Gene CALM1 - ENSG00000198668 | NCBI Gene ID: 801

Details for: CALM1

Gene ID: 801

Symbol: CALM1

Ensembl ID: ENSG00000198668

Description: calmodulin 1

Associated with

Activation of kainate receptors upon glutamate binding
(R-HSA-451326)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Bacterial infection pathways
(R-HSA-9824439)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Ca2+ pathway
(R-HSA-4086398)
Cardiac conduction
(R-HSA-5576891)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of developmental biology
(R-HSA-9675151)
Disorders of nervous system development
(R-HSA-9697154)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Enos activation
(R-HSA-203615)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
G alpha (i) signalling events
(R-HSA-418594)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glycogen breakdown (glycogenolysis)
(R-HSA-70221)
Glycogen metabolism
(R-HSA-8982491)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Inactivation, recovery and regulation of the phototransduction cascade
(R-HSA-2514859)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Inositol phosphate metabolism
(R-HSA-1483249)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion channel transport
(R-HSA-983712)
Ion homeostasis
(R-HSA-5578775)
Ion transport by p-type atpases
(R-HSA-936837)
Leishmania infection
(R-HSA-9658195)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of cofactors
(R-HSA-8978934)
Metabolism of nitric oxide: nos3 activation and regulation
(R-HSA-202131)
Metabolism of proteins
(R-HSA-392499)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Mitochondrial biogenesis
(R-HSA-1592230)
Muscle contraction
(R-HSA-397014)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Oncogenic mapk signaling
(R-HSA-6802957)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Parasitic infection pathways
(R-HSA-9824443)
Pervasive developmental disorders
(R-HSA-9005895)
Phase 0 - rapid depolarisation
(R-HSA-5576892)
Pka activation
(R-HSA-163615)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet calcium homeostasis
(R-HSA-418360)
Platelet degranulation
(R-HSA-114608)
Platelet homeostasis
(R-HSA-418346)
Post-translational protein modification
(R-HSA-597592)
Protein methylation
(R-HSA-8876725)
Raf/map kinase cascade
(R-HSA-5673001)
Reduction of cytosolic ca++ levels
(R-HSA-418359)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Sensory perception
(R-HSA-9709957)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by gpcr
(R-HSA-372790)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by vegf
(R-HSA-194138)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Slc-mediated transmembrane transport
(R-HSA-425407)
Smooth muscle contraction
(R-HSA-445355)
Sodium/calcium exchangers
(R-HSA-425561)
Stimuli-sensing channels
(R-HSA-2672351)
Synthesis of ip3 and ip4 in the cytosol
(R-HSA-1855204)
Tetrahydrobiopterin (bh4) synthesis, recycling, salvage and regulation
(R-HSA-1474151)
The phototransduction cascade
(R-HSA-2514856)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Transmission across chemical synapses
(R-HSA-112315)
Transport of inorganic cations/anions and amino acids/oligopeptides
(R-HSA-425393)
Transport of small molecules
(R-HSA-382551)
Uptake and actions of bacterial toxins
(R-HSA-5339562)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vesicle-mediated transport
(R-HSA-5653656)
Visual phototransduction
(R-HSA-2187338)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: GABAergic neuron (CL0000617)
Fold Change: 6.33
Marker Score: 26392.5
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 5.38
Marker Score: 11346.5
Cell Name: chromaffin cell (CL0000166)
Fold Change: 5.33
Marker Score: 7500
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 5.32
Marker Score: 27900
Cell Name: stellate neuron (CL0000122)
Fold Change: 4.94
Marker Score: 26563
Cell Name: mature T cell (CL0002419)
Fold Change: 4.93
Marker Score: 48785
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.72
Marker Score: 13778
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.71
Marker Score: 14852
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.35
Marker Score: 229878
Cell Name: naive T cell (CL0000898)
Fold Change: 4.16
Marker Score: 2681
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.15
Marker Score: 11652
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 4.15
Marker Score: 3245
Cell Name: blood cell (CL0000081)
Fold Change: 4.04
Marker Score: 46952
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.04
Marker Score: 4873
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.03
Marker Score: 3898
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4
Marker Score: 5897
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.99
Marker Score: 17124
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 3.99
Marker Score: 2897
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 3.97
Marker Score: 2038.5
Cell Name: endocrine cell (CL0000163)
Fold Change: 3.96
Marker Score: 2049
Cell Name: granule cell (CL0000120)
Fold Change: 3.96
Marker Score: 29858
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.92
Marker Score: 3703
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.88
Marker Score: 3449
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 3.86
Marker Score: 17875.5
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 3.84
Marker Score: 4262
Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.83
Marker Score: 3002
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 3.81
Marker Score: 1989
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.79
