Details for: CAMK4

Gene ID: 814

Symbol: CAMK4

Ensembl ID: ENSG00000152495

Description: calcium/calmodulin dependent protein kinase IV

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 237.2300
    Cell Significance Index: -36.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 146.1107
    Cell Significance Index: -37.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.4386
    Cell Significance Index: -31.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 74.0486
    Cell Significance Index: -34.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.9119
    Cell Significance Index: -36.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 11.5565
    Cell Significance Index: 198.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.1204
    Cell Significance Index: -29.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.1102
    Cell Significance Index: -24.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 6.5320
    Cell Significance Index: 288.9300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 6.1078
    Cell Significance Index: 231.2900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.6316
    Cell Significance Index: 35.7000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 4.2485
    Cell Significance Index: 121.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.3945
    Cell Significance Index: 1217.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 3.2080
    Cell Significance Index: 76.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.9735
    Cell Significance Index: 65.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6250
    Cell Significance Index: 526.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.4676
    Cell Significance Index: 165.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.1547
    Cell Significance Index: 132.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8804
    Cell Significance Index: 105.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.7416
    Cell Significance Index: 1204.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6711
    Cell Significance Index: 36.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1991
    Cell Significance Index: 54.3500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.0125
    Cell Significance Index: 13.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0060
    Cell Significance Index: 52.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9682
    Cell Significance Index: 184.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6646
    Cell Significance Index: 65.7500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.6574
    Cell Significance Index: 8.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5932
    Cell Significance Index: 535.6400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.4934
    Cell Significance Index: 5.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4237
    Cell Significance Index: 12.4500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.3951
    Cell Significance Index: 3.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3137
    Cell Significance Index: 51.0200
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.3042
    Cell Significance Index: 3.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.2705
    Cell Significance Index: 5.4300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2556
    Cell Significance Index: 3.1700
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.1944
    Cell Significance Index: 1.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1191
    Cell Significance Index: 12.9600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0560
    Cell Significance Index: 0.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0502
    Cell Significance Index: 94.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0361
    Cell Significance Index: 55.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0211
    Cell Significance Index: 0.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0064
    Cell Significance Index: 11.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0021
    Cell Significance Index: 0.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0063
    Cell Significance Index: -0.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0106
    Cell Significance Index: -0.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0171
    Cell Significance Index: -23.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0194
    Cell Significance Index: -0.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0461
    Cell Significance Index: -29.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0462
    Cell Significance Index: -20.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0471
    Cell Significance Index: -34.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0473
    Cell Significance Index: -34.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0499
    Cell Significance Index: -37.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0536
    Cell Significance Index: -1.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0618
    Cell Significance Index: -33.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0627
    Cell Significance Index: -39.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0629
    Cell Significance Index: -35.4600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0666
    Cell Significance Index: -0.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0687
    Cell Significance Index: -31.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0867
    Cell Significance Index: -10.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1008
    Cell Significance Index: -18.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1033
    Cell Significance Index: -3.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1082
    Cell Significance Index: -31.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1153
    Cell Significance Index: -1.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1157
    Cell Significance Index: -22.9600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1177
