Details for: CALD1

Gene ID: 800

Symbol: CALD1

Ensembl ID: ENSG00000122786

Description: caldesmon 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: contractile cell (CL0000183)
    Fold Change: 6.74
    Marker Score: 3651
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 5.99
    Marker Score: 5715
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.7
    Marker Score: 7423
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 4.53
    Marker Score: 8721
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.46
    Marker Score: 3195
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.39
    Marker Score: 98089.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.29
    Marker Score: 56631
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.29
    Marker Score: 2383.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.18
    Marker Score: 2975
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.07
    Marker Score: 3472.5
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 4.03
    Marker Score: 4972
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.93
    Marker Score: 133823.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.92
    Marker Score: 1258
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.89
    Marker Score: 5351
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.87
    Marker Score: 7272
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.8
    Marker Score: 4736.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.74
    Marker Score: 2463.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.7
    Marker Score: 18189
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.67
    Marker Score: 3922
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.62
    Marker Score: 4377
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.52
    Marker Score: 9223
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.49
    Marker Score: 7656
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.44
    Marker Score: 3322
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.41
    Marker Score: 12117
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 3.38
    Marker Score: 877
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.21
    Marker Score: 20888
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.13
    Marker Score: 3608
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.12
    Marker Score: 4202
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.11
    Marker Score: 2048
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.1
    Marker Score: 34952
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 3.04
    Marker Score: 1150
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 3.03
    Marker Score: 7133
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.02
    Marker Score: 4393
  • Cell Name: pericyte (CL0000669)
    Fold Change: 3.01
    Marker Score: 1756
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3
    Marker Score: 1250
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.95
    Marker Score: 4272
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.95
    Marker Score: 12709
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.91
    Marker Score: 1693
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.83
    Marker Score: 4364
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.8
    Marker Score: 9159
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.79
    Marker Score: 1593
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.76
    Marker Score: 1617
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.74
    Marker Score: 1180
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.74
    Marker Score: 864
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.71
    Marker Score: 6618
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.57
    Marker Score: 578.5
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.57
    Marker Score: 728
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.51
    Marker Score: 25255
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.49
    Marker Score: 2139
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.48
    Marker Score: 4957.5
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.46
    Marker Score: 1214
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.45
    Marker Score: 6680
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.42
    Marker Score: 558
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.38
    Marker Score: 6052
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.37
    Marker Score: 3882.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.35
    Marker Score: 2537
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.35
    Marker Score: 794
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.34
    Marker Score: 596
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.32
    Marker Score: 2183
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.32
    Marker Score: 657
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.29
    Marker Score: 1335
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.29
    Marker Score: 2443
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.27
    Marker Score: 9504
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.27
    Marker Score: 664
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.19
    Marker Score: 1379
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.18
    Marker Score: 7736
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.17
    Marker Score: 2046
  • Cell Name: neural cell (CL0002319)
    Fold Change: 2.13
    Marker Score: 1030
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.11
    Marker Score: 2274
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.1
    Marker Score: 1881
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.1
    Marker Score: 522
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.1
    Marker Score: 1859
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.09
    Marker Score: 4372
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.09
    Marker Score: 11246
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.08
    Marker Score: 522
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.07
    Marker Score: 7646
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.05
    Marker Score: 711.5
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.03
    Marker Score: 1665
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.02
    Marker Score: 4827
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.95
    Marker Score: 1300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.94
    Marker Score: 1217
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.92
    Marker Score: 1998
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.92
    Marker Score: 1086
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.91
    Marker Score: 719
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.91
    Marker Score: 16731
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.9
    Marker Score: 795
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.88
    Marker Score: 7391
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.88
    Marker Score: 1997
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.88
    Marker Score: 436
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.86
    Marker Score: 941
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.86
    Marker Score: 8019
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.85
    Marker Score: 3130
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.83
    Marker Score: 941
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.83
    Marker Score: 11742.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.81
    Marker Score: 1130
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.8
    Marker Score: 722
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.72
    Marker Score: 1930
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.72
    Marker Score: 897
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.71
    Marker Score: 1140
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.71
    Marker Score: 10134.5

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Other Information

**Key characteristics:** - It is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a calcium-dependent protein that binds to the actin cytoskeleton. - It is involved in the regulation of smooth muscle contraction and is expressed in cells that are under the control of the nervous system. **Pathways and functions:** - Cald1 is involved in the regulation of smooth muscle contraction. - It binds to the actin cytoskeleton and recruits calcium ions to the cytosol, which leads to the activation of myosin. - This activation of myosin leads to the contraction of smooth muscle cells. - In addition to its role in smooth muscle contraction, cald1 is also involved in the regulation of cell cycle regulation, cell signaling, and apoptosis. **Clinical significance:** Cald1 gene mutations have been linked to various human diseases, including hypertension, cardiac hypertrophy, and cancer. These mutations can disrupt the normal function of cald1, leading to the development of these diseases. **Additional information:** - The CALD1 gene is located on chromosome 1q21.1. - It is a highly conserved protein, with a similar protein found in other vertebrates. - It is a target for a number of drugs, including diltiazem, which is used to treat hypertension.

