CALM3 | ENSG00000160014 | NCBI 808

Details for: CALM3

Associated with

Adenylate cyclase activator activity
(GO:0010856)
Adenylate cyclase binding
(GO:0008179)
Calcium-dependent protein binding
(GO:0048306)
Calcium channel complex
(GO:0034704)
Calcium ion binding
(GO:0005509)
Calyx of held
(GO:0044305)
Catalytic complex
(GO:1902494)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Detection of calcium ion
(GO:0005513)
G2/m transition of mitotic cell cycle
(GO:0000086)
G protein-coupled receptor signaling pathway
(GO:0007186)
Myelin sheath
(GO:0043209)
Negative regulation of calcium ion export across plasma membrane
(GO:1905913)
Negative regulation of high voltage-gated calcium channel activity
(GO:1901842)
Negative regulation of peptidyl-threonine phosphorylation
(GO:0010801)
Negative regulation of ryanodine-sensitive calcium-release channel activity
(GO:0060315)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of cyclic-nucleotide phosphodiesterase activity
(GO:0051343)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of protein autophosphorylation
(GO:0031954)
Positive regulation of protein serine/threonine kinase activity
(GO:0071902)
Positive regulation of ryanodine-sensitive calcium-release channel activity
(GO:0060316)
Presynaptic cytosol
(GO:0099523)
Presynaptic endocytosis
(GO:0140238)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphatase activator activity
(GO:0072542)
Protein serine/threonine kinase activator activity
(GO:0043539)
Regulation of calcium-mediated signaling
(GO:0050848)
Regulation of cardiac muscle cell action potential
(GO:0098901)
Regulation of cardiac muscle contraction
(GO:0055117)
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
(GO:0010881)
Regulation of cell communication by electrical coupling involved in cardiac conduction
(GO:1901844)
Regulation of cytokinesis
(GO:0032465)
Regulation of heart rate
(GO:0002027)
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
(GO:0010880)
Response to calcium ion
(GO:0051592)
Sarcomere
(GO:0030017)
Sperm midpiece
(GO:0097225)
Spindle microtubule
(GO:0005876)
Spindle pole
(GO:0000922)
Substantia nigra development
(GO:0021762)
Titin binding
(GO:0031432)
Transmembrane transporter binding
(GO:0044325)
Vesicle
(GO:0031982)
Voltage-gated potassium channel complex
(GO:0008076)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