Marker Score: 10458
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 3.74
Marker Score: 9507
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.74
Marker Score: 3144
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.7
Marker Score: 206676
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 3.69
Marker Score: 5686.5
Cell Name: endocardial cell (CL0002350)
Fold Change: 3.69
Marker Score: 2084
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 3.68
Marker Score: 31935.5
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.65
Marker Score: 8314
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 3.65
Marker Score: 871
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.62
Marker Score: 3087
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 3.59
Marker Score: 5195
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.56
Marker Score: 12656.5
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.51
Marker Score: 3777
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.5
Marker Score: 2649
Cell Name: endothelial cell (CL0000115)
Fold Change: 3.49
Marker Score: 3125
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.48
Marker Score: 2039
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 3.47
Marker Score: 13420
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 3.46
Marker Score: 5928.5
Cell Name: macroglial cell (CL0000126)
Fold Change: 3.43
Marker Score: 7882
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 3.43
Marker Score: 7183
Cell Name: memory T cell (CL0000813)
Fold Change: 3.42
Marker Score: 1470
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 3.36
Marker Score: 3660
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 3.34
Marker Score: 10487
Cell Name: ependymal cell (CL0000065)
Fold Change: 3.33
Marker Score: 1162
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.33
Marker Score: 26000
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.32
Marker Score: 3797
Cell Name: secretory cell (CL0000151)
Fold Change: 3.31
Marker Score: 6041
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 3.3
Marker Score: 3090
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 3.3
Marker Score: 4554.5
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 3.29
Marker Score: 2026
Cell Name: acinar cell (CL0000622)
Fold Change: 3.27
Marker Score: 2310
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.27
Marker Score: 1807
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 3.27
Marker Score: 2778
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.27
Marker Score: 21311
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 3.26
Marker Score: 863
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.26
Marker Score: 1626
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 3.25
Marker Score: 2350
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.23
Marker Score: 2851
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.23
Marker Score: 2299
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.23
Marker Score: 2779
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.22
Marker Score: 3170
Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.21
Marker Score: 19060
Cell Name: ciliated cell (CL0000064)
Fold Change: 3.21
Marker Score: 11041
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 3.21
Marker Score: 4414
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 3.2
Marker Score: 1116
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.2
Marker Score: 110674
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.19
Marker Score: 23765
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 3.19
Marker Score: 1375
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.18
Marker Score: 837
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 3.17
Marker Score: 6441
Cell Name: granulocyte (CL0000094)
Fold Change: 3.16
Marker Score: 1415.5
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.16
Marker Score: 7706
Cell Name: stromal cell (CL0000499)
Fold Change: 3.15
Marker Score: 3693
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.14
Marker Score: 720
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 3.14
Marker Score: 2137
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 3.14
Marker Score: 16478.5
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.13
Marker Score: 1622
Cell Name: muscle precursor cell (CL0000680)
Fold Change: 3.13
Marker Score: 811
Cell Name: Unknown (CL0000548)
Fold Change: 3.12
Marker Score: 2277
Cell Name: malignant cell (CL0001064)
Fold Change: 3.11
Marker Score: 41820
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.09
Marker Score: 2035
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 3.07
Marker Score: 2251
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 3.06
Marker Score: 1008
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.06
Marker Score: 2507
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 3.05
Marker Score: 5981
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.05
Marker Score: 1391.5
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.05
Marker Score: 5441
Cell Name: mature NK T cell (CL0000814)
Fold Change: 3.02
Marker Score: 1400
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 3.02
Marker Score: 1231
Cell Name: promonocyte (CL0000559)
Fold Change: 3.02
Marker Score: 1945
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3.02
Marker Score: 980.5
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.01
Marker Score: 859
Cell Name: leukocyte (CL0000738)
Fold Change: 3.01
Marker Score: 1727.5

