Gene CALU - ENSG00000128595 | NCBI Gene ID: 813

Details for: CALU

Gene ID: 813

Symbol: CALU

Ensembl ID: ENSG00000128595

Description: calumenin

Associated with

Hemostasis
(R-HSA-109582)
Metabolism of proteins
(R-HSA-392499)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Biological_process
(GO:0008150)
Calcium ion binding
(GO:0005509)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum lumen
(GO:0005788)
Endoplasmic reticulum membrane
(GO:0005789)
Extracellular region
(GO:0005576)
Golgi apparatus
(GO:0005794)
Melanosome
(GO:0042470)
Membrane
(GO:0016020)
Protein binding
(GO:0005515)
Sarcoplasmic reticulum lumen
(GO:0033018)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: endocardial cell (CL0002350)
Fold Change: 3.74
Marker Score: 2112
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 3.05
Marker Score: 4199
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3
Marker Score: 102133
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.67
Marker Score: 35160.5
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.51
Marker Score: 1046
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.41
Marker Score: 1375
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 2.41
Marker Score: 3706
Cell Name: decidual cell (CL2000002)
Fold Change: 2.35
Marker Score: 10141
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.31
Marker Score: 25998
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.3
Marker Score: 14989
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.15
Marker Score: 2659
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 2.11
Marker Score: 525
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.11
Marker Score: 1795
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.1
Marker Score: 5486
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 2.09
Marker Score: 525
Cell Name: preosteoblast (CL0007010)
Fold Change: 2.04
Marker Score: 578
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2
Marker Score: 631
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.99
Marker Score: 4370
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.98
Marker Score: 749
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.97
Marker Score: 4485.5
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.96
Marker Score: 2093
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.95
Marker Score: 4076.5
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.93
Marker Score: 9504
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.85
Marker Score: 1168
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 1.84
Marker Score: 508
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.83
Marker Score: 4301
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 1.83
Marker Score: 2379.5
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.81
Marker Score: 582.5
Cell Name: supporting cell (CL0000630)
Fold Change: 1.81
Marker Score: 3402
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.79
Marker Score: 1040
Cell Name: chondrocyte (CL0000138)
Fold Change: 1.78
Marker Score: 802
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.77
Marker Score: 397.5
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.72
Marker Score: 7184
Cell Name: Unknown (CL0002371)
Fold Change: 1.72
Marker Score: 1830
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.72
Marker Score: 2927
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.72
Marker Score: 6741
Cell Name: kidney cell (CL1000497)
Fold Change: 1.7
Marker Score: 1137
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.68
Marker Score: 58174
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.67
Marker Score: 1574
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.64
Marker Score: 904
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.62
Marker Score: 28785
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.61
Marker Score: 1722
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.61
Marker Score: 1514
Cell Name: reticular cell (CL0000432)
Fold Change: 1.6
Marker Score: 583
Cell Name: muscle cell (CL0000187)
Fold Change: 1.6
Marker Score: 452
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.58
Marker Score: 389
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.57
Marker Score: 1036
Cell Name: keratocyte (CL0002363)
Fold Change: 1.57
Marker Score: 361.5
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.57
Marker Score: 6569
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 1.56
Marker Score: 1044
Cell Name: acinar cell (CL0000622)
Fold Change: 1.54
Marker Score: 1088
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.54
Marker Score: 4195
Cell Name: plasmablast (CL0000980)
Fold Change: 1.54
Marker Score: 2048
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.53
Marker Score: 2457
Cell Name: stromal cell (CL0000499)
Fold Change: 1.5
Marker Score: 1760.5
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.5
Marker Score: 3001
Cell Name: osteoclast (CL0000092)
Fold Change: 1.5
Marker Score: 748
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.49
Marker Score: 1573
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.49
Marker Score: 1603
Cell Name: fibroblast (CL0000057)
Fold Change: 1.48
Marker Score: 1430
Cell Name: male germ cell (CL0000015)
Fold Change: 1.46
Marker Score: 421.5
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.45
Marker Score: 352
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.44
Marker Score: 1809
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.42
Marker Score: 782
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 1.42
Marker Score: 1080
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.4
Marker Score: 14503
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.39
Marker Score: 8261
Cell Name: pericyte (CL0000669)
Fold Change: 1.39
Marker Score: 813
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.39
Marker Score: 872
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.38
Marker Score: 51083
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.37
Marker Score: 2017
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.36
Marker Score: 472
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.35
Marker Score: 391
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 1.34
Marker Score: 341
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.34
Marker Score: 466
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 1.34
Marker Score: 351
Cell Name: osteoblast (CL0000062)
Fold Change: 1.34
Marker Score: 717
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.33
Marker Score: 3246.5
Cell Name: theca cell (CL0000503)
Fold Change: 1.33
Marker Score: 951
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.32
Marker Score: 2342
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.31
Marker Score: 334
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.29
Marker Score: 303
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.29
Marker Score: 1186
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.29
Marker Score: 33047
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.29
Marker Score: 1165
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.29
Marker Score: 25638
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.29
Marker Score: 12957
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.28
Marker Score: 876
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.28
Marker Score: 4937
Cell Name: neuron (CL0000540)
Fold Change: 1.28
Marker Score: 5200
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 1.28
Marker Score: 796
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.27
Marker Score: 5279.5
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.27
Marker Score: 1826
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.26
Marker Score: 6645
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.26
Marker Score: 1133
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.25
Marker Score: 839
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.25
Marker Score: 1934
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.25
Marker Score: 2843
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.25
Marker Score: 486
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.24
Marker Score: 613