intestinal epithelial cell CL0002563

CSI 64.96

rCSI 67.9%

PRS 11.49
megakaryocyte-erythroid progenitor cell CL0000050

CSI 61.78

rCSI 55.79%

PRS 9.61
peripheral nervous system neuron CL2000032

CSI 58.28

rCSI 79.41%

PRS 9.73
granulocyte monocyte progenitor cell CL0000557

CSI 49.93

rCSI 43.24%

PRS 12.1
promonocyte CL0000559

CSI 47.71

rCSI 81.74%

PRS 14.57
multi-ciliated epithelial cell CL0005012

CSI 47.23

rCSI 47.14%

PRS 9.33
transit amplifying cell of colon CL0009011

CSI 46.98

rCSI 55.17%

PRS 12.92
common myeloid progenitor CL0000049

CSI 45.63

rCSI 36.89%

PRS 10.73
promyelocyte CL0000836

CSI 43.91

rCSI 63.33%

PRS 15.13
pancreatic D cell CL0000173

CSI 43.89

rCSI 43.16%

PRS 11.84
enterocyte CL0000584

CSI 41.47

rCSI 66.87%

PRS 17.42
plasmablast CL0000980

CSI 39.6

rCSI 31.15%

PRS 12.89
pancreatic A cell CL0000171

CSI 39.1

rCSI 40.96%

PRS 11.6
stem cell CL0000034

CSI 38.88

rCSI 37.49%

PRS 7.32
epithelial cell of lung CL0000082

CSI 37.89

rCSI 31.41%

PRS 10.28
colon epithelial cell CL0011108

CSI 35.48

rCSI 37.16%

PRS 10.13
fraction A pre-pro B cell CL0002045

CSI 32.24

rCSI 36.9%

PRS 22.31
CD14-low, CD16-positive monocyte CL0002396

CSI 30.71

rCSI 23.66%

PRS 9.84
large pre-B-II cell CL0000957

CSI 30.35

rCSI 86.63%

PRS 18.84
cardiac muscle cell CL0000746

CSI 30.24

rCSI 43.4%

PRS 8.56
double-positive, alpha-beta thymocyte CL0000809

CSI 30.17

rCSI 30.75%

PRS 15.48
neural crest cell CL0011012

CSI 29.88

rCSI 23.62%

PRS 7.5
hematopoietic stem cell CL0000037

CSI 29.01

rCSI 19.28%

PRS 12.96
extravillous trophoblast CL0008036

CSI 28.96

rCSI 35.83%

PRS 9.56
common dendritic progenitor CL0001029

CSI 28.96

rCSI 36.35%

PRS 13.85
enteric smooth muscle cell CL0002504

CSI 27.77

rCSI 39.64%

PRS 12.28
elicited macrophage CL0000861

CSI 27.17

rCSI 24.94%

PRS 12.46
OFF-bipolar cell CL0000750

CSI 24.76

rCSI 33.86%

PRS 18.16
colonocyte CL1000347

CSI 24.66

rCSI 35.35%

PRS 14.94
intestine goblet cell CL0019031

CSI 23.82

rCSI 21.14%

PRS 10.89
type B pancreatic cell CL0000169

CSI 22.4

rCSI 49.59%

PRS 10.1
pancreatic ductal cell CL0002079

CSI 21.09

rCSI 41.02%

PRS 11.1
microcirculation associated smooth muscle cell CL0008035

CSI 20.59

rCSI 59.6%

PRS 12.31
mesodermal cell CL0000222

CSI 20.44

rCSI 24.54%

PRS 10.77
myeloid leukocyte CL0000766

CSI 20.29

rCSI 18.72%

PRS 11.04
Hofbauer cell CL3000001

CSI 19.6

rCSI 37%

PRS 13.5
pro-B cell CL0000826

CSI 19.44

rCSI 16.1%

PRS 10.86
foveolar cell of stomach CL0002179

CSI 18.83

rCSI 40.08%

PRS 17.58
lamp5 GABAergic cortical interneuron CL4023011

CSI 18.47

rCSI 31%

PRS 6.39
kidney epithelial cell CL0002518

CSI 18.07

rCSI 34.5%

PRS 25.82
transit amplifying cell CL0009010

CSI 18.06

rCSI 27.62%

PRS 17.69
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 17.65

rCSI 42.89%

PRS 6.21
enteroendocrine cell CL0000164

CSI 17.38

rCSI 23.74%

PRS 12.02
pancreatic PP cell CL0002275

CSI 17.36

rCSI 69.12%

PRS 19.12
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 17.07

rCSI 19.71%

PRS 9.6
deuterosomal cell CL4033044

CSI 16.92

rCSI 57.21%

PRS 18.44
platelet CL0000233

CSI 16.54

rCSI 68.64%

PRS 24.24
epithelial cell CL0000066

CSI 16.4

rCSI 25.21%

PRS 15.56
forebrain radial glial cell CL0013000

CSI 15.95

rCSI 51.17%

PRS 15.96
M cell of gut CL0000682

CSI 15.38

rCSI 16.34%

PRS 19.38
early lymphoid progenitor CL0000936

CSI 15.06

rCSI 13.22%

PRS 12.21
neuron CL0000540

CSI 14.5

rCSI 38.61%

PRS 8.66
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 14.18

rCSI 51.02%

PRS 5.87
pancreatic epsilon cell CL0005019

CSI 14.04

rCSI 65.47%

PRS 26.26
erythroblast CL0000765

CSI 13.97

rCSI 37.06%

PRS 18.1
double negative thymocyte CL0002489

CSI 13.66

rCSI 9.5%

PRS 12.7
