ACTN4 | ENSG00000130402 | NCBI 81

Details for: ACTN4

Associated with

Cell-cell communication
(R-HSA-1500931)
Hemostasis
(R-HSA-109582)
Nephrin family interactions
(R-HSA-373753)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin cytoskeleton organization
(GO:0030036)
Actin filament binding
(GO:0051015)
Calcium ion binding
(GO:0005509)
Cell junction
(GO:0030054)
Cell projection
(GO:0042995)
Chromatin dna binding
(GO:0031490)
Cortical actin cytoskeleton
(GO:0030864)
Cytoplasm
(GO:0005737)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Focal adhesion
(GO:0005925)
Integrin binding
(GO:0005178)
Muscle cell development
(GO:0055001)
Negative regulation of substrate adhesion-dependent cell spreading
(GO:1900025)
Nuclear receptor binding
(GO:0016922)
Nuclear receptor coactivator activity
(GO:0030374)
Nuclear retinoic acid receptor binding
(GO:0042974)
Nucleoside binding
(GO:0001882)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Peroxisome proliferator activated receptor signaling pathway
(GO:0035357)
Plasma membrane
(GO:0005886)
Platelet alpha granule lumen
(GO:0031093)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of sodium:proton antiporter activity
(GO:0032417)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Postsynaptic actin cytoskeleton
(GO:0098871)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein transport
(GO:0015031)
Pseudopodium
(GO:0031143)
Regulation of apoptotic process
(GO:0042981)
Retinoic acid receptor signaling pathway
(GO:0048384)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Stress fiber
(GO:0001725)
Transcription coactivator activity
(GO:0003713)
Transmembrane transporter binding
(GO:0044325)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Vesicle transport along actin filament
(GO:0030050)
Z disc
(GO:0030018)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

