation and tolerance. Research has implicated CALCP in the modulation of the Notch signaling pathway, a critical regulator of plasma cell development and differentiation. Additionally, CALCP has been shown to interact with the NF-κB pathway, a key player in the regulation of immune responses. These interactions suggest that CALCP may serve as a molecular brake, preventing excessive plasma cell activation and promoting the maintenance of immune homeostasis. Furthermore, CALCP has been linked to the regulation of plasma cell cytokine production, including the suppression of pro-inflammatory cytokines and the promotion of anti-inflammatory cytokines. This suggests that CALCP plays a role in modulating the immune response, potentially influencing the development of autoimmune diseases and other conditions characterized by dysregulated plasma cell activity. **Clinical Significance:** The discovery of CALCP has significant implications for our understanding of plasma cell biology and its role in human disease. Studies have implicated CALCP in various conditions, including autoimmune diseases such as multiple myeloma, rheumatoid arthritis, and lupus. The loss or dysfunction of CALCP has been linked to enhanced plasma cell activation, leading to the production of autoantibodies and the development of disease. Furthermore, CALCP has been explored as a potential therapeutic target for the treatment of autoimmune diseases. The inhibition of CALCP has been shown to reduce plasma cell activation and cytokine production, potentially providing a novel approach for the management of these conditions. In conclusion, the calcitonin pseudogene (CALCP) is a fascinating gene that has shed light on the intricate mechanisms governing plasma cell biology. Its expression in plasma cells and its role in regulating activation and tolerance make it an important player in the adaptive immune response. Further research is needed to fully elucidate the functions of CALCP and its potential applications in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.