Gene CALR - ENSG00000179218 | NCBI Gene ID: 811

Details for: CALR

Gene ID: 811

Symbol: CALR

Ensembl ID: ENSG00000179218

Description: calreticulin

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen presentation: folding, assembly and peptide loading of class i mhc
(R-HSA-983170)
Antigen processing-cross presentation
(R-HSA-1236975)
Asparagine n-linked glycosylation
(R-HSA-446203)
Assembly of viral components at the budding site
(R-HSA-168316)
Atf6 (atf6-alpha) activates chaperone genes
(R-HSA-381183)
Atf6 (atf6-alpha) activates chaperones
(R-HSA-381033)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Calnexin/calreticulin cycle
(R-HSA-901042)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Disease
(R-HSA-1643685)
Er-phagosome pathway
(R-HSA-1236974)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Metabolism of proteins
(R-HSA-392499)
N-glycan trimming in the er and calnexin/calreticulin cycle
(R-HSA-532668)
Post-translational protein modification
(R-HSA-597592)
Scavenging by class a receptors
(R-HSA-3000480)
Scavenging by class f receptors
(R-HSA-3000484)
Unfolded protein response (upr)
(R-HSA-381119)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Virus assembly and release
(R-HSA-168268)
Acrosomal vesicle
(GO:0001669)
Calcium ion binding
(GO:0005509)
Carbohydrate binding
(GO:0030246)
Cardiac muscle cell differentiation
(GO:0055007)
Cellular response to electrical stimulus
(GO:0071257)
Cellular response to lithium ion
(GO:0071285)
Cellular response to virus
(GO:0098586)
Cellular senescence
(GO:0090398)
Complement component c1q complex binding
(GO:0001849)
Cortical actin cytoskeleton organization
(GO:0030866)
Dna binding
(GO:0003677)
Erad pathway
(GO:0036503)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glucocorticoid receptor signaling pathway
(GO:0042921)
Hormone binding
(GO:0042562)
Integrin binding
(GO:0005178)
Intracellular calcium ion homeostasis
(GO:0006874)
Iron ion binding
(GO:0005506)
Molecular sequestering activity
(GO:0140313)
Mrna binding
(GO:0003729)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of intracellular steroid hormone receptor signaling pathway
(GO:0033144)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of retinoic acid receptor signaling pathway
(GO:0048387)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of translation
(GO:0017148)
Negative regulation of trophoblast cell migration
(GO:1901164)
Nuclear androgen receptor binding
(GO:0050681)
Nuclear envelope
(GO:0005635)
Nuclear export signal receptor activity
(GO:0005049)
Nucleus
(GO:0005634)
Peptide antigen assembly with mhc class i protein complex
(GO:0002502)
Peptide binding
(GO:0042277)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dendritic cell chemotaxis
(GO:2000510)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein export from nucleus
(GO:0006611)
Protein folding
(GO:0006457)
Protein folding chaperone
(GO:0044183)
Protein folding in endoplasmic reticulum
(GO:0034975)
Protein localization to nucleus
(GO:0034504)
Protein maturation by protein folding
(GO:0022417)
Protein stabilization
(GO:0050821)
Regulation of apoptotic process
(GO:0042981)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of meiotic nuclear division
(GO:0040020)
Response to estradiol
(GO:0032355)
Response to glycoside
(GO:1903416)
Response to testosterone
(GO:0033574)
Response to xenobiotic stimulus
(GO:0009410)
Rna binding
(GO:0003723)
Sequestering of calcium ion
(GO:0051208)
Spermatogenesis
(GO:0007283)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: endocardial cell (CL0002350)
Fold Change: 5.24
Marker Score: 2960
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 4.39
Marker Score: 18290
Cell Name: acinar cell (CL0000622)
Fold Change: 3.89
Marker Score: 2746
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.53
Marker Score: 9456
Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.42
Marker Score: 45109
Cell Name: endocrine cell (CL0000163)
Fold Change: 3.37
Marker Score: 1745
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.34
Marker Score: 2616
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 3.32
Marker Score: 10492
Cell Name: mature T cell (CL0002419)
Fold Change: 3.28
Marker Score: 32519
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.27
Marker Score: 9022
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.25
Marker Score: 8200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.18
Marker Score: 7245
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.18
Marker Score: 56405
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.16
Marker Score: 20547
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.14
Marker Score: 7679
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 3.13
Marker Score: 8769
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 3.12
Marker Score: 859
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.09
Marker Score: 2632
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.08
Marker Score: 106567
Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.01
Marker Score: 17866
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.01
Marker Score: 102454
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3
Marker Score: 3043
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.99
Marker Score: 7613
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.97
Marker Score: 2607
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.93
Marker Score: 8538
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.89
Marker Score: 929
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.88
