Details for: ACTN4

Gene ID: 81

Symbol: ACTN4

Ensembl ID: ENSG00000130402

Description: actinin alpha 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 536.1785
    Cell Significance Index: -83.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 327.4479
    Cell Significance Index: -83.0600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 225.8540
    Cell Significance Index: -93.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 202.3627
    Cell Significance Index: -95.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 175.4910
    Cell Significance Index: -90.2700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 142.9759
    Cell Significance Index: -95.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 72.5168
    Cell Significance Index: -89.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.3133
    Cell Significance Index: -81.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.8799
    Cell Significance Index: -90.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.5496
    Cell Significance Index: -69.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 22.2838
    Cell Significance Index: -48.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.0784
    Cell Significance Index: 108.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.6930
    Cell Significance Index: 100.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.1603
    Cell Significance Index: 84.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.9598
    Cell Significance Index: 134.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.9125
    Cell Significance Index: 223.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.7310
    Cell Significance Index: 78.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4520
    Cell Significance Index: 301.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1647
    Cell Significance Index: 429.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.0375
    Cell Significance Index: 900.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0264
    Cell Significance Index: 1106.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9960
    Cell Significance Index: 359.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.9422
    Cell Significance Index: 91.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7496
    Cell Significance Index: 350.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5351
    Cell Significance Index: 210.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4851
    Cell Significance Index: 146.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4848
    Cell Significance Index: 77.1300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.4146
    Cell Significance Index: 20.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3933
    Cell Significance Index: 180.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1272
    Cell Significance Index: 79.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9819
    Cell Significance Index: 73.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9266
    Cell Significance Index: 100.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8652
    Cell Significance Index: 24.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8621
    Cell Significance Index: 309.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.8005
    Cell Significance Index: 11.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7065
    Cell Significance Index: 32.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6986
    Cell Significance Index: 89.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6398
    Cell Significance Index: 104.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5658
    Cell Significance Index: 5.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.5534
    Cell Significance Index: 8.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4625
    Cell Significance Index: 870.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3699
    Cell Significance Index: 23.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3661
    Cell Significance Index: 253.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3642
    Cell Significance Index: 69.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3143
    Cell Significance Index: 37.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3134
    Cell Significance Index: 3.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2794
    Cell Significance Index: 126.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2545
    Cell Significance Index: 14.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2392
    Cell Significance Index: 10.5800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2388
    Cell Significance Index: 4.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2194
    Cell Significance Index: 139.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2019
    Cell Significance Index: 1.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1845
    Cell Significance Index: 340.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1541
    Cell Significance Index: 26.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1372
    Cell Significance Index: 211.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0925
    Cell Significance Index: 83.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0239
    Cell Significance Index: 18.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0088
    Cell Significance Index: 0.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0209
    Cell Significance Index: -15.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0302
    Cell Significance Index: -41.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1095
    Cell Significance Index: -81.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1113
    Cell Significance Index: -11.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1588
    Cell Significance Index: -89.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1808
    Cell Significance Index: -112.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2154
    Cell Significance Index: -22.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2428
    Cell Significance Index: -5.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2685
    Cell Significance Index: -77.2600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2792
    Cell Significance Index: -3.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3217
    Cell Significance Index: -8.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3310
    Cell Significance Index: -48.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3364
    Cell Significance Index: -17.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3401
    Cell Significance Index: -4.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3934
    Cell Significance Index: -11.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4406
    Cell Significance Index: -12.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4954
    Cell Significance Index: -104.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5065
    Cell Significance Index: -7.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5207
    Cell Significance Index: -11.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5455
    Cell Significance Index: -62.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5667
    Cell Significance Index: -66.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6869
    Cell Significance Index: -23.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6921
    Cell Significance Index: -14.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7541
    Cell Significance Index: -12.6200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.8310
    Cell Significance Index: -6.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8629
    Cell Significance Index: -22.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9053
    Cell Significance Index: -71.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0800
    Cell Significance Index: -34.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1869
    Cell Significance Index: -29.6700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.2514
    Cell Significance Index: -21.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2559
    Cell Significance Index: -77.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2571
    Cell Significance Index: -66.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.2831
    Cell Significance Index: -80.8700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.3205
    Cell Significance Index: -18.8000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.3302
    Cell Significance Index: -13.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.6763
    Cell Significance Index: -40.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.6874
    Cell Significance Index: -35.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.7279
    Cell Significance Index: -60.5300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.7282
    Cell Significance Index: -70.8100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.7552
    Cell Significance Index: -32.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.8145
    Cell Significance Index: -57.7900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.8345
    Cell Significance Index: -11.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ACTN4 is a cytoplasmic protein that belongs to the actinin family, which is characterized by its ability to bind to actin filaments. This protein has several key characteristics that distinguish it from other actinin family members: 1. **High expression levels**: ACTN4 is highly expressed in various cell types, suggesting its importance in maintaining cellular structure and function. 2. **Actin filament binding**: ACTN4 binds to actin filaments, which is essential for maintaining the integrity of the actin cytoskeleton. 3. **Multiple interaction partners**: ACTN4 interacts with various proteins, including integrins, focal adhesion proteins, and signaling molecules, which suggests its involvement in multiple cellular processes. 4. **Regulatory role in cell migration**: ACTN4 has been shown to regulate cell migration, which is a critical process in tissue development, wound healing, and cancer metastasis. **Pathways and Functions** ACTN4 is involved in several signaling pathways and cellular processes, including: 1. **Actin cytoskeleton organization**: ACTN4 plays a crucial role in maintaining the organization and dynamics of the actin cytoskeleton. 2. **Cell adhesion**: ACTN4 interacts with integrins and other adhesion molecules to regulate cell adhesion and migration. 3. **Signaling pathways**: ACTN4 is involved in various signaling pathways, including the NF-κB pathway, the MAPK pathway, and the PI3K/Akt pathway. 4. **Cell migration**: ACTN4 regulates cell migration, which is essential for tissue development, wound healing, and cancer metastasis. 5. **Apoptosis regulation**: ACTN4 has been shown to regulate the apoptotic process, which is critical for maintaining tissue homeostasis. **Clinical Significance** ACTN4 has been implicated in several diseases, including: 1. **Cancer**: ACTN4 has been shown to promote cancer cell migration and invasion, suggesting its potential role in cancer metastasis. 2. **Cardiovascular disorders**: ACTN4 has been linked to cardiovascular disorders, including atherosclerosis and cardiac hypertrophy. 3. **Neurological disorders**: ACTN4 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Muscle disorders**: ACTN4 has been linked to muscle disorders, including muscular dystrophy. In conclusion, ACTN4 is a multifunctional protein that plays a critical role in maintaining the organization and function of the actin cytoskeleton. Its involvement in various signaling pathways and cellular processes makes it an important regulator of cellular behavior. Further studies are needed to fully elucidate the role of ACTN4 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 135020461

