CAMK2A | ENSG00000070808 | NCBI 815

Details for: CAMK2A

Gene ID: 815

Symbol: CAMK2A

Ensembl ID: ENSG00000070808

Description: calcium/calmodulin dependent protein kinase II alpha

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Assembly and cell surface presentation of nmda receptors
(R-HSA-9609736)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca-dependent events
(R-HSA-111996)
Ca2+ pathway
(R-HSA-4086398)
Calmodulin induced events
(R-HSA-111933)
Camk iv-mediated phosphorylation of creb
(R-HSA-111932)
Cam pathway
(R-HSA-111997)
Cardiac conduction
(R-HSA-5576891)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Creb1 phosphorylation through nmda receptor-mediated activation of ras signaling
(R-HSA-442742)
Cytokine signaling in immune system
(R-HSA-1280215)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-HSA-399721)
Gpcr downstream signalling
(R-HSA-388396)
Hsf1-dependent transactivation
(R-HSA-3371571)
Immune system
(R-HSA-168256)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion channel transport
(R-HSA-983712)
Ion homeostasis
(R-HSA-5578775)
Ion transport by p-type atpases
(R-HSA-936837)
Long-term potentiation
(R-HSA-9620244)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Muscle contraction
(R-HSA-397014)
Negative regulation of nmda receptor-mediated neuronal transmission
(R-HSA-9617324)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Oncogenic mapk signaling
(R-HSA-6802957)
Opioid signalling
(R-HSA-111885)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Phase 0 - rapid depolarisation
(R-HSA-5576892)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Ras activation upon ca2+ influx through nmda receptor
(R-HSA-442982)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by gpcr
(R-HSA-372790)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by wnt
(R-HSA-195721)
Signaling downstream of ras mutants
(R-HSA-9649948)
Trafficking of ampa receptors
(R-HSA-399719)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Unblocking of nmda receptors, glutamate binding and activation
(R-HSA-438066)
Angiotensin-activated signaling pathway
(GO:0038166)
Atp binding
(GO:0005524)
Calcium/calmodulin-dependent protein kinase activity
(GO:0004683)
Calcium ion transport
(GO:0006816)
Calmodulin binding
(GO:0005516)
Cellular response to interferon-beta
(GO:0035458)
Cellular response to type ii interferon
(GO:0071346)
Dendritic spine development
(GO:0060996)
G1/s transition of mitotic cell cycle
(GO:0000082)
Glutamate receptor binding
(GO:0035254)
Identical protein binding
(GO:0042802)
Kinase activity
(GO:0016301)
Metal ion binding
(GO:0046872)
Negative regulation of hydrolase activity
(GO:0051346)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine autophosphorylation
(GO:1990443)
Positive regulation of calcium ion transport
(GO:0051928)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of endocannabinoid signaling pathway
(GO:2000124)
Regulation of mitochondrial membrane permeability involved in apoptotic process
(GO:1902108)
Regulation of neuronal synaptic plasticity
(GO:0048168)
Regulation of neuron migration
(GO:2001222)
Regulation of neurotransmitter secretion
(GO:0046928)
Regulation of protein localization to plasma membrane
(GO:1903076)
Response to ischemia
(GO:0002931)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 6.0280
Cell Significance Index: 172.0200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 4.4879
Cell Significance Index: 301.7700
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 4.2917
Cell Significance Index: 57.2500
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 3.7054
Cell Significance Index: 28.4200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.9751
Cell Significance Index: 596.8100
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 2.9351
Cell Significance Index: 45.4100
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.3668
Cell Significance Index: -5.1800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.2626
Cell Significance Index: 100.0800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.1567
Cell Significance Index: 81.6700
Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: 1.6668
Cell Significance Index: 18.3900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.4747
Cell Significance Index: 528.9700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.9896
Cell Significance Index: 684.4400
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.9385
Cell Significance Index: 20.5500
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.7541
Cell Significance Index: 9.7800
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.5663
Cell Significance Index: 12.1100
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.5519
Cell Significance Index: 13.4700
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.5499
Cell Significance Index: 6.8200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.4135
Cell Significance Index: 10.6300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2505
Cell Significance Index: 13.1500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1987
Cell Significance Index: 270.1800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1985
Cell Significance Index: 12.2000
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.1161
Cell Significance Index: 1.1100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1013
Cell Significance Index: 7.7800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0367
Cell Significance Index: 1.9100
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0367
Cell Significance Index: 0.8800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0103
Cell Significance Index: -19.3400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0111
Cell Significance Index: -20.4900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0136
Cell Significance Index: -20.9200
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0174
Cell Significance Index: -0.1900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0318
Cell Significance Index: -20.2200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0348
Cell Significance Index: -25.7900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0349
Cell Significance Index: -26.4000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0409
Cell Significance Index: -18.5500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0454
Cell Significance Index: -25.6200
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0466
Cell Significance Index: -25.4500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0570
Cell Significance Index: -25.1900
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0637
Cell Significance Index: -1.2600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0695
Cell Significance Index: -19.9900
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0726
Cell Significance Index: -14.4000
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0986
Cell Significance Index: -2.1300
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0992
Cell Significance Index: -1.4200
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1032
Cell Significance Index: -2.1900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1061
Cell Significance Index: -15.4200
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.1094
Cell Significance Index: -1.5300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1126
Cell Significance Index: -20.3000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1295
Cell Significance Index: -27.2800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1329
Cell Significance Index: -22.6900
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1415
Cell Significance Index: -2.8400
