Details for: CALCR

Gene ID: 799

Symbol: CALCR

Ensembl ID: ENSG00000004948

Description: calcitonin receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.27
    Marker Score: 2408
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.22
    Marker Score: 2484
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.09
    Marker Score: 729
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.05
    Marker Score: 1124
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.99
    Marker Score: 6583
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.9
    Marker Score: 474
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.77
    Marker Score: 450
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.75
    Marker Score: 452
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 215
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 404.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.61
    Marker Score: 9540
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.51
    Marker Score: 231
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.43
    Marker Score: 112
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 392
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.37
    Marker Score: 178
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.36
    Marker Score: 113
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.34
    Marker Score: 170
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.33
    Marker Score: 252
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 319
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.31
    Marker Score: 328
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.3
    Marker Score: 710
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.29
    Marker Score: 128
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.28
    Marker Score: 302
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.26
    Marker Score: 68
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.25
    Marker Score: 293.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.25
    Marker Score: 156
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.25
    Marker Score: 143
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.25
    Marker Score: 275
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.24
    Marker Score: 243
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.24
    Marker Score: 123
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 381
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 137
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.22
    Marker Score: 602
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.21
    Marker Score: 732
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 110
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.19
    Marker Score: 71
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.18
    Marker Score: 61
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.18
    Marker Score: 1833
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.18
    Marker Score: 3136
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.17
    Marker Score: 304
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.17
    Marker Score: 158
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.15
    Marker Score: 132
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.15
    Marker Score: 625
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.15
    Marker Score: 115
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.12
    Marker Score: 25
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 108
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.12
    Marker Score: 167
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.12
    Marker Score: 63
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.11
    Marker Score: 211
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 121
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.11
    Marker Score: 149
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.1
    Marker Score: 57.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.1
    Marker Score: 207
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1
    Marker Score: 64
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.09
    Marker Score: 47
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.09
    Marker Score: 301
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.09
    Marker Score: 152
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 62
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.09
    Marker Score: 360
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.08
    Marker Score: 74

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Other Information

**Key characteristics:** - The CALCR gene is located on chromosome 17q21.1. - It is a member of the class b/2 (secretin family receptors) of cell surface receptors. - It is a single-pass membrane protein with a molecular weight of approximately 130 kDa. - It is expressed in a variety of cell types, including granulocyte monocyte progenitor cell, cardiac endothelial cell, immature innate lymphoid cell, skeletal muscle satellite cell, skeletal muscle satellite stem cell, early T lineage precursor, cerebral cortex GABAergic interneuron, forebrain radial glial cell, goblet cell, and absorptive cell. **Pathways and functions:** - The CALCR gene is involved in the Adenylate cyclase-activating g protein-coupled receptor signaling pathway, the Amylin receptor activity, the Amyloid-beta binding, the Calcitonin-like ligand receptors, the Calcitonin binding, the Calcitonin receptor activity, the Cell surface receptor signaling pathway, and the G alpha (s) signalling events. - It is a key regulator of bone and cartilage development and function. - It is involved in the regulation of inflammation and fibrosis. - It is also involved in the regulation of cell migration and differentiation. **Clinical significance:** - Mutations in the CALCR gene have been linked to several human diseases, including osteoporosis, rheumatoid arthritis, and Alzheimer's disease. - Calcitonin is a hormone that is produced by osteoblasts, cells that are responsible for bone formation. - CALCR is a key regulator of osteoblast activity, and mutations in the CALCR gene can lead to a decrease in osteoblast activity and an increase in bone resorption. - This can lead to osteoporosis and other bone diseases.

Genular Protein ID: 544432098

Symbol: CALCR_HUMAN

Name: N/A

UniProtKB Accession Codes:

P30988 A0A0C4DG16 A4D1G6 F5H605 O14585 Q13941 Q5ZGL8 Q659U6 Q6DJU8 Q6T712

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 21 EMDB 10 Ensembl 5 ExpressionAtlas 1 GO 30 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 19 PIR 2 PRINTS 3 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 2 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1331173

Title: Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line.

