Details for: CALU

Gene ID: 813

Symbol: CALU

Ensembl ID: ENSG00000128595

Description: calumenin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 391.3653
    Cell Significance Index: -60.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 240.9682
    Cell Significance Index: -61.1200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 163.5159
    Cell Significance Index: -67.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 139.7942
    Cell Significance Index: -66.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 133.2654
    Cell Significance Index: -54.1400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 120.9016
    Cell Significance Index: -62.1900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 99.4751
    Cell Significance Index: -66.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 56.7692
    Cell Significance Index: -54.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.7415
    Cell Significance Index: -63.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.8422
    Cell Significance Index: -63.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.2441
    Cell Significance Index: -64.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.3417
    Cell Significance Index: -44.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.5025
    Cell Significance Index: 94.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.2938
    Cell Significance Index: 114.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.6409
    Cell Significance Index: 104.3700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.2838
    Cell Significance Index: 14.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8893
    Cell Significance Index: 88.0900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.7124
    Cell Significance Index: 21.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5076
    Cell Significance Index: 52.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4948
    Cell Significance Index: 296.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4519
    Cell Significance Index: 199.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1286
    Cell Significance Index: 1019.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1161
    Cell Significance Index: 609.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9965
    Cell Significance Index: 199.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9781
    Cell Significance Index: 19.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7533
    Cell Significance Index: 81.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7235
    Cell Significance Index: 88.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6830
    Cell Significance Index: 123.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6733
    Cell Significance Index: 7.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6721
    Cell Significance Index: 40.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6412
    Cell Significance Index: 82.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5475
    Cell Significance Index: 242.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5422
    Cell Significance Index: 41.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5213
    Cell Significance Index: 186.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5189
    Cell Significance Index: 84.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4292
    Cell Significance Index: 31.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4182
    Cell Significance Index: 19.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3903
    Cell Significance Index: 50.4200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.3443
    Cell Significance Index: 2.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3117
    Cell Significance Index: 215.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2394
    Cell Significance Index: 6.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2361
    Cell Significance Index: 40.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2269
    Cell Significance Index: 6.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2117
    Cell Significance Index: 20.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1932
    Cell Significance Index: 10.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1868
    Cell Significance Index: 351.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1844
    Cell Significance Index: 83.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1678
    Cell Significance Index: 4.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1592
    Cell Significance Index: 2.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1261
    Cell Significance Index: 8.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0483
    Cell Significance Index: 89.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0419
    Cell Significance Index: 1.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0359
    Cell Significance Index: 22.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0326
    Cell Significance Index: 50.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0171
    Cell Significance Index: 12.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0062
    Cell Significance Index: -1.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0176
    Cell Significance Index: -23.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0179
    Cell Significance Index: -13.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0380
    Cell Significance Index: -27.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0458
    Cell Significance Index: -28.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0706
    Cell Significance Index: -7.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0739
    Cell Significance Index: -41.6600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1126
    Cell Significance Index: -0.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1746
    Cell Significance Index: -20.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1796
    Cell Significance Index: -37.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1872
    Cell Significance Index: -9.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1883
    Cell Significance Index: -54.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1890
    Cell Significance Index: -4.9700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2151
    Cell Significance Index: -4.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2221
    Cell Significance Index: -26.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2317
    Cell Significance Index: -33.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2426
    Cell Significance Index: -25.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2554
    Cell Significance Index: -17.6700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2555
    Cell Significance Index: -2.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2919
    Cell Significance Index: -19.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3269
    Cell Significance Index: -37.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3715
    Cell Significance Index: -23.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4136
    Cell Significance Index: -20.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4479
    Cell Significance Index: -27.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5302
    Cell Significance Index: -23.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5385
    Cell Significance Index: -61.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5654
    Cell Significance Index: -15.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5693
    Cell Significance Index: -18.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5703
    Cell Significance Index: -11.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5880
    Cell Significance Index: -6.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6374
    Cell Significance Index: -17.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6384
    Cell Significance Index: -13.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6655
    Cell Significance Index: -25.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6765
    Cell Significance Index: -35.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7167
    Cell Significance Index: -43.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7253
    Cell Significance Index: -57.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7270
    Cell Significance Index: -45.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7331
    Cell Significance Index: -18.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7729
    Cell Significance Index: -40.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7851
    Cell Significance Index: -20.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8869
    Cell Significance Index: -12.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9118
    Cell Significance Index: -26.0200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.1115
    Cell Significance Index: -16.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.2142
    Cell Significance Index: -35.6600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.2448
    Cell Significance Index: -17.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Calumenin is a calcium-binding protein that is predominantly expressed in endocardial cells, fibroblasts, and mesenchymal stem cells. Its expression is also observed in other cell types, including bronchus fibroblasts, fibroblasts of mammary glands, and decidual cells. The protein's ability to bind calcium ions suggests its involvement in calcium homeostasis and cellular signaling. **Pathways and Functions:** Calumenin is implicated in various cellular processes, including: 1. **Calcium signaling and homeostasis**: Calumenin's calcium-binding properties suggest its role in regulating calcium levels within cells, which is crucial for numerous cellular processes, including muscle contraction, neurotransmission, and cell proliferation. 2. **Endoplasmic reticulum (ER) function**: Calumenin is localized to the ER, where it may participate in protein folding, transport, and modification. 3. **Golgi apparatus function**: Calumenin's presence in the Golgi apparatus suggests its involvement in protein modification, glycosylation, and secretion. 4. **Platelet activation and aggregation**: Calumenin is expressed in platelets, where it may play a role in regulating platelet function, particularly in response to elevated cytosolic calcium levels. 5. **Hemostasis**: Calumenin's involvement in platelet activation and aggregation suggests its potential role in maintaining hemostasis and preventing excessive bleeding. **Clinical Significance:** Calumenin's expression in various tissues and cell types highlights its potential involvement in numerous diseases and disorders, including: 1. **Cancer**: Calumenin's expression in cancer cells may contribute to cancer progression, metastasis, and resistance to therapy. 2. **Cardiovascular disease**: Calumenin's role in platelet activation and aggregation suggests its potential involvement in cardiovascular disease, including atherosclerosis and thrombosis. 3. **Endocrine disorders**: Calumenin's expression in endocrine tissues, such as the prostate and mammary glands, may contribute to endocrine disorders, including prostate cancer and breast cancer. 4. **Neurological disorders**: Calumenin's presence in the ER and Golgi apparatus suggests its potential involvement in neurological disorders, including neurodegenerative diseases and neurological cancer. In conclusion, calumenin is a multifaceted protein with diverse expression patterns and involvement in various cellular processes. Further research is necessary to fully elucidate its functions and clinical significance, but its potential implications in human health and disease make it an exciting area of investigation. **Recommendations:** 1. **Further studies on calumenin's expression and function**: Investigate calumenin's expression patterns in various tissues and cell types to elucidate its involvement in different diseases and disorders. 2. **Mechanistic studies on calumenin's role in cellular processes**: Investigate calumenin's role in calcium signaling, ER function, Golgi apparatus function, and platelet activation and aggregation. 3. **Clinical studies on calumenin's involvement in human disease**: Investigate calumenin's expression and function in human disease models, including cancer, cardiovascular disease, and endocrine disorders. By further exploring calumenin's functions and clinical significance, we can gain a deeper understanding of its role in human health and disease, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 4222203126

