Details for: CALM2

Gene ID: 805

Symbol: CALM2

Ensembl ID: ENSG00000143933

Description: calmodulin 2

Associated with

  • Adenylate cyclase activator activity
    (GO:0010856)
  • Adenylate cyclase binding
    (GO:0008179)
  • Calcium-dependent protein binding
    (GO:0048306)
  • Calcium channel complex
    (GO:0034704)
  • Calcium channel inhibitor activity
    (GO:0019855)
  • Calcium ion binding
    (GO:0005509)
  • Catalytic complex
    (GO:1902494)
  • Centrosome
    (GO:0005813)
  • Cytoplasm
    (GO:0005737)
  • Detection of calcium ion
    (GO:0005513)
  • G2/m transition of mitotic cell cycle
    (GO:0000086)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Membrane
    (GO:0016020)
  • Myelin sheath
    (GO:0043209)
  • Negative regulation of calcium ion export across plasma membrane
    (GO:1905913)
  • Negative regulation of calcium ion transmembrane transporter activity
    (GO:1901020)
  • Negative regulation of peptidyl-threonine phosphorylation
    (GO:0010801)
  • Negative regulation of ryanodine-sensitive calcium-release channel activity
    (GO:0060315)
  • Nucleus
    (GO:0005634)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cyclic-nucleotide phosphodiesterase activity
    (GO:0051343)
  • Positive regulation of peptidyl-threonine phosphorylation
    (GO:0010800)
  • Positive regulation of phosphoprotein phosphatase activity
    (GO:0032516)
  • Positive regulation of protein autophosphorylation
    (GO:0031954)
  • Positive regulation of protein dephosphorylation
    (GO:0035307)
  • Positive regulation of protein serine/threonine kinase activity
    (GO:0071902)
  • Positive regulation of ryanodine-sensitive calcium-release channel activity
    (GO:0060316)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein kinase binding
    (GO:0019901)
  • Protein phosphatase activator activity
    (GO:0072542)
  • Protein serine/threonine kinase activator activity
    (GO:0043539)
  • Regulation of calcium-mediated signaling
    (GO:0050848)
  • Regulation of cardiac muscle contraction
    (GO:0055117)
  • Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
    (GO:0010881)
  • Regulation of cell communication by electrical coupling involved in cardiac conduction
    (GO:1901844)
  • Regulation of cytokinesis
    (GO:0032465)
  • Regulation of heart rate
    (GO:0002027)
  • Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
    (GO:0010880)
  • Regulation of ryanodine-sensitive calcium-release channel activity
    (GO:0060314)
  • Response to calcium ion
    (GO:0051592)
  • Sarcomere
    (GO:0030017)
  • Sperm midpiece
    (GO:0097225)
  • Spindle microtubule
    (GO:0005876)
  • Spindle pole
    (GO:0000922)
  • Substantia nigra development
    (GO:0021762)
  • Titin binding
    (GO:0031432)
  • Transmembrane transporter binding
    (GO:0044325)
  • Vesicle
    (GO:0031982)
  • Voltage-gated potassium channel complex
    (GO:0008076)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 6
    Marker Score: 25027
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 5.71
    Marker Score: 8033.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 5.63
    Marker Score: 1651
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.23
    Marker Score: 6811
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.94
    Marker Score: 3489
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 4.94
    Marker Score: 4191
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.67
    Marker Score: 7188
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.6
    Marker Score: 5556
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.59
    Marker Score: 2786
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 4.27
    Marker Score: 20974
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.24
    Marker Score: 1563
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.23
    Marker Score: 3034
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.22
    Marker Score: 3301
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 4.18
    Marker Score: 2160
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.15
    Marker Score: 41147
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.15
    Marker Score: 3918
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 4.12
    Marker Score: 17112.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 4.07
    Marker Score: 4073
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.93
    Marker Score: 2796
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.91
    Marker Score: 7354
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.89
    Marker Score: 52299
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.89
    Marker Score: 2073
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.88
    Marker Score: 4141
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.87
    Marker Score: 9463
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.85
    Marker Score: 2907
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.77
    Marker Score: 19815
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.76
    Marker Score: 49645
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.75
    Marker Score: 23950
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.69
    Marker Score: 3147
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.67
    Marker Score: 4421
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.65
    Marker Score: 22187
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.61
    Marker Score: 9974
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.6
    Marker Score: 122408
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.58
    Marker Score: 31081
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.56
    Marker Score: 1228
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.54
    Marker Score: 1594
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.53
    Marker Score: 2326
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.51
    Marker Score: 196475
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.45
    Marker Score: 40110
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.42
    Marker Score: 6954.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.42
    Marker Score: 3565
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.42
    Marker Score: 22220
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.41
    Marker Score: 3045.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.4
    Marker Score: 2470
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.35
    Marker Score: 8975
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.33
    Marker Score: 1859
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.3
    Marker Score: 1696
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 3.3
    Marker Score: 12764.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.3
    Marker Score: 3343
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.29
    Marker Score: 12694
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.28
    Marker Score: 10308.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.25
    Marker Score: 9127
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.24
    Marker Score: 1184
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.24
    Marker Score: 3703
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.24
    Marker Score: 2539
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.23
    Marker Score: 112046
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.23
    Marker Score: 21021
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.22
    Marker Score: 1669.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.22
    Marker Score: 4429
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.22
    Marker Score: 5335
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.2
    Marker Score: 1279
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.2
    Marker Score: 1083
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.2
    Marker Score: 7257
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.2
    Marker Score: 3063
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.19
    Marker Score: 15305
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.18
    Marker Score: 2677
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.17
    Marker Score: 7232
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.17
    Marker Score: 6322
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.15
    Marker Score: 5163.5
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.14
    Marker Score: 1351
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.14
    Marker Score: 1004
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 3.12
    Marker Score: 1959
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.11
    Marker Score: 1295
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.1
    Marker Score: 1390
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.09
    Marker Score: 2432
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.08
    Marker Score: 9731.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.07
    Marker Score: 733
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 3.05
    Marker Score: 1810
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.04
    Marker Score: 8887
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.02
    Marker Score: 5891
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 3.02
    Marker Score: 7421
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.02
    Marker Score: 3248
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3
    Marker Score: 4345
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3
    Marker Score: 4243
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.99
    Marker Score: 5054
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.98
    Marker Score: 4792
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.97
    Marker Score: 23163
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.96
    Marker Score: 17573
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.96
    Marker Score: 1232
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.95
    Marker Score: 7736
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.95
    Marker Score: 6932.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.93
    Marker Score: 5237.5
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.93
    Marker Score: 1614.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.92
    Marker Score: 7430
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.9
    Marker Score: 1371
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.89
    Marker Score: 1932
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.88
    Marker Score: 152501
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.88
    Marker Score: 2456.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.88
    Marker Score: 912
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.88
    Marker Score: 1237

