Details for: CALM2

Gene ID: 805

Symbol: CALM2

Ensembl ID: ENSG00000143933

Description: calmodulin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 917.8038
    Cell Significance Index: -142.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 614.0511
    Cell Significance Index: -155.7500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 466.5156
    Cell Significance Index: -192.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 413.7061
    Cell Significance Index: -195.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 369.1202
    Cell Significance Index: -189.8700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 292.0768
    Cell Significance Index: -195.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 145.8974
    Cell Significance Index: -179.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 55.0684
    Cell Significance Index: -169.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 49.5534
    Cell Significance Index: -195.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 46.8184
    Cell Significance Index: -125.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 14.9305
    Cell Significance Index: 783.9100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 11.1251
    Cell Significance Index: 65.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 9.7528
    Cell Significance Index: 256.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 7.7851
    Cell Significance Index: 270.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 7.1789
    Cell Significance Index: 337.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.0116
    Cell Significance Index: 448.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.8501
    Cell Significance Index: 272.7600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.8115
    Cell Significance Index: 35.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.0859
    Cell Significance Index: 651.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.4898
    Cell Significance Index: 580.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.3333
    Cell Significance Index: 2366.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.2784
    Cell Significance Index: 587.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.9397
    Cell Significance Index: 484.4300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.9273
    Cell Significance Index: 69.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 3.7218
    Cell Significance Index: 1070.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.6081
    Cell Significance Index: 40.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.4476
    Cell Significance Index: 621.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.2307
    Cell Significance Index: 381.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.1548
    Cell Significance Index: 85.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.1476
    Cell Significance Index: 72.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8978
    Cell Significance Index: 581.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.7728
    Cell Significance Index: 1225.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.7169
    Cell Significance Index: 56.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.5940
    Cell Significance Index: 256.6000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 2.4579
    Cell Significance Index: 37.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.3866
    Cell Significance Index: 133.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.1680
    Cell Significance Index: 40.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.1062
    Cell Significance Index: 129.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7346
    Cell Significance Index: 122.6800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.5724
    Cell Significance Index: 12.1200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.3975
    Cell Significance Index: 17.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3199
    Cell Significance Index: 473.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9320
    Cell Significance Index: 60.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8236
    Cell Significance Index: 23.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.8173
    Cell Significance Index: 618.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3086
    Cell Significance Index: 226.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1882
    Cell Significance Index: 3.1500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1741
    Cell Significance Index: 1.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1521
    Cell Significance Index: 25.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0463
    Cell Significance Index: 1.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0411
    Cell Significance Index: 7.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0700
    Cell Significance Index: -51.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0825
    Cell Significance Index: -155.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1006
    Cell Significance Index: -10.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1059
    Cell Significance Index: -66.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1105
    Cell Significance Index: -203.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1297
    Cell Significance Index: -199.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1449
    Cell Significance Index: -197.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1687
    Cell Significance Index: -7.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.2008
    Cell Significance Index: -138.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2318
    Cell Significance Index: -11.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2407
    Cell Significance Index: -135.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2681
    Cell Significance Index: -170.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3567
    Cell Significance Index: -75.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4011
    Cell Significance Index: -10.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4092
    Cell Significance Index: -185.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4881
    Cell Significance Index: -37.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5458