Marker Score: 688
Cell Name: erythroblast (CL0000765)
Fold Change: 2.87
Marker Score: 1791
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.85
Marker Score: 1657
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.84
Marker Score: 4661
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.84
Marker Score: 4183
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 2.84
Marker Score: 746
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.84
Marker Score: 13932.5
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 2.83
Marker Score: 2409
Cell Name: blood cell (CL0000081)
Fold Change: 2.82
Marker Score: 32829
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.78
Marker Score: 3185
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.76
Marker Score: 4570
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.75
Marker Score: 17558
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.74
Marker Score: 2942.5
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.72
Marker Score: 14314
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.71
Marker Score: 17663
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.7
Marker Score: 4346
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.7
Marker Score: 2274
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.7
Marker Score: 142543
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.67
Marker Score: 2389
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.66
Marker Score: 20795.5
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.66
Marker Score: 1108
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.64
Marker Score: 11340
Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 2.64
Marker Score: 1198
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.63
Marker Score: 2810
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.61
Marker Score: 4663
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.61
Marker Score: 8192
Cell Name: Unknown (CL0000548)
Fold Change: 2.6
Marker Score: 1896
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.59
Marker Score: 5403
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.56
Marker Score: 2474
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.56
Marker Score: 3526.5
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 2.55
Marker Score: 2091
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.55
Marker Score: 16320
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 2.54
Marker Score: 3918.5
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.54
Marker Score: 9806
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.54
Marker Score: 28575
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.54
Marker Score: 6184
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.53
Marker Score: 3481
Cell Name: paneth cell (CL0000510)
Fold Change: 2.53
Marker Score: 1760
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.52
Marker Score: 1439
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.52
Marker Score: 10323
Cell Name: decidual cell (CL2000002)
Fold Change: 2.52
Marker Score: 10874
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 2.52
Marker Score: 2239
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 2.52
Marker Score: 662
Cell Name: chromaffin cell (CL0000166)
Fold Change: 2.51
Marker Score: 3534.5
Cell Name: hepatoblast (CL0005026)
Fold Change: 2.51
Marker Score: 8227
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 2.51
Marker Score: 1686
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.5
Marker Score: 3981
Cell Name: adventitial cell (CL0002503)
Fold Change: 2.48
Marker Score: 613
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 2.48
Marker Score: 858
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 2.48
Marker Score: 1545
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.47
Marker Score: 8788
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.47
Marker Score: 6476
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.47
Marker Score: 24841
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.47
Marker Score: 5595
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.46
Marker Score: 3489
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.46
Marker Score: 3485
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 2.46
Marker Score: 652
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.45
Marker Score: 1776
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.45
Marker Score: 2960
Cell Name: enterocyte (CL0000584)
Fold Change: 2.45
Marker Score: 11766
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.45
Marker Score: 2662
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.45
Marker Score: 4156
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.44
Marker Score: 3014
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 2.44
Marker Score: 1849
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.44
Marker Score: 18170
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.43
Marker Score: 6618
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.43
Marker Score: 20922
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.42
Marker Score: 4284
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.42
Marker Score: 2079
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.41
Marker Score: 2274
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.41
Marker Score: 1250
Cell Name: stromal cell (CL0000499)
Fold Change: 2.41
Marker Score: 2824
Cell Name: malignant cell (CL0001064)
Fold Change: 2.4
Marker Score: 32277
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 2.4
Marker Score: 682

