Details for: CALM3

Gene ID: 808

Symbol: CALM3

Ensembl ID: ENSG00000160014

Description: calmodulin 3

Associated with

  • Adenylate cyclase activator activity
    (GO:0010856)
  • Adenylate cyclase binding
    (GO:0008179)
  • Calcium-dependent protein binding
    (GO:0048306)
  • Calcium channel complex
    (GO:0034704)
  • Calcium ion binding
    (GO:0005509)
  • Catalytic complex
    (GO:1902494)
  • Centrosome
    (GO:0005813)
  • Cytoplasm
    (GO:0005737)
  • Detection of calcium ion
    (GO:0005513)
  • G2/m transition of mitotic cell cycle
    (GO:0000086)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Myelin sheath
    (GO:0043209)
  • Negative regulation of calcium ion export across plasma membrane
    (GO:1905913)
  • Negative regulation of high voltage-gated calcium channel activity
    (GO:1901842)
  • Negative regulation of peptidyl-threonine phosphorylation
    (GO:0010801)
  • Negative regulation of ryanodine-sensitive calcium-release channel activity
    (GO:0060315)
  • Nucleus
    (GO:0005634)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cyclic-nucleotide phosphodiesterase activity
    (GO:0051343)
  • Positive regulation of peptidyl-threonine phosphorylation
    (GO:0010800)
  • Positive regulation of phosphoprotein phosphatase activity
    (GO:0032516)
  • Positive regulation of protein autophosphorylation
    (GO:0031954)
  • Positive regulation of protein dephosphorylation
    (GO:0035307)
  • Positive regulation of protein serine/threonine kinase activity
    (GO:0071902)
  • Positive regulation of ryanodine-sensitive calcium-release channel activity
    (GO:0060316)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein kinase binding
    (GO:0019901)
  • Protein phosphatase activator activity
    (GO:0072542)
  • Protein serine/threonine kinase activator activity
    (GO:0043539)
  • Regulation of calcium-mediated signaling
    (GO:0050848)
  • Regulation of cardiac muscle cell action potential
    (GO:0098901)
  • Regulation of cardiac muscle contraction
    (GO:0055117)
  • Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
    (GO:0010881)
  • Regulation of cell communication by electrical coupling involved in cardiac conduction
    (GO:1901844)
  • Regulation of cytokinesis
    (GO:0032465)
  • Regulation of heart rate
    (GO:0002027)
  • Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
    (GO:0010880)
  • Response to calcium ion
    (GO:0051592)
  • Sarcomere
    (GO:0030017)
  • Sperm midpiece
    (GO:0097225)
  • Spindle microtubule
    (GO:0005876)
  • Spindle pole
    (GO:0000922)
  • Substantia nigra development
    (GO:0021762)
  • Titin binding
    (GO:0031432)
  • Transmembrane transporter binding
    (GO:0044325)
  • Vesicle
    (GO:0031982)
  • Voltage-gated potassium channel complex
    (GO:0008076)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.79
    Marker Score: 4,578
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.58
    Marker Score: 7,557
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.47
    Marker Score: 3,276
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 3.26
    Marker Score: 13,586
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.15
    Marker Score: 6,410
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.89
    Marker Score: 28,593
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.86
    Marker Score: 3,457
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.8
    Marker Score: 7,726
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.68
    Marker Score: 35,289
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.61
    Marker Score: 1,089
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.6
    Marker Score: 3,685
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.59
    Marker Score: 2,703
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.55
    Marker Score: 16,291
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.5
    Marker Score: 11,990
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.48
    Marker Score: 138,498
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.42
    Marker Score: 2,722
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.42
    Marker Score: 28,163
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.39
    Marker Score: 126,228
  • Cell Name: platelet (CL0000233)
    Fold Change: 2.37
    Marker Score: 1,073
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.37
    Marker Score: 2,228
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.34
    Marker Score: 15,218
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.33
    Marker Score: 2,327
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.31
    Marker Score: 759
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.3
    Marker Score: 1,679
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.29
    Marker Score: 2,442
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.24
    Marker Score: 3,713
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.24
    Marker Score: 1,231
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.23
    Marker Score: 9,563
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.23
    Marker Score: 6,603
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.22
    Marker Score: 3,419
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.21
    Marker Score: 5,201
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.2
    Marker Score: 1,038
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.17
    Marker Score: 7,712
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.17
    Marker Score: 728
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.16
    Marker Score: 4,210
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.16
    Marker Score: 9,315
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.15
    Marker Score: 4,492
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.14
    Marker Score: 3,820
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.13
    Marker Score: 1,338
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.11
    Marker Score: 3,254
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.11
    Marker Score: 5,742
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.1
    Marker Score: 1,209
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.09
    Marker Score: 5,852
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.08
    Marker Score: 1,237
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.07
    Marker Score: 5,641
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.06
    Marker Score: 493
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.06
    Marker Score: 6,475
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.05
    Marker Score: 71,182
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.04
    Marker Score: 2,935
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.04
    Marker Score: 12,993
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.03
    Marker Score: 2,189
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.02
    Marker Score: 20,372
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.02
    Marker Score: 8,284
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.02
    Marker Score: 2,315
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.02
    Marker Score: 1,346
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.01
    Marker Score: 2,028
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.01
    Marker Score: 1,453
  • Cell Name: basophil (CL0000767)
    Fold Change: 2
    Marker Score: 952
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2
    Marker Score: 2,212
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.98
    Marker Score: 6,257
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.98
    Marker Score: 826
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.97
    Marker Score: 1,048
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.97
    Marker Score: 1,635
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.97
    Marker Score: 11,669
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.96
    Marker Score: 2,176
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.95
    Marker Score: 3,320
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.95
    Marker Score: 2,058
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.94
    Marker Score: 1,381
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.94
    Marker Score: 1,815
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.93
    Marker Score: 7,474
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.93
    Marker Score: 1,691
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.92
    Marker Score: 859
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.92
    Marker Score: 1,351
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.91
    Marker Score: 507
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.91
    Marker Score: 3,736
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.91
    Marker Score: 939
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.9
    Marker Score: 1,280
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.9
    Marker Score: 4,515
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.9
    Marker Score: 499
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.89
    Marker Score: 6,981
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.88
    Marker Score: 4,593
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.88
    Marker Score: 2,500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.87
    Marker Score: 7,363
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.87
    Marker Score: 2,759
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.87
    Marker Score: 1,243
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.87
    Marker Score: 3,252
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.86
    Marker Score: 956
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.86
    Marker Score: 1,972
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.86
    Marker Score: 3,043
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.85
    Marker Score: 641
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 1.85
    Marker Score: 479
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.84
    Marker Score: 5,373
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.84
    Marker Score: 1,545
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.83
    Marker Score: 4,627
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.82
    Marker Score: 2,687
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.82
    Marker Score: 484
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.82
    Marker Score: 2,133
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.82
    Marker Score: 515
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.81
    Marker Score: 1,974
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.81
    Marker Score: 1,062