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1523
Cell Significance Index: -4.8500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1692
Cell Significance Index: -20.8100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1692
Cell Significance Index: -5.5400
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1748
Cell Significance Index: -24.0100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1829
Cell Significance Index: -23.6300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1914
Cell Significance Index: -5.3500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2161
Cell Significance Index: -22.0700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2227
Cell Significance Index: -25.5200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2364
Cell Significance Index: -24.6200
Cell Name: neural cell (CL0002319)
Fold Change: -0.2417
Cell Significance Index: -2.8200
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2507
Cell Significance Index: -10.9000
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.2842
Cell Significance Index: -7.0900
Cell Name: neuron (CL0000540)
Fold Change: -0.3017
Cell Significance Index: -2.8600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3096
Cell Significance Index: -17.3800
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.3297
Cell Significance Index: -4.1600
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.3458
Cell Significance Index: -4.6100
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3500
Cell Significance Index: -12.2600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3630
Cell Significance Index: -22.8800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3718
Cell Significance Index: -22.8000
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3932
Cell Significance Index: -25.3700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3933
Cell Significance Index: -20.4300
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.3952
Cell Significance Index: -12.5000
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.4513
Cell Significance Index: -9.4200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4845
Cell Significance Index: -22.7700
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.5185
Cell Significance Index: -12.9500
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.5594
Cell Significance Index: -6.6900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.5826
Cell Significance Index: -20.4700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5969
Cell Significance Index: -27.8300
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.6082
Cell Significance Index: -11.9700
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6167
Cell Significance Index: -22.6400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.6285
Cell Significance Index: -21.8400
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: -0.6305
Cell Significance Index: -5.7000
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.6553
Cell Significance Index: -11.3300
Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
Fold Change: -0.6680
Cell Significance Index: -6.7500
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.6801
Cell Significance Index: -10.0400
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.6924
Cell Significance Index: -19.9500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.7208
Cell Significance Index: -21.2300
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.7434
Cell Significance Index: -14.8300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.7535
Cell Significance Index: -21.6000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.7963
Cell Significance Index: -21.6800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.8011
Cell Significance Index: -10.9300
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.8162
Cell Significance Index: -5.5300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.8317
Cell Significance Index: -20.7900
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.8340
Cell Significance Index: -9.4700
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.8356
Cell Significance Index: -20.2400
Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.8705
Cell Significance Index: -14.0500
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.8876
Cell Significance Index: -18.0600
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.9093
Cell Significance Index: -23.9100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.9155
Cell Significance Index: -24.4900
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.9169
Cell Significance Index: -23.3600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.9325
Cell Significance Index: -15.9800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.9640
Cell Significance Index: -25.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Calcium/calmodulin-dependent activation**: CAMK2A is activated by the binding of calcium/calmodulin, which triggers a conformational change that allows the enzyme to interact with its substrates. 2. **Broad substrate specificity**: CAMK2A phosphorylates a wide range of proteins, including transcription factors, receptors, and kinases, modulating various cellular processes. 3. **Neuronal expression**: CAMK2A is predominantly expressed in neurons, particularly in pyramidal neurons and other cortical interneurons, suggesting its critical role in neural signaling and plasticity. 4. **Cardiac conduction**: CAMK2A is also expressed in cardiac muscle cells, where it regulates cardiac conduction and contractility. **Pathways and Functions** 1. **Neuronal signaling**: CAMK2A mediates synaptic plasticity, neuronal migration, and neurotransmitter secretion through its phosphorylation of various proteins involved in these processes. 2. **Immune responses**: CAMK2A regulates cytokine signaling, immune cell function, and inflammation through its phosphorylation of immune-related proteins. 3. **Cardiovascular functions**: CAMK2A modulates cardiac conduction, contractility, and blood pressure through its phosphorylation of cardiac muscle proteins. 4. **Wnt signaling**: CAMK2A interacts with the Wnt signaling pathway, regulating cell proliferation, differentiation, and survival. 5. **MAPK signaling**: CAMK2A phosphorylates and activates MAPK proteins, which are involved in cell growth, differentiation, and survival. **Clinical Significance** 1. **Neurological disorders**: CAMK2A dysregulation has been implicated in various neurological disorders, including epilepsy, Alzheimer's disease, and Parkinson's disease. 2. **Cardiovascular diseases**: CAMK2A mutations have been associated with cardiovascular diseases, such as arrhythmias, hypertension, and cardiac conduction disorders. 3. **Cancer**: CAMK2A is involved in cancer development and progression, particularly in the regulation of cell proliferation, migration, and invasion. 4. **Immunological disorders**: CAMK2A dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, CAMK2A is a critical regulator of various cellular processes, including neuronal signaling, immune responses, and cardiovascular functions. Its dysregulation has been implicated in various neurological and cardiovascular disorders, highlighting the importance of CAMK2A in maintaining normal physiological and pathological processes.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 3508354350

Symbol: KCC2A_HUMAN

Name: Calcium/calmodulin-dependent protein kinase type II subunit alpha

UniProtKB Accession Codes:

Q9UQM7 Q9UL21 Q9Y2H4 Q9Y352

Database IDs:

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 11972023

Title: Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.

