Details for: CALR

Gene ID: 811

Symbol: CALR

Ensembl ID: ENSG00000179218

Description: calreticulin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 680.1237
    Cell Significance Index: -105.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 396.3833
    Cell Significance Index: -100.5400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 315.2585
    Cell Significance Index: -129.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 291.3918
    Cell Significance Index: -118.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 279.7790
    Cell Significance Index: -132.0900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 252.2234
    Cell Significance Index: -129.7400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 197.8027
    Cell Significance Index: -132.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 124.4995
    Cell Significance Index: -118.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 100.0360
    Cell Significance Index: -123.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 39.6027
    Cell Significance Index: -106.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 32.4990
    Cell Significance Index: -128.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 32.1639
    Cell Significance Index: -98.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.9013
    Cell Significance Index: -36.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 11.0223
    Cell Significance Index: 294.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.6940
    Cell Significance Index: 131.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.5768
    Cell Significance Index: 95.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.0310
    Cell Significance Index: 553.5700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.9828
    Cell Significance Index: 185.7000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.7543
    Cell Significance Index: 29.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.6037
    Cell Significance Index: 1968.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.5029
    Cell Significance Index: 164.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.2664
    Cell Significance Index: 95.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.2631
    Cell Significance Index: 113.3900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.2089
    Cell Significance Index: 41.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.6014
    Cell Significance Index: 69.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5258
    Cell Significance Index: 68.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2452
    Cell Significance Index: 404.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.2393
    Cell Significance Index: 287.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1623
    Cell Significance Index: 265.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.1427
    Cell Significance Index: 159.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.9606
    Cell Significance Index: 231.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.8064
    Cell Significance Index: 233.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6648
    Cell Significance Index: 736.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6557
    Cell Significance Index: 180.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.6522
    Cell Significance Index: 18.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5374
    Cell Significance Index: 305.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4644
    Cell Significance Index: 13.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4421
    Cell Significance Index: 41.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3991
    Cell Significance Index: 36.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3919
    Cell Significance Index: 63.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3821
    Cell Significance Index: 39.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3403
    Cell Significance Index: 132.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3190
    Cell Significance Index: 85.1000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.2933
    Cell Significance Index: 14.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2187
    Cell Significance Index: 86.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7329
    Cell Significance Index: 125.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6541
    Cell Significance Index: 124.4900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6228
    Cell Significance Index: 3.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5416
    Cell Significance Index: 409.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3853
    Cell Significance Index: 62.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2924
    Cell Significance Index: 214.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2427
    Cell Significance Index: 12.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1490
    Cell Significance Index: 53.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1246
    Cell Significance Index: 2.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0497
    Cell Significance Index: 9.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0383
    Cell Significance Index: 2.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0186
    Cell Significance Index: 12.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0113
    Cell Significance Index: -21.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0259
    Cell Significance Index: -2.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0472
    Cell Significance Index: -34.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0880
    Cell Significance Index: -162.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1042
    Cell Significance Index: -160.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1227
    Cell Significance Index: -166.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1391