megakaryocyte CL0000556

CSI 12.96

rCSI 56.22%

PRS 19.62
primitive red blood cell CL0002355

CSI 12.59

rCSI 67.91%

PRS 20.5
eosinophil CL0000771

CSI 11.94

rCSI 78.34%

PRS 28.19
mesangial cell CL0000650

CSI 11.93

rCSI 48.63%

PRS 14.73
paneth cell CL0000510

CSI 11.78

rCSI 17.39%

PRS 17.11
Cajal-Retzius cell CL0000695

CSI 11.76

rCSI 92.17%

PRS 23.88
near-projecting glutamatergic cortical neuron CL4023012

CSI 11.65

rCSI 44.03%

PRS 6.53
myofibroblast cell CL0000186

CSI 11.64

rCSI 16.12%

PRS 15.69
glutamatergic neuron CL0000679

CSI 11.59

rCSI 23.83%

PRS 11.23
retinal ganglion cell CL0000740

CSI 11.53

rCSI 25.47%

PRS 7.8
L6b glutamatergic cortical neuron CL4023038

CSI 11.52

rCSI 36%

PRS 6.85
transit amplifying cell of small intestine CL0009012

CSI 11.15

rCSI 48.96%

PRS 20.34
type EC enteroendocrine cell CL0000577

CSI 10.93

rCSI 38.8%

PRS 17.81
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 10.78

rCSI 13.55%

PRS 48.26
pancreatic acinar cell CL0002064

CSI 10.66

rCSI 14.17%

PRS 11.87
radial glial cell CL0000681

CSI 10.49

rCSI 14.57%

PRS 11.24
neuroblast (sensu Vertebrata) CL0000031

CSI 10.46

rCSI 13.43%

PRS 10.59
small intestine goblet cell CL1000495

CSI 10.25

rCSI 22.45%

PRS 14.62
interstitial cell of Cajal CL0002088

CSI 10.01

rCSI 12.75%

PRS 12.66
perivascular cell CL4033054

CSI 9.84

rCSI 13.45%

PRS 12.37
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 9.81

rCSI 19.55%

PRS 18.12
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 9.55

rCSI 6.71%

PRS 28.9
goblet cell CL0000160

CSI 9.53

rCSI 9%

PRS 11.36
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 9.46

rCSI 29.59%

PRS 7.35
Bergmann glial cell CL0000644

CSI 9.26

rCSI 12.66%

PRS 11.22
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 8.92

rCSI 52.52%

PRS 6.69
pancreatic stellate cell CL0002410

CSI 8.87

rCSI 51.61%

PRS 16.36
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 8.84

rCSI 12.54%

PRS 10.21
precursor B cell CL0000817

CSI 8.77

rCSI 7.68%

PRS 14.44
group 2 innate lymphoid cell CL0001069

CSI 8.56

rCSI 46.28%

PRS 36.46
cerebral cortex GABAergic interneuron CL0010011

CSI 8.39

rCSI 24.77%

PRS 13.41
non-classical monocyte CL0000875

CSI 8.27

rCSI 13.26%

PRS 33.9
regulatory T cell CL0000815

CSI 8.27

rCSI 9.58%

PRS 33.25
GABAergic neuron CL0000617

CSI 8.15

rCSI 27.31%

PRS 7.77
type L enteroendocrine cell CL0002279

CSI 8.09

rCSI 15.19%

PRS 21.54
plasma cell CL0000786

CSI 8.07

rCSI 10.58%

PRS 47.93
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 7.96

rCSI 48.17%

PRS 24.46
ciliated epithelial cell CL0000067

CSI 7.95

rCSI 6.99%

PRS 7.89
naive T cell CL0000898

CSI 7.56

rCSI 5.26%

PRS 15.44
granulocyte CL0000094

CSI 7.46

rCSI 11.4%

PRS 13.73
CD14-positive, CD16-positive monocyte CL0002397

CSI 7.32

rCSI 9.6%

PRS 15.21
mature NK T cell CL0000814

CSI 7.22

rCSI 9.24%

PRS 44.14
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 7.17

rCSI 5.38%

PRS 31.2
basophil mast progenitor cell CL0002028

CSI 7.08

rCSI 37.78%

PRS 39.63

pulmonary artery endothelial cell CL1001568

CSI -10.9

rCSI -14.8%

PRS 16.7%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI -9.6

rCSI -8.7%

PRS 16.5%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI -7.0

rCSI -8.3%

PRS 18.8%
choroid plexus epithelial cell CL0000706

CSI -6.5

rCSI -10.6%

PRS 8.4%
intrahepatic cholangiocyte CL0002538

CSI -6.0

rCSI -14.4%

PRS 20.1%
melanocyte CL0000148

CSI -4.9

rCSI -3.6%

PRS 9.8%
cerebral cortex endothelial cell CL1001602

CSI -4.8

rCSI -8.4%

PRS 8.3%
nasal mucosa goblet cell CL0002480

CSI -4.8

rCSI -5.5%

PRS 16.1%
respiratory suprabasal cell CL4033048

CSI -4.4

rCSI -5.7%

PRS 12.6%
retinal bipolar neuron CL0000748

CSI -4.1

rCSI -7.6%