    Cell Significance Index: -28.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5609
    Cell Significance Index: -35.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5783
    Cell Significance Index: -66.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6710
    Cell Significance Index: -25.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.7065
    Cell Significance Index: -140.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7194
    Cell Significance Index: -32.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7916
    Cell Significance Index: -90.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8057
    Cell Significance Index: -63.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.8502
    Cell Significance Index: -138.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.1221
    Cell Significance Index: -45.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.1397
    Cell Significance Index: -132.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1755
    Cell Significance Index: -37.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.2955
    Cell Significance Index: -188.3200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.3569
    Cell Significance Index: -12.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.5158
    Cell Significance Index: -38.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.7425
    Cell Significance Index: -41.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.7660
    Cell Significance Index: -47.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.8931
    Cell Significance Index: -197.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.8363
    Cell Significance Index: -42.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.8712
    Cell Significance Index: -193.0600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -2.9006
    Cell Significance Index: -17.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.9744
    Cell Significance Index: -64.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.1111
    Cell Significance Index: -190.7400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -3.2501
    Cell Significance Index: -27.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.6667
    Cell Significance Index: -108.0000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -3.6753
    Cell Significance Index: -76.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -3.7042
    Cell Significance Index: -40.2700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.8813
    Cell Significance Index: -23.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -3.9215
    Cell Significance Index: -128.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -3.9863
    Cell Significance Index: -126.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.0216
    Cell Significance Index: -54.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -4.2209
    Cell Significance Index: -113.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -4.2921
    Cell Significance Index: -150.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CALM2 is a member of the calmodulin family, characterized by its high calcium-binding affinity and its ability to interact with a wide range of target proteins. It is a small, 15-kDa protein that is widely expressed in various tissues, including the nervous system, muscle, and immune cells. CALM2 is known for its ability to regulate calcium-dependent signaling pathways, which are essential for various cellular processes, including muscle contraction, cell proliferation, and differentiation. **Pathways and Functions:** CALM2 is involved in numerous cellular pathways, including: 1. **Calcium-mediated signaling:** CALM2 binds to calcium ions, which triggers a series of downstream signaling events that regulate various cellular processes, including muscle contraction, cell proliferation, and differentiation. 2. **Cardiac muscle contraction:** CALM2 plays a critical role in regulating cardiac muscle contraction by modulating the release of sequestered calcium ions into the cytosol. 3. **Cell cycle regulation:** CALM2 regulates the G2/M transition of the mitotic cell cycle by interacting with cyclin-dependent kinases and other regulatory proteins. 4. **Immune cell function:** CALM2 is expressed in immune cells, including T cells and dendritic cells, where it regulates calcium-dependent signaling pathways that modulate immune responses. 5. **Neurotransmission:** CALM2 is involved in the regulation of neurotransmission, particularly in the GABAergic and glycinergic systems, where it modulates calcium-dependent signaling pathways that regulate synaptic transmission. **Clinical Significance:** CALM2 has been implicated in various human diseases, including: 1. **Cardiovascular disease:** Mutations in the CALM2 gene have been associated with cardiac muscle dysfunction and arrhythmias. 2. **Neurological disorders:** CALM2 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it regulates calcium-dependent signaling pathways that modulate neuronal function. 3. **Immune disorders:** CALM2 has been implicated in the regulation of immune responses, particularly in the context of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Cancer:** CALM2 has been shown to regulate the growth and proliferation of cancer cells, particularly in the context of breast and lung cancer. In conclusion, CALM2 is a multifaceted protein that plays a critical role in various cellular processes, including calcium-mediated signaling, cell cycle regulation, and cardiac muscle contraction. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the molecular mechanisms underlying CALM2 function and its role in human health and disease.

Genular Protein ID: 4035469967

Symbol: Q96HY3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96HY3 A0A9K3Y7M0 D6W5B3 E7ETZ0 H0Y7A7

Database IDs:

ARBA 5 Antibodypedia 3 Bgee 1 BioGRID-ORCS 3 CDD 1 CTD 2 ChiTaRS 2 DNASU 1 DisGeNET 2 EMBL 11 Ensembl 17 GO 3 Gene3D 1 GeneTree 1 HGNC 3 HOGENOM 2 IntAct 1 InterPro 4 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 PharmGKB 1 Proteomes 2 ProteomicsDB 3 RefSeq 7 SMART 1 SUPFAM 1 UCSC 3 VEuPathDB 3

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 113
  • Mass: 12876
  • Checksum: B8CDD96451018E44
  • Sequence:
    • MRSLGQNPTE AELQDMINEV DADGNGTIDF PEFLTMMARK MKDTDSEEEI REAFRVFDKD 
GNGYISAAEL RHVMTNLGEK LTDEEVDEMI READIDGDGQ VNYEEFVQMM TAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.