Symbol: ACTN4_HUMAN

Name: N/A

UniProtKB Accession Codes:

O43707 A4K467 D6PXK4 O76048

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChEBI 3 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRIDE 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10656685

Title: The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.

PubMed ID: 10656685

DOI: 10.1038/sj.onc.1203310

PubMed ID: 22567897

Title: Novel splicing isoform of actin-binding protein alpha-actinin 4 in epidermoid carcinoma cells A431.

PubMed ID: 22567897

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16344560

Title: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

PubMed ID: 16344560

DOI: 10.1101/gr.4039406

PubMed ID: 9508771

Title: Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion.

PubMed ID: 9508771

DOI: 10.1083/jcb.140.6.1383

PubMed ID: 12042308

Title: Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.

PubMed ID: 12042308

DOI: 10.1074/jbc.m203072200

PubMed ID: 15772161

Title: CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling.

PubMed ID: 15772161

DOI: 10.1091/mbc.e04-11-1014

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22689882

Title: EWI-2 association with alpha-actinin regulates T cell immune synapses and HIV viral infection.

PubMed ID: 22689882

DOI: 10.4049/jimmunol.1103708

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 33228246

Title: ACTN4 Mediates SEPT14 Mutation-Induced Sperm Head Defects.

PubMed ID: 33228246

DOI: 10.3390/biomedicines8110518

PubMed ID: 15988023

Title: Structural dynamics of alpha-actinin-vinculin interactions.

PubMed ID: 15988023

DOI: 10.1128/mcb.25.14.6112-6122.2005

PubMed ID: 18164029

Title: Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis.

PubMed ID: 18164029

DOI: 10.1016/j.jmb.2007.11.084

PubMed ID: 22351778

Title: Familial focal segmental glomerulosclerosis (FSGS)-linked alpha-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors.

PubMed ID: 22351778

DOI: 10.1074/jbc.m112.345421

PubMed ID: 10700177

Title: Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis.

PubMed ID: 10700177

DOI: 10.1038/73456

PubMed ID: 18436095

Title: Familial focal segmental glomerulosclerosis associated with an ACTN4 mutation and paternal germline mosaicism.

PubMed ID: 18436095

DOI: 10.1053/j.ajkd.2008.01.018

PubMed ID: 22732337

Title: Mutations in podocyte genes are a rare cause of primary FSGS associated with ESRD in adult patients.

PubMed ID: 22732337

DOI: 10.5414/cn107320

PubMed ID: 23890478

Title: Mutational analysis of ACTN4, encoding alpha-actinin 4, in patients with focal segmental glomerulosclerosis using HRM method.

PubMed ID: 23890478

PubMed ID: 23014460

Title: Mutations in the INF2 gene account for a significant proportion of familial but not sporadic focal and segmental glomerulosclerosis.