colon epithelial cell CL0011108

CSI 67.03

rCSI 70.21%

PRS 8.41
BEST4+ enteroycte CL4030026

CSI 64.66

rCSI 80.42%

PRS 9.62
conjunctival epithelial cell CL1000432

CSI 58.61

rCSI 89.52%

PRS 9.07
fallopian tube secretory epithelial cell CL4030006

CSI 56.12

rCSI 54.02%

PRS 9.36
stem cell CL0000034

CSI 50.97

rCSI 49.14%

PRS 5.92
intestine goblet cell CL0019031

CSI 50.31

rCSI 44.66%

PRS 9.05
enterocyte CL0000584

CSI 44.33

rCSI 71.49%

PRS 14.48
multi-ciliated epithelial cell CL0005012

CSI 44

rCSI 43.91%

PRS 7.76
M cell of gut CL0000682

CSI 42.71

rCSI 45.38%

PRS 16.15
goblet cell CL0000160

CSI 42.23

rCSI 39.9%

PRS 9.44
transit amplifying cell of colon CL0009011

CSI 41.59

rCSI 48.85%

PRS 10.77
ciliated epithelial cell CL0000067

CSI 41.23

rCSI 36.26%

PRS 6.56
small intestine goblet cell CL1000495

CSI 37.71

rCSI 82.59%

PRS 12.19
extravillous trophoblast CL0008036

CSI 37.48

rCSI 46.36%

PRS 7.93
pancreatic ductal cell CL0002079

CSI 36.92

rCSI 71.8%

PRS 9.22
nasal mucosa goblet cell CL0002480

CSI 35.52

rCSI 41.2%

PRS 13.46
lung ciliated cell CL1000271

CSI 35.05

rCSI 40.53%

PRS 6.62
colonocyte CL1000347

CSI 34.95

rCSI 50.1%

PRS 12.41
transit amplifying cell CL0009010

CSI 33.73

rCSI 51.59%

PRS 14.71
respiratory suprabasal cell CL4033048

CSI 32.83

rCSI 42.1%

PRS 10.43
cerebral cortex endothelial cell CL1001602

CSI 31.45

rCSI 54.4%

PRS 6.91
keratinocyte CL0000312

CSI 29.44

rCSI 24.68%

PRS 10.82
colon goblet cell CL0009039

CSI 29.11

rCSI 69.2%

PRS 13.59
intestinal epithelial cell CL0002563

CSI 28.79

rCSI 30.09%

PRS 9.55
foveolar cell of stomach CL0002179

CSI 28.56

rCSI 60.79%

PRS 14.61
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 27.9

rCSI 72.11%

PRS 8.44
myoepithelial cell CL0000185

CSI 26.32

rCSI 66.58%

PRS 11.29
endothelial cell of artery CL1000413

CSI 26.08

rCSI 38.21%

PRS 46.47
intrahepatic cholangiocyte CL0002538

CSI 25.95

rCSI 62.27%

PRS 16.76
enteroendocrine cell of small intestine CL0009006

CSI 24.81

rCSI 54.62%

PRS 13.87
perivascular cell CL4033054

CSI 24.6

rCSI 33.63%

PRS 10.28
intestinal crypt stem cell of small intestine CL0009017

CSI 24.31

rCSI 65.54%

PRS 11.68
epithelial cell CL0000066

CSI 24.31

rCSI 37.35%

PRS 12.98
retinal blood vessel endothelial cell CL0002585

CSI 23.97

rCSI 38.28%

PRS 9.86
smooth muscle cell CL0000192

CSI 23.76

rCSI 56.65%

PRS 29.13
corneal epithelial cell CL0000575

CSI 23.67

rCSI 67.71%

PRS 16.69
podocyte CL0000653

CSI 23.45

rCSI 100%

PRS 9.03
placental villous trophoblast CL2000060

CSI 23.37

rCSI 36.12%

PRS 8.47
pancreatic acinar cell CL0002064

CSI 23.06

rCSI 30.65%

PRS 9.86
basal-myoepithelial cell of mammary gland CL0002324

CSI 22.56

rCSI 42.64%

PRS 19.88
microcirculation associated smooth muscle cell CL0008035

CSI 22.35

rCSI 64.71%

PRS 10.25
enteric smooth muscle cell CL0002504

CSI 22.02

rCSI 31.42%

PRS 10.23
blood vessel endothelial cell CL0000071

CSI 21.47

rCSI 44.54%

PRS 9.03
glandular epithelial cell CL0000150

CSI 21.13

rCSI 55.63%

PRS 17.74
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 20.54

rCSI 29.11%

PRS 8.5
tracheal goblet cell CL1000329

CSI 20.2

rCSI 44.1%

PRS 18.4
type EC enteroendocrine cell CL0000577

CSI 20

rCSI 71%

PRS 14.84
type L enteroendocrine cell CL0002279

CSI 19.72

rCSI 37.01%

PRS 17.91
epithelial cell of lower respiratory tract CL0002632

CSI 19.64

rCSI 15.23%

PRS 8.63
epithelial cell of proximal tubule CL0002306

CSI 19.24

rCSI 47%

PRS 9.15
paneth cell of epithelium of small intestine CL1000343

CSI 18.85

rCSI 52.83%

PRS 14.07
deuterosomal cell CL4033044

CSI 18.78

rCSI 63.48%

PRS 15.5
cardiac muscle cell CL0000746

CSI 18.7

rCSI 26.83%

PRS 7.19
duct epithelial cell CL0000068

CSI 18.41

rCSI 26.93%

PRS 9.57
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 18.08

rCSI 43.94%

PRS 5.18
renal interstitial pericyte CL1001318

CSI 17.95

rCSI 49.48%

PRS 8.94
club cell CL0000158

CSI 17.06

rCSI 24.98%

PRS 10.59
endothelial cell of placenta CL0009092

CSI 16.83

rCSI 82.94%

PRS 12.29
secretory cell CL0000151

CSI 16.8

rCSI 17.53%

PRS 9.29
transit amplifying cell of small intestine CL0009012

CSI 16.64

rCSI 73.07%

PRS 16.93
plasmacytoid dendritic cell, human CL0001058

CSI 15.96

rCSI 11.14%

PRS 9.54
capillary endothelial cell CL0002144

CSI 15.09

rCSI 27.66%

PRS 44.13
