CAMK4 | ENSG00000152495 | NCBI 814

Details for: CAMK4

Gene ID: 814

Symbol: CAMK4

Ensembl ID: ENSG00000152495

Description: calcium/calmodulin dependent protein kinase IV

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Camk iv-mediated phosphorylation of creb
(R-HSA-111932)
Cam pathway
(R-HSA-111997)
Creb1 phosphorylation through the activation of camkii/camkk/camkiv cascasde
(R-HSA-442729)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Disorders of developmental biology
(R-HSA-9675151)
Disorders of nervous system development
(R-HSA-9697154)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gpcr downstream signalling
(R-HSA-388396)
Intracellular signaling by second messengers
(R-HSA-9006925)
Loss of function of mecp2 in rett syndrome
(R-HSA-9005891)
Loss of phosphorylation of mecp2 at t308
(R-HSA-9022535)
Mitochondrial biogenesis
(R-HSA-1592230)
Negative regulation of nmda receptor-mediated neuronal transmission
(R-HSA-9617324)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Pervasive developmental disorders
(R-HSA-9005895)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by gpcr
(R-HSA-372790)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transmission across chemical synapses
(R-HSA-112315)
Adaptive immune response
(GO:0002250)
Atp binding
(GO:0005524)
Calcium-dependent protein serine/threonine kinase activity
(GO:0009931)
Calmodulin-dependent protein kinase activity
(GO:0004683)
Calmodulin binding
(GO:0005516)
Cytoplasm
(GO:0005737)
Extracellular exosome
(GO:0070062)
Fibrillar center
(GO:0001650)
Inflammatory response
(GO:0006954)
Intracellular signal transduction
(GO:0035556)
Long-term memory
(GO:0007616)
Myeloid dendritic cell differentiation
(GO:0043011)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of myeloid dendritic cell cytokine production
(GO:0002735)
Protein autophosphorylation
(GO:0046777)
Protein phosphorylation
(GO:0006468)
Protein serine kinase activity
(GO:0106310)
Regulation of osteoclast differentiation
(GO:0045670)
Regulation of t cell differentiation in thymus
(GO:0033081)
Signal transduction
(GO:0007165)

Other Information

Proteins

Calcium/calmodulin-dependent protein kinase type IV

Genular Protein ID: 3046038767

Symbol: KCC4_HUMAN

Name: Calcium/calmodulin-dependent protein kinase type IV

UniProtKB Accession Codes:

Q16566 D3DSZ7

Database IDs:

Citations:

PubMed ID: 8089075

Title: cDNA cloning and expression of human calmodulin-dependent protein kinase IV.

PubMed ID: 8089075

DOI: 10.1093/oxfordjournals.jbchem.a124387

PubMed ID: 8194751

Title: The cDNA sequence and characterization of the Ca2+/calmodulin-dependent protein kinase-Gr from human brain and thymus.

PubMed ID: 8194751

DOI: 10.1016/0378-1119(94)90260-7

PubMed ID: 8107230

Title: A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1.

PubMed ID: 8107230

DOI: 10.1128/jvi.68.3.1697-1705.1994

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8397199

Title: Expression of a Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, in human T lymphocytes. Regulation of kinase activity by T cell receptor signaling.

PubMed ID: 8397199

DOI: 10.1016/s0021-9258(20)80693-0

PubMed ID: 7961813

Title: Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase.

PubMed ID: 7961813

DOI: 10.1016/s0021-9258(19)61953-8

PubMed ID: 8065343

Title: Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.

PubMed ID: 8065343

DOI: 10.1128/mcb.14.9.6107-6116.1994

PubMed ID: 8980227

Title: CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression.

PubMed ID: 8980227

DOI: 10.1016/s0092-8674(00)81816-4

PubMed ID: 8702940

Title: A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR.

PubMed ID: 8702940

DOI: 10.1074/jbc.271.35.21542

PubMed ID: 8855261

Title: Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.

PubMed ID: 8855261

DOI: 10.1073/pnas.93.20.10803

PubMed ID: 9154845

Title: Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18.

