CALM1 | ENSG00000198668 | NCBI 801

Details for: CALM1

Gene ID: 801

Symbol: CALM1

Ensembl ID: ENSG00000198668

Description: calmodulin 1

Associated with

Activation of kainate receptors upon glutamate binding
(R-HSA-451326)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Bacterial infection pathways
(R-HSA-9824439)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Ca2+ pathway
(R-HSA-4086398)
Cardiac conduction
(R-HSA-5576891)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of developmental biology
(R-HSA-9675151)
Disorders of nervous system development
(R-HSA-9697154)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Enos activation
(R-HSA-203615)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
G alpha (i) signalling events
(R-HSA-418594)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glycogen breakdown (glycogenolysis)
(R-HSA-70221)
Glycogen metabolism
(R-HSA-8982491)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Inactivation, recovery and regulation of the phototransduction cascade
(R-HSA-2514859)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Inositol phosphate metabolism
(R-HSA-1483249)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion channel transport
(R-HSA-983712)
Ion homeostasis
(R-HSA-5578775)
Ion transport by p-type atpases
(R-HSA-936837)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of cofactors
(R-HSA-8978934)
Metabolism of nitric oxide: nos3 activation and regulation
(R-HSA-202131)
Metabolism of proteins
(R-HSA-392499)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Mitochondrial biogenesis
(R-HSA-1592230)
Muscle contraction
(R-HSA-397014)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Oncogenic mapk signaling
(R-HSA-6802957)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Parasitic infection pathways
(R-HSA-9824443)
Pervasive developmental disorders
(R-HSA-9005895)
Phase 0 - rapid depolarisation
(R-HSA-5576892)
Pka activation
(R-HSA-163615)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet calcium homeostasis
(R-HSA-418360)
Platelet degranulation
(R-HSA-114608)
Platelet homeostasis
(R-HSA-418346)
Post-translational protein modification
(R-HSA-597592)
Protein methylation
(R-HSA-8876725)
Raf/map kinase cascade
(R-HSA-5673001)
Reduction of cytosolic ca++ levels
(R-HSA-418359)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Sensory perception
(R-HSA-9709957)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by gpcr
(R-HSA-372790)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by vegf
(R-HSA-194138)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Slc-mediated transmembrane transport
(R-HSA-425407)
Smooth muscle contraction
(R-HSA-445355)
Sodium/calcium exchangers
(R-HSA-425561)
Stimuli-sensing channels
(R-HSA-2672351)
Synthesis of ip3 and ip4 in the cytosol
(R-HSA-1855204)
Tetrahydrobiopterin (bh4) synthesis, recycling, salvage and regulation
(R-HSA-1474151)
The phototransduction cascade
(R-HSA-2514856)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Transmission across chemical synapses
(R-HSA-112315)
Transport of inorganic cations/anions and amino acids/oligopeptides
(R-HSA-425393)
Transport of small molecules
(R-HSA-382551)
Uptake and actions of bacterial toxins
(R-HSA-5339562)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vesicle-mediated transport
(R-HSA-5653656)
Visual phototransduction
(R-HSA-2187338)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 1379.4059
Cell Significance Index: -214.5600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 834.7153
Cell Significance Index: -211.7200
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 560.3382
Cell Significance Index: -230.8300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 454.1193
Cell Significance Index: -214.4000
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 418.6551
Cell Significance Index: -215.3500
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 320.8985
Cell Significance Index: -215.3300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 180.4485
Cell Significance Index: -222.4900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 59.6916
Cell Significance Index: -183.3400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 57.6349
Cell Significance Index: -227.4300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 45.7825
Cell Significance Index: -122.6500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 36.3294
Cell Significance Index: -79.5100
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 7.6663
Cell Significance Index: 402.5100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 6.6931
Cell Significance Index: 312.0600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 4.5255
Cell Significance Index: 556.4600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 4.3951
Cell Significance Index: 129.0800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 4.3832
Cell Significance Index: 790.1600
Cell Name: cell in vitro (CL0001034)
Fold Change: 4.2399
Cell Significance Index: 2315.4900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.8516
Cell Significance Index: 181.0200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 3.5646