respiratory basal cell CL0002633

CSI 14.98

rCSI 15.52%

PRS 10.64
enterocyte of epithelium of large intestine CL0002071

CSI 14.76

rCSI 77.51%

PRS 16.77
myofibroblast cell CL0000186

CSI 14.68

rCSI 20.33%

PRS 13.02
ciliated cell CL0000064

CSI 14.43

rCSI 23.37%

PRS 9.24
parietal epithelial cell CL1000452

CSI 14.37

rCSI 38.4%

PRS 8.27
basal cell of prostate epithelium CL0002341

CSI 14.28

rCSI 41.31%

PRS 20.29
squamous epithelial cell CL0000076

CSI 14.15

rCSI 33.58%

PRS 11.79
epithelial cell of lung CL0000082

CSI 13.87

rCSI 11.5%

PRS 8.58
mucous neck cell CL0000651

CSI 13.85

rCSI 19.96%

PRS 14.6
pulmonary capillary endothelial cell CL4028001

CSI 12.93

rCSI 24.66%

PRS 14.54
renal principal cell CL0005009

CSI 12.83

rCSI 33.34%

PRS 12.57
kidney connecting tubule epithelial cell CL1000768

CSI 12.83

rCSI 32.55%

PRS 7.01
respiratory hillock cell CL4030023

CSI 12.57

rCSI 22.41%

PRS 15.45
lung endothelial cell CL1001567

CSI 12.49

rCSI 29.12%

PRS 22.17
basal cell CL0000646

CSI 12.07

rCSI 16.15%

PRS 9.87
pulmonary artery endothelial cell CL1001568

CSI 11.86

rCSI 16.14%

PRS 13.88
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 11.61

rCSI 8.71%

PRS 26.55
mammary gland epithelial cell CL0002327

CSI 11.41

rCSI 40.03%

PRS 16.41
class switched memory B cell CL0000972

CSI 11.3

rCSI 8.43%

PRS 15.28
vascular leptomeningeal cell CL4023051

CSI 11.17

rCSI 19.58%

PRS 6.66
endothelial cell of arteriole CL1000412

CSI 11.15

rCSI 61.88%

PRS 31.18
tuft cell of colon CL0009041

CSI 10.55

rCSI 24.58%

PRS 20.29
activated type II NK T cell CL0000931

CSI 10.44

rCSI 11.74%

PRS 14.64
enteroendocrine cell of colon CL0009042

CSI 10.25

rCSI 48.04%

PRS 24.61
endothelial cell of uterus CL0009095

CSI 10.21

rCSI 74.68%

PRS 25.25
vascular associated smooth muscle cell CL0000359

CSI 10.14

rCSI 32.89%

PRS 11.09
brush cell of tracheobronchial tree CL0002075

CSI 10.05

rCSI 29.84%

PRS 14.2
stromal cell of ovary CL0002132

CSI 10

rCSI 27.47%

PRS 15.08
T-helper 17 cell CL0000899

CSI 9.64

rCSI 7.65%

PRS 15.94
common dendritic progenitor CL0001029

CSI 9.56

rCSI 12%

PRS 11.54
pancreatic D cell CL0000173

CSI 9.34

rCSI 9.18%

PRS 9.82
promonocyte CL0000559

CSI 9.14

rCSI 15.65%

PRS 12.14
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 9.13

rCSI 6.09%

PRS 24.64
syncytiotrophoblast cell CL0000525

CSI 9.09

rCSI 26.18%

PRS 17.97
Mueller cell CL0000636

CSI 8.93

rCSI 20.37%

PRS 8.16
intestinal crypt stem cell of colon CL0009043

CSI 8.57

rCSI 64.39%

PRS 16.79
smooth muscle cell of the pulmonary artery CL0002591

CSI 8.53

rCSI 65.39%

PRS 38.82
plasmablast CL0000980

CSI 8.45

rCSI 6.65%

PRS 10.78

lung neuroendocrine cell CL1000223

CSI -10.7

rCSI -15.9%

PRS 10.4%
germinal center B cell CL0000844

CSI -8.1

rCSI -24.1%

PRS 23.4%
sncg GABAergic cortical interneuron CL4023015

CSI -7.2

rCSI -11.5%

PRS 5.9%
lamp5 GABAergic cortical interneuron CL4023011

CSI -6.0

rCSI -10.1%

PRS 5.3%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI -5.8

rCSI -18.1%

PRS 6.2%
cardiac neuron CL0010022

CSI -4.2

rCSI -13.5%

PRS 6.5%
neuroblast (sensu Vertebrata) CL0000031

CSI -3.9

rCSI -5.0%

PRS 8.8%
near-projecting glutamatergic cortical neuron CL4023012

CSI -3.7

rCSI -13.9%

PRS 5.5%
inflammatory macrophage CL0000863

CSI -2.5

rCSI -4.3%

PRS 18.4%
CD14-positive, CD16-positive monocyte CL0002397

CSI -2.5

rCSI -3.3%

PRS 12.6%
platelet CL0000233

CSI -1.1

rCSI -4.6%

PRS 21.8%
retinal cone cell CL0000573

CSI -1.1

rCSI -1.8%

PRS 6.9%
fibroblast of cardiac tissue CL0002548

CSI -1.0

rCSI -4.7%

PRS 5.7%
mesenchymal cell CL0008019

CSI -1.0

rCSI -2.5%

PRS 9.2%
central nervous system neuron CL2000029

CSI -0.5

rCSI -3.7%

PRS 4.3%
L6b glutamatergic cortical neuron CL4023038

CSI -0.3

rCSI -0.9%

PRS 5.7%
T-helper 1 cell CL0000545

CSI -0.1

rCSI -0.2%

PRS 25.6%
lymphoid lineage restricted progenitor cell CL0000838

CSI 0.1

rCSI 0.2%

PRS 15.0%
medium spiny neuron CL1001474

CSI 0.1

rCSI 0.7%

PRS 2.1%
cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.6%

PRS 13.6%
amacrine cell CL0000561

CSI 0.1

rCSI 0.3%

PRS 7.3%
pre-conventional dendritic cell CL0002010

CSI 0.2

rCSI 2.0%

PRS 30.6%
Hofbauer cell CL3000001

CSI 0.2

rCSI 0.3%

PRS 11.2%
retinal bipolar neuron CL0000748

CSI 0.2

rCSI 0.4%

PRS 6.7%
enteric neuron CL0007011