PubMed ID: 9154845

DOI: 10.1128/mcb.17.6.3459

PubMed ID: 10617605

Title: Ca(2+)-dependent gene expression mediated by MEF2 transcription factors.

PubMed ID: 10617605

DOI: 10.1074/jbc.275.1.197

PubMed ID: 12065094

Title: Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.

PubMed ID: 12065094

DOI: 10.1016/s0304-3835(02)00107-6

PubMed ID: 15143065

Title: Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex.

PubMed ID: 15143065

DOI: 10.1074/jbc.m404523200

PubMed ID: 15769749

Title: The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription.

PubMed ID: 15769749

DOI: 10.1074/jbc.m500067200

PubMed ID: 17909078

Title: Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells.

PubMed ID: 17909078

DOI: 10.1182/blood-2007-05-091173

PubMed ID: 18829949

Title: Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging.

PubMed ID: 18829949

DOI: 10.1523/jneurosci.2625-08.2008

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19506079

Title: Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification.

PubMed ID: 19506079

DOI: 10.1074/jbc.m109.007310

PubMed ID: 9920409

Title: Calmodulin-dependent protein kinase IV: regulation of function and expression.

PubMed ID: 9920409

DOI: 10.1016/s0167-4889(98)00142-6

PubMed ID: 18817731

Title: Calmodulin-kinases: modulators of neuronal development and plasticity.

PubMed ID: 18817731

DOI: 10.1016/j.neuron.2008.08.021

PubMed ID: 18930438

Title: Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller.

PubMed ID: 18930438

DOI: 10.1016/j.it.2008.08.005

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 473
Mass: 51926
Checksum: EFEE51E5612326DC
Sequence:

MLKVTVPSCS ASSCSSVTAS AAPGTASLVP DYWIDGSNRD ALSDFFEVES ELGRGATSIV 
YRCKQKGTQK PYALKVLKKT VDKKIVRTEI GVLLRLSHPN IIKLKEIFET PTEISLVLEL 
VTGGELFDRI VEKGYYSERD AADAVKQILE AVAYLHENGI VHRDLKPENL LYATPAPDAP 
LKIADFGLSK IVEHQVLMKT VCGTPGYCAP EILRGCAYGP EVDMWSVGII TYILLCGFEP 
FYDERGDQFM FRRILNCEYY FISPWWDEVS LNAKDLVRKL IVLDPKKRLT TFQALQHPWV 
TGKAANFVHM DTAQKKLQEF NARRKLKAAV KAVVASSRLG SASSSHGSIQ ESHKASRDPS 
PIQDGNEDMK AIPEGEKIQG DGAQAAVKGA QAELMKVQAL EKVKGADINA EEAPKMVPKA 
VEDGIKVADL ELEEGLAEEK LKTVEEAAAP REGQGSSAVG FEVPQQDVIL PEY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CAMK4

Associated with

Other Information

cDNA cloning and expression of human calmodulin-dependent protein kinase IV. PubMed ID: 8089075

The cDNA sequence and characterization of the Ca2+/calmodulin-dependent protein kinase-Gr from human brain and thymus. PubMed ID: 8194751

A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. PubMed ID: 8107230

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of a Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, in human T lymphocytes. Regulation of kinase activity by T cell receptor signaling. PubMed ID: 8397199

Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase. PubMed ID: 7961813

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. PubMed ID: 8065343

CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression. PubMed ID: 8980227

A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR. PubMed ID: 8702940

Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. PubMed ID: 8855261

Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18. PubMed ID: 9154845

Ca(2+)-dependent gene expression mediated by MEF2 transcription factors. PubMed ID: 10617605

Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer. PubMed ID: 12065094

Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. PubMed ID: 15143065

The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription. PubMed ID: 15769749

Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. PubMed ID: 17909078

Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging. PubMed ID: 18829949

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification. PubMed ID: 19506079

Calmodulin-dependent protein kinase IV: regulation of function and expression. PubMed ID: 9920409

Calmodulin-kinases: modulators of neuronal development and plasticity. PubMed ID: 18817731

Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller. PubMed ID: 18930438

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846