Details for: CALM3

Gene ID: 808

Symbol: CALM3

Ensembl ID: ENSG00000160014

Description: calmodulin 3

Associated with

  • Adenylate cyclase activator activity
    (GO:0010856)
  • Adenylate cyclase binding
    (GO:0008179)
  • Calcium-dependent protein binding
    (GO:0048306)
  • Calcium channel complex
    (GO:0034704)
  • Calcium ion binding
    (GO:0005509)
  • Catalytic complex
    (GO:1902494)
  • Centrosome
    (GO:0005813)
  • Cytoplasm
    (GO:0005737)
  • Detection of calcium ion
    (GO:0005513)
  • G2/m transition of mitotic cell cycle
    (GO:0000086)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Myelin sheath
    (GO:0043209)
  • Negative regulation of calcium ion export across plasma membrane
    (GO:1905913)
  • Negative regulation of high voltage-gated calcium channel activity
    (GO:1901842)
  • Negative regulation of peptidyl-threonine phosphorylation
    (GO:0010801)
  • Negative regulation of ryanodine-sensitive calcium-release channel activity
    (GO:0060315)
  • Nucleus
    (GO:0005634)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cyclic-nucleotide phosphodiesterase activity
    (GO:0051343)
  • Positive regulation of peptidyl-threonine phosphorylation
    (GO:0010800)
  • Positive regulation of phosphoprotein phosphatase activity
    (GO:0032516)
  • Positive regulation of protein autophosphorylation
    (GO:0031954)
  • Positive regulation of protein dephosphorylation
    (GO:0035307)
  • Positive regulation of protein serine/threonine kinase activity
    (GO:0071902)
  • Positive regulation of ryanodine-sensitive calcium-release channel activity
    (GO:0060316)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein kinase binding
    (GO:0019901)
  • Protein phosphatase activator activity
    (GO:0072542)
  • Protein serine/threonine kinase activator activity
    (GO:0043539)
  • Regulation of calcium-mediated signaling
    (GO:0050848)
  • Regulation of cardiac muscle cell action potential
    (GO:0098901)
  • Regulation of cardiac muscle contraction
    (GO:0055117)
  • Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
    (GO:0010881)
  • Regulation of cell communication by electrical coupling involved in cardiac conduction
    (GO:1901844)
  • Regulation of cytokinesis
    (GO:0032465)
  • Regulation of heart rate
    (GO:0002027)
  • Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
    (GO:0010880)
  • Response to calcium ion
    (GO:0051592)
  • Sarcomere
    (GO:0030017)
  • Sperm midpiece
    (GO:0097225)
  • Spindle microtubule
    (GO:0005876)
  • Spindle pole
    (GO:0000922)
  • Substantia nigra development
    (GO:0021762)
  • Titin binding
    (GO:0031432)
  • Transmembrane transporter binding
    (GO:0044325)
  • Vesicle
    (GO:0031982)
  • Voltage-gated potassium channel complex
    (GO:0008076)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.79
    Marker Score: 4578
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.58
    Marker Score: 7557
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.47
    Marker Score: 3276
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 3.26
    Marker Score: 13586
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.15
    Marker Score: 6410
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.89
    Marker Score: 28593
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.86
    Marker Score: 3457
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.8
    Marker Score: 7726
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.68
    Marker Score: 35289
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.61
    Marker Score: 1089
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.6
    Marker Score: 3685
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.59
    Marker Score: 2702.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.55
    Marker Score: 16291
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.5
    Marker Score: 11990
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.48
    Marker Score: 138498
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.42
    Marker Score: 2722
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.42
    Marker Score: 28163
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.39
    Marker Score: 126228
  • Cell Name: platelet (CL0000233)
    Fold Change: 2.37
    Marker Score: 1073
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.37
    Marker Score: 2228
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.34
    Marker Score: 15218
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.33
    Marker Score: 2327
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.31
    Marker Score: 759
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.3
    Marker Score: 1678.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.29
    Marker Score: 2442
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.24
    Marker Score: 3712.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.24
    Marker Score: 1231
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.23
    Marker Score: 9563
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.23
    Marker Score: 6602.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.22
    Marker Score: 3418.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.21
    Marker Score: 5201
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.2
    Marker Score: 1038
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.17
    Marker Score: 7711.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.17
    Marker Score: 728
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.16
    Marker Score: 4210
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.16
    Marker Score: 9314.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.15
    Marker Score: 4492
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.14
    Marker Score: 3820
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.13
    Marker Score: 1338
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.11
    Marker Score: 3254
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 2.11
    Marker Score: 5742
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.1
    Marker Score: 1209
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.09
    Marker Score: 5852
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.08
    Marker Score: 1236.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.07
    Marker Score: 5641
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.06
    Marker Score: 493
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.06
    Marker Score: 6475
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.05
    Marker Score: 71182
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.04
    Marker Score: 2935
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.04
    Marker Score: 12993
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.03
    Marker Score: 2189
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.02
    Marker Score: 20372
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.02
    Marker Score: 8284
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.02
    Marker Score: 2315
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.02
    Marker Score: 1346
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.01
    Marker Score: 2028
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.01
    Marker Score: 1453
  • Cell Name: basophil (CL0000767)
    Fold Change: 2
    Marker Score: 952
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2
    Marker Score: 2212
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.98
    Marker Score: 6257
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.98
    Marker Score: 826
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.97
    Marker Score: 1048
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.97
    Marker Score: 1635
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.97
    Marker Score: 11669
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.96
    Marker Score: 2176
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.95
    Marker Score: 3320
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.95
    Marker Score: 2057.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.94
    Marker Score: 1381
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.94
    Marker Score: 1815
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.93
    Marker Score: 7474
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.93
    Marker Score: 1691
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.92
    Marker Score: 859
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.92
    Marker Score: 1351
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.91
    Marker Score: 507
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.91
    Marker Score: 3736
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.91
    Marker Score: 939
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.9
    Marker Score: 1280
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.9
    Marker Score: 4515
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.9
    Marker Score: 499
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.89
    Marker Score: 6981
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.88
    Marker Score: 4593
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.88
    Marker Score: 2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.87
    Marker Score: 7363
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.87
    Marker Score: 2759
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.87
    Marker Score: 1243
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.87
    Marker Score: 3252
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.86
    Marker Score: 956
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.86
    Marker Score: 1972
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.86
    Marker Score: 3043
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.85
    Marker Score: 641
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 1.85
    Marker Score: 479
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.84
    Marker Score: 5373
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.84
    Marker Score: 1545
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.83
    Marker Score: 4627
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.82
    Marker Score: 2687
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 1.82
    Marker Score: 484
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.82
    Marker Score: 2133
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.82
    Marker Score: 515
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.81
    Marker Score: 1974
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.81
    Marker Score: 1062

