CALM3 | ENSG00000160014 | NCBI 808

Details for: CALM3

Gene ID: 808

Symbol: CALM3

Ensembl ID: ENSG00000160014

Description: calmodulin 3

Associated with

Adenylate cyclase activator activity
(GO:0010856)
Adenylate cyclase binding
(GO:0008179)
Calcium-dependent protein binding
(GO:0048306)
Calcium channel complex
(GO:0034704)
Calcium ion binding
(GO:0005509)
Calyx of held
(GO:0044305)
Catalytic complex
(GO:1902494)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Detection of calcium ion
(GO:0005513)
G2/m transition of mitotic cell cycle
(GO:0000086)
G protein-coupled receptor signaling pathway
(GO:0007186)
Myelin sheath
(GO:0043209)
Negative regulation of calcium ion export across plasma membrane
(GO:1905913)
Negative regulation of high voltage-gated calcium channel activity
(GO:1901842)
Negative regulation of peptidyl-threonine phosphorylation
(GO:0010801)
Negative regulation of ryanodine-sensitive calcium-release channel activity
(GO:0060315)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of cyclic-nucleotide phosphodiesterase activity
(GO:0051343)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of protein autophosphorylation
(GO:0031954)
Positive regulation of protein serine/threonine kinase activity
(GO:0071902)
Positive regulation of ryanodine-sensitive calcium-release channel activity
(GO:0060316)
Presynaptic cytosol
(GO:0099523)
Presynaptic endocytosis
(GO:0140238)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphatase activator activity
(GO:0072542)
Protein serine/threonine kinase activator activity
(GO:0043539)
Regulation of calcium-mediated signaling
(GO:0050848)
Regulation of cardiac muscle cell action potential
(GO:0098901)
Regulation of cardiac muscle contraction
(GO:0055117)
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
(GO:0010881)
Regulation of cell communication by electrical coupling involved in cardiac conduction
(GO:1901844)
Regulation of cytokinesis
(GO:0032465)
Regulation of heart rate
(GO:0002027)
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
(GO:0010880)
Response to calcium ion
(GO:0051592)
Sarcomere
(GO:0030017)
Sperm midpiece
(GO:0097225)
Spindle microtubule
(GO:0005876)
Spindle pole
(GO:0000922)
Substantia nigra development
(GO:0021762)
Titin binding
(GO:0031432)
Transmembrane transporter binding
(GO:0044325)
Vesicle
(GO:0031982)
Voltage-gated potassium channel complex
(GO:0008076)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 320.2927
Cell Significance Index: -49.8200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 293.7195
Cell Significance Index: -74.5000
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 218.8142
Cell Significance Index: -90.1400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 185.8798
Cell Significance Index: -75.5200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 176.5643
Cell Significance Index: -83.3600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 163.8655
Cell Significance Index: -84.2900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 124.6755
Cell Significance Index: -83.6600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 80.5138
Cell Significance Index: -76.8700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 64.8928
Cell Significance Index: -80.0100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 24.3175
Cell Significance Index: -74.6900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 22.3844
Cell Significance Index: -88.3300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 18.0562
Cell Significance Index: -48.3700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.2715
Cell Significance Index: -22.4800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 5.5409
Cell Significance Index: 290.9200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 4.0877
Cell Significance Index: 664.8300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 4.0008
Cell Significance Index: 117.5000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.5612
Cell Significance Index: 53.6100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.4062
Cell Significance Index: 283.7700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.2980
Cell Significance Index: 460.9700
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.0008
Cell Significance Index: 52.6100
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.6403
Cell Significance Index: 46.8100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.5947
Cell Significance Index: 218.9900
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.5693
Cell Significance Index: 857.0400
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.2763
Cell Significance Index: 23.5900
Cell Name: odontoblast (CL0000060)
Fold Change: 1.1756
Cell Significance Index: 150.7100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.1529
Cell Significance Index: 413.5200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.1406
Cell Significance Index: 140.2500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.1371
Cell Significance Index: 76.4600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1233
Cell Significance Index: 202.4900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.0627
Cell Significance Index: 65.3200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.0095
Cell Significance Index: 35.0800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8221
Cell Significance Index: 23.6900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.7640
Cell Significance Index: 56.9400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.7623
Cell Significance Index: 49.1800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6771
Cell Significance Index: 14.6700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6262
Cell Significance Index: 32.6200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5956
Cell Significance Index: 30.9400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5657
Cell Significance Index: 55.9700
Cell Name: kidney cell (CL1000497)
Fold Change: 0.5298
Cell Significance Index: 4.2300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4722
Cell Significance Index: 28.3500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4463
Cell Significance Index: 197.3100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4281
Cell Significance Index: 84.9600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4231
Cell Significance Index: 80.5100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4086
Cell Significance Index: 18.5200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3512
Cell Significance Index: 9.4100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.2824
Cell Significance Index: 4.8400
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.1878
Cell Significance Index: 2.4100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1379
Cell Significance Index: 6.4800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.1023
Cell Significance Index: 13.2100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0783
Cell Significance Index: 2.7500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0753
Cell Significance Index: 2.0100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0466
Cell Significance Index: 0.7800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0418
Cell Significance Index: 31.6500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0239