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The CALM3 protein exhibits several key characteristics that distinguish it from other calmodulins. One of its most notable features is its ability to regulate the activity of various enzymes and signaling pathways, including adenylate cyclase, protein kinases, and phosphatases. CALM3 also interacts with other proteins, such as titin and the voltage-gated potassium channel complex, to modulate muscle contraction and cell communication. Furthermore, CALM3 has been shown to play a critical role in regulating the release of sequestered calcium ions into the cytosol, which is essential for maintaining proper muscle contraction and cardiac function. **Pathways and Functions** CALM3 is involved in numerous signaling pathways that regulate various cellular processes, including: 1. **Calcium-mediated signaling**: CALM3 binds to calcium ions, triggering a cascade of downstream signaling events that influence various cellular processes, including muscle contraction, cell communication, and gene expression. 2. **Muscle contraction**: CALM3 regulates the release of sequestered calcium ions into the cytosol, which is essential for maintaining proper muscle contraction and cardiac function. 3. **Cell communication**: CALM3 interacts with other proteins to modulate cell communication, including electrical coupling involved in cardiac conduction. 4. **Cardiac function**: CALM3 plays a critical role in regulating cardiac muscle contraction and heart rate. 5. **Immune cell function**: CALM3 is expressed in various immune cells, including T cells and natural killer cells, where it regulates cytokine production and cell activation. **Clinical Significance** The dysregulation of CALM3 has been implicated in various diseases, including: 1. **Cardiac arrhythmias**: Mutations in the CALM3 gene have been associated with cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. 2. **Muscular dystrophy**: CALM3 has been shown to play a critical role in regulating muscle contraction, and mutations in the CALM3 gene have been associated with muscular dystrophy. 3. **Neurological disorders**: CALM3 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 4. **Cancer**: CALM3 has been shown to play a role in regulating cell growth and proliferation, and its dysregulation has been implicated in various types of cancer. In conclusion, CALM3 is a gene of unparalleled significance in calcium-mediated signaling, muscle contraction, and cell communication. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand the complexities of CALM3 and its role in maintaining cellular homeostasis.

Genular Protein ID: 3140326336

Symbol: Q9BRL5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BRL5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 2 PharmGKB 1 RefSeq 4 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 147
  • Mass: 16507
  • Checksum: EAA976F9BD6D3A11
  • Sequence:
    • MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG 
NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE 
SLSMPLISSF CPRLFHPCLP RPDAFIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.