    Cell Significance Index: -1.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1370
    Cell Significance Index: -16.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1460
    Cell Significance Index: -21.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1711
    Cell Significance Index: -36.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1922
    Cell Significance Index: -26.4000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1955
    Cell Significance Index: -2.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1963
    Cell Significance Index: -25.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1993
    Cell Significance Index: -34.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2034
    Cell Significance Index: -14.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2244
    Cell Significance Index: -4.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2323
    Cell Significance Index: -7.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2587
    Cell Significance Index: -5.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2736
    Cell Significance Index: -35.3500
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.2842
    Cell Significance Index: -2.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2878
    Cell Significance Index: -33.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3041
    Cell Significance Index: -4.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3072
    Cell Significance Index: -18.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3165
    Cell Significance Index: -36.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3257
    Cell Significance Index: -6.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3402
    Cell Significance Index: -34.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3444
    Cell Significance Index: -24.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3467
    Cell Significance Index: -36.1000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3530
    Cell Significance Index: -8.8100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.3540
    Cell Significance Index: -2.1900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3915
    Cell Significance Index: -4.9400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4041
    Cell Significance Index: -5.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4343
    Cell Significance Index: -33.3300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4554
    Cell Significance Index: -7.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4750
    Cell Significance Index: -35.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5185
    Cell Significance Index: -24.3700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5280
    Cell Significance Index: -22.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5448
    Cell Significance Index: -35.1500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5494
    Cell Significance Index: -6.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5617
    Cell Significance Index: -35.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5829
    Cell Significance Index: -12.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5953
    Cell Significance Index: -15.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CAMK4 is a calcium/calmodulin-dependent protein kinase that exhibits a high degree of specificity for calcium/calmodulin binding. This enzyme is characterized by its ability to phosphorylate specific serine or threonine residues on target proteins, which can activate or inhibit various cellular processes. CAMK4 is also known for its involvement in the regulation of neuronal functions, including synaptic plasticity and long-term memory. Additionally, this enzyme plays a role in the adaptive immune response, regulating the production of cytokines and the differentiation of T cells. **Pathways and Functions** CAMK4 is involved in a wide range of signaling pathways, including: 1. **Activation of NMDA receptors and postsynaptic events**: CAMK4 phosphorylates and regulates the activity of NMDA receptors, which are critical for synaptic plasticity and learning. 2. **Adaptive immune response**: CAMK4 regulates the production of cytokines and the differentiation of T cells, which are essential for the adaptive immune response. 3. **ATP binding and Ca-dependent events**: CAMK4 is activated by calcium/calmodulin binding, which triggers a downstream cascade of events involved in various cellular processes. 4. **Protein phosphorylation**: CAMK4 phosphorylates specific serine or threonine residues on target proteins, which can activate or inhibit various cellular processes. 5. **Calmodulin-dependent protein kinase activity**: CAMK4 is a member of the calcium/calmodulin-dependent protein kinase family, which is involved in the regulation of various cellular processes. **Clinical Significance** CAMK4 has been implicated in various diseases and disorders, including: 1. **Disorders of developmental biology**: CAMK4 plays a crucial role in the development of the nervous system and has been implicated in disorders such as Rett syndrome. 2. **Pervasive developmental disorders**: CAMK4 has been linked to pervasive developmental disorders, including autism spectrum disorder. 3. **Neurotransmitter receptors and postsynaptic signal transmission**: CAMK4 regulates the activity of NMDA receptors, which are critical for synaptic plasticity and learning. 4. **Opioid signalling**: CAMK4 has been implicated in the regulation of opioid signalling pathways, which are involved in pain modulation and addiction. 5. **Regulation of mecp2 expression and activity**: CAMK4 regulates the expression and activity of the MECP2 gene, which is critical for the development of the nervous system. In conclusion, CAMK4 is a crucial enzyme involved in various cellular processes, including signal transduction, transcriptional regulation, and protein phosphorylation. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 3046038767