Cell Significance Index: 219.1000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.0386
Cell Significance Index: 609.5500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 3.0309
Cell Significance Index: 1087.1500
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.7503
Cell Significance Index: 177.4400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.4884
Cell Significance Index: 1100.2000
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 2.4757
Cell Significance Index: 19.0800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.3966
Cell Significance Index: 329.1200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.3866
Cell Significance Index: 44.1100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.1541
Cell Significance Index: 254.0400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.0754
Cell Significance Index: 139.5500
Cell Name: odontoblast (CL0000060)
Fold Change: 2.0076
Cell Significance Index: 257.3600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.6522
Cell Significance Index: 1491.8000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.4160
Cell Significance Index: 37.8100
Cell Name: lactocyte (CL0002325)
Fold Change: 1.2407
Cell Significance Index: 160.2900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.0985
Cell Significance Index: 12.4800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 1.0959
Cell Significance Index: 18.7800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.0217
Cell Significance Index: 27.8100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2128
Cell Significance Index: 21.0600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1874
Cell Significance Index: 6.5900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1738
Cell Significance Index: 33.0700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1632
Cell Significance Index: 11.5400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1576
Cell Significance Index: 115.5300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1268
Cell Significance Index: 95.9800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0814
Cell Significance Index: 6.0700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0572
Cell Significance Index: 9.3100
Cell Name: peg cell (CL4033014)
Fold Change: 0.0493
Cell Significance Index: 1.1400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0403
Cell Significance Index: 8.0000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0636
Cell Significance Index: -119.8200
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.1232
Cell Significance Index: -227.2500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1450
Cell Significance Index: -197.1800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1537
Cell Significance Index: -236.6800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1562
Cell Significance Index: -99.2200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1565
Cell Significance Index: -15.9900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2161
Cell Significance Index: -98.0800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.2386
Cell Significance Index: -176.7600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2412
Cell Significance Index: -12.5300
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3399
Cell Significance Index: -9.7000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.3588
Cell Significance Index: -202.3700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.4089
Cell Significance Index: -255.3700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.4341
Cell Significance Index: -74.1200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.5160
Cell Significance Index: -56.1300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.7046
Cell Significance Index: -202.7200
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.7697
Cell Significance Index: -18.4600
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.8731
Cell Significance Index: -8.0400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -1.1435
Cell Significance Index: -240.8600
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.1739
Cell Significance Index: -20.7500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -1.2372
Cell Significance Index: -144.1800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.2546
Cell Significance Index: -182.3700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.3021
Cell Significance Index: -57.6000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.3436
Cell Significance Index: -106.4100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.4283
Cell Significance Index: -64.7400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.4510
Cell Significance Index: -166.2400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.4893
Cell Significance Index: -89.4100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.6167
Cell Significance Index: -27.0600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.7047
Cell Significance Index: -95.6600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.7758
Cell Significance Index: -136.2800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.7818
Cell Significance Index: -24.3100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.7845
Cell Significance Index: -112.4700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.8174
Cell Significance Index: -68.8200
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.8517
Cell Significance Index: -48.6900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.9262
Cell Significance Index: -41.7300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -2.0742
Cell Significance Index: -215.9700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -2.1273
Cell Significance Index: -59.4500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -2.4578
Cell Significance Index: -51.4500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -2.5250
Cell Significance Index: -72.3800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -2.8849
Cell Significance Index: -17.4300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.9898
Cell Significance Index: -95.7600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -3.0395
Cell Significance Index: -210.2000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -3.0904
Cell Significance Index: -107.3900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -3.2664
Cell Significance Index: -200.2600
Cell Name: neuron associated cell (CL0000095)
Fold Change: -3.8169
Cell Significance Index: -156.4000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -4.1160
Cell Significance Index: -110.1000
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -4.2872
Cell Significance Index: -64.2400
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -4.2931
Cell Significance Index: -126.4500
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -4.4781
Cell Significance Index: -95.7200
Cell Name: pro-T cell (CL0000827)
Fold Change: -4.6233
Cell Significance Index: -118.1100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -4.6536
Cell Significance Index: -152.3600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -4.8105
Cell Significance Index: -153.2100
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -5.1133
Cell Significance Index: -179.1300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -5.2450
Cell Significance Index: -192.5400
Cell Name: preadipocyte (CL0002334)
Fold Change: -5.6699
Cell Significance Index: -110.6600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -5.7733
Cell Significance Index: -148.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** CALM1 is a calcium-binding protein that consists of four EF-hand domains, which are responsible for binding and releasing calcium ions. It is a small protein, with a molecular weight of approximately 17 kDa. CALM1 is highly expressed in the nervous system, where it is found in neurons and glial cells, as well as in immune cells, such as T cells and natural killer cells. It is also present in other tissues, including the pancreas, adrenal glands, and the heart. CALM1 has a unique ability to bind and release calcium ions, which allows it to modulate a wide range of cellular activities. This property is essential for its role in neurotransmission, immune responses, and cell growth. CALM1 can also interact with other proteins, such as receptors, kinases, and phosphatases, to regulate their activity. **Pathways and Functions** CALM1 participates in a wide range of cellular processes, including: 1. **Neurotransmission**: CALM1 is involved in the regulation of neurotransmitter release and synaptic plasticity in the nervous system. 2. **Immune responses**: CALM1 plays a crucial role in the regulation of immune cell activation, proliferation, and differentiation. 3. **Cell growth and differentiation**: CALM1 is involved in the regulation of cell growth, differentiation, and survival in various cell types. 4. **Ion homeostasis**: CALM1 helps to regulate calcium ion homeostasis in cells, which is essential for maintaining proper cellular function. 5. **Signaling pathways**: CALM1 interacts with a wide range of signaling proteins, including receptors, kinases, and phosphatases, to regulate their activity. **Clinical Significance** Dysregulation of CALM1 has been implicated in various diseases, including: 1. **Neurological disorders**: CALM1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Autoimmune conditions**: CALM1 plays a crucial role in the regulation of immune responses, and its dysregulation has been implicated in autoimmune conditions, such as rheumatoid arthritis and lupus. 3. **Cancer**: CALM1 has been implicated in the regulation of cell growth and differentiation, and its dysregulation has been linked to cancer development and progression. 4. **Cardiovascular disease**: CALM1 has been implicated in the regulation of cardiac conduction and calcium ion homeostasis, and its dysregulation has been linked to cardiovascular disease. Overall, CALM1 is a multifunctional protein that plays a crucial role in various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its mechanisms of action and potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CALM1_HUMAN