PRS 7.9%
mucus secreting cell CL0000319

CSI -3.3

rCSI -5.2%

PRS 14.1%
astrocyte of the cerebral cortex CL0002605

CSI -1.9

rCSI -4.2%

PRS 6.7%
luminal epithelial cell of mammary gland CL0002326

CSI -1.7

rCSI -3.2%

PRS 16.6%
neural cell CL0002319

CSI -1.6

rCSI -5.8%

PRS 17.5%
pulmonary alveolar type 2 cell CL0002063

CSI -1.4

rCSI -2.1%

PRS 16.7%
squamous epithelial cell CL0000076

CSI -0.8

rCSI -1.8%

PRS 13.8%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI -0.7

rCSI -1.8%

PRS 10.1%
pulmonary alveolar type 1 cell CL0002062

CSI -0.7

rCSI -4.0%

PRS 14.7%
alveolar type 1 fibroblast cell CL4028004

CSI -0.5

rCSI -0.6%

PRS 12.6%
lung pericyte CL0009089

CSI -0.5

rCSI -1.4%

PRS 13.0%
renal interstitial pericyte CL1001318

CSI -0.5

rCSI -1.4%

PRS 10.4%
primordial germ cell CL0000670

CSI -0.5

rCSI -2.4%

PRS 59.4%
smooth muscle cell of prostate CL1000487

CSI -0.3

rCSI -1.7%

PRS 46.3%
exhausted T cell CL0011025

CSI -0.2

rCSI -3.2%

PRS 43.2%
decidual natural killer cell, human CL0002343

CSI -0.2

rCSI -1.9%

PRS 64.5%
immature B cell CL0000816

CSI -0.1

rCSI -0.1%

PRS 16.1%
acinar cell of salivary gland CL0002623

CSI 0.0

rCSI 1.0%

PRS 19.2%
luminal cell of prostate epithelium CL0002340

CSI 0.1

rCSI 0.3%

PRS 19.7%
B-2 B cell CL0000822

CSI 0.1

rCSI 1.4%

PRS 55.1%
cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.5%

PRS 16.0%
cone retinal bipolar cell CL0000752

CSI 0.1

rCSI 1.2%

PRS 43.4%
peptic cell CL0000155

CSI 0.2

rCSI 1.5%

PRS 32.6%
respiratory goblet cell CL0002370

CSI 0.2

rCSI 2.1%

PRS 21.1%
immature alpha-beta T cell CL0000790

CSI 0.2

rCSI 2.7%

PRS 81.3%
vasa recta descending limb cell CL1001285

CSI 0.2

rCSI 1.6%

PRS 44.4%
chondrocyte CL0000138

CSI 0.2

rCSI 0.3%

PRS 9.4%
odontoblast CL0000060

CSI 0.2

rCSI 4.8%

PRS 49.2%
OFF midget ganglion cell CL4033047

CSI 0.2

rCSI 4.5%

PRS 9.4%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 0.2

rCSI 0.4%

PRS 9.0%
endothelial cell of placenta CL0009092

CSI 0.2

rCSI 1.2%

PRS 14.8%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.3

rCSI 1.0%

PRS 17.9%
smooth muscle cell of the pulmonary artery CL0002591

CSI 0.3

rCSI 2.0%

PRS 42.1%
ON midget ganglion cell CL4033046

CSI 0.3

rCSI 5.3%

PRS 8.6%
macroglial cell CL0000126

CSI 0.3

rCSI 0.7%

PRS 16.0%
helper T cell CL0000912

CSI 0.3

rCSI 0.4%

PRS 15.4%
ON parasol ganglion cell CL4033052

CSI 0.3

rCSI 4.7%

PRS 7.5%
endocardial cell CL0002350

CSI 0.4

rCSI 1.8%

PRS 14.5%
central nervous system neuron CL2000029

CSI 0.4

rCSI 2.8%

PRS 5.4%
retinal pigment epithelial cell CL0002586

CSI 0.4

rCSI 0.8%

PRS 11.7%
tracheal goblet cell CL1000329

CSI 0.4

rCSI 0.8%

PRS 22.0%
retinal rod cell CL0000604

CSI 0.4

rCSI 0.7%

PRS 11.0%
serotonergic neuron CL0000850

CSI 0.4

rCSI 1.7%

PRS 3.8%
suprabasal keratinocyte CL4033013

CSI 0.4

rCSI 0.7%

PRS 6.9%
epithelial cell of esophagus CL0002252

CSI 0.4

rCSI 4.1%

PRS 39.3%
alveolar adventitial fibroblast CL4028006

CSI 0.5

rCSI 0.7%

PRS 10.9%
IgM plasma cell CL0000986

CSI 0.5

rCSI 2.3%

PRS 50.2%
renal intercalated cell CL0005010

CSI 0.5

rCSI 4.6%

PRS 69.2%
myeloid dendritic cell, human CL0001057

CSI 0.5

rCSI 2.9%

PRS 34.6%
basophil CL0000767

CSI 0.6

rCSI 1.2%

PRS 22.4%
lung microvascular endothelial cell CL2000016

CSI 0.6

rCSI 11.1%

PRS 35.4%
double negative T regulatory cell CL0011024

CSI 0.6

rCSI 10.9%

PRS 59.7%
tissue-resident macrophage CL0000864

CSI 0.6

rCSI 3.0%

PRS 23.8%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 0.7

rCSI 2.0%

PRS 15.7%
mammary gland epithelial cell CL0002327

CSI 0.7

rCSI 2.4%

PRS 19.7%
transitional stage B cell CL0000818

CSI 0.7

rCSI 2.3%

PRS 31.0%
bronchial goblet cell CL1000312

CSI 0.7

rCSI 2.9%

PRS 24.1%