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Other Information

**Key characteristics:** - CALM2 is a transmembrane protein with a molecular weight of approximately 140 kDa. - It is a calcium-dependent protein kinase, meaning its activity is regulated by calcium ions. - It is a key regulator of the G2/m transition of the mitotic cell cycle. - It also plays a role in the regulation of calcium release from the sarcoplasmic reticulum. **Pathways and functions:** - CALM2 is involved in the regulation of heart rate, release of calcium ions from the sarcoplasmic reticulum, and the regulation of cell cycle progression. - It is a key regulator of the release of calcium ions from the sarcoplasmic reticulum, which is important for muscle contraction. - It also plays a role in the regulation of the G2/m transition of the mitotic cell cycle. **Clinical significance:** - Mutations in CALM2 have been linked to several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), multiple sclerosis, and schizophrenia. - Calmodulin 2 inhibitors have been developed as potential treatments for these diseases, but they have not been successful due to the lack of specificity of these inhibitors. **Additional information:** - CALM2 is a key regulator of the activity of the adenylate cyclase enzyme. - It is also involved in the regulation of calcium signaling in the heart, blood pressure, and immune responses. - Mutations in CALM2 have been linked to a number of human diseases, including hypertension, heart failure, and cancer.

Genular Protein ID: 4035469967

Symbol: Q96HY3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96HY3 A0A9K3Y7M0 D6W5B3 E7ETZ0 H0Y7A7

Database IDs:

ARBA 5 Antibodypedia 3 Bgee 1 BioGRID-ORCS 3 CDD 1 CTD 2 ChiTaRS 2 DNASU 1 EMBL 11 EPD 1 Ensembl 17 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 3 HOGENOM 2 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 7 SMART 1 SUPFAM 1 UCSC 3 VEuPathDB 3

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 113
  • Mass: 12876
  • Checksum: B8CDD96451018E44
  • Sequence:
    • MRSLGQNPTE AELQDMINEV DADGNGTIDF PEFLTMMARK MKDTDSEEEI REAFRVFDKD 
GNGYISAAEL RHVMTNLGEK LTDEEVDEMI READIDGDGQ VNYEEFVQMM TAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.