Genular Protein ID: 1532091721

Symbol: CALM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P0DP23 P02593 P62158 P70667 P99014 Q13942 Q53S29 Q61379 Q61380 Q96HK3

Database IDs:

Citations:

PubMed ID: 6385987

Title: Isolation and nucleotide sequence of a cDNA encoding human calmodulin.

PubMed ID: 6385987

PubMed ID: 7925473

Title: Structure of the human CALM1 calmodulin gene and identification of two CALM1-related pseudogenes CALM1P1 and CALM1P2.

PubMed ID: 7925473

DOI: 10.1111/j.1432-1033.1994.00071.x

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7093203

Title: Complete amino acid sequence of human brain calmodulin.

PubMed ID: 7093203

DOI: 10.1021/bi00539a041

PubMed ID: 9804419

Title: Structural basis for activation of the titin kinase domain during myofibrillogenesis.

PubMed ID: 9804419

DOI: 10.1038/27603

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 12871148

Title: Recombinant expression, purification and characterisation of the HMG domain of human SRY.

PubMed ID: 12871148

DOI: 10.2174/0929866033479004

PubMed ID: 16127172

Title: Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6.

PubMed ID: 16127172

DOI: 10.1074/jbc.m505220200

PubMed ID: 15746192

Title: Defective calmodulin-mediated nuclear transport of the sex-determining region of the Y chromosome (SRY) in XY sex reversal.

PubMed ID: 15746192

DOI: 10.1210/me.2004-0334

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16760425

Title: CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.

PubMed ID: 16760425

DOI: 10.1091/mbc.e06-04-0371

PubMed ID: 17719545

Title: Cep97 and CP110 suppress a cilia assembly program.

PubMed ID: 17719545

DOI: 10.1016/j.cell.2007.06.027

PubMed ID: 18165683

Title: The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction.

PubMed ID: 18165683

DOI: 10.1074/jbc.m707541200

PubMed ID: 18650434

Title: S100A1 and calmodulin compete for the same binding site on ryanodine receptor.

PubMed ID: 18650434

DOI: 10.1074/jbc.m804432200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20466722

Title: Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex.

PubMed ID: 20466722

DOI: 10.1074/jbc.m110.105965

PubMed ID: 20086014

Title: Calcium-dependent association of calmodulin with the rubella virus nonstructural protease domain.

PubMed ID: 20086014

DOI: 10.1074/jbc.m109.097063

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23109337

Title: Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode.

PubMed ID: 23109337

DOI: 10.1074/jbc.m112.380964

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22484487

Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.

PubMed ID: 22484487

DOI: 10.1038/ncb2473

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25582440

Title: KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.

PubMed ID: 25582440

DOI: 10.1074/mcp.m114.042168

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28890335

Title: The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.

PubMed ID: 28890335

DOI: 10.1016/j.molcel.2017.08.005

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30021165

Title: Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to Postsynaptic Sites.

PubMed ID: 30021165

DOI: 10.1016/j.celrep.2018.06.071

PubMed ID: 30287853

Title: Calcineurin B homologous protein 3 binds with high affinity to the CHP binding domain of the human sodium/proton exchanger NHE1.

PubMed ID: 30287853

DOI: 10.1038/s41598-018-33096-5

PubMed ID: 31155282

Title: Gain-of-function mutations in KCNN3 encoding the small-conductance Ca2+-activated K+ channel SK3 cause Zimmermann-Laband syndrome.

PubMed ID: 31155282

DOI: 10.1016/j.ajhg.2019.04.012

PubMed ID: 31330532

Title: Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation.

PubMed ID: 31330532

DOI: 10.1038/s41586-019-1440-8

PubMed ID: 33667636

Title: Calmodulin binds to the STAS domain of SLC26A5 prestin with a calcium-dependent, one-lobe, binding mode.

PubMed ID: 33667636

DOI: 10.1016/j.jsb.2021.107714

PubMed ID: 35338844

Title: Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases.

PubMed ID: 35338844

DOI: 10.1016/j.molcel.2022.03.010

PubMed ID: 35446120

Title: Calmodulin binding activates chromobacterium CopC effector to ADP-riboxanate host apoptotic caspases.

PubMed ID: 35446120

DOI: 10.1128/mbio.00690-22

PubMed ID: 35568036

Title: A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling.

PubMed ID: 35568036

DOI: 10.1016/j.cell.2022.04.028

PubMed ID: 38297121

Title: Stress response silencing by an E3 ligase mutated in neurodegeneration.

PubMed ID: 38297121

DOI: 10.1038/s41586-023-06985-7

PubMed ID: 9927666

Title: Alpha-helix nucleation by a calcium-binding peptide loop.

PubMed ID: 9927666

DOI: 10.1073/pnas.96.3.903

PubMed ID: 11685248

Title: Solution structure of Ca(2+)-calmodulin reveals flexible hand-like properties of its domains.

PubMed ID: 11685248

DOI: 10.1038/nsb1101-990

PubMed ID: 1474585

Title: Calmodulin structure refined at 1.7 A resolution.

PubMed ID: 1474585

DOI: 10.1016/0022-2836(92)90324-d

PubMed ID: 7803388

Title: Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex.