Hover over a box to see details here...

**Key characteristics:** - CALM1 is a calcium-binding protein that belongs to the calmodulin family of proteins. - It is a highly conserved protein with a molecular weight of approximately 140 kDa. - It is expressed in high levels in various immune cell types, including dendritic cells, macrophages, and lymphocytes. - It is a key regulator of innate immune responses and is involved in the regulation of inflammation and immune cell activation. **Pathways and functions:** - CALM1 is involved in the regulation of innate immune responses and is expressed in immune cells such as dendritic cells and macrophages. - It helps to regulate the activation and differentiation of immune cells by binding to calcium ions and modulating the activity of signaling pathways. - It also plays a role in the regulation of inflammation and immune cell activation. - It helps to maintain immune homeostasis and prevent excessive inflammation. **Clinical significance:** - Mutations in the CALM1 gene have been linked to several autoimmune diseases, including rheumatoid arthritis, Crohn's disease, and multiple sclerosis. - CALM1 is a potential therapeutic target for autoimmune diseases that are characterized by excessive inflammation and immune cell activation. **Additional notes:** - CALM1 is a key regulator of the adaptive immune system and is involved in the regulation of inflammation and immune cell activation. - It is also involved in the regulation of cell signaling and metabolism. - It is a highly conserved protein with important functions in immune regulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CALM1_HUMAN

Genular Protein ID: 1532091721

Symbol: CALM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P0DP23 P02593 P62158 P70667 P99014 Q13942 Q53S29 Q61379 Q61380 Q96HK3

Database IDs:

Citations:

PubMed ID: 6385987

Title: Isolation and nucleotide sequence of a cDNA encoding human calmodulin.

PubMed ID: 6385987

PubMed ID: 7925473

Title: Structure of the human CALM1 calmodulin gene and identification of two CALM1-related pseudogenes CALM1P1 and CALM1P2.

PubMed ID: 7925473

DOI: 10.1111/j.1432-1033.1994.00071.x

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7093203

Title: Complete amino acid sequence of human brain calmodulin.

PubMed ID: 7093203

DOI: 10.1021/bi00539a041

PubMed ID: 9804419

Title: Structural basis for activation of the titin kinase domain during myofibrillogenesis.

PubMed ID: 9804419

DOI: 10.1038/27603

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 12871148

Title: Recombinant expression, purification and characterisation of the HMG domain of human SRY.

PubMed ID: 12871148

DOI: 10.2174/0929866033479004

PubMed ID: 16127172

Title: Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6.

PubMed ID: 16127172

DOI: 10.1074/jbc.m505220200

PubMed ID: 15746192

Title: Defective calmodulin-mediated nuclear transport of the sex-determining region of the Y chromosome (SRY) in XY sex reversal.

PubMed ID: 15746192

DOI: 10.1210/me.2004-0334

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16760425

Title: CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.

PubMed ID: 16760425

DOI: 10.1091/mbc.e06-04-0371

PubMed ID: 17719545

Title: Cep97 and CP110 suppress a cilia assembly program.

PubMed ID: 17719545

DOI: 10.1016/j.cell.2007.06.027

PubMed ID: 18165683

Title: The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction.

PubMed ID: 18165683

DOI: 10.1074/jbc.m707541200

PubMed ID: 18650434

Title: S100A1 and calmodulin compete for the same binding site on ryanodine receptor.

PubMed ID: 18650434

DOI: 10.1074/jbc.m804432200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20466722

Title: Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex.

PubMed ID: 20466722

DOI: 10.1074/jbc.m110.105965

PubMed ID: 20086014

Title: Calcium-dependent association of calmodulin with the rubella virus nonstructural protease domain.

PubMed ID: 20086014

DOI: 10.1074/jbc.m109.097063

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23109337

Title: Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode.

PubMed ID: 23109337

DOI: 10.1074/jbc.m112.380964

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22484487

Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.

PubMed ID: 22484487

DOI: 10.1038/ncb2473

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28890335

Title: The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.

PubMed ID: 28890335

DOI: 10.1016/j.molcel.2017.08.005

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30021165

Title: Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to Postsynaptic Sites.

PubMed ID: 30021165

DOI: 10.1016/j.celrep.2018.06.071

PubMed ID: 30287853

Title: Calcineurin B homologous protein 3 binds with high affinity to the CHP binding domain of the human sodium/proton exchanger NHE1.

PubMed ID: 30287853

DOI: 10.1038/s41598-018-33096-5

PubMed ID: 31155282

Title: Gain-of-function mutations in KCNN3 encoding the small-conductance Ca2+-activated K+ channel SK3 cause Zimmermann-Laband syndrome.

PubMed ID: 31155282

DOI: 10.1016/j.ajhg.2019.04.012

PubMed ID: 31330532

Title: Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation.