CSI 0.2

rCSI 3.6%

PRS 24.1%
metallothionein-positive alveolar macrophage CL4033042

CSI 0.3

rCSI 2.7%

PRS 38.3%
regular ventricular cardiac myocyte CL0002131

CSI 0.3

rCSI 1.7%

PRS 7.2%
Merkel cell CL0000242

CSI 0.4

rCSI 8.4%

PRS 57.8%
OFF midget ganglion cell CL4033047

CSI 0.4

rCSI 7.5%

PRS 8.1%
P/D1 enteroendocrine cell CL0002268

CSI 0.4

rCSI 2.1%

PRS 22.9%
erythroblast CL0000765

CSI 0.4

rCSI 1.0%

PRS 15.2%
choroid plexus epithelial cell CL0000706

CSI 0.4

rCSI 0.6%

PRS 7.0%
neuroendocrine cell CL0000165

CSI 0.4

rCSI 1.5%

PRS 19.1%
paneth cell CL0000510

CSI 0.4

rCSI 0.6%

PRS 14.3%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.4

rCSI 2.6%

PRS 20.6%
retina horizontal cell CL0000745

CSI 0.5

rCSI 0.7%

PRS 8.5%
kidney granular cell CL0000648

CSI 0.5

rCSI 6.5%

PRS 52.8%
mesenchymal stem cell CL0000134

CSI 0.5

rCSI 5.7%

PRS 16.5%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.5

rCSI 2.6%

PRS 11.9%
cardiac blood vessel endothelial cell CL0010006

CSI 0.5

rCSI 3.8%

PRS 11.3%
erythroid progenitor cell CL0000038

CSI 0.6

rCSI 3.2%

PRS 14.2%
lung macrophage CL1001603

CSI 0.6

rCSI 1.4%

PRS 10.2%
smooth muscle cell of prostate CL1000487

CSI 0.7

rCSI 3.8%

PRS 41.7%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.7

rCSI 1.2%

PRS 5.3%
mesangial cell CL0000650

CSI 0.7

rCSI 2.9%

PRS 12.7%
ON midget ganglion cell CL4033046

CSI 0.7

rCSI 14.4%

PRS 7.3%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 0.7

rCSI 0.6%

PRS 8.0%
cerebellar granule cell CL0001031

CSI 0.8

rCSI 1.1%

PRS 8.6%
large pre-B-II cell CL0000957

CSI 0.8

rCSI 2.3%

PRS 16.0%
peripheral nervous system neuron CL2000032

CSI 0.8

rCSI 1.2%

PRS 8.1%
endocardial cell CL0002350

CSI 0.9

rCSI 4.1%

PRS 12.6%
group 2 innate lymphoid cell CL0001069

CSI 0.9

rCSI 4.8%

PRS 31.1%
uterine smooth muscle cell CL0002601

CSI 0.9

rCSI 5.9%

PRS 55.6%
fraction A pre-pro B cell CL0002045

CSI 0.9

rCSI 1.0%

PRS 18.7%
myelocyte CL0002193

CSI 0.9

rCSI 6.0%

PRS 30.1%
basophil CL0000767

CSI 0.9

rCSI 1.9%

PRS 19.1%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.9

rCSI 4.8%

PRS 18.1%
colon macrophage CL0009038

CSI 0.9

rCSI 4.4%

PRS 19.3%
myeloid dendritic cell, human CL0001057

CSI 1.0

rCSI 5.5%

PRS 28.8%
astrocyte of the cerebral cortex CL0002605

CSI 1.0

rCSI 2.3%

PRS 5.6%
serous secreting cell of bronchus submucosal gland CL4033005

CSI 1.0

rCSI 5.9%

PRS 38.4%
dopaminergic neuron CL0000700

CSI 1.1

rCSI 5.9%

PRS 3.3%
skeletal muscle satellite cell CL0000594

CSI 1.1

rCSI 3.1%

PRS 32.3%
hair follicular keratinocyte CL2000092

CSI 1.1

rCSI 18.7%

PRS 36.9%
ventricular cardiac muscle cell CL2000046

CSI 1.1

rCSI 3.7%

PRS 37.4%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 1.1

rCSI 2.7%

PRS 4.8%
pancreatic stellate cell CL0002410

CSI 1.1

rCSI 6.6%

PRS 13.6%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 1.1

rCSI 1.6%

PRS 19.1%
primitive red blood cell CL0002355

CSI 1.2

rCSI 6.3%

PRS 17.2%
peptic cell CL0000155

CSI 1.2

rCSI 11.8%

PRS 27.7%
early lymphoid progenitor CL0000936

CSI 1.2

rCSI 1.1%

PRS 10.2%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 1.2

rCSI 14.1%

PRS 36.1%
airway submucosal gland duct basal cell CL4033024

CSI 1.3

rCSI 8.0%

PRS 32.0%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 1.3

rCSI 5.7%

PRS 28.0%
epicardial adipocyte CL1000309

CSI 1.4

rCSI 4.4%

PRS 12.2%
retinal ganglion cell CL0000740

CSI 1.4

rCSI 3.0%

PRS 6.5%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 1.4

rCSI 14.7%

PRS 13.5%
Langerhans cell CL0000453

CSI 1.5

rCSI 2.4%

PRS 15.8%
common lymphoid progenitor CL0000051

CSI 1.5

rCSI 2.1%

PRS 17.3%
radial glial cell CL0000681

CSI 1.6

rCSI 2.2%

PRS 9.4%
fibroblast of breast CL4006000

CSI 1.6

rCSI 6.7%

PRS 24.2%
innate lymphoid cell CL0001065

CSI 1.6

rCSI 3.3%

PRS 14.2%
bronchiolar smooth muscle cell CL4033017

CSI 1.6

rCSI 24.2%

PRS 29.5%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 1.6

rCSI 5.3%

PRS 4.3%
midzonal region hepatocyte CL0019028

CSI 1.6

rCSI 3.8%

PRS 14.6%
sst GABAergic cortical interneuron CL4023017

CSI 1.6

rCSI 2.1%

PRS 5.7%
epithelial cell of esophagus CL0002252

CSI 1.7

rCSI 16.4%

PRS 34.2%
elicited macrophage CL0000861

CSI 1.7

rCSI 1.5%

PRS 10.3%
centrilobular region hepatocyte CL0019029

CSI 1.7