PubMed ID: 7803388

DOI: 10.1021/bi00255a006

PubMed ID: 11807546

Title: Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.

PubMed ID: 11807546

DOI: 10.1038/415396a

PubMed ID: 12485993

Title: Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins.

PubMed ID: 12485993

DOI: 10.1093/emboj/cdf681

PubMed ID: 12577052

Title: Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin.

PubMed ID: 12577052

DOI: 10.1038/nsb900

PubMed ID: 16299511

Title: Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex.

PubMed ID: 16299511

DOI: 10.1038/nsmb1027

PubMed ID: 15719022

Title: Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.

PubMed ID: 15719022

DOI: 10.1038/sj.emboj.7600574

PubMed ID: 21167176

Title: Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5.

PubMed ID: 21167176

DOI: 10.1016/j.jmb.2010.11.046

PubMed ID: 23893133

Title: Allosteric mechanism of water-channel gating by Ca(2+)-calmodulin.

PubMed ID: 23893133

DOI: 10.1038/nsmb.2630

PubMed ID: 25441029

Title: Structural basis of a Kv7.1 potassium channel gating module: studies of the intracellular c-terminal domain in complex with calmodulin.

PubMed ID: 25441029

DOI: 10.1016/j.str.2014.07.016

PubMed ID: 27564677

Title: Structural insights into the M-channel proximal C-terminus/calmodulin complex.

PubMed ID: 27564677

DOI: 10.1021/acs.biochem.6b00477

PubMed ID: 27876793

Title: PEP-19 modulates calcium binding to calmodulin by electrostatic steering.

PubMed ID: 27876793

DOI: 10.1038/ncomms13583

PubMed ID: 23607618

Title: NMR structure of calmodulin complexed to an N-terminally acetylated alpha-synuclein peptide.

PubMed ID: 23607618

DOI: 10.1021/bi400199p

PubMed ID: 29724949

Title: Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.

PubMed ID: 29724949

DOI: 10.1126/science.aas9466

PubMed ID: 36423631

Title: Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin.

PubMed ID: 36423631

DOI: 10.1016/j.molcel.2022.10.032

PubMed ID: 36624349

Title: Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis.

PubMed ID: 36624349

DOI: 10.1038/s41594-022-00888-3

PubMed ID: 23040497

Title: Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death.

PubMed ID: 23040497

DOI: 10.1016/j.ajhg.2012.08.015

PubMed ID: 23388215

Title: Calmodulin mutations associated with recurrent cardiac arrest in infants.

PubMed ID: 23388215

DOI: 10.1161/circulationaha.112.001216

PubMed ID: 25036739

Title: Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death.

PubMed ID: 25036739

DOI: 10.1016/j.febslet.2014.07.007

PubMed ID: 24076290

Title: A mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence.

PubMed ID: 24076290

DOI: 10.1016/j.jacc.2013.07.091

PubMed ID: 26164367

Title: Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease.

PubMed ID: 26164367

DOI: 10.1016/j.bbagen.2015.07.001

PubMed ID: 27516456

Title: Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.

PubMed ID: 27516456

DOI: 10.1161/circep.116.004161

PubMed ID: 26969752

Title: Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G.

PubMed ID: 26969752

DOI: 10.1161/circgenetics.115.001323

PubMed ID: 27165696

Title: Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current.

PubMed ID: 27165696

DOI: 10.1016/j.hrthm.2016.05.009

PubMed ID: 28158429

Title: Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes.

PubMed ID: 28158429

DOI: 10.1093/cvr/cvx006

PubMed ID: 31454269

Title: Genetic mosaicism in calmodulinopathy.

