Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 680.1237
Cell Significance Index: -105.7900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 396.3833
Cell Significance Index: -100.5400 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 315.2585
Cell Significance Index: -129.8700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 291.3918
Cell Significance Index: -118.3800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 279.7790
Cell Significance Index: -132.0900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 252.2234
Cell Significance Index: -129.7400 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 197.8027
Cell Significance Index: -132.7300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 124.4995
Cell Significance Index: -118.8700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 100.0360
Cell Significance Index: -123.3400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 39.6027
Cell Significance Index: -106.0900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 32.4990
Cell Significance Index: -128.2400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 32.1639
Cell Significance Index: -98.7900 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 16.9013
Cell Significance Index: -36.9900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 11.0223
Cell Significance Index: 294.8400 - Cell Name: peg cell (CL4033014)
Fold Change: 5.6940
Cell Significance Index: 131.5500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 4.5768
Cell Significance Index: 95.8000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 4.0310
Cell Significance Index: 553.5700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.9828
Cell Significance Index: 185.7000 - Cell Name: kidney cell (CL1000497)
Fold Change: 3.7543
Cell Significance Index: 29.9800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 3.6037
Cell Significance Index: 1968.0900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.5029
Cell Significance Index: 164.6300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.2664
Cell Significance Index: 95.9300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 3.2631
Cell Significance Index: 113.3900 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.2089
Cell Significance Index: 41.1000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.6014
Cell Significance Index: 69.4600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.5258
Cell Significance Index: 68.7500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.2452
Cell Significance Index: 404.7400 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.2393
Cell Significance Index: 287.0600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.1623
Cell Significance Index: 265.8800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.1427
Cell Significance Index: 159.6900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.9606
Cell Significance Index: 231.2100 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.8064
Cell Significance Index: 233.3800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.6648
Cell Significance Index: 736.0700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.6557
Cell Significance Index: 180.0900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.6522
Cell Significance Index: 18.7700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.5374
Cell Significance Index: 305.1000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.4644
Cell Significance Index: 13.4900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.4421
Cell Significance Index: 41.5500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.3991
Cell Significance Index: 36.7900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.3919
Cell Significance Index: 63.0900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.3821
Cell Significance Index: 39.6200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.3403
Cell Significance Index: 132.5900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.3190
Cell Significance Index: 85.1000 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.2933
Cell Significance Index: 14.0600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.2187
Cell Significance Index: 86.1900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.7329
Cell Significance Index: 125.1400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6541
Cell Significance Index: 124.4900 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.6228
Cell Significance Index: 3.8700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.5416
Cell Significance Index: 409.9200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3853
Cell Significance Index: 62.6700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.2924
Cell Significance Index: 214.3900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2427
Cell Significance Index: 12.6100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1490
Cell Significance Index: 53.4500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1246
Cell Significance Index: 2.0900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0497
Cell Significance Index: 9.9700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0383
Cell Significance Index: 2.0000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0186
Cell Significance Index: 12.8600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0113
Cell Significance Index: -21.3500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0259
Cell Significance Index: -2.6500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0472
Cell Significance Index: -34.9400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0880
Cell Significance Index: -162.3800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1042
Cell Significance Index: -160.4700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1227
Cell Significance Index: -166.9000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1391
Cell Significance Index: -86.8400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1626
Cell Significance Index: -103.2500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1687
Cell Significance Index: -8.8600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1737
Cell Significance Index: -97.9700 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.2196
Cell Significance Index: -3.0800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2349
Cell Significance Index: -106.6200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2797
Cell Significance Index: -9.8300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3384
Cell Significance Index: -71.2700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3704
Cell Significance Index: -106.5800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.5732
Cell Significance Index: -16.0200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.6793
Cell Significance Index: -17.3600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.7058
Cell Significance Index: -80.8600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7415
Cell Significance Index: -23.7500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.7611
Cell Significance Index: -42.7100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.7647
Cell Significance Index: -89.1200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.7958
Cell Significance Index: -115.6900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.9007
Cell Significance Index: -102.8100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.9173
Cell Significance Index: -16.2100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.9882
Cell Significance Index: -26.4800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.0645
Cell Significance Index: -26.6100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.1481
Cell Significance Index: -70.5700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.1971
Cell Significance Index: -124.6500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.2515
Cell Significance Index: -78.8800 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -1.2785
Cell Significance Index: -23.6300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.4314
Cell Significance Index: -113.3700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.4621
Cell Significance Index: -112.2000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.4651
Cell Significance Index: -19.9900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.4813
Cell Significance Index: -8.9500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.5611
Cell Significance Index: -33.8200 - Cell Name: early promyelocyte (CL0002154)
Fold Change: -1.6151
Cell Significance Index: -10.3100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.6243
Cell Significance Index: -109.2200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.7236
Cell Significance Index: -119.2000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -1.8569
Cell Significance Index: -93.8400 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.9087
Cell Significance Index: -28.6000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.0428
Cell Significance Index: -125.2400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -2.1890
Cell Significance Index: -22.6600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -2.2472
Cell Significance Index: -92.0800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3509270520
Symbol: CALR_HUMAN
Name: CRP55
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2332496
Title: Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen.