rCSI 4.4%

PRS 15.1%
brush cell CL0002204

CSI 1.7

rCSI 3.4%

PRS 24.9%
adventitial cell CL0002503

CSI 1.7

rCSI 4.1%

PRS 14.4%
retinal pigment epithelial cell CL0002586

CSI 1.7

rCSI 3.5%

PRS 9.7%
mucus secreting cell CL0000319

CSI 1.8

rCSI 2.8%

PRS 11.7%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.8

rCSI 2.1%

PRS 15.8%
mesodermal cell CL0000222

CSI 1.8

rCSI 2.2%

PRS 9.0%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 1.8

rCSI 2.2%

PRS 12.7%
alternatively activated macrophage CL0000890

CSI 1.8

rCSI 2.3%

PRS 13.9%
glioblast CL0000030

CSI 1.9

rCSI 3.0%

PRS 7.8%
respiratory epithelial cell CL0002368

CSI 1.9

rCSI 11.9%

PRS 29.8%
eosinophil CL0000771

CSI 1.9

rCSI 12.7%

PRS 23.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [ACTN4](/details-gene/81) (actinin alpha 4) is a protein-coding gene located on chromosome 19q13.2. It encodes a non-muscle, actin-binding protein that plays a crucial role in cytoskeleton organization, cell motility, and adhesion. Functionally, [ACTN4](/details-gene/81) is involved in crosslinking actin filaments and anchoring them to the cell membrane and focal adhesions. Expression data reveals its high significance primarily in various epithelial cell types, such as [colon epithelial cell](/details-cell/CL0011108) and [BEST4+ enteroycte](/details-cell/CL4030026), suggesting a fundamental role in maintaining the structural integrity and dynamic properties of epithelial tissues. Beyond its structural functions, it also acts as a transcriptional coactivator in the nucleus, linking mechanical signals from the cytoskeleton to gene regulation. ## Cellular Roles and Expression Landscape The expression profile of [ACTN4](/details-gene/81) underscores its importance as a key structural protein in epithelial tissues. **Overall**, the gene shows the highest significance in a range of epithelial cells lining various organs. It is a top marker in [colon epithelial cell](/details-cell/CL0011108) (CSI: 67.03), [BEST4+ enteroycte](/details-cell/CL4030026) (CSI: 64.66), [conjunctival epithelial cell](/details-cell/CL1000432) (CSI: 58.61), and [fallopian tube secretory epithelial cell](/details-cell/CL4030006) (CSI: 56.12). Its high expression is also noted in secretory cells like [intestine goblet cell](/details-cell/CL0019031) and proliferative populations such as [transit amplifying cell of colon](/details-cell/CL0009011), indicating a role in both stable barrier function and tissue renewal. Conversely, the gene's expression is notably low or absent in cells of the nervous system and hematopoietic lineage. It is a significant anti-marker for neuronal populations, including [sncg GABAergic cortical interneuron](/details-cell/CL4023015) (CSI: -7.17) and [cardiac neuron](/details-cell/CL0010022) (CSI: -4.21), as well as specific immune cells like [germinal center B cell](/details-cell/CL0000844) (CSI: -8.09) and [inflammatory macrophage](/details-cell/CL0000863) (CSI: -2.52). This restricted expression pattern suggests a highly specialized function for [ACTN4](/details-gene/81) in cytoskeletal dynamics specific to non-neuronal and non-hematopoietic tissues, particularly in maintaining the architecture of epithelial layers. ## Pathways and Molecular Function The functions of [ACTN4](/details-gene/81) are well-aligned with its cellular expression pattern. As an actin-binding protein, it is a central component of the [Actin cytoskeleton](/details-ontology/GO:0015629), localizing to structures such as [Focal adhesion](/details-ontology/GO:0005925) and [Stress fiber](/details-ontology/GO:0001725). Its molecular functions include [Actin binding](/details-ontology/GO:0003779) and [Integrin binding](/details-ontology/GO:0005178), which are critical for linking the cytoskeleton to the extracellular matrix and mediating cell adhesion and migration. This is consistent with its role in biological processes like [Actin cytoskeleton organization](/details-ontology/GO:0030036) and [Positive regulation of cell migration](/details-ontology/GO:0030335), as highlighted by research linking it to cell motility and cancer invasion ([Link](https://doi.org/10.1083/jcb.140.6.1383)). Beyond its canonical structural role, [ACTN4](/details-gene/81) also functions in the [Nucleus](/details-ontology/GO:0005634) as a [Transcription coactivator](/details-ontology/GO:0003713), where