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Other Information

**Key characteristics:** - CALM3 is a calcium-dependent protein kinase (CDPK). - It is expressed in a variety of cell types, including cardiac muscle cells, pancreatic acinar cells, and immune cells. - It is a key regulator of the cardiac contractile cycle, heart rate, and calcium signaling. **Pathways and functions:** - CALM3 is involved in the regulation of cardiac muscle contraction by controlling the release of calcium ions from the sarcoplasmic reticulum. - It is also involved in the regulation of heart rate by controlling the release of calcium ions into the cytosol. - It plays a role in the regulation of calcium signaling by binding to the G protein-coupled receptor pathway. - It also regulates the release of calcium ions into the cytosol by binding to titin and the transmembrane transporter. **Clinical significance:** - Mutations in the CALM3 gene have been linked to a number of human diseases, including hypertrophic cardiomyopathy, heart failure, and arrhythmias. - Targeting CALM3 has been investigated as a therapeutic strategy for these diseases. **Additional information:** - The CALM3 gene is located on chromosome 17q21.1. - It is a highly conserved protein, with a similar sequence in mammals and humans. - It is a well-studied protein that has been extensively characterized in research.

Genular Protein ID: 3140326336

Symbol: Q9BRL5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BRL5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 2 PharmGKB 1 RefSeq 4 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 147
  • Mass: 16507
  • Checksum: EAA976F9BD6D3A11
  • Sequence:
    • MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG 
NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE 
SLSMPLISSF CPRLFHPCLP RPDAFIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.