Symbol: KCC4_HUMAN

Name: Calcium/calmodulin-dependent protein kinase type IV

UniProtKB Accession Codes:

Q16566 D3DSZ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 3 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8089075

Title: cDNA cloning and expression of human calmodulin-dependent protein kinase IV.

PubMed ID: 8089075

DOI: 10.1093/oxfordjournals.jbchem.a124387

PubMed ID: 8194751

Title: The cDNA sequence and characterization of the Ca2+/calmodulin-dependent protein kinase-Gr from human brain and thymus.

PubMed ID: 8194751

DOI: 10.1016/0378-1119(94)90260-7

PubMed ID: 8107230

Title: A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1.

PubMed ID: 8107230

DOI: 10.1128/jvi.68.3.1697-1705.1994

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8397199

Title: Expression of a Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, in human T lymphocytes. Regulation of kinase activity by T cell receptor signaling.

PubMed ID: 8397199

DOI: 10.1016/s0021-9258(20)80693-0

PubMed ID: 7961813

Title: Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase.

PubMed ID: 7961813

DOI: 10.1016/s0021-9258(19)61953-8

PubMed ID: 8065343

Title: Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.

PubMed ID: 8065343

DOI: 10.1128/mcb.14.9.6107-6116.1994

PubMed ID: 8980227

Title: CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression.

PubMed ID: 8980227

DOI: 10.1016/s0092-8674(00)81816-4

PubMed ID: 8702940

Title: A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR.

PubMed ID: 8702940

DOI: 10.1074/jbc.271.35.21542

PubMed ID: 8855261

Title: Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.

PubMed ID: 8855261

DOI: 10.1073/pnas.93.20.10803

PubMed ID: 9154845

Title: Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18.

PubMed ID: 9154845

DOI: 10.1128/mcb.17.6.3459

PubMed ID: 10617605

Title: Ca(2+)-dependent gene expression mediated by MEF2 transcription factors.

PubMed ID: 10617605

DOI: 10.1074/jbc.275.1.197

PubMed ID: 12065094

Title: Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer.

PubMed ID: 12065094

DOI: 10.1016/s0304-3835(02)00107-6

PubMed ID: 15143065

Title: Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex.

PubMed ID: 15143065

DOI: 10.1074/jbc.m404523200

PubMed ID: 15769749

Title: The autonomous activity of calcium/calmodulin-dependent protein kinase IV is required for its role in transcription.

PubMed ID: 15769749

DOI: 10.1074/jbc.m500067200

PubMed ID: 17909078

Title: Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells.

PubMed ID: 17909078

DOI: 10.1182/blood-2007-05-091173

PubMed ID: 18829949

Title: Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging.

PubMed ID: 18829949

DOI: 10.1523/jneurosci.2625-08.2008

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19506079

Title: Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification.

PubMed ID: 19506079

DOI: 10.1074/jbc.m109.007310

PubMed ID: 9920409

Title: Calmodulin-dependent protein kinase IV: regulation of function and expression.

PubMed ID: 9920409

DOI: 10.1016/s0167-4889(98)00142-6

PubMed ID: 18817731

Title: Calmodulin-kinases: modulators of neuronal development and plasticity.

PubMed ID: 18817731

DOI: 10.1016/j.neuron.2008.08.021

PubMed ID: 18930438

Title: Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller.

PubMed ID: 18930438

DOI: 10.1016/j.it.2008.08.005

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 473
  • Mass: 51926
  • Checksum: EFEE51E5612326DC
  • Sequence:
    • MLKVTVPSCS ASSCSSVTAS AAPGTASLVP DYWIDGSNRD ALSDFFEVES ELGRGATSIV 
YRCKQKGTQK PYALKVLKKT VDKKIVRTEI GVLLRLSHPN IIKLKEIFET PTEISLVLEL 
VTGGELFDRI VEKGYYSERD AADAVKQILE AVAYLHENGI VHRDLKPENL LYATPAPDAP 
LKIADFGLSK IVEHQVLMKT VCGTPGYCAP EILRGCAYGP EVDMWSVGII TYILLCGFEP 
FYDERGDQFM FRRILNCEYY FISPWWDEVS LNAKDLVRKL IVLDPKKRLT TFQALQHPWV 
TGKAANFVHM DTAQKKLQEF NARRKLKAAV KAVVASSRLG SASSSHGSIQ ESHKASRDPS 
PIQDGNEDMK AIPEGEKIQG DGAQAAVKGA QAELMKVQAL EKVKGADINA EEAPKMVPKA 
VEDGIKVADL ELEEGLAEEK LKTVEEAAAP REGQGSSAVG FEVPQQDVIL PEY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.