it can engage in [Chromatin dna binding](/details-ontology/GO:0031490) and interact with nuclear receptors ([Nuclear receptor binding](/details-ontology/GO:0016922)). This dual localization suggests it may function as a mechanosensor, shuttling between the cytoplasm and nucleus to translate physical cues into changes in gene expression. The gene is also implicated in signaling pathways such as the [Tumor necrosis factor-mediated signaling pathway](/details-ontology/GO:0033209). In a broader context, its involvement in the Reactome pathway [Cell-cell communication](/details-pathway/R-HSA-1500931) reinforces its importance in maintaining tissue coherence, a role paramount in the epithelial cell types where it is most prominently expressed. ## Research Directions The dual function of [ACTN4](/details-gene/81) as both a structural protein and a nuclear regulator presents compelling avenues for future research, particularly in the context of disease pathogenesis. Its high expression in epithelial cells, coupled with its known role in cell migration, makes it a gene of significant interest in cancer biology. **Proposed Hypotheses:** 1. Mechanical stress or loss of cell-cell contacts in epithelial tissues, such as during the initial stages of tumorigenesis, induces the nuclear translocation of [ACTN4](/details-gene/81). Once in the nucleus, it acts as a transcriptional co-activator for genes that drive the epithelial-mesenchymal transition (EMT), thereby promoting cell invasion and metastasis. 2. Mutations or post-translational modifications of [ACTN4](/details-gene/81) associated with cancer disrupt its homodimerization ([Protein homodimerization activity](/details-ontology/GO:0042803)), leading to aberrant actin bundling. This results in altered cell stiffness and increased migratory capacity, facilitating the escape of cancer cells from the primary tumor. **Experimental Approach:** To test the first hypothesis, one could utilize a 3D organoid model of [colon epithelial cell](/details-cell/CL0011108)s. Applying mechanical stress (e.g., stretching the substrate) or treating the organoids with EMT-inducing factors (e.g., TGF-β) would serve as the stimulus. The subcellular localization of [ACTN4](/details-gene/81) could be tracked using immunofluorescence microscopy and quantified via cell fractionation followed by western blotting. To establish a causal link to gene expression, chromatin immunoprecipitation sequencing (ChIP-seq) could be performed to identify the genomic binding sites of nuclear [ACTN4](/details-gene/81), followed by RNA-sequencing to correlate its binding with changes in the expression of target genes involved in EMT. **Therapeutic Potential:** Given its documented association with cancer invasion ([Link](https://doi.org/10.1083/jcb.140.6.1383)) and its role in promoting cell motility, [ACTN4](/details-gene/81) represents a potential therapeutic target for metastatic cancers. As an intracellular protein, the most viable strategy would likely involve the development of small molecule inhibitors. Such compounds could be designed to interfere with its actin-binding domain, preventing cytoskeletal reorganization, or to block its nuclear import, thereby disrupting its function as a transcriptional co-activator. Therefore, **inhibition** of [ACTN4](/details-gene/81) function, rather than activation, would be the desired therapeutic outcome to reduce cancer cell migration and invasion.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

ACTN4_HUMAN
H7C144_HUMAN

Genular Protein ID: 135020461

Symbol: ACTN4_HUMAN

Name: N/A

UniProtKB Accession Codes:

O43707 A4K467 D6PXK4 O76048

Database IDs:

Citations:

PubMed ID: 10656685

Title: The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.

PubMed ID: 10656685

DOI: 10.1038/sj.onc.1203310

PubMed ID: 22567897

Title: Novel splicing isoform of actin-binding protein alpha-actinin 4 in epidermoid carcinoma cells A431.

PubMed ID: 22567897

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16344560

Title: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

PubMed ID: 16344560

DOI: 10.1101/gr.4039406

PubMed ID: 9508771

Title: Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion.

PubMed ID: 9508771

DOI: 10.1083/jcb.140.6.1383

PubMed ID: 12042308

Title: Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.