acinar cell CL0000622

CSI 0.7

rCSI 1.1%

PRS 14.3%
myeloid dendritic cell CL0000782

CSI 0.7

rCSI 1.1%

PRS 16.0%
respiratory basal cell CL0002633

CSI 0.7

rCSI 0.8%

PRS 12.8%
retinal blood vessel endothelial cell CL0002585

CSI 0.8

rCSI 1.2%

PRS 11.9%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 0.8

rCSI 8.7%

PRS 41.7%
GABAergic amacrine cell CL4030027

CSI 0.8

rCSI 2.6%

PRS 10.1%
small pre-B-II cell CL0000954

CSI 0.8

rCSI 0.8%

PRS 22.7%
keratocyte CL0002363

CSI 0.8

rCSI 1.9%

PRS 16.5%
Schwann cell CL0002573

CSI 0.8

rCSI 2.3%

PRS 13.4%
cerebral cortex pyramidal neuron CL4023111

CSI 0.8

rCSI 5.0%

PRS 31.4%
hepatocyte CL0000182

CSI 0.8

rCSI 1.5%

PRS 10.2%
glandular epithelial cell CL0000150

CSI 0.8

rCSI 2.2%

PRS 21.3%
mesenchymal lymphangioblast CL0005021

CSI 0.8

rCSI 21.8%

PRS 50.8%
lung endothelial cell CL1001567

CSI 0.9

rCSI 2.0%

PRS 26.5%
fibroblast of breast CL4006000

CSI 0.9

rCSI 3.7%

PRS 28.5%
tracheobronchial smooth muscle cell CL0019019

CSI 0.9

rCSI 1.6%

PRS 14.4%
conjunctival epithelial cell CL1000432

CSI 0.9

rCSI 1.4%

PRS 10.9%
ionocyte CL0005006

CSI 0.9

rCSI 1.0%

PRS 10.0%
mature astrocyte CL0002627

CSI 1.0

rCSI 4.2%

PRS 14.4%
colon macrophage CL0009038

CSI 1.0

rCSI 4.6%

PRS 22.9%
class switched memory B cell CL0000972

CSI 1.0

rCSI 0.8%

PRS 18.3%
respiratory epithelial cell CL0002368

CSI 1.0

rCSI 6.3%

PRS 35.2%
T-helper 17 cell CL0000899

CSI 1.1

rCSI 0.8%

PRS 19.1%
dopaminergic neuron CL0000700

CSI 1.1

rCSI 6.0%

PRS 4.1%
pre-conventional dendritic cell CL0002010

CSI 1.1

rCSI 14.4%

PRS 35.7%
brush cell CL0002204

CSI 1.1

rCSI 2.2%

PRS 29.4%
endothelial cell of uterus CL0009095

CSI 1.1

rCSI 8.3%

PRS 30.0%
tracheobronchial serous cell CL0019001

CSI 1.2

rCSI 5.1%

PRS 20.9%
pulmonary ionocyte CL0017000

CSI 1.2

rCSI 1.5%

PRS 13.7%
B-1 B cell CL0000819

CSI 1.2

rCSI 30.8%

PRS 51.5%
duct epithelial cell CL0000068

CSI 1.2

rCSI 1.8%

PRS 11.5%
epithelial cell of nephron CL1000449

CSI 1.3

rCSI 12.4%

PRS 45.7%
cerebellar granule cell CL0001031

CSI 1.4

rCSI 2.0%

PRS 10.1%
blood vessel endothelial cell CL0000071

CSI 1.4

rCSI 2.8%

PRS 10.9%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [CALM3](/details-gene/808) encodes Calmodulin 3, a member of the highly conserved family of calmodulin proteins. As a primary intracellular calcium sensor, it plays a fundamental role in transducing calcium signals into a wide range of cellular responses. The protein is characterized by its ability to bind calcium ions, which induces a conformational change allowing it to interact with and modulate the activity of numerous target proteins. **Overall**, expression data indicates that [CALM3](/details-gene/808) is a crucial component in diverse cell types, showing particularly high significance in highly proliferative cells such as [intestinal epithelial cell](/details-cell/CL0002563) and hematopoietic progenitors like [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), as well as in functionally dynamic cells like [peripheral nervous system neuron](/details-cell/CL2000032). This broad but distinct expression pattern underscores its central role in mediating calcium-dependent processes essential for cell cycle progression, signal transduction, and metabolism. ## Cellular Roles and Expression Landscape The expression profile of [CALM3](/details-gene/808) highlights its role as a key regulator in cells with high metabolic activity, rapid proliferation, or complex signaling requirements. **Overall**, the gene shows the highest significance in epithelial cells of the intestine, specifically [intestinal epithelial cell](/details-cell/CL0002563) (CSI: 64.96) and [transit amplifying cell of colon](/details-cell/CL0009011) (CSI: 