    Cell Significance Index: -86.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1626
    Cell Significance Index: -103.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1687
    Cell Significance Index: -8.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1737
    Cell Significance Index: -97.9700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2196
    Cell Significance Index: -3.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2349
    Cell Significance Index: -106.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2797
    Cell Significance Index: -9.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3384
    Cell Significance Index: -71.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3704
    Cell Significance Index: -106.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5732
    Cell Significance Index: -16.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6793
    Cell Significance Index: -17.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7058
    Cell Significance Index: -80.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7415
    Cell Significance Index: -23.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7611
    Cell Significance Index: -42.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7647
    Cell Significance Index: -89.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7958
    Cell Significance Index: -115.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9007
    Cell Significance Index: -102.8100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9173
    Cell Significance Index: -16.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9882
    Cell Significance Index: -26.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0645
    Cell Significance Index: -26.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1481
    Cell Significance Index: -70.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1971
    Cell Significance Index: -124.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.2515
    Cell Significance Index: -78.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2785
    Cell Significance Index: -23.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4314
    Cell Significance Index: -113.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.4621
    Cell Significance Index: -112.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.4651
    Cell Significance Index: -19.9900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.4813
    Cell Significance Index: -8.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.5611
    Cell Significance Index: -33.8200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -1.6151
    Cell Significance Index: -10.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.6243
    Cell Significance Index: -109.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.7236
    Cell Significance Index: -119.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.8569
    Cell Significance Index: -93.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.9087
    Cell Significance Index: -28.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.0428
    Cell Significance Index: -125.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -2.1890
    Cell Significance Index: -22.6600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -2.2472
    Cell Significance Index: -92.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Molecular Chaperone Function**: Calreticulin acts as a molecular chaperone, assisting in the proper folding and assembly of proteins in the ER and Golgi apparatus. 2. **Antigen Presentation**: CALR is involved in the presentation of antigens to the immune system, particularly through the MHC class I pathway. 3. **Immune System Regulation**: Calreticulin plays a role in regulating immune responses, including the activation and function of T cells and dendritic cells. 4. **Cellular Stress Response**: CALR is involved in the regulation of cellular stress responses, including the unfolded protein response (UPR) and the ER stress response. 5. **Protein Degradation**: Calreticulin regulates protein degradation, particularly through its interaction with the proteasome. **Pathways and Functions** 1. **Acrosomal Vesicle Formation**: CALR is involved in the formation of acrosomal vesicles in sperm cells. 2. **Adaptive Immune System**: Calreticulin plays a role in the regulation of adaptive immune responses, including T cell activation and function. 3. **Antigen Presentation: Folding, Assembly, and Peptide Loading of Class I MHC**: CALR is involved in the presentation of antigens to the immune system through the MHC class I pathway. 4. **Asparagine N-Linked Glycosylation**: Calreticulin regulates asparagine N-linked glycosylation, a process involved in protein folding and stability. 5. **Cellular Responses to Stimuli**: CALR is involved in the regulation of cellular responses to various stimuli, including stress, heat shock, and oxidative stress. **Clinical Significance** 1. **Cancer**: Calreticulin is overexpressed in various types of cancer, including breast, lung, and colon cancer. 2. **Immunodeficiency**: Mutations in the CALR gene have been associated with immunodeficiency disorders, such as hyper-IgM syndrome. 3. **Autoimmune Diseases**: CALR has been implicated in the pathogenesis of autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. 4. **Infectious Diseases**: Calreticulin plays a role in the regulation of immune responses to infectious diseases, including HIV and influenza. 5. **Protein Folding Disorders**: Mutations in the CALR gene have been associated with protein folding disorders, such as folding-related neurodegenerative diseases. In summary, calreticulin is a multifunctional protein that plays a crucial role in various cellular processes, including protein folding, antigen presentation, and immune system regulation. Its dysregulation has been implicated in various diseases, including cancer, immunodeficiency, autoimmune diseases, infectious diseases, and protein folding disorders.