Symbol: CALU_HUMAN

Name: Calumenin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9675259

Title: Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity.

PubMed ID: 9675259

DOI: 10.1016/s0167-4838(98)00089-2

PubMed ID: 9598325

Title: Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32.

PubMed ID: 9598325

DOI: 10.1006/geno.1998.5245

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 10222138

Title: Human calumenin localizes to the secretory pathway and is secreted to the medium.

PubMed ID: 10222138

DOI: 10.1006/excr.1999.4431

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 315
  • Mass: 37107
  • Checksum: 25BAE5A99B527375
  • Sequence:
  • MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 
    FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA QKRWIYEDVE RQWKGHDLNE 
    DGLVSWEEYK NATYGYVLDD PDPDDGFNYK QMMVRDERRF KMADKDGDLI ATKEEFTAFL 
    HPEEYDYMKD IVVQETMEDI DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF 
    RDKNRDGKMD KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS 
    QATDFGEALV RHDEF

Genular Protein ID: 4124246364

Symbol: B3KQF5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 315
  • Mass: 37019
  • Checksum: 3C682EB04980A366
  • Sequence:
  • MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 
    FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA QKRWIYEDVE RQWKGHDLNE 
    DGLVSWEEYK NATYGYVLDD PDPDDGFNYK QMMVRDERRF KMADKDGDLI ATKEEFTAFL 
    HPEEYDYMKD IVVQETMEDI DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF 
    RDKNRDGKMG KVETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS 
    QATDFGEALV RHDEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.