PubMed ID: 12042308

DOI: 10.1074/jbc.m203072200

PubMed ID: 15772161

Title: CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling.

PubMed ID: 15772161

DOI: 10.1091/mbc.e04-11-1014

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22689882

Title: EWI-2 association with alpha-actinin regulates T cell immune synapses and HIV viral infection.

PubMed ID: 22689882

DOI: 10.4049/jimmunol.1103708

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 33228246

Title: ACTN4 Mediates SEPT14 Mutation-Induced Sperm Head Defects.

PubMed ID: 33228246

DOI: 10.3390/biomedicines8110518

PubMed ID: 15988023

Title: Structural dynamics of alpha-actinin-vinculin interactions.

PubMed ID: 15988023

DOI: 10.1128/mcb.25.14.6112-6122.2005

PubMed ID: 18164029

Title: Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis.

PubMed ID: 18164029

DOI: 10.1016/j.jmb.2007.11.084

PubMed ID: 22351778

Title: Familial focal segmental glomerulosclerosis (FSGS)-linked alpha-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors.

PubMed ID: 22351778

DOI: 10.1074/jbc.m112.345421

PubMed ID: 10700177

Title: Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis.

PubMed ID: 10700177

DOI: 10.1038/73456

PubMed ID: 18436095

Title: Familial focal segmental glomerulosclerosis associated with an ACTN4 mutation and paternal germline mosaicism.

PubMed ID: 18436095

DOI: 10.1053/j.ajkd.2008.01.018

PubMed ID: 22732337

Title: Mutations in podocyte genes are a rare cause of primary FSGS associated with ESRD in adult patients.

PubMed ID: 22732337

DOI: 10.5414/cn107320

PubMed ID: 23890478

Title: Mutational analysis of ACTN4, encoding alpha-actinin 4, in patients with focal segmental glomerulosclerosis using HRM method.

PubMed ID: 23890478

PubMed ID: 23014460

Title: Mutations in the INF2 gene account for a significant proportion of familial but not sporadic focal and segmental glomerulosclerosis.

PubMed ID: 23014460

DOI: 10.1038/ki.2012.349

Sequence Information:

Length: 911
Mass: 104854
Checksum: 461580C3F22937D1
Sequence:

MVDYHAANQS YQYGPSSAGN GAGGGGSMGD YMAQEDDWDR DLLLDPAWEK QQRKTFTAWC 
NSHLRKAGTQ IENIDEDFRD GLKLMLLLEV ISGERLPKPE RGKMRVHKIN NVNKALDFIA 
SKGVKLVSIG AEEIVDGNAK MTLGMIWTII LRFAIQDISV EETSAKEGLL LWCQRKTAPY 
KNVNVQNFHI SWKDGLAFNA LIHRHRPELI EYDKLRKDDP VTNLNNAFEV AEKYLDIPKM 
LDAEDIVNTA RPDEKAIMTY VSSFYHAFSG AQKAETAANR ICKVLAVNQE NEHLMEDYEK 
LASDLLEWIR RTIPWLEDRV PQKTIQEMQQ KLEDFRDYRR VHKPPKVQEK CQLEINFNTL 
QTKLRLSNRP AFMPSEGKMV SDINNGWQHL EQAEKGYEEW LLNEIRRLER LDHLAEKFRQ 
KASIHEAWTD GKEAMLKHRD YETATLSDIK ALIRKHEAFE SDLAAHQDRV EQIAAIAQEL 
NELDYYDSHN VNTRCQKICD QWDALGSLTH SRREALEKTE KQLEAIDQLH LEYAKRAAPF 
NNWMESAMED LQDMFIVHTI EEIEGLISAH DQFKSTLPDA DREREAILAI HKEAQRIAES 
NHIKLSGSNP YTTVTPQIIN SKWEKVQQLV PKRDHALLEE QSKQQSNEHL RRQFASQANV 
VGPWIQTKME EIGRISIEMN GTLEDQLSHL KQYERSIVDY KPNLDLLEQQ HQLIQEALIF 
DNKHTNYTME HIRVGWEQLL TTIARTINEV ENQILTRDAK GISQEQMQEF RASFNHFDKD 
HGGALGPEEF KACLISLGYD VENDRQGEAE FNRIMSLVDP NHSGLVTFQA FIDFMSRETT 
DTDTADQVIA SFKVLAGDKN FITAEELRRE LPPDQAEYCI ARMAPYQGPD AVPGALDYKS 
FSTALYGESD L

Genular Protein ID: 2303997419

Symbol: H7C144_HUMAN

Name: N/A

UniProtKB Accession Codes:

H7C144

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

Length: 906
Mass: 104327
Checksum: 85B7706D09DAFED7
Sequence:

