Details for: UBXN8

Gene ID: 7993

Symbol: UBXN8

Ensembl ID: ENSG00000104691

Description: UBX domain protein 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169071
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.17
    Marker Score: 935
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.05
    Marker Score: 1311
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.01
    Marker Score: 721
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71779.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48004
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 15011
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 491
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2724
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5015
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.82
    Marker Score: 295
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.8
    Marker Score: 597.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.78
    Marker Score: 1121.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1574
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 572.5
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.75
    Marker Score: 2105
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 675
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.73
    Marker Score: 211
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.73
    Marker Score: 492
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.67
    Marker Score: 2646
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.67
    Marker Score: 335
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2774
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 385
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.62
    Marker Score: 261
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.6
    Marker Score: 170
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.59
    Marker Score: 1473.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.57
    Marker Score: 605
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.57
    Marker Score: 3424
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.56
    Marker Score: 605
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.54
    Marker Score: 5606
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.52
    Marker Score: 284
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.51
    Marker Score: 2204
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.51
    Marker Score: 274
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.51
    Marker Score: 346
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.51
    Marker Score: 335
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.5
    Marker Score: 158
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 317
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 201
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.48
    Marker Score: 766
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.47
    Marker Score: 5309
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.47
    Marker Score: 1180
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.47
    Marker Score: 272
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.46
    Marker Score: 3066
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.46
    Marker Score: 611
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.44
    Marker Score: 212
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.44
    Marker Score: 461
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.44
    Marker Score: 133
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.43
    Marker Score: 294
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.43
    Marker Score: 633
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.42
    Marker Score: 2762
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.42
    Marker Score: 678
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.42
    Marker Score: 959
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.42
    Marker Score: 422
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.41
    Marker Score: 109
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.41
    Marker Score: 2425
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.41
    Marker Score: 429
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.4
    Marker Score: 807
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4
    Marker Score: 269
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.4
    Marker Score: 195.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4
    Marker Score: 841
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.39
    Marker Score: 160
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.39
    Marker Score: 14789
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.39
    Marker Score: 595
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.38
    Marker Score: 1006
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 367.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.38
    Marker Score: 397
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.38
    Marker Score: 368
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.38
    Marker Score: 891
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.37
    Marker Score: 781
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.37
    Marker Score: 618
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.37
    Marker Score: 436
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.37
    Marker Score: 1420
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.37
    Marker Score: 152
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.37
    Marker Score: 1298
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.36
    Marker Score: 561
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.36
    Marker Score: 343
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.36
    Marker Score: 90
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.36
    Marker Score: 381
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.36
    Marker Score: 961
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.35
    Marker Score: 97
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 156
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.35
    Marker Score: 829
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.35
    Marker Score: 555
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.35
    Marker Score: 310
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.35
    Marker Score: 104
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.35
    Marker Score: 1409
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.34
    Marker Score: 347
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.34
    Marker Score: 192
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.34
    Marker Score: 2590
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.34
    Marker Score: 86

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Other Information

**Key Characteristics** The UBX domain protein 8 (UBXN8) is a ubiquitin-like protein that contains a UBX domain, which is characterized by a conserved sequence of amino acids. The UBX domain is known to interact with ubiquitin and other ubiquitin-like proteins, suggesting a role in the regulation of protein degradation and the ubiquitination of target proteins. The protein is also characterized by its ability to bind to other proteins, which may play a role in its function. **Pathways and Functions** UBXN8 is involved in several cellular pathways, including the Endoplasmic Reticulum (ER) pathway, the Nucleolus pathway, and the Protein-macromolecule adaptor activity pathway. The ER pathway is involved in the regulation of protein folding and degradation, while the Nucleolus pathway is involved in the regulation of ribosome biogenesis. The Protein-macromolecule adaptor activity pathway is involved in the regulation of protein-protein interactions. The functions of UBXN8 are not fully understood, but it is likely involved in the regulation of protein degradation and the ubiquitination of target proteins. The protein may also play a role in cellular differentiation and development, given its expression in various cell types. **Clinical Significance** The clinical significance of UBXN8 is not well established, but its expression in various cell types suggests that it may play a role in the development and progression of certain diseases. For example, the expression of UBXN8 in pulmonary interstitial fibroblasts suggests that it may play a role in the development of pulmonary fibrosis. Additionally, the expression of UBXN8 in cerebral cortex GABAergic interneurons suggests that it may play a role in the regulation of neuronal function and the development of neurological disorders. Future studies are needed to fully understand the role of UBXN8 in disease and to identify potential therapeutic targets.

Genular Protein ID: 468059295

Symbol: UBXN8_HUMAN

Name: UBX domain-containing protein 8

UniProtKB Accession Codes:

O00124 Q7Z6F2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9027507

Title: Cloning and characterization of Rep-8 (D8S2298E) in the human chromosome 8p11.2-p12.

PubMed ID: 9027507

DOI: 10.1006/geno.1996.4480

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21949850

Title: The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins.

PubMed ID: 21949850

DOI: 10.1371/journal.pone.0025061

Sequence Information:

  • Length: 270
  • Mass: 30541
  • Checksum: 13398A33D0CAC076
  • Sequence:
    • MASRGVVGIF FLSAVPLVCL ELRRGIPDIG IKDFLLLCGR ILLLLALLTL IISVTTSWLN 
SFKSPQVYLK EEEEKNEKRQ KLVRKKQQEA QGEKASRYIE NVLKPHQEMK LRKLEERFYQ 
MTGEAWKLSS GHKLGGDEGT SQTSFETSNR EAAKSQNLPK PLTEFPSPAE QPTCKEIPDL 
PEEPSQTAEE VVTVALRCPS GNVLRRRFLK SYSSQVLFDW MTRIGYHISL YSLSTSFPRR 
PLAVEGGQSL EDIGITVDTV LILEEKEQTN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.