Details for: CALML3

Gene ID: 810

Symbol: CALML3

Ensembl ID: ENSG00000178363

Description: calmodulin like 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 25.6432
    Cell Significance Index: 29.5200
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 11.5683
    Cell Significance Index: 64.3900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 10.8810
    Cell Significance Index: 93.5000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 6.5287
    Cell Significance Index: 54.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.2245
    Cell Significance Index: 1425.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9710
    Cell Significance Index: -6.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.8502
    Cell Significance Index: 201.5800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.8002
    Cell Significance Index: 6.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.7987
    Cell Significance Index: 69.9600
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 2.5256
    Cell Significance Index: 3.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.3398
    Cell Significance Index: 74.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.0755
    Cell Significance Index: 127.2500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.0100
    Cell Significance Index: 39.3000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.6285
    Cell Significance Index: 10.8100
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 1.4137
    Cell Significance Index: 10.8700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.3651
    Cell Significance Index: 28.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3198
    Cell Significance Index: 36.8800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2992
    Cell Significance Index: 31.4700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.2179
    Cell Significance Index: 11.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7716
    Cell Significance Index: 34.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6921
    Cell Significance Index: 131.7200
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.5521
    Cell Significance Index: 4.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4956
    Cell Significance Index: 36.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3801
    Cell Significance Index: 37.6000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3316
    Cell Significance Index: 4.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3193
    Cell Significance Index: 288.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2439
    Cell Significance Index: 26.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2412
    Cell Significance Index: 14.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2112
    Cell Significance Index: 34.3500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2105
    Cell Significance Index: 2.6600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.1097
    Cell Significance Index: 1.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1093
    Cell Significance Index: 7.5600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0013
    Cell Significance Index: 0.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0059
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0112
    Cell Significance Index: -8.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0133
    Cell Significance Index: -10.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0151
    Cell Significance Index: -2.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0168
    Cell Significance Index: -7.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0176
    Cell Significance Index: -0.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0177
    Cell Significance Index: -2.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0226
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0304
    Cell Significance Index: -5.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0307
    Cell Significance Index: -0.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0361
    Cell Significance Index: -1.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0362
    Cell Significance Index: -1.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0377
    Cell Significance Index: -4.6300
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0384
    Cell Significance Index: -0.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0403
    Cell Significance Index: -5.5300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0436
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0443
    Cell Significance Index: -5.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0444
    Cell Significance Index: -8.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0444
    Cell Significance Index: -8.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0651
    Cell Significance Index: -2.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0752
    Cell Significance Index: -1.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0844
    Cell Significance Index: -1.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0868
    Cell Significance Index: -8.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0948
    Cell Significance Index: -2.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0964
    Cell Significance Index: -5.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0969
    Cell Significance Index: -2.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0991
    Cell Significance Index: -7.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1008
    Cell Significance Index: -6.3500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1142
    Cell Significance Index: -1.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1176
    Cell Significance Index: -3.2000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1196
    Cell Significance Index: -0.7100
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1251
    Cell Significance Index: -1.3400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1254
    Cell Significance Index: -1.8900
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1320
    Cell Significance Index: -1.0100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1425
    Cell Significance Index: -1.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1470
    Cell Significance Index: -6.9100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1536
    Cell Significance Index: -1.6200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1687
    Cell Significance Index: -2.1800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1728
    Cell Significance Index: -2.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1915
    Cell Significance Index: -3.5400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1975
    Cell Significance Index: -2.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2152
    Cell Significance Index: -11.3000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2174
    Cell Significance Index: -5.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2315
    Cell Significance Index: -8.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2418
    Cell Significance Index: -6.9300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.2440
    Cell Significance Index: -1.5100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2516
    Cell Significance Index: -3.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2579
    Cell Significance Index: -8.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2625
    Cell Significance Index: -11.6100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2725
    Cell Significance Index: -3.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2884
    Cell Significance Index: -9.1900
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.2972
    Cell Significance Index: -3.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3055
    Cell Significance Index: -11.5700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3178
    Cell Significance Index: -8.1200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3189
    Cell Significance Index: -4.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3327
    Cell Significance Index: -8.9200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3329
    Cell Significance Index: -5.6900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3335
    Cell Significance Index: -5.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3390
    Cell Significance Index: -8.9200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3543
    Cell Significance Index: -4.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3556
    Cell Significance Index: -8.2200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3641
    Cell Significance Index: -5.5300
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.3661
    Cell Significance Index: -6.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3712
    Cell Significance Index: -9.2600
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.3782
    Cell Significance Index: -1.9900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.3802
    Cell Significance Index: -4.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium-binding protein:** CALML3 contains a calcium-binding domain, which allows it to interact with calcium ions and modulate its activity. 2. **Protein binding:** CALML3 has the ability to bind to various proteins, including calmodulin, actin, and myosin, influencing their functions and interactions. 3. **Tissue specificity:** CALML3 is expressed in different tissues, including epithelial, endothelial, and thymic cells, suggesting its role in maintaining tissue homeostasis. 4. **Cellular localization:** CALML3 is primarily localized to the cytoplasm and nucleus, where it can influence cellular processes such as proliferation, differentiation, and survival. **Pathways and Functions:** 1. **Calcium signaling:** CALML3 plays a crucial role in calcium signaling pathways, influencing the activity of calmodulin and other calcium-binding proteins. 2. **Cell proliferation and differentiation:** CALML3 modulates cell proliferation and differentiation by interacting with proteins involved in these processes, such as myosin and actin. 3. **Apoptosis regulation:** CALML3 has been shown to regulate apoptosis (programmed cell death) by interacting with proteins involved in the apoptotic pathway. 4. **Endothelial function:** CALML3 is expressed in endothelial cells and plays a role in maintaining endothelial function, including nitric oxide production and vascular tone regulation. **Clinical Significance:** 1. **Cancer:** CALML3 has been implicated in various cancers, including colorectal, breast, and lung cancer, where it may contribute to tumorigenesis and metastasis. 2. **Cardiovascular disease:** CALML3 has been shown to play a role in cardiovascular disease, including hypertension, atherosclerosis, and cardiac arrhythmias. 3. **Neurological disorders:** CALML3 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Immunological disorders:** CALML3 has been shown to play a role in immunological disorders, including autoimmune diseases and immunodeficiency syndromes. In conclusion, CALML3 is a multifunctional protein that plays a crucial role in various cellular processes, including calcium signaling, cell proliferation, differentiation, and apoptosis regulation. Its involvement in various diseases, including cancer, cardiovascular disease, neurological disorders, and immunological disorders, highlights its potential as a therapeutic target for the treatment of these conditions. Further research is needed to fully elucidate the role of CALML3 in human disease and to explore its therapeutic potential.