MVDYHAANQS YQYGPSSAGN GAGGGGSMGD YMAQEDDWDR DLLLDPAWEK QQRKTFTAWC 
NSHLRKAGTQ IENIDEDFRD GLKLMLLLEV ISGERLPKPE RGKMRVHKIN NVNKALDFIA 
SKGVKLVSIG AEEIVDGNAK MTLGMIWTII LRFAIQDISV EETSAKEGLL LWCQRKTAPY 
KNVNVQNFHI SWKDGLAFNA LIHRHRPELI EYDKLRKDDP VTNLNNAFEV AEKYLDIPKM 
LDAEDIVGTL RPDEKAIMTY VSCFYHAFSG AQKAETAANR ICKVLAVNQE NEHLMEDYEK 
LASDLLEWIR RTIPWLEDRV PQKTIQEMQQ KLEDFRDYRR VHKPPKVQEK CQLEINFNTL 
QTKLRLSNRP AFMPSEGKMV SDINNGWQHL EQAEKGYEEW LLNEIRRLER LDHLAEKFRQ 
KASIHEAWTD GKEAMLKHRD YETATLSDIK ALIRKHEAFE SDLAAHQDRV EQIAAIAQEL 
NELDYYDSHN VNTRCQKICD QWDALGSLTH SRREALEKTE KQLEAIDQLH LEYAKRAAPF 
NNWMESAMED LQDMFIVHTI EEIEGLISAH DQFKSTLPDA DREREAILAI HKEAQRIAES 
NHIKLSGSNP YTTVTPQIIN SKWEKVQQLV PKRDHALLEE QSKQQSNEHL RRQFASQANV 
VGPWIQTKME EIGRISIEMN GTLEDQLSHL KQYERSIVDY KPNLDLLEQQ HQLIQEALIF 
DNKHTNYTME HIRVGWEQLL TTIARTINEV ENQILTRDAK GISQEQMQEF RASFNHFDKK 
QTGSMDSDDF RALLISTGYS LGEAEFNRIM SLVDPNHSGL VTFQAFIDFM SRETTDTDTA 
DQVIASFKVL AGDKNFITAE ELRRELPPDQ AEYCIARMAP YQGPDAVPGA LDYKSFSTAL 
YGESDL

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Ascending colon UBERON0001156
	Atherosclerosis MONDO0005311
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Breast cancer UBERON0000310_MONDO0007254
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fovea centralis UBERON0001786
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	\|— Lung parenchyma UBERON0008946
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Rectum UBERON0001052
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	\|— Stomach Healthy UBERON0000945_PATO0000461
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Trachea UBERON0003126
	Type 2 diabetes mellitus MONDO0005148
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: ACTN4

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells. PubMed ID: 10656685

Novel splicing isoform of actin-binding protein alpha-actinin 4 in epidermoid carcinoma cells A431. PubMed ID: 22567897

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. PubMed ID: 16344560

Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion. PubMed ID: 9508771

Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1. PubMed ID: 12042308

CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling. PubMed ID: 15772161

Molecular composition of IMP1 ribonucleoprotein granules. PubMed ID: 17289661

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

EWI-2 association with alpha-actinin regulates T cell immune synapses and HIV viral infection. PubMed ID: 22689882

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

ACTN4 Mediates SEPT14 Mutation-Induced Sperm Head Defects. PubMed ID: 33228246

Structural dynamics of alpha-actinin-vinculin interactions. PubMed ID: 15988023

Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis. PubMed ID: 18164029

Familial focal segmental glomerulosclerosis (FSGS)-linked alpha-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors. PubMed ID: 22351778

Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. PubMed ID: 10700177

Familial focal segmental glomerulosclerosis associated with an ACTN4 mutation and paternal germline mosaicism. PubMed ID: 18436095

Mutations in podocyte genes are a rare cause of primary FSGS associated with ESRD in adult patients. PubMed ID: 22732337

Mutational analysis of ACTN4, encoding alpha-actinin 4, in patients with focal segmental glomerulosclerosis using HRM method. PubMed ID: 23890478

Mutations in the INF2 gene account for a significant proportion of familial but not sporadic focal and segmental glomerulosclerosis. PubMed ID: 23014460

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

PubMed ID: 10656685

PubMed ID: 22567897

PubMed ID: 15057824

PubMed ID: 15489334

PubMed ID: 17974005

PubMed ID: 16344560

PubMed ID: 9508771

PubMed ID: 12042308

PubMed ID: 15772161

PubMed ID: 17289661

PubMed ID: 19608861

PubMed ID: 21269460

PubMed ID: 22689882

PubMed ID: 24275569

PubMed ID: 25944712

PubMed ID: 33228246

PubMed ID: 15988023

PubMed ID: 18164029

PubMed ID: 22351778

PubMed ID: 10700177

PubMed ID: 18436095

PubMed ID: 22732337

PubMed ID: 23890478

PubMed ID: 23014460

PubMed ID: 11237011

PubMed ID: 15057824

PubMed ID: 15496913

PubMed ID: 19608861

PubMed ID: 21269460

PubMed ID: 24275569

PubMed ID: 25944712