Genular Protein ID: 3509270520

Symbol: CALR_HUMAN

Name: CRP55

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2332496

Title: Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen.

PubMed ID: 2332496

DOI: 10.1172/jci114582

PubMed ID: 1919005

Title: Characterization of the autoantigen calreticulin.

PubMed ID: 1919005

PubMed ID: 1733953

Title: The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters.

PubMed ID: 1733953

DOI: 10.1016/s0021-9258(18)45916-9

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7841019

Title: Human placental calreticulin: purification, characterization and association with other proteins.

PubMed ID: 7841019

DOI: 10.3891/acta.chem.scand.48-0905

PubMed ID: 3260607

Title: Molecular characterization of human Ro/SS-A antigen. Amino terminal sequence of the protein moiety of human Ro/SS-A antigen and immunological activity of a corresponding synthetic peptide.

PubMed ID: 3260607

DOI: 10.1172/jci113607

PubMed ID: 1911778

Title: In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits.

PubMed ID: 1911778

DOI: 10.1021/bi00105a008

PubMed ID: 2400400

Title: Sequence similarity of calreticulin with a Ca2(+)-binding protein that co-purifies with an Ins(1,4,5)P3-sensitive Ca2+ store in HL-60 cells.

PubMed ID: 2400400

DOI: 10.1042/bj2700545

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 8418194

Title: The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes.

PubMed ID: 8418194

DOI: 10.1084/jem.177.1.1

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 7876246

Title: Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidase.

PubMed ID: 7876246

DOI: 10.1074/jbc.270.9.4741

PubMed ID: 8666824

Title: Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen.

PubMed ID: 8666824

PubMed ID: 9427624

Title: TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.

PubMed ID: 9427624

DOI: 10.1016/s0960-9822(98)70014-4

PubMed ID: 9640257

Title: Calreticulin associates with non-HLA-A,-B class I proteins in the human choriocarcinoma cell lines JEG-3 and BeWo.

PubMed ID: 9640257

DOI: 10.1046/j.1365-2567.1998.00439.x

PubMed ID: 10358038

Title: Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules.

PubMed ID: 10358038

DOI: 10.1074/jbc.274.24.16917

PubMed ID: 10605026

Title: HLA-F is a predominantly empty, intracellular, TAP-associated MHC class Ib protein with a restricted expression pattern.

PubMed ID: 10605026

DOI: 10.4049/jimmunol.164.1.319

PubMed ID: 11149926

Title: Calreticulin is a receptor for nuclear export.

PubMed ID: 11149926

DOI: 10.1083/jcb.152.1.127

PubMed ID: 11322874

Title: Human placental calreticulin characterization of domain structure and post-translational modifications.

PubMed ID: 11322874

DOI: 10.1046/j.1432-1327.2001.02138.x

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20801878

Title: Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.

PubMed ID: 20801878

DOI: 10.1074/jbc.m110.160101

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23614004

Title: Structure of the non-catalytic domain of the protein disulfide isomerase-related protein (PDIR) reveals function in protein binding.

PubMed ID: 23614004

DOI: 10.1371/journal.pone.0062021

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 30157172

Title: Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa.

PubMed ID: 30157172

DOI: 10.1371/journal.pgen.1007504

PubMed ID: 24325356

Title: Somatic mutations of calreticulin in myeloproliferative neoplasms.

PubMed ID: 24325356

DOI: 10.1056/nejmoa1311347

PubMed ID: 24325359

Title: Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.

PubMed ID: 24325359

DOI: 10.1056/nejmoa1312542

PubMed ID: 19154346

Title: Structural framework of the GABARAP-calreticulin interface -- implications for substrate binding to endoplasmic reticulum chaperones.

PubMed ID: 19154346

DOI: 10.1111/j.1742-4658.2008.06857.x

PubMed ID: 21423620

Title: X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism.

PubMed ID: 21423620

DOI: 10.1371/journal.pone.0017886

PubMed ID: 27840680

Title: Structures of parasite calreticulins provide insights into their flexibility and dual carbohydrate/peptide-binding properties.

PubMed ID: 27840680

DOI: 10.1107/s2052252516012847

Sequence Information:

  • Length: 417
  • Mass: 48142
  • Checksum: BC37C3C0F1054FB2
  • Sequence:
  • MLLSVPLLLG LLGLAVAEPA VYFKEQFLDG DGWTSRWIES KHKSDFGKFV LSSGKFYGDE 
    EKDKGLQTSQ DARFYALSAS FEPFSNKGQT LVVQFTVKHE QNIDCGGGYV KLFPNSLDQT 
    DMHGDSEYNI MFGPDICGPG TKKVHVIFNY KGKNVLINKD IRCKDDEFTH LYTLIVRPDN 
    TYEVKIDNSQ VESGSLEDDW DFLPPKKIKD PDASKPEDWD ERAKIDDPTD SKPEDWDKPE 
    HIPDPDAKKP EDWDEEMDGE WEPPVIQNPE YKGEWKPRQI DNPDYKGTWI HPEIDNPEYS 
    PDPSIYAYDN FGVLGLDLWQ VKSGTIFDNF LITNDEAYAE EFGNETWGVT KAAEKQMKDK 
    QDEEQRLKEE EEDKKRKEEE EAEDKEDDED KDEDEEDEED KEEDEEEDVP GQAKDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.