46.98), which is consistent with the constant cellular turnover and calcium-dependent signaling required for nutrient absorption and barrier function in the gut. Furthermore, [CALM3](/details-gene/808) is highly significant across multiple stages of hematopoiesis, including in [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) (CSI: 61.78), [granulocyte monocyte progenitor cell](/details-cell/CL0000557) (CSI: 49.93), and [common myeloid progenitor](/details-cell/CL0000049) (CSI: 45.63). This suggests a critical function in the differentiation and proliferation of blood cell lineages. Its high CSI in [peripheral nervous system neuron](/details-cell/CL2000032) (CSI: 58.28) and various pancreatic endocrine cells ([pancreatic D cell](/details-cell/CL0000173) and [pancreatic A cell](/details-cell/CL0000171)) points to its involvement in neurotransmission and hormone secretion, respectively. Conversely, the gene's significance is notably low in several terminally differentiated cell types, including [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913) (CSI: -9.58), and various endothelial cells such as [pulmonary artery endothelial cell](/details-cell/CL1001568) (CSI: -10.88). This pattern suggests that while [CALM3](/details-gene/808) is a housekeeping protein, its expression level and functional importance are particularly elevated during cell division and specialized signaling events, rather than in maintaining quiescent or terminally differentiated states. ## Pathways and Molecular Function The functional annotations for [CALM3](/details-gene/808) confirm its identity as a central hub in calcium-mediated signaling. Its primary molecular function is [Calcium ion binding](/details-go/GO:0005509), which enables it to participate in a vast array of biological processes. A key annotated pathway is the [G protein-coupled receptor signaling pathway](/details-go/GO:0007186), which is consistent with its high expression in neurons and endocrine cells that rely on this signaling cascade. A significant aspect of its function relates to cell cycle regulation, highlighted by its involvement in the [G2/m transition of mitotic cell cycle](/details-go/GO:0000086). This is further supported by its localization to the [Centrosome](/details-go/GO:0005813), [Spindle microtubule](/details-go/GO:0005876), and [Spindle pole](/details-go/GO:0000922). This role aligns perfectly with its high significance in rapidly dividing progenitor cell populations observed in the expression data. Additionally, [CALM3](/details-gene/808) is heavily implicated in muscle function and cardiac electrophysiology through processes such as [Regulation of cardiac muscle contraction](/details-go/GO:0055117) and [Regulation of cardiac muscle cell action potential](/details-go/GO:0098901). It modulates the activity of key ion channels, including the [ryanodine-sensitive calcium-release channel](/details-go/GO:0060315) and [high voltage-gated calcium channel](/details-go/GO:1901842), underscoring its role as a master regulator of calcium homeostasis and cellular excitability. ## Research Directions Given the fundamental role of [CALM3](/details-gene/808) in cell proliferation and signaling, its dysregulation is likely implicated in various pathologies, particularly cancer and developmental disorders. ### Proposed Hypotheses: 1. **Role in Hematological Malignancies:** Based on its high significance in multiple hematopoietic progenitor populations ([megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050), [granulocyte monocyte progenitor cell](/details-cell/CL0000557)) and its direct involvement in the [G2/m transition of mitotic cell cycle](/details-go/GO:0000086), we hypothesize that overexpression or gain-of-function mutations in [CALM3](/details-gene/808) contribute to the uncontrolled proliferation characteristic of myeloid or erythroid leukemias by accelerating cell cycle progression. 