Genular Protein ID: 2044985882

Symbol: CALD1_HUMAN

Name: Caldesmon

UniProtKB Accession Codes:

Q05682 A8K0X1 Q13978 Q13979 Q14741 Q14742 Q9UD91

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 1 RefSeq 7 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1885618

Title: Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells.

PubMed ID: 1885618

DOI: 10.1016/s0021-9258(18)55390-4

PubMed ID: 1555769

Title: Cloning of cDNAs encoding human caldesmons.

PubMed ID: 1555769

DOI: 10.1016/0378-1119(92)90376-z

PubMed ID: 1465449

Title: Genomic structure of the human caldesmon gene.

PubMed ID: 1465449

DOI: 10.1073/pnas.89.24.12122

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8227296

Title: Identification of functioning regulatory sites and a new myosin binding site in the C-terminal 288 amino acids of caldesmon expressed from a human clone.

PubMed ID: 8227296

DOI: 10.1007/bf00121289

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 793
  • Mass: 93231
  • Checksum: 7468E2C3E40BF697
  • Sequence:
    • MDDFERRREL RRQKREEMRL EAERIAYQRN DDDEEEAARE RRRRARQERL RQKQEEESLG 
QVTDQVEVNA QNSVPDEEAK TTTTNTQVEG DDEAAFLERL ARREERRQKR LQEALERQKE 
FDPTITDASL SLPSRRMQND TAENETTEKE EKSESRQERY EIEETETVTK SYQKNDWRDA 
EENKKEDKEK EEEEEEKPKR GSIGENQVEV MVEEKTTESQ EETVVMSLKN GQISSEEPKQ 
EEEREQGSDE ISHHEKMEEE DKERAEAERA RLEAEERERI KAEQDKKIAD ERARIEAEEK 
AAAQERERRE AEERERMREE EKRAAEERQR IKEEEKRAAE ERQRIKEEEK RAAEERQRIK 
EEEKRAAEER QRARAEEEEK AKVEEQKRNK QLEEKKHAMQ ETKIKGEKVE QKIEGKWVNE 
KKAQEDKLQT AVLKKQGEEK GTKVQAKREK LQEDKPTFKK EEIKDEKIKK DKEPKEEVKS 
FMDRKKGFTE VKSQNGEFMT HKLKHTENTF SRPGGRASVD TKEAEGAPQV EAGKRLEELR 
RRRGETESEE FEKLKQKQQE AALELEELKK KREERRKVLE EEEQRRKQEE ADRKLREEEE 
KRRLKEEIER RRAEAAEKRQ KMPEDGLSDD KKPFKCFTPK GSSLKIEERA EFLNKSVQKS 
SGVKSTHQAA IVSKIDSRLE QYTSAIEGTK SAKPTKPAAS DLPVPAEGVR NIKSMWEKGN 
VFSSPTAAGT PNKETAGLKV GVSSRINEWL TKTPDGNKSP APKPSDLRPG DVSSKRNLWE 
KQSVDKVTSP TKV

Genular Protein ID: 746793180

Symbol: A0A140VKA0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VKA0

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 6 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 Pfam 1 RefSeq 2 SAM 1 SMR 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 538
  • Mass: 62663
  • Checksum: 7EBF78B53217E77A
  • Sequence:
    • MDDFERRREL RRQKREEMRL EAERIAYQRN DDDEEEAARE RRRRARQERL RQKQEEESLG 
QVTDQVEVNA QNSVPDEEAK TTTTNTQVEG DDEAAFLERL ARREERRQKR LQEALERQKE 
FDPTITDASL SLPSRRMQND TAENETTEKE EKSESRQERY EIEETETVTK SYQKNDWRDA 
EENKKEDKEK EEEEEEKPKR GSIGENQIKD EKIKKDKEPK EEVKSFMDRK KGFTEVKSQN 
GEFMTHKLKH TENTFSRPGG RASVDTKEAE GAPQVEAGKR LEELRRRRGE TESEEFEKLK 
QKQQEAALEL EELKKKREER RKVLEEEEQR RKQEEADRKL REEEEKRRLK EEIERRRAEA 
AEKRQKMPED GLSDDKKPFK CFTPKGSSLK IEERAEFLNK SVQKSSGVKS THQAAIVSKI 
DSRLEQYTSA IEGTKSAKPT KPAASDLPVP AEGVRNIKSM WEKGNVFSSP TAAGTPNKET 
AGLKVGVSSR INEWLTKTPD GNKSPAPKPS DLRPGDVSSK RNLWEKQSVD KVTSPTKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.