Genular Protein ID: 1447006133

Symbol: CALL3_HUMAN

Name: Calmodulin-like protein 3

UniProtKB Accession Codes:

P27482 B2R9V6 Q5SQI4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2217169

Title: Down-regulation of a calmodulin-related gene during transformation of human mammary epithelial cells.

PubMed ID: 2217169

DOI: 10.1073/pnas.87.19.7360

PubMed ID: 3181418

Title: Characterization of an intronless human calmodulin-like pseudogene.

PubMed ID: 3181418

DOI: 10.1016/0014-5793(88)80558-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1334432

Title: Characterization of the human calmodulin-like protein expressed in Escherichia coli.

PubMed ID: 1334432

DOI: 10.1021/bi00166a017

PubMed ID: 11278607

Title: The tumor-sensitive calmodulin-like protein is a specific light chain of human unconventional myosin X.

PubMed ID: 11278607

DOI: 10.1074/jbc.m010056200

PubMed ID: 18295593

Title: Calmodulin-like protein enhances myosin-10 translation.

PubMed ID: 18295593

DOI: 10.1016/j.bbrc.2008.02.056

PubMed ID: 12067719

Title: Crystal structure of human calmodulin-like protein: insights into its functional role.

PubMed ID: 12067719

DOI: 10.1016/s0014-5793(02)02780-1

Sequence Information:

  • Length: 149
  • Mass: 16891
  • Checksum: 1AB883E8ED4D263D
  • Sequence:
    • MADQLTEEQV TEFKEAFSLF DKDGDGCITT RELGTVMRSL GQNPTEAELR DMMSEIDRDG 
NGTVDFPEFL GMMARKMKDT DNEEEIREAF RVFDKDGNGF VSAAELRHVM TRLGEKLSDE 
EVDEMIRAAD TDGDGQVNYE EFVRVLVSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.