Details for: CALCR

Gene ID: 799

Symbol: CALCR

Ensembl ID: ENSG00000004948

Description: calcitonin receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.2362
    Cell Significance Index: -2.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.3814
    Cell Significance Index: 37.0200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.1188
    Cell Significance Index: 11.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8684
    Cell Significance Index: 101.2000
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8279
    Cell Significance Index: 7.5900
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.6770
    Cell Significance Index: 4.6300
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.5401
    Cell Significance Index: 5.7000
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.2089
    Cell Significance Index: 2.5300
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: 0.1536
    Cell Significance Index: 1.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0621
    Cell Significance Index: 9.0300
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.0502
    Cell Significance Index: 0.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0442
    Cell Significance Index: 2.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0209
    Cell Significance Index: 0.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0054
    Cell Significance Index: 3.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0026
    Cell Significance Index: 0.5200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0013
    Cell Significance Index: 2.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0013
    Cell Significance Index: -1.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0014
    Cell Significance Index: -0.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0014
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0032
    Cell Significance Index: -0.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0034
    Cell Significance Index: -2.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0036
    Cell Significance Index: -2.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0044
    Cell Significance Index: -2.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0049
    Cell Significance Index: -2.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0052
    Cell Significance Index: -2.3400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0058
    Cell Significance Index: -0.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0064
    Cell Significance Index: -1.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0085
    Cell Significance Index: -1.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0090
    Cell Significance Index: -0.1600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0105
    Cell Significance Index: -0.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0113
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0128
    Cell Significance Index: -2.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0135
    Cell Significance Index: -1.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0195
    Cell Significance Index: -2.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0197
    Cell Significance Index: -2.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0205
    Cell Significance Index: -2.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0205
    Cell Significance Index: -2.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0282
    Cell Significance Index: -0.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0294
    Cell Significance Index: -2.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0297
    Cell Significance Index: -1.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0318
    Cell Significance Index: -2.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0338
    Cell Significance Index: -0.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0342
    Cell Significance Index: -1.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0349
    Cell Significance Index: -1.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0350
    Cell Significance Index: -2.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0356
    Cell Significance Index: -2.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0386
    Cell Significance Index: -1.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0444
    Cell Significance Index: -2.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0456
    Cell Significance Index: -2.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0498
    Cell Significance Index: -0.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0513
    Cell Significance Index: -2.6700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0528
    Cell Significance Index: -1.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0573
    Cell Significance Index: -1.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0577
    Cell Significance Index: -2.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0580
    Cell Significance Index: -1.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0590
    Cell Significance Index: -2.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0629
    Cell Significance Index: -2.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0648
    Cell Significance Index: -2.1200
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0656
    Cell Significance Index: -0.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0664
    Cell Significance Index: -3.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0700
    Cell Significance Index: -2.2300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0734
    Cell Significance Index: -1.0300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0757
    Cell Significance Index: -1.5200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0757
    Cell Significance Index: -1.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0764
    Cell Significance Index: -2.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0764
    Cell Significance Index: -1.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0770
    Cell Significance Index: -2.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0771
    Cell Significance Index: -1.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0773
    Cell Significance Index: -1.6400
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.0820
    Cell Significance Index: -0.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0837
    Cell Significance Index: -2.9100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0859
    Cell Significance Index: -1.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0885
    Cell Significance Index: -2.5300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0910
    Cell Significance Index: -2.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0923
    Cell Significance Index: -2.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0942
    Cell Significance Index: -2.7000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0942
    Cell Significance Index: -1.1700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0943
    Cell Significance Index: -0.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0958
    Cell Significance Index: -2.0700
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: -0.0966
    Cell Significance Index: -0.3600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0971
    Cell Significance Index: -1.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0981
    Cell Significance Index: -2.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0982
    Cell Significance Index: -3.4500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0995
    Cell Significance Index: -1.4500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0996
    Cell Significance Index: -1.9700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1003
    Cell Significance Index: -1.0900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1033
    Cell Significance Index: -2.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1034
    Cell Significance Index: -5.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1052
    Cell Significance Index: -1.7700
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.1066
    Cell Significance Index: -1.1200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1075
    Cell Significance Index: -3.4000
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1103
    Cell Significance Index: -1.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1104
    Cell Significance Index: -2.8200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1106
    Cell Significance Index: -1.2300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1111
    Cell Significance Index: -1.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor Function:** CALCR is a G-protein coupled receptor (GPCR) that activates various signaling pathways upon ligand binding. 2. **Ligand Binding:** CALCR binds to calcitonin, amylin, calcitonin gene-related peptide, and amyloid-beta, among others. 3. **Expression:** CALCR is expressed in multiple cell types, including granulocyte-monocyte progenitor cells, cardiac endothelial cells, and skeletal muscle satellite cells. 4. **Signaling Pathways:** CALCR activates multiple signaling pathways, including adenylate cyclase-activating GPCR signaling, amylin receptor activity, and positive regulation of calcium-mediated signaling. **Pathways and Functions:** 1. **Calcium Homeostasis:** CALCR plays a crucial role in maintaining calcium homeostasis by regulating osteoclast differentiation and bone metabolism. 2. **Cell Proliferation and Differentiation:** CALCR signaling pathways influence cell proliferation, differentiation, and survival in various cell types, including granulocyte-monocyte progenitor cells and skeletal muscle satellite cells. 3. **Amyloid-Beta Binding:** CALCR binds to amyloid-beta, a peptide involved in Alzheimer's disease, and modulates its effects on neuronal function and survival. 4. **Amylin Receptor Activity:** CALCR binds to amylin, a hormone involved in glucose regulation, and modulates its effects on pancreatic beta-cell function and insulin secretion. **Clinical Significance:** 1. **Osteoporosis:** CALCR is involved in bone metabolism, and alterations in CALCR expression or function may contribute to osteoporosis. 2. **Alzheimer's Disease:** CALCR binding to amyloid-beta may modulate its effects on neuronal function and survival, and CALCR has been implicated in the pathogenesis of Alzheimer's disease. 3. **Diabetes:** CALCR binding to amylin may influence pancreatic beta-cell function and insulin secretion, and alterations in CALCR expression or function may contribute to diabetes. 4. **Cancer:** CALCR is expressed in various cancer types, including breast, lung, and colon cancer, and its signaling pathways may influence tumor growth and metastasis. In conclusion, the calcitonin receptor gene (CALCR) is a complex gene involved in multiple biological processes, including calcium homeostasis, cell proliferation and differentiation, and amyloid-beta binding. Its dysregulation has been implicated in various diseases, including osteoporosis, Alzheimer's disease, diabetes, and cancer. Further research is needed to fully understand the role of CALCR in human disease and to develop therapeutic strategies targeting this gene.