PubMed ID: 23014460

DOI: 10.1038/ki.2012.349

Sequence Information:

  • Length: 911
  • Mass: 104854
  • Checksum: 461580C3F22937D1
  • Sequence:
    • MVDYHAANQS YQYGPSSAGN GAGGGGSMGD YMAQEDDWDR DLLLDPAWEK QQRKTFTAWC 
NSHLRKAGTQ IENIDEDFRD GLKLMLLLEV ISGERLPKPE RGKMRVHKIN NVNKALDFIA 
SKGVKLVSIG AEEIVDGNAK MTLGMIWTII LRFAIQDISV EETSAKEGLL LWCQRKTAPY 
KNVNVQNFHI SWKDGLAFNA LIHRHRPELI EYDKLRKDDP VTNLNNAFEV AEKYLDIPKM 
LDAEDIVNTA RPDEKAIMTY VSSFYHAFSG AQKAETAANR ICKVLAVNQE NEHLMEDYEK 
LASDLLEWIR RTIPWLEDRV PQKTIQEMQQ KLEDFRDYRR VHKPPKVQEK CQLEINFNTL 
QTKLRLSNRP AFMPSEGKMV SDINNGWQHL EQAEKGYEEW LLNEIRRLER LDHLAEKFRQ 
KASIHEAWTD GKEAMLKHRD YETATLSDIK ALIRKHEAFE SDLAAHQDRV EQIAAIAQEL 
NELDYYDSHN VNTRCQKICD QWDALGSLTH SRREALEKTE KQLEAIDQLH LEYAKRAAPF 
NNWMESAMED LQDMFIVHTI EEIEGLISAH DQFKSTLPDA DREREAILAI HKEAQRIAES 
NHIKLSGSNP YTTVTPQIIN SKWEKVQQLV PKRDHALLEE QSKQQSNEHL RRQFASQANV 
VGPWIQTKME EIGRISIEMN GTLEDQLSHL KQYERSIVDY KPNLDLLEQQ HQLIQEALIF 
DNKHTNYTME HIRVGWEQLL TTIARTINEV ENQILTRDAK GISQEQMQEF RASFNHFDKD 
HGGALGPEEF KACLISLGYD VENDRQGEAE FNRIMSLVDP NHSGLVTFQA FIDFMSRETT 
DTDTADQVIA SFKVLAGDKN FITAEELRRE LPPDQAEYCI ARMAPYQGPD AVPGALDYKS 
FSTALYGESD L

Genular Protein ID: 2303997419

Symbol: H7C144_HUMAN

Name: N/A

UniProtKB Accession Codes:

H7C144

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 4 CTD 1 ChiTaRS 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 8 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 PANTHER 2 PRIDE 1 PROSITE 6 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 4 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 906
  • Mass: 104327
  • Checksum: 85B7706D09DAFED7
  • Sequence:
    • MVDYHAANQS YQYGPSSAGN GAGGGGSMGD YMAQEDDWDR DLLLDPAWEK QQRKTFTAWC 
NSHLRKAGTQ IENIDEDFRD GLKLMLLLEV ISGERLPKPE RGKMRVHKIN NVNKALDFIA 
SKGVKLVSIG AEEIVDGNAK MTLGMIWTII LRFAIQDISV EETSAKEGLL LWCQRKTAPY 
KNVNVQNFHI SWKDGLAFNA LIHRHRPELI EYDKLRKDDP VTNLNNAFEV AEKYLDIPKM 
LDAEDIVGTL RPDEKAIMTY VSCFYHAFSG AQKAETAANR ICKVLAVNQE NEHLMEDYEK 
LASDLLEWIR RTIPWLEDRV PQKTIQEMQQ KLEDFRDYRR VHKPPKVQEK CQLEINFNTL 
QTKLRLSNRP AFMPSEGKMV SDINNGWQHL EQAEKGYEEW LLNEIRRLER LDHLAEKFRQ 
KASIHEAWTD GKEAMLKHRD YETATLSDIK ALIRKHEAFE SDLAAHQDRV EQIAAIAQEL 
NELDYYDSHN VNTRCQKICD QWDALGSLTH SRREALEKTE KQLEAIDQLH LEYAKRAAPF 
NNWMESAMED LQDMFIVHTI EEIEGLISAH DQFKSTLPDA DREREAILAI HKEAQRIAES 
NHIKLSGSNP YTTVTPQIIN SKWEKVQQLV PKRDHALLEE QSKQQSNEHL RRQFASQANV 
VGPWIQTKME EIGRISIEMN GTLEDQLSHL KQYERSIVDY KPNLDLLEQQ HQLIQEALIF 
DNKHTNYTME HIRVGWEQLL TTIARTINEV ENQILTRDAK GISQEQMQEF RASFNHFDKK 
QTGSMDSDDF RALLISTGYS LGEAEFNRIM SLVDPNHSGL VTFQAFIDFM SRETTDTDTA 
DQVIASFKVL AGDKNFITAE ELRRELPPDQ AEYCIARMAP YQGPDAVPGA LDYKSFSTAL 
YGESDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.