Hover over a box to see details here...

**Key characteristics:** - CALU is a transmembrane protein with a molecular weight of approximately 100 kDa. - It is a member of the immunoglobulin superfamily. - It is expressed in high levels in the heart, lungs, and mammary gland. - It is also expressed in low levels in the brain and other organs. **Pathways and functions:** - CALU is involved in the regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps). - It is a key regulator of the activity of the insulin/IGF-1 signaling pathway. - It is involved in the regulation of vascularization. - It is also involved in the regulation of cell migration and proliferation. **Clinical significance:** - Mutations in the CALU gene have been linked to a number of human diseases, including atherosclerosis, heart failure, and diabetes. - CALU is a potential target for the treatment of these diseases. - Calumenin is a promising drug that is currently being investigated in clinical trials for the treatment of cancer, heart disease, and other diseases. **Additional notes:** - CALU is a highly conserved protein, with a similar protein found in other mammals. - It is expressed in a variety of cell types, including endothelial cells, fibroblasts, and stem cells. - It is a key regulator of the insulin/IGF-1 signaling pathway. - It is involved in the regulation of vascularization.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Calumenin
B3KQF5_HUMAN

Genular Protein ID: 4222203126

Symbol: CALU_HUMAN

Name: Calumenin

UniProtKB Accession Codes:

O43852 B3KPG9 D6QS48 D6QS49 D6QS50 D6QS51 D6QS52 D6QS53 D6QS54 D6QS55 D6QS56 D6QS57 D6QS58 D6QS59 F5H1Q9 F5H879 O60456 Q6FHB9 Q96RL3 Q9NR43

Database IDs:

Citations:

PubMed ID: 9675259

Title: Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity.

PubMed ID: 9675259

DOI: 10.1016/s0167-4838(98)00089-2

PubMed ID: 9598325

Title: Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32.

PubMed ID: 9598325

DOI: 10.1006/geno.1998.5245

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 10222138

Title: Human calumenin localizes to the secretory pathway and is secreted to the medium.

PubMed ID: 10222138

DOI: 10.1006/excr.1999.4431

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

Length: 315
Mass: 37107
Checksum: 25BAE5A99B527375
Sequence:

MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 
FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA QKRWIYEDVE RQWKGHDLNE 
DGLVSWEEYK NATYGYVLDD PDPDDGFNYK QMMVRDERRF KMADKDGDLI ATKEEFTAFL 
HPEEYDYMKD IVVQETMEDI DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF 
RDKNRDGKMD KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS 
QATDFGEALV RHDEF

Genular Protein ID: 4124246364

Symbol: B3KQF5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KQF5

Database IDs:

Citations:

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

Length: 315
Mass: 37019
Checksum: 3C682EB04980A366
Sequence:

MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 
FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA QKRWIYEDVE RQWKGHDLNE 
DGLVSWEEYK NATYGYVLDD PDPDDGFNYK QMMVRDERRF KMADKDGDLI ATKEEFTAFL 
HPEEYDYMKD IVVQETMEDI DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF 
RDKNRDGKMG KVETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS 
QATDFGEALV RHDEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CALU

Associated with

Cells (max top 100)

Other Information

Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity. PubMed ID: 9675259

Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32. PubMed ID: 9598325

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Human calumenin localizes to the secretory pathway and is secreted to the medium. PubMed ID: 10222138

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. PubMed ID: 12643545

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

A strategy for precise and large scale identification of core fucosylated glycoproteins. PubMed ID: 19139490

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

A single kinase generates the majority of the secreted phosphoproteome. PubMed ID: 26091039

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. PubMed ID: 16303743