PubMed ID: 31454269

DOI: 10.1161/circgen.119.002581

Sequence Information:

Length: 149
Mass: 16838
Checksum: 6B4BC3FCDE10727B
Sequence:

MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG 
NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE 
EVDEMIREAD IDGDGQVNYE EFVQMMTAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CALM1

Associated with

Cells (max top 100)

Other Information

Isolation and nucleotide sequence of a cDNA encoding human calmodulin. PubMed ID: 6385987

Structure of the human CALM1 calmodulin gene and identification of two CALM1-related pseudogenes CALM1P1 and CALM1P2. PubMed ID: 7925473

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete amino acid sequence of human brain calmodulin. PubMed ID: 7093203

Structural basis for activation of the titin kinase domain during myofibrillogenesis. PubMed ID: 9804419

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Recombinant expression, purification and characterisation of the HMG domain of human SRY. PubMed ID: 12871148

Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6. PubMed ID: 16127172

Defective calmodulin-mediated nuclear transport of the sex-determining region of the Y chromosome (SRY) in XY sex reversal. PubMed ID: 15746192

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. PubMed ID: 16760425

Cep97 and CP110 suppress a cilia assembly program. PubMed ID: 17719545

The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction. PubMed ID: 18165683

S100A1 and calmodulin compete for the same binding site on ryanodine receptor. PubMed ID: 18650434

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex. PubMed ID: 20466722

Calcium-dependent association of calmodulin with the rubella virus nonstructural protease domain. PubMed ID: 20086014

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode. PubMed ID: 23109337

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. PubMed ID: 22484487

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. PubMed ID: 25582440

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. PubMed ID: 28890335

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-alpha/TANC2 Recruits DCVs to Postsynaptic Sites. PubMed ID: 30021165

Calcineurin B homologous protein 3 binds with high affinity to the CHP binding domain of the human sodium/proton exchanger NHE1. PubMed ID: 30287853

Gain-of-function mutations in KCNN3 encoding the small-conductance Ca2+-activated K+ channel SK3 cause Zimmermann-Laband syndrome. PubMed ID: 31155282

Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation. PubMed ID: 31330532

Calmodulin binds to the STAS domain of SLC26A5 prestin with a calcium-dependent, one-lobe, binding mode. PubMed ID: 33667636

Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases. PubMed ID: 35338844

Calmodulin binding activates chromobacterium CopC effector to ADP-riboxanate host apoptotic caspases. PubMed ID: 35446120

A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling. PubMed ID: 35568036

Stress response silencing by an E3 ligase mutated in neurodegeneration. PubMed ID: 38297121

Alpha-helix nucleation by a calcium-binding peptide loop. PubMed ID: 9927666

Solution structure of Ca(2+)-calmodulin reveals flexible hand-like properties of its domains. PubMed ID: 11685248

Calmodulin structure refined at 1.7 A resolution. PubMed ID: 1474585

Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex. PubMed ID: 7803388

Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. PubMed ID: 11807546

Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins. PubMed ID: 12485993

Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin. PubMed ID: 12577052

Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. PubMed ID: 16299511

Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. PubMed ID: 15719022

Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5. PubMed ID: 21167176

Allosteric mechanism of water-channel gating by Ca(2+)-calmodulin. PubMed ID: 23893133

Structural basis of a Kv7.1 potassium channel gating module: studies of the intracellular c-terminal domain in complex with calmodulin. PubMed ID: 25441029

Structural insights into the M-channel proximal C-terminus/calmodulin complex. PubMed ID: 27564677

PEP-19 modulates calcium binding to calmodulin by electrostatic steering. PubMed ID: 27876793

NMR structure of calmodulin complexed to an N-terminally acetylated alpha-synuclein peptide. PubMed ID: 23607618

Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures. PubMed ID: 29724949

Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. PubMed ID: 36423631

Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. PubMed ID: 36624349

Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death. PubMed ID: 23040497

Calmodulin mutations associated with recurrent cardiac arrest in infants. PubMed ID: 23388215

Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death. PubMed ID: 25036739

A mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence. PubMed ID: 24076290

Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease. PubMed ID: 26164367

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks. PubMed ID: 27516456

Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G. PubMed ID: 26969752

Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current. PubMed ID: 27165696

Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes. PubMed ID: 28158429

Genetic mosaicism in calmodulinopathy. PubMed ID: 31454269