PubMed ID: 31330532

DOI: 10.1038/s41586-019-1440-8

PubMed ID: 33667636

Title: Calmodulin binds to the STAS domain of SLC26A5 prestin with a calcium-dependent, one-lobe, binding mode.

PubMed ID: 33667636

DOI: 10.1016/j.jsb.2021.107714

PubMed ID: 35338844

Title: Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases.

PubMed ID: 35338844

DOI: 10.1016/j.molcel.2022.03.010

PubMed ID: 35446120

Title: Calmodulin binding activates chromobacterium CopC effector to ADP-riboxanate host apoptotic caspases.

PubMed ID: 35446120

DOI: 10.1128/mbio.00690-22

PubMed ID: 35568036

Title: A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling.

PubMed ID: 35568036

DOI: 10.1016/j.cell.2022.04.028

PubMed ID: 9927666

Title: Alpha-helix nucleation by a calcium-binding peptide loop.

PubMed ID: 9927666

DOI: 10.1073/pnas.96.3.903

PubMed ID: 11685248

Title: Solution structure of Ca(2+)-calmodulin reveals flexible hand-like properties of its domains.

PubMed ID: 11685248

DOI: 10.1038/nsb1101-990

PubMed ID: 1474585

Title: Calmodulin structure refined at 1.7 A resolution.

PubMed ID: 1474585

DOI: 10.1016/0022-2836(92)90324-d

PubMed ID: 7803388

Title: Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex.

PubMed ID: 7803388

DOI: 10.1021/bi00255a006

PubMed ID: 11807546

Title: Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.

PubMed ID: 11807546

DOI: 10.1038/415396a

PubMed ID: 12485993

Title: Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins.

PubMed ID: 12485993

DOI: 10.1093/emboj/cdf681

PubMed ID: 12577052

Title: Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin.

PubMed ID: 12577052

DOI: 10.1038/nsb900

PubMed ID: 16299511

Title: Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex.

PubMed ID: 16299511

DOI: 10.1038/nsmb1027

PubMed ID: 15719022

Title: Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.

PubMed ID: 15719022

DOI: 10.1038/sj.emboj.7600574

PubMed ID: 21167176

Title: Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5.

PubMed ID: 21167176

DOI: 10.1016/j.jmb.2010.11.046

PubMed ID: 23893133

Title: Allosteric mechanism of water-channel gating by Ca(2+)-calmodulin.

PubMed ID: 23893133

DOI: 10.1038/nsmb.2630

PubMed ID: 25441029

Title: Structural basis of a Kv7.1 potassium channel gating module: studies of the intracellular c-terminal domain in complex with calmodulin.

PubMed ID: 25441029

DOI: 10.1016/j.str.2014.07.016

PubMed ID: 27564677

Title: Structural insights into the M-channel proximal C-terminus/calmodulin complex.

PubMed ID: 27564677

DOI: 10.1021/acs.biochem.6b00477

PubMed ID: 27876793

Title: PEP-19 modulates calcium binding to calmodulin by electrostatic steering.

PubMed ID: 27876793

DOI: 10.1038/ncomms13583

PubMed ID: 23607618

Title: NMR structure of calmodulin complexed to an N-terminally acetylated alpha-synuclein peptide.

PubMed ID: 23607618

DOI: 10.1021/bi400199p

PubMed ID: 36423631

Title: Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin.

PubMed ID: 36423631

DOI: 10.1016/j.molcel.2022.10.032

PubMed ID: 23040497

Title: Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death.

PubMed ID: 23040497

DOI: 10.1016/j.ajhg.2012.08.015

PubMed ID: 23388215

Title: Calmodulin mutations associated with recurrent cardiac arrest in infants.

PubMed ID: 23388215

DOI: 10.1161/circulationaha.112.001216

PubMed ID: 25036739

Title: Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death.

PubMed ID: 25036739

DOI: 10.1016/j.febslet.2014.07.007

PubMed ID: 24076290

Title: A mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence.

PubMed ID: 24076290

DOI: 10.1016/j.jacc.2013.07.091

PubMed ID: 26164367

Title: Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease.

PubMed ID: 26164367

DOI: 10.1016/j.bbagen.2015.07.001

PubMed ID: 27516456

Title: Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.

PubMed ID: 27516456

DOI: 10.1161/circep.116.004161

PubMed ID: 26969752

Title: Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G.

PubMed ID: 26969752

DOI: 10.1161/circgenetics.115.001323

PubMed ID: 27165696

Title: Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current.