Genular Protein ID: 544432098

Symbol: CALCR_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1331173

Title: Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line.

PubMed ID: 1331173

DOI: 10.1172/jci116046

PubMed ID: 8078488

Title: Cloning and characterization of an abundant subtype of the human calcitonin receptor.

PubMed ID: 8078488

PubMed ID: 7588285

Title: Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene.

PubMed ID: 7588285

DOI: 10.1210/endo.136.12.7588285

PubMed ID: 8143880

Title: An isoform of the human calcitonin receptor is expressed in TT cells and in medullary carcinoma of the thyroid.

PubMed ID: 8143880

DOI: 10.1016/0014-5793(94)80503-2

PubMed ID: 10570950

Title: A novel calcitonin receptor gene in human osteoclasts from normal bone marrow.

PubMed ID: 10570950

DOI: 10.1016/s0014-5793(99)01176-x

PubMed ID: 15563840

Title: Molecular characterization of two novel isoforms of the human calcitonin receptor.

PubMed ID: 15563840

DOI: 10.1016/j.gene.2004.08.019

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 7720653

Title: Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor.

PubMed ID: 7720653

DOI: 10.1210/endo.136.5.7720653

PubMed ID: 7733946

Title: A new type of human calcitonin receptor isoform generated by alternative splicing.

PubMed ID: 7733946

DOI: 10.1006/bbrc.1995.1562

PubMed ID: 7476993

Title: Functionally different isoforms of the human calcitonin receptor result from alternative splicing of the gene transcript.

PubMed ID: 7476993

DOI: 10.1210/mend.9.8.7476993

PubMed ID: 10860825

Title: Multiple promoters regulate human calcitonin receptor gene expression.

PubMed ID: 10860825

DOI: 10.1006/bbrc.2000.2842

PubMed ID: 15086532

Title: Identification of a novel family of G protein-coupled receptor associated sorting proteins.

PubMed ID: 15086532

DOI: 10.1111/j.1471-4159.2004.02411.x

PubMed ID: 9675109

Title: Polymorphisms of the calcitonin receptor gene are associated with bone mineral density in postmenopausal Italian women.

PubMed ID: 9675109

DOI: 10.1006/bbrc.1998.8880

PubMed ID: 22946511

Title: Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Delta(1-47)hCT((a)) function.

PubMed ID: 22946511

DOI: 10.1111/j.1476-5381.2012.02197.x

PubMed ID: 9571205

Title: Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women.

PubMed ID: 9571205

DOI: 10.1006/bbrc.1998.8445

PubMed ID: 9817931

Title: Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women.

PubMed ID: 9817931

DOI: 10.1093/hmg/7.13.2129

Sequence Information:

  • Length: 474
  • Mass: 55345
  • Checksum: 0D9FA81230B282D9
  • Sequence:
  • MRFTFTSRCL ALFLLLNHPT PILPAFSNQT YPTIEPKPFL YVVGRKKMMD AQYKCYDRMQ 
    QLPAYQGEGP YCNRTWDGWL CWDDTPAGVL SYQFCPDYFP DFDPSEKVTK YCDEKGVWFK 
    HPENNRTWSN YTMCNAFTPE KLKNAYVLYY LAIVGHSLSI FTLVISLGIF VFFRSLGCQR 
    VTLHKNMFLT YILNSMIIII HLVEVVPNGE LVRRDPVSCK ILHFFHQYMM ACNYFWMLCE 
    GIYLHTLIVV AVFTEKQRLR WYYLLGWGFP LVPTTIHAIT RAVYFNDNCW LSVETHLLYI 
    IHGPVMAALV VNFFFLLNIV RVLVTKMRET HEAESHMYLK AVKATMILVP LLGIQFVVFP 
    WRPSNKMLGK IYDYVMHSLI HFQGFFVATI YCFCNNEVQT TVKRQWAQFK IQWNQRWGRR 
    PSNRSARAAA AAAEAGDIPI YICHQELRNE PANNQGEESA EIIPLNIIEQ ESSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.