Hover over a box to see details here...

**Key characteristics:** * CALR is a glycoprotein with a molecular weight of approximately 140 kDa. * It is a chaperone protein, which means it helps to fold and assemble other proteins. * CALR is a key regulator of the adaptive immune system, particularly in the context of antigen processing and presentation. * It interacts with various immune receptors and signaling pathways, including those involved in inflammation, cell death, and immune surveillance. **Pathways and functions:** * CALR is involved in the adaptive immune system through its interactions with various receptors and signaling pathways. * It is a key regulator of the activation of macrophages and dendritic cells, which are critical for initiating immune responses. * It also plays a role in the regulation of inflammation, cell death, and apoptosis. * CALR is involved in the processing and presentation of antigens by antigen-presenting cells (APCs). * It is also involved in the recognition of pathogens by immune cells, including macrophages, dendritic cells, and lymphocytes. **Clinical significance:** * Mutations in the CALR gene have been linked to several human diseases, including rheumatoid arthritis, atherosclerosis, and cancer. * In rheumatoid arthritis, CALR mutations can lead to the accumulation of misfolded proteins, resulting in inflammation and joint damage. * In atherosclerosis, CALR mutations can impair the clearance of oxidized proteins, leading to the accumulation of toxic substances and tissue damage. * CALR mutations are also associated with certain types of cancer, such as breast cancer and lung cancer. **Conclusion:** CALR is a critical protein with a wide range of functions in the innate immune system. Its involvement in antigen processing, presentation, and recognition makes it a key regulator of immune responses. Mutations in the CALR gene have significant implications for human health, contributing to the development of various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CRP55

Genular Protein ID: 3509270520

Symbol: CALR_HUMAN

Name: CRP55

UniProtKB Accession Codes:

P27797 Q6IAT4 Q9UDG2

Database IDs:

Citations:

PubMed ID: 2332496

Title: Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen.

PubMed ID: 2332496

DOI: 10.1172/jci114582

PubMed ID: 1919005

Title: Characterization of the autoantigen calreticulin.

PubMed ID: 1919005

PubMed ID: 1733953

Title: The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters.

PubMed ID: 1733953

DOI: 10.1016/s0021-9258(18)45916-9

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7841019

Title: Human placental calreticulin: purification, characterization and association with other proteins.

PubMed ID: 7841019

DOI: 10.3891/acta.chem.scand.48-0905

PubMed ID: 3260607

Title: Molecular characterization of human Ro/SS-A antigen. Amino terminal sequence of the protein moiety of human Ro/SS-A antigen and immunological activity of a corresponding synthetic peptide.

PubMed ID: 3260607

DOI: 10.1172/jci113607

PubMed ID: 1911778

Title: In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits.

PubMed ID: 1911778

DOI: 10.1021/bi00105a008

PubMed ID: 2400400

Title: Sequence similarity of calreticulin with a Ca2(+)-binding protein that co-purifies with an Ins(1,4,5)P3-sensitive Ca2+ store in HL-60 cells.

PubMed ID: 2400400

DOI: 10.1042/bj2700545

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 8418194

Title: The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes.

PubMed ID: 8418194

DOI: 10.1084/jem.177.1.1

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 7876246

Title: Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidase.

PubMed ID: 7876246

DOI: 10.1074/jbc.270.9.4741

PubMed ID: 8666824

Title: Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen.

PubMed ID: 8666824

PubMed ID: 9427624

Title: TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.

PubMed ID: 9427624

DOI: 10.1016/s0960-9822(98)70014-4

PubMed ID: 9640257

Title: Calreticulin associates with non-HLA-A,-B class I proteins in the human choriocarcinoma cell lines JEG-3 and BeWo.

PubMed ID: 9640257

DOI: 10.1046/j.1365-2567.1998.00439.x

PubMed ID: 10358038

Title: Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules.

PubMed ID: 10358038

DOI: 10.1074/jbc.274.24.16917

PubMed ID: 10605026

Title: HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern.

PubMed ID: 10605026

DOI: 10.4049/jimmunol.164.1.319

PubMed ID: 11149926

Title: Calreticulin is a receptor for nuclear export.

PubMed ID: 11149926

DOI: 10.1083/jcb.152.1.127

PubMed ID: 11322874

Title: Human placental calreticulin characterization of domain structure and post-translational modifications.

PubMed ID: 11322874

DOI: 10.1046/j.1432-1327.2001.02138.x

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20801878

Title: Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.

PubMed ID: 20801878

DOI: 10.1074/jbc.m110.160101

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23614004

Title: Structure of the non-catalytic domain of the protein disulfide isomerase-related protein (PDIR) reveals function in protein binding.

PubMed ID: 23614004

DOI: 10.1371/journal.pone.0062021

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 30157172

Title: Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa.

PubMed ID: 30157172

DOI: 10.1371/journal.pgen.1007504

PubMed ID: 24325356

Title: Somatic mutations of calreticulin in myeloproliferative neoplasms.

