Details for: CALML3

Gene ID: 810

Symbol: CALML3

Ensembl ID: ENSG00000178363

Description: calmodulin like 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 6.53
    Marker Score: 9380
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.24
    Marker Score: 25310
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.97
    Marker Score: 25556
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.45
    Marker Score: 9070
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.36
    Marker Score: 3863
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1995
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.86
    Marker Score: 1954
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.65
    Marker Score: 3125
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.61
    Marker Score: 389
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.29
    Marker Score: 409
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4816
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.1
    Marker Score: 8198
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.06
    Marker Score: 1173
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.06
    Marker Score: 14176
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.04
    Marker Score: 710
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5342
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.91
    Marker Score: 418
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.75
    Marker Score: 2664
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.71
    Marker Score: 401
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 325
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.65
    Marker Score: 738
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.64
    Marker Score: 3854
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1298
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.64
    Marker Score: 390
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.63
    Marker Score: 1767
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 473
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.57
    Marker Score: 8862
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.56
    Marker Score: 717
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.52
    Marker Score: 1996
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 279
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 289
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.42
    Marker Score: 197
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.41
    Marker Score: 249
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.37
    Marker Score: 193
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.36
    Marker Score: 381
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.36
    Marker Score: 131
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.35
    Marker Score: 844.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.33
    Marker Score: 138
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.31
    Marker Score: 204
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.29
    Marker Score: 229
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.29
    Marker Score: 240
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.28
    Marker Score: 387.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.27
    Marker Score: 120
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.25
    Marker Score: 80
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.22
    Marker Score: 79
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.21
    Marker Score: 1043.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.2
    Marker Score: 396
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.17
    Marker Score: 49
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 406
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.16
    Marker Score: 86
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.14
    Marker Score: 48
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.14
    Marker Score: 41
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.13
    Marker Score: 52
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.11
    Marker Score: 196
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.1
    Marker Score: 66
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.09
    Marker Score: 82
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 97
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.08
    Marker Score: 61
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.08
    Marker Score: 56
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.08
    Marker Score: 82
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.08
    Marker Score: 240
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.08
    Marker Score: 371
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.07
    Marker Score: 42

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Other Information

**Key characteristics:** * CALML3 is a transmembrane protein with a molecular weight of approximately 110 kDa. * It is a member of the calmodulin superfamily of calcium-binding proteins. * CALML3 is found in a variety of cellular compartments, including the cytoplasm, nucleus, and mitochondria. * It is a key regulator of intracellular calcium signaling, and its expression is often associated with cellular growth, differentiation, and migration. **Pathways and functions:** * CALML3 is a key regulator of calcium signaling in various cell types. * It is involved in the regulation of cell cycle progression, apoptosis, and differentiation. * It is also involved in the regulation of inflammation and immunity. * In respiratory cells, CALML3 is involved in the regulation of epithelial barrier function and the inflammatory response to injury. * In epithelial cells of the small intestine, CALML3 is involved in the regulation of epithelial cell migration and differentiation. * In cardiac endothelial cells, CALML3 is involved in the regulation of vascular tone and blood pressure. **Clinical significance:** CALML3 gene mutations have been linked to a number of human diseases, including breast cancer, cardiac disease, and inflammatory bowel disease. These mutations can lead to the activation of the calmodulin signaling pathway, which can promote cell growth, proliferation, and survival. **Conclusion:** CALML3 is a key regulator of calcium signaling in a variety of cell types. Its expression and function are tightly regulated by calcium levels and other environmental cues. Mutations in the CALML3 gene have been linked to a number of human diseases, underscoring the importance of this protein in human health.

Genular Protein ID: 1447006133

Symbol: CALL3_HUMAN

Name: Calmodulin-like protein 3

UniProtKB Accession Codes:

P27482 B2R9V6 Q5SQI4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2217169

Title: Down-regulation of a calmodulin-related gene during transformation of human mammary epithelial cells.

PubMed ID: 2217169

DOI: 10.1073/pnas.87.19.7360

PubMed ID: 3181418

Title: Characterization of an intronless human calmodulin-like pseudogene.

PubMed ID: 3181418

DOI: 10.1016/0014-5793(88)80558-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1334432

Title: Characterization of the human calmodulin-like protein expressed in Escherichia coli.

PubMed ID: 1334432

DOI: 10.1021/bi00166a017

PubMed ID: 11278607

Title: The tumor-sensitive calmodulin-like protein is a specific light chain of human unconventional myosin X.

PubMed ID: 11278607

DOI: 10.1074/jbc.m010056200

PubMed ID: 18295593

Title: Calmodulin-like protein enhances myosin-10 translation.

PubMed ID: 18295593

DOI: 10.1016/j.bbrc.2008.02.056

PubMed ID: 12067719

Title: Crystal structure of human calmodulin-like protein: insights into its functional role.

PubMed ID: 12067719

DOI: 10.1016/s0014-5793(02)02780-1

Sequence Information:

  • Length: 149
  • Mass: 16891
  • Checksum: 1AB883E8ED4D263D
  • Sequence:
    • MADQLTEEQV TEFKEAFSLF DKDGDGCITT RELGTVMRSL GQNPTEAELR DMMSEIDRDG 
NGTVDFPEFL GMMARKMKDT DNEEEIREAF RVFDKDGNGF VSAAELRHVM TRLGEKLSDE 
EVDEMIRAAD TDGDGQVNYE EFVRVLVSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.