PubMed ID: 2332496
DOI: 10.1172/jci114582
PubMed ID: 1919005
Title: Characterization of the autoantigen calreticulin.
PubMed ID: 1919005
PubMed ID: 1733953
Title: The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters.
PubMed ID: 1733953
PubMed ID: 19054851
Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
PubMed ID: 19054851
DOI: 10.1038/nmeth.1273
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7841019
Title: Human placental calreticulin: purification, characterization and association with other proteins.
PubMed ID: 7841019
PubMed ID: 3260607
Title: Molecular characterization of human Ro/SS-A antigen. Amino terminal sequence of the protein moiety of human Ro/SS-A antigen and immunological activity of a corresponding synthetic peptide.
PubMed ID: 3260607
DOI: 10.1172/jci113607
PubMed ID: 1911778
Title: In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits.
PubMed ID: 1911778
DOI: 10.1021/bi00105a008
PubMed ID: 2400400
Title: Sequence similarity of calreticulin with a Ca2(+)-binding protein that co-purifies with an Ins(1,4,5)P3-sensitive Ca2+ store in HL-60 cells.
PubMed ID: 2400400
DOI: 10.1042/bj2700545
PubMed ID: 1286669
Title: Human liver protein map: a reference database established by microsequencing and gel comparison.
PubMed ID: 1286669
PubMed ID: 1286667
Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.
PubMed ID: 1286667
PubMed ID: 8418194
Title: The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes.
PubMed ID: 8418194
DOI: 10.1084/jem.177.1.1
PubMed ID: 9150948
Title: A two-dimensional gel database of human colon carcinoma proteins.
PubMed ID: 9150948
PubMed ID: 7876246
Title: Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidase.
PubMed ID: 7876246
PubMed ID: 8666824
Title: Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen.
PubMed ID: 8666824
PubMed ID: 9427624
Title: TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.
PubMed ID: 9427624
PubMed ID: 9640257
Title: Calreticulin associates with non-HLA-A,-B class I proteins in the human choriocarcinoma cell lines JEG-3 and BeWo.
PubMed ID: 9640257
PubMed ID: 10358038
Title: Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules.
PubMed ID: 10358038
PubMed ID: 10605026
Title: HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern.
PubMed ID: 10605026
PubMed ID: 11149926
Title: Calreticulin is a receptor for nuclear export.
PubMed ID: 11149926
PubMed ID: 11322874
Title: Human placental calreticulin characterization of domain structure and post-translational modifications.
PubMed ID: 11322874
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20801878
Title: Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.
PubMed ID: 20801878
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22905912
Title: Resveratrol-induced changes of the human adipocyte secretion profile.
PubMed ID: 22905912
DOI: 10.1021/pr300539b
PubMed ID: 23614004
Title: Structure of the non-catalytic domain of the protein disulfide isomerase-related protein (PDIR) reveals function in protein binding.
PubMed ID: 23614004
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 29192674
Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.
PubMed ID: 29192674
DOI: 10.1038/cr.2017.149
PubMed ID: 30157172
Title: Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa.
PubMed ID: 30157172
PubMed ID: 24325356
Title: Somatic mutations of calreticulin in myeloproliferative neoplasms.
PubMed ID: 24325356
PubMed ID: 24325359
Title: Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.
PubMed ID: 24325359
PubMed ID: 19154346
Title: Structural framework of the GABARAP-calreticulin interface -- implications for substrate binding to endoplasmic reticulum chaperones.
PubMed ID: 19154346
PubMed ID: 21423620
Title: X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism.
PubMed ID: 21423620
PubMed ID: 27840680
Title: Structures of parasite calreticulins provide insights into their flexibility and dual carbohydrate/peptide-binding properties.
PubMed ID: 27840680
Sequence Information:
- Length: 417
- Mass: 48142
- Checksum: BC37C3C0F1054FB2
- Sequence:
MLLSVPLLLG LLGLAVAEPA VYFKEQFLDG DGWTSRWIES KHKSDFGKFV LSSGKFYGDE EKDKGLQTSQ DARFYALSAS FEPFSNKGQT LVVQFTVKHE QNIDCGGGYV KLFPNSLDQT DMHGDSEYNI MFGPDICGPG TKKVHVIFNY KGKNVLINKD IRCKDDEFTH LYTLIVRPDN TYEVKIDNSQ VESGSLEDDW DFLPPKKIKD PDASKPEDWD ERAKIDDPTD SKPEDWDKPE HIPDPDAKKP EDWDEEMDGE WEPPVIQNPE YKGEWKPRQI DNPDYKGTWI HPEIDNPEYS PDPSIYAYDN FGVLGLDLWQ VKSGTIFDNF LITNDEAYAE EFGNETWGVT KAAEKQMKDK QDEEQRLKEE EEDKKRKEEE EAEDKEDDED KDEDEEDEED KEEDEEEDVP GQAKDEL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.