PubMed ID: 11972023

DOI: 10.1073/pnas.052159099

PubMed ID: 14722083

Title: Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II.

PubMed ID: 14722083

DOI: 10.1074/jbc.m313597200

PubMed ID: 15312654

Title: SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.

PubMed ID: 15312654

DOI: 10.1016/j.neuron.2004.08.003

PubMed ID: 23805378

Title: CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16.

PubMed ID: 23805378

DOI: 10.7554/elife.00518

PubMed ID: 28130356

Title: Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.

PubMed ID: 28130356

DOI: 10.1523/jneurosci.2068-16.2017

PubMed ID: 25533962

Title: Large-scale discovery of novel genetic causes of developmental disorders.

PubMed ID: 25533962

DOI: 10.1038/nature14135

PubMed ID: 29100089

Title: De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.

PubMed ID: 29100089

DOI: 10.1016/j.ajhg.2017.10.003

PubMed ID: 29560374

Title: De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders.

PubMed ID: 29560374

DOI: 10.1002/acn3.528

PubMed ID: 29784083

Title: A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability.

PubMed ID: 29784083

DOI: 10.7554/elife.32451

PubMed ID: 35568036

Title: A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling.

PubMed ID: 35568036

DOI: 10.1016/j.cell.2022.04.028

Sequence Information:

Length: 478
Mass: 54088
Checksum: 208143A311BA9262
Sequence:

MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARDHQKLERE 
ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL 
EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGFAGTPGYL 
SPEVLRKDPY GKPVDLWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV 
TPEAKDLINK MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK 
GAILTTMLAT RNFSGGKSGG NKKSDGVKES SESTNTTIED EDTKVRKQEI IKVTEQLIEA 
ISNGDFESYT KMCDPGMTAF EPEALGNLVE GLDFHRFYFE NLWSRNSKPV HTTILNPHIH 
LMGDESACIA YIRITQYLDA GGIPRTAQSE ETRVWHRRDG KWQIVHFHRS GAPSVLPH

Genular Protein ID: 67767485

Symbol: Q8IWE0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IWE0

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 478
Mass: 54088
Checksum: BAE143AA03BA9264
Sequence:

MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARDHQKLERE 
ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL 
EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGFAGTPGYL 
SPEVLRKDPY GKPVDLWACG VILYILLVGY PPFWDEDQHR LYKQIKAGAY DFPSPEWDTV 
TPEAKDLINK MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK 
GAILTTMLAT RNFSGGKSGG NKKSDGVKES SESTNTTIED EDTKVRKQEI IKVTEQLIEA 
ISNGDFESYT KMCDPGMTAF EPEALGNLVE GLDFHRFYFE NLWSRNSKPV HTTILNPHIH 
LMGDESACIA YIRITQYLDA GGIPRTAQSE ETRVWHRRDG KWQIVHFHRS GAPSVLPH

Genular Protein ID: 2861623886

Symbol: A8K161_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K161

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 489
Mass: 55320
Checksum: 41E67A1E15EB142B
Sequence:

MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARDHQKLERE 
ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL 
EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGFAGTPGYL 
SPEVLRKDPY GKPVDLWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV 
TPEAKDLINK MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK 
GAILTTMLAT RNFSGGKSGG NKKSDGVKKR KSSSSVQLME SSESTNTTIE DEDTKVRKQE 
IIKVTEQLIE AISNGDFESY TKMCDPGMTA FEPEALGNLV EGLDFHRFYF ENLWSRNSKP 
VHTTILNPHI HLMGDESACI AYIRITQYLD AGGIPRTAQS EETRVWHRRD GKWQIVHFHR 
SGAPSVLPH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CAMK2A

Associated with

Cells (max top 100)

Other Information

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10231032

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma. PubMed ID: 11972023

Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. PubMed ID: 14722083

SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. PubMed ID: 15312654

CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16. PubMed ID: 23805378

Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. PubMed ID: 28130356

Large-scale discovery of novel genetic causes of developmental disorders. PubMed ID: 25533962

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. PubMed ID: 29100089

De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders. PubMed ID: 29560374

A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability. PubMed ID: 29784083

A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling. PubMed ID: 35568036

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The sequence of the human genome. PubMed ID: 11181995

Database document:

PubMed ID: 10231032

PubMed ID: 15372022

PubMed ID: 11972023

PubMed ID: 14722083

PubMed ID: 15312654

PubMed ID: 23805378

PubMed ID: 28130356

PubMed ID: 25533962

PubMed ID: 29100089

PubMed ID: 29560374

PubMed ID: 29784083

PubMed ID: 35568036

PubMed ID: 15489334

PubMed ID: 11181995