PubMed ID: 1331173

DOI: 10.1172/jci116046

PubMed ID: 8078488

Title: Cloning and characterization of an abundant subtype of the human calcitonin receptor.

PubMed ID: 8078488

PubMed ID: 7588285

Title: Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene.

PubMed ID: 7588285

DOI: 10.1210/endo.136.12.7588285

PubMed ID: 8143880

Title: An isoform of the human calcitonin receptor is expressed in TT cells and in medullary carcinoma of the thyroid.

PubMed ID: 8143880

DOI: 10.1016/0014-5793(94)80503-2

PubMed ID: 10570950

Title: A novel calcitonin receptor gene in human osteoclasts from normal bone marrow.

PubMed ID: 10570950

DOI: 10.1016/s0014-5793(99)01176-x

PubMed ID: 15563840

Title: Molecular characterization of two novel isoforms of the human calcitonin receptor.

PubMed ID: 15563840

DOI: 10.1016/j.gene.2004.08.019

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 7720653

Title: Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor.

PubMed ID: 7720653

DOI: 10.1210/endo.136.5.7720653

PubMed ID: 7733946

Title: A new type of human calcitonin receptor isoform generated by alternative splicing.

PubMed ID: 7733946

DOI: 10.1006/bbrc.1995.1562

PubMed ID: 7476993

Title: Functionally different isoforms of the human calcitonin receptor result from alternative splicing of the gene transcript.

PubMed ID: 7476993

DOI: 10.1210/mend.9.8.7476993

PubMed ID: 10860825

Title: Multiple promoters regulate human calcitonin receptor gene expression.

PubMed ID: 10860825

DOI: 10.1006/bbrc.2000.2842

PubMed ID: 15086532

Title: Identification of a novel family of G protein-coupled receptor associated sorting proteins.

PubMed ID: 15086532

DOI: 10.1111/j.1471-4159.2004.02411.x

PubMed ID: 9675109

Title: Polymorphisms of the calcitonin receptor gene are associated with bone mineral density in postmenopausal Italian women.

PubMed ID: 9675109

DOI: 10.1006/bbrc.1998.8880

PubMed ID: 22946511

Title: Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Delta(1-47)hCT((a)) function.

PubMed ID: 22946511

DOI: 10.1111/j.1476-5381.2012.02197.x

PubMed ID: 9571205

Title: Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women.

PubMed ID: 9571205

DOI: 10.1006/bbrc.1998.8445

PubMed ID: 9817931

Title: Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women.

PubMed ID: 9817931

DOI: 10.1093/hmg/7.13.2129

Sequence Information:

  • Length: 474
  • Mass: 55345
  • Checksum: 0D9FA81230B282D9
  • Sequence:
    • MRFTFTSRCL ALFLLLNHPT PILPAFSNQT YPTIEPKPFL YVVGRKKMMD AQYKCYDRMQ 
QLPAYQGEGP YCNRTWDGWL CWDDTPAGVL SYQFCPDYFP DFDPSEKVTK YCDEKGVWFK 
HPENNRTWSN YTMCNAFTPE KLKNAYVLYY LAIVGHSLSI FTLVISLGIF VFFRSLGCQR 
VTLHKNMFLT YILNSMIIII HLVEVVPNGE LVRRDPVSCK ILHFFHQYMM ACNYFWMLCE 
GIYLHTLIVV AVFTEKQRLR WYYLLGWGFP LVPTTIHAIT RAVYFNDNCW LSVETHLLYI 
IHGPVMAALV VNFFFLLNIV RVLVTKMRET HEAESHMYLK AVKATMILVP LLGIQFVVFP 
WRPSNKMLGK IYDYVMHSLI HFQGFFVATI YCFCNNEVQT TVKRQWAQFK IQWNQRWGRR 
PSNRSARAAA AAAEAGDIPI YICHQELRNE PANNQGEESA EIIPLNIIEQ ESSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.