2. **Function in Intestinal Homeostasis and Disease:** The prominent expression of [CALM3](/details-gene/808) in [intestinal epithelial cell](/details-cell/CL0002563) and [transit amplifying cell of colon](/details-cell/CL0009011) suggests a critical role in maintaining the gut barrier. We hypothesize that impaired [CALM3](/details-gene/808) function, perhaps due to downstream signaling defects, compromises epithelial regeneration and tight junction integrity, thereby contributing to the pathology of inflammatory bowel disease (IBD). ### Key Experimental Approach: To test the hypothesis regarding its role in hematological malignancies, a targeted functional genomics approach could be employed. Specifically, CRISPR-Cas9-mediated knockout or shRNA-mediated knockdown of [CALM3](/details-gene/808) could be performed in human acute myeloid leukemia (AML) cell lines (e.g., HL-60, THP-1). The consequences of its depletion would be assessed by measuring changes in cell proliferation rates using a colorimetric assay (e.g., MTS), analyzing cell cycle distribution via flow cytometry after propidium iodide staining, and quantifying apoptosis using an Annexin V/7-AAD assay. A significant reduction in proliferation and an arrest at the G2/M checkpoint would provide strong evidence for its role as a driver of leukemic cell growth. ### Therapeutic Potential: As an intracellular signaling hub, [CALM3](/details-gene/808) presents a challenging but potentially valuable therapeutic target. Direct inhibition is likely to cause significant toxicity due to its ubiquitous and essential roles. However, its overexpression in certain cancers may create a therapeutic window. A more promising strategy would be the development of small molecule inhibitors designed to selectively disrupt the interaction of [CALM3](/details-gene/808) with specific downstream effectors known to be critical for oncogenesis, such as particular protein kinases. Such an approach would target a specific pathogenic function while potentially sparing its essential housekeeping roles, making targeted **inhibition** a plausible therapeutic strategy in contexts like leukemia where it may be a key dependency.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Q9BRL5_HUMAN

Genular Protein ID: 3140326336

Symbol: Q9BRL5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BRL5

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 147
Mass: 16507
Checksum: EAA976F9BD6D3A11
Sequence:

MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG 
NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE 
SLSMPLISSF CPRLFHPCLP RPDAFIS

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Ascending colon UBERON0001156
	Atherosclerosis MONDO0005311
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	\|— Caecum Healthy UBERON0001153_PATO0000461
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	\|— Colonic epithelium Healthy UBERON0000397_PATO0000461
	Colorectal cancer MONDO0005575
	Colorectum UBERON0012652
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileal epithelium UBERON0008345
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Nonpapillary renal cell carcinoma MONDO0007763
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	\|— Placenta Healthy UBERON0001987_PATO0000461
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Primary visual cortex UBERON0002436
	Rectum UBERON0001052
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	\|— Stomach Healthy UBERON0000945_PATO0000461
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Transverse colon UBERON0001157
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648