PubMed ID: 24325356

DOI: 10.1056/nejmoa1311347

PubMed ID: 24325359

Title: Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.

PubMed ID: 24325359

DOI: 10.1056/nejmoa1312542

PubMed ID: 19154346

Title: Structural framework of the GABARAP-calreticulin interface -- implications for substrate binding to endoplasmic reticulum chaperones.

PubMed ID: 19154346

DOI: 10.1111/j.1742-4658.2008.06857.x

PubMed ID: 21423620

Title: X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism.

PubMed ID: 21423620

DOI: 10.1371/journal.pone.0017886

PubMed ID: 27840680

Title: Structures of parasite calreticulins provide insights into their flexibility and dual carbohydrate/peptide-binding properties.

PubMed ID: 27840680

DOI: 10.1107/s2052252516012847

Sequence Information:

Length: 417
Mass: 48142
Checksum: BC37C3C0F1054FB2
Sequence:

MLLSVPLLLG LLGLAVAEPA VYFKEQFLDG DGWTSRWIES KHKSDFGKFV LSSGKFYGDE 
EKDKGLQTSQ DARFYALSAS FEPFSNKGQT LVVQFTVKHE QNIDCGGGYV KLFPNSLDQT 
DMHGDSEYNI MFGPDICGPG TKKVHVIFNY KGKNVLINKD IRCKDDEFTH LYTLIVRPDN 
TYEVKIDNSQ VESGSLEDDW DFLPPKKIKD PDASKPEDWD ERAKIDDPTD SKPEDWDKPE 
HIPDPDAKKP EDWDEEMDGE WEPPVIQNPE YKGEWKPRQI DNPDYKGTWI HPEIDNPEYS 
PDPSIYAYDN FGVLGLDLWQ VKSGTIFDNF LITNDEAYAE EFGNETWGVT KAAEKQMKDK 
QDEEQRLKEE EEDKKRKEEE EAEDKEDDED KDEDEEDEED KEEDEEEDVP GQAKDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CALR

Associated with

Cells (max top 100)

Other Information

Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen. PubMed ID: 2332496

Characterization of the autoantigen calreticulin. PubMed ID: 1919005

The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters. PubMed ID: 1733953

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human placental calreticulin: purification, characterization and association with other proteins. PubMed ID: 7841019

Molecular characterization of human Ro/SS-A antigen. Amino terminal sequence of the protein moiety of human Ro/SS-A antigen and immunological activity of a corresponding synthetic peptide. PubMed ID: 3260607

In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits. PubMed ID: 1911778

Sequence similarity of calreticulin with a Ca2(+)-binding protein that co-purifies with an Ins(1,4,5)P3-sensitive Ca2+ store in HL-60 cells. PubMed ID: 2400400

Human liver protein map: a reference database established by microsequencing and gel comparison. PubMed ID: 1286669

Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. PubMed ID: 1286667

The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes. PubMed ID: 8418194

A two-dimensional gel database of human colon carcinoma proteins. PubMed ID: 9150948

Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidase. PubMed ID: 7876246

Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen. PubMed ID: 8666824

TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide. PubMed ID: 9427624

Calreticulin associates with non-HLA-A,-B class I proteins in the human choriocarcinoma cell lines JEG-3 and BeWo. PubMed ID: 9640257

Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules. PubMed ID: 10358038

HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern. PubMed ID: 10605026

Calreticulin is a receptor for nuclear export. PubMed ID: 11149926

Human placental calreticulin characterization of domain structure and post-translational modifications. PubMed ID: 11322874

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain. PubMed ID: 20801878

Initial characterization of the human central proteome. PubMed ID: 21269460

Resveratrol-induced changes of the human adipocyte secretion profile. PubMed ID: 22905912

Structure of the non-catalytic domain of the protein disulfide isomerase-related protein (PDIR) reveals function in protein binding. PubMed ID: 23614004

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. PubMed ID: 29192674

Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa. PubMed ID: 30157172

Somatic mutations of calreticulin in myeloproliferative neoplasms. PubMed ID: 24325356

Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. PubMed ID: 24325359

Structural framework of the GABARAP-calreticulin interface -- implications for substrate binding to endoplasmic reticulum chaperones. PubMed ID: 19154346

X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism. PubMed ID: 21423620

Structures of parasite calreticulins provide insights into their flexibility and dual carbohydrate/peptide-binding properties. PubMed ID: 27840680