PubMed ID: 27165696

DOI: 10.1016/j.hrthm.2016.05.009

PubMed ID: 28158429

Title: Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes.

PubMed ID: 28158429

DOI: 10.1093/cvr/cvx006

PubMed ID: 31454269

Title: Genetic mosaicism in calmodulinopathy.

PubMed ID: 31454269

DOI: 10.1161/circgen.119.002581

Sequence Information:

Length: 149
Mass: 16838
Checksum: 6B4BC3FCDE10727B
Sequence:

MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG 
NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE 
EVDEMIREAD IDGDGQVNYE EFVQMMTAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CALM1

Associated with

Cells (max top 100)

Other Information

Isolation and nucleotide sequence of a cDNA encoding human calmodulin. PubMed ID: 6385987

Structure of the human CALM1 calmodulin gene and identification of two CALM1-related pseudogenes CALM1P1 and CALM1P2. PubMed ID: 7925473

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete amino acid sequence of human brain calmodulin. PubMed ID: 7093203

Structural basis for activation of the titin kinase domain during myofibrillogenesis. PubMed ID: 9804419

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Recombinant expression, purification and characterisation of the HMG domain of human SRY. PubMed ID: 12871148

Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6. PubMed ID: 16127172

Defective calmodulin-mediated nuclear transport of the sex-determining region of the Y chromosome (SRY) in XY sex reversal. PubMed ID: 15746192

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. PubMed ID: 16760425

Cep97 and CP110 suppress a cilia assembly program. PubMed ID: 17719545

The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction. PubMed ID: 18165683

S100A1 and calmodulin compete for the same binding site on ryanodine receptor. PubMed ID: 18650434

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex. PubMed ID: 20466722

Calcium-dependent association of calmodulin with the rubella virus nonstructural protease domain. PubMed ID: 20086014

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode. PubMed ID: 23109337

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. PubMed ID: 22484487

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. PubMed ID: 28890335

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to Postsynaptic Sites. PubMed ID: 30021165

Calcineurin B homologous protein 3 binds with high affinity to the CHP binding domain of the human sodium/proton exchanger NHE1. PubMed ID: 30287853

Gain-of-function mutations in KCNN3 encoding the small-conductance Ca2+-activated K+ channel SK3 cause Zimmermann-Laband syndrome. PubMed ID: 31155282

Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation. PubMed ID: 31330532

Calmodulin binds to the STAS domain of SLC26A5 prestin with a calcium-dependent, one-lobe, binding mode. PubMed ID: 33667636

Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases. PubMed ID: 35338844

Calmodulin binding activates chromobacterium CopC effector to ADP-riboxanate host apoptotic caspases. PubMed ID: 35446120

A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling. PubMed ID: 35568036

Alpha-helix nucleation by a calcium-binding peptide loop. PubMed ID: 9927666

Solution structure of Ca(2+)-calmodulin reveals flexible hand-like properties of its domains. PubMed ID: 11685248

Calmodulin structure refined at 1.7 A resolution. PubMed ID: 1474585

Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex. PubMed ID: 7803388

Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. PubMed ID: 11807546

Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins. PubMed ID: 12485993

Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin. PubMed ID: 12577052

Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. PubMed ID: 16299511

Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. PubMed ID: 15719022

Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5. PubMed ID: 21167176

Allosteric mechanism of water-channel gating by Ca(2+)-calmodulin. PubMed ID: 23893133

Structural basis of a Kv7.1 potassium channel gating module: studies of the intracellular c-terminal domain in complex with calmodulin. PubMed ID: 25441029

Structural insights into the M-channel proximal C-terminus/calmodulin complex. PubMed ID: 27564677

PEP-19 modulates calcium binding to calmodulin by electrostatic steering. PubMed ID: 27876793

NMR structure of calmodulin complexed to an N-terminally acetylated alpha-synuclein peptide. PubMed ID: 23607618

Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. PubMed ID: 36423631

Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death. PubMed ID: 23040497

Calmodulin mutations associated with recurrent cardiac arrest in infants. PubMed ID: 23388215

Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death. PubMed ID: 25036739

A mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence. PubMed ID: 24076290

Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease. PubMed ID: 26164367

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks. PubMed ID: 27516456

Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G. PubMed ID: 26969752

Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current. PubMed ID: 27165696

Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes. PubMed ID: 28158429

Genetic mosaicism in calmodulinopathy. PubMed ID: 31454269