Cell Significance Index: 21.6300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0234
Cell Significance Index: -44.1100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0259
Cell Significance Index: -19.0100
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0417
Cell Significance Index: -76.8400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0424
Cell Significance Index: -4.3300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0440
Cell Significance Index: -67.7800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0515
Cell Significance Index: -2.4000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0537
Cell Significance Index: -73.0300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0927
Cell Significance Index: -68.7000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0970
Cell Significance Index: -16.5700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1148
Cell Significance Index: -72.8900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1331
Cell Significance Index: -75.0700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1428
Cell Significance Index: -64.8000
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1611
Cell Significance Index: -100.6300
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2014
Cell Significance Index: -4.8300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2519
Cell Significance Index: -72.4800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2943
Cell Significance Index: -34.3000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3046
Cell Significance Index: -13.4800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3311
Cell Significance Index: -23.4200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4322
Cell Significance Index: -49.5200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4401
Cell Significance Index: -27.7400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4547
Cell Significance Index: -95.7700
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.5082
Cell Significance Index: -5.5300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.5209
Cell Significance Index: -75.7200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.5258
Cell Significance Index: -36.3700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5280
Cell Significance Index: -16.9100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5633
Cell Significance Index: -14.3900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6018
Cell Significance Index: -22.7900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.7257
Cell Significance Index: -20.2800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.7379
Cell Significance Index: -6.7900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7754
Cell Significance Index: -61.4200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.8146
Cell Significance Index: -84.8200
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.8381
Cell Significance Index: -6.4600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.8662
Cell Significance Index: -9.8400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.9089
Cell Significance Index: -51.0100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.9996
Cell Significance Index: -76.7100
Cell Name: peg cell (CL4033014)
Fold Change: -1.0063
Cell Significance Index: -23.2500
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.0161
Cell Significance Index: -15.2300
Cell Name: Sertoli cell (CL0000216)
Fold Change: -1.0395
Cell Significance Index: -14.5800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -1.0491
Cell Significance Index: -28.5600
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.2244
Cell Significance Index: -12.6800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2310
Cell Significance Index: -75.4700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.2643
Cell Significance Index: -37.2400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.3178
Cell Significance Index: -28.0700
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.3866
Cell Significance Index: -29.4300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.5552
Cell Significance Index: -44.5800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.5574
Cell Significance Index: -38.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** The CALM3 protein exhibits several key characteristics that distinguish it from other calmodulins. One of its most notable features is its ability to regulate the activity of various enzymes and signaling pathways, including adenylate cyclase, protein kinases, and phosphatases. CALM3 also interacts with other proteins, such as titin and the voltage-gated potassium channel complex, to modulate muscle contraction and cell communication. Furthermore, CALM3 has been shown to play a critical role in regulating the release of sequestered calcium ions into the cytosol, which is essential for maintaining proper muscle contraction and cardiac function. **Pathways and Functions** CALM3 is involved in numerous signaling pathways that regulate various cellular processes, including: 1. **Calcium-mediated signaling**: CALM3 binds to calcium ions, triggering a cascade of downstream signaling events that influence various cellular processes, including muscle contraction, cell communication, and gene expression. 2. **Muscle contraction**: CALM3 regulates the release of sequestered calcium ions into the cytosol, which is essential for maintaining proper muscle contraction and cardiac function. 3. **Cell communication**: CALM3 interacts with other proteins to modulate cell communication, including electrical coupling involved in cardiac conduction. 4. **Cardiac function**: CALM3 plays a critical role in regulating cardiac muscle contraction and heart rate. 5. **Immune cell function**: CALM3 is expressed in various immune cells, including T cells and natural killer cells, where it regulates cytokine production and cell activation. **Clinical Significance** The dysregulation of CALM3 has been implicated in various diseases, including: 1. **Cardiac arrhythmias**: Mutations in the CALM3 gene have been associated with cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. 2. **Muscular dystrophy**: CALM3 has been shown to play a critical role in regulating muscle contraction, and mutations in the CALM3 gene have been associated with muscular dystrophy. 3. **Neurological disorders**: CALM3 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 4. **Cancer**: CALM3 has been shown to play a role in regulating cell growth and proliferation, and its dysregulation has been implicated in various types of cancer. In conclusion, CALM3 is a gene of unparalleled significance in calcium-mediated signaling, muscle contraction, and cell communication. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand the complexities of CALM3 and its role in maintaining cellular homeostasis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Q9BRL5_HUMAN

Genular Protein ID: 3140326336

Symbol: Q9BRL5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BRL5

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 147
Mass: 16507
Checksum: EAA976F9BD6D3A11
Sequence:

MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG 
NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE 
SLSMPLISSF CPRLFHPCLP RPDAFIS

Database document: