Gene CAMK2A - ENSG00000070808 | NCBI Gene ID: 815

Details for: CAMK2A

Gene ID: 815

Symbol: CAMK2A

Ensembl ID: ENSG00000070808

Description: calcium/calmodulin dependent protein kinase II alpha

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Assembly and cell surface presentation of nmda receptors
(R-HSA-9609736)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca-dependent events
(R-HSA-111996)
Ca2+ pathway
(R-HSA-4086398)
Calmodulin induced events
(R-HSA-111933)
Camk iv-mediated phosphorylation of creb
(R-HSA-111932)
Cam pathway
(R-HSA-111997)
Cardiac conduction
(R-HSA-5576891)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Creb1 phosphorylation through nmda receptor-mediated activation of ras signaling
(R-HSA-442742)
Cytokine signaling in immune system
(R-HSA-1280215)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-HSA-399721)
Gpcr downstream signalling
(R-HSA-388396)
Hsf1-dependent transactivation
(R-HSA-3371571)
Immune system
(R-HSA-168256)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion channel transport
(R-HSA-983712)
Ion homeostasis
(R-HSA-5578775)
Ion transport by p-type atpases
(R-HSA-936837)
Long-term potentiation
(R-HSA-9620244)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Muscle contraction
(R-HSA-397014)
Negative regulation of nmda receptor-mediated neuronal transmission
(R-HSA-9617324)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Oncogenic mapk signaling
(R-HSA-6802957)
Opioid signalling
(R-HSA-111885)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Phase 0 - rapid depolarisation
(R-HSA-5576892)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Ras activation upon ca2+ influx through nmda receptor
(R-HSA-442982)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by gpcr
(R-HSA-372790)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by wnt
(R-HSA-195721)
Signaling downstream of ras mutants
(R-HSA-9649948)
Signal transduction
(R-HSA-162582)
Trafficking of ampa receptors
(R-HSA-399719)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Unblocking of nmda receptors, glutamate binding and activation
(R-HSA-438066)
Angiotensin-activated signaling pathway
(GO:0038166)
Atp binding
(GO:0005524)
Calcium ion transport
(GO:0006816)
Calmodulin-dependent protein kinase activity
(GO:0004683)
Calmodulin binding
(GO:0005516)
Cellular response to interferon-beta
(GO:0035458)
Cellular response to type ii interferon
(GO:0071346)
Dendritic spine development
(GO:0060996)
G1/s transition of mitotic cell cycle
(GO:0000082)
Glutamate receptor binding
(GO:0035254)
Identical protein binding
(GO:0042802)
Kinase activity
(GO:0016301)
Metal ion binding
(GO:0046872)
Negative regulation of hydrolase activity
(GO:0051346)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine autophosphorylation
(GO:1990443)
Positive regulation of calcium ion transport
(GO:0051928)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of endocannabinoid signaling pathway
(GO:2000124)
Regulation of mitochondrial membrane permeability involved in apoptotic process
(GO:1902108)
Regulation of neuronal synaptic plasticity
(GO:0048168)
Regulation of neuron migration
(GO:2001222)
Regulation of neurotransmitter secretion
(GO:0046928)
Response to ischemia
(GO:0002931)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.65
Marker Score: 4450
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.56
Marker Score: 7317
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.33
Marker Score: 46346
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.25
Marker Score: 85285
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.06
Marker Score: 8529
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.05
Marker Score: 15701.5
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.05
Marker Score: 19260
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.04
Marker Score: 125191
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.93
Marker Score: 71168
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.91
Marker Score: 18146
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 1.88
Marker Score: 1429
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.85
Marker Score: 15932.5
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.77
Marker Score: 6845
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.72
Marker Score: 25774
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.65
Marker Score: 2550
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1169
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.58
Marker Score: 1572
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.57
Marker Score: 920
Cell Name: neuron (CL0000540)
Fold Change: 1.52
Marker Score: 6208
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 854
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 486
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.16
Marker Score: 11969
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4810.5
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.13
Marker Score: 715.5
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 502
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.05
Marker Score: 333
Cell Name: goblet cell (CL0000160)
Fold Change: 1.04
Marker Score: 6938
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 795
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.03
Marker Score: 681
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71819
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48044
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 508
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 461
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.97
Marker Score: 8203
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.95
Marker Score: 471
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.94
Marker Score: 3936
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5351
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.94
Marker Score: 1775
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 373
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.89
Marker Score: 13944
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.87
Marker Score: 18634
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5286
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.81
Marker Score: 1681
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 708
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.76
Marker Score: 1548
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.65
Marker Score: 6584
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.65
Marker Score: 429
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.62
Marker Score: 394
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.59
Marker Score: 471
Cell Name: plasma cell (CL0000786)
Fold Change: 0.58
Marker Score: 651
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.57
Marker Score: 661
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 232
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.55
Marker Score: 262
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 173
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.55
Marker Score: 18462
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.54
Marker Score: 196
Cell Name: astrocyte (CL0000127)
Fold Change: 0.54
Marker Score: 465.5
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.48
Marker Score: 286
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.46
Marker Score: 435
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.45
Marker Score: 142
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.44
Marker Score: 1035
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.42
Marker Score: 859
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.42
Marker Score: 506
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.42
Marker Score: 243
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.42
Marker Score: 403
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.42
Marker Score: 106
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.41
Marker Score: 142
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.38
Marker Score: 1780
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.38
Marker Score: 229
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 371
Cell Name: B cell (CL0000236)
Fold Change: 0.37
Marker Score: 349
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.37
Marker Score: 95
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.36
Marker Score: 113
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.35
Marker Score: 113
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.35
Marker Score: 3060
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.32
Marker Score: 767
Cell Name: podocyte (CL0000653)
Fold Change: 0.31
Marker Score: 113
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.29
Marker Score: 111
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.29
Marker Score: 100
Cell Name: oocyte (CL0000023)
Fold Change: 0.29
Marker Score: 71
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.27
Marker Score: 119
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.26
Marker Score: 116
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.25
Marker Score: 78
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.25
Marker Score: 306.5
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.24
Marker Score: 868
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 0.24
Marker Score: 135
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.24
Marker Score: 298
Cell Name: microglial cell (CL0000129)
Fold Change: 0.23
Marker Score: 422
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 64.5
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.23
Marker Score: 181
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: interneuron (CL0000099)
Fold Change: 0.22
Marker Score: 98.5

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## Summary The CAMK2A gene encodes a protein belonging to the calcium/calmodulin-dependent protein kinase family. It is significantly expressed in various brain regions, particularly in neurons of the cerebral cortex, thalamus, and basal ganglia. ## Key characteristics * **Function:** CAMK2A is a key regulator of cardiac conduction, cellular responses to stimuli, cellular responses to stress, and cytokine signaling in the immune system. * **Expression:** It is highly expressed in pyramidal neurons, which are specialized neurons involved in learning and memory. * **Localization:** It is also expressed in other brain regions, including the cerebral cortex, thalamus, and basal ganglia. ## Pathways and functions * **Cardiac conduction:** CAMK2A is involved in maintaining cardiac conduction by regulating the heart rate and contractility of cardiac cells. * **Cellular responses to stimuli:** It plays a role in the regulation of cellular responses to various stimuli, such as those caused by growth factors, cytokines, and stress factors. * **Cytokine signaling in immune system:** CAMK2A is a key regulator of cytokine signaling in the immune system. It is expressed in immune cells and is involved in the regulation of immune responses to pathogens and inflammatory stimuli. * **Diseases of signal transduction by growth factor receptors and second messengers:** CAMK2A is involved in the regulation of signal transduction by growth factor receptors and second messengers. ## Clinical significance Mutations in the CAMK2A gene have been linked to several neurological and psychiatric disorders, including schizophrenia, autism, and anxiety disorders. These disorders are characterized by abnormal brain function and synaptic plasticity. CAMK2A is a promising target for the treatment of neurological and psychiatric disorders. Inhibition of CAMK2A has been shown to ameliorate many of the symptoms of these disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 3508354350

Symbol: KCC2A_HUMAN

Name: Calcium/calmodulin-dependent protein kinase type II subunit alpha

UniProtKB Accession Codes:

Q9UQM7 Q9UL21 Q9Y2H4 Q9Y352

Database IDs:

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 11972023

Title: Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.

PubMed ID: 11972023

DOI: 10.1073/pnas.052159099

PubMed ID: 14722083

Title: Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II.

PubMed ID: 14722083

DOI: 10.1074/jbc.m313597200

PubMed ID: 15312654

Title: SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.

PubMed ID: 15312654

DOI: 10.1016/j.neuron.2004.08.003

PubMed ID: 23805378

Title: CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16.

PubMed ID: 23805378

DOI: 10.7554/elife.00518

PubMed ID: 28130356

Title: Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.

PubMed ID: 28130356

DOI: 10.1523/jneurosci.2068-16.2017

PubMed ID: 25533962

Title: Large-scale discovery of novel genetic causes of developmental disorders.

PubMed ID: 25533962

DOI: 10.1038/nature14135

PubMed ID: 29100089

Title: De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.

PubMed ID: 29100089

DOI: 10.1016/j.ajhg.2017.10.003

PubMed ID: 29560374

Title: De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders.

PubMed ID: 29560374

DOI: 10.1002/acn3.528

PubMed ID: 29784083

Title: A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability.

PubMed ID: 29784083

DOI: 10.7554/elife.32451

PubMed ID: 35568036

Title: A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling.

PubMed ID: 35568036

DOI: 10.1016/j.cell.2022.04.028

Sequence Information:

Length: 478
Mass: 54088
Checksum: 208143A311BA9262
Sequence:

MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARDHQKLERE 
ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL 
EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGFAGTPGYL 
SPEVLRKDPY GKPVDLWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV 
TPEAKDLINK MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK 
GAILTTMLAT RNFSGGKSGG NKKSDGVKES SESTNTTIED EDTKVRKQEI IKVTEQLIEA 
ISNGDFESYT KMCDPGMTAF EPEALGNLVE GLDFHRFYFE NLWSRNSKPV HTTILNPHIH 
LMGDESACIA YIRITQYLDA GGIPRTAQSE ETRVWHRRDG KWQIVHFHRS GAPSVLPH

Genular Protein ID: 2861623886

Symbol: A8K161_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K161

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 489
Mass: 55320
Checksum: 41E67A1E15EB142B
Sequence:

MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARDHQKLERE 
ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL 
EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGFAGTPGYL 
SPEVLRKDPY GKPVDLWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV 
TPEAKDLINK MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK 
GAILTTMLAT RNFSGGKSGG NKKSDGVKKR KSSSSVQLME SSESTNTTIE DEDTKVRKQE 
IIKVTEQLIE AISNGDFESY TKMCDPGMTA FEPEALGNLV EGLDFHRFYF ENLWSRNSKP 
VHTTILNPHI HLMGDESACI AYIRITQYLD AGGIPRTAQS EETRVWHRRD GKWQIVHFHR 
SGAPSVLPH

Genular Protein ID: 67767485

Symbol: Q8IWE0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IWE0

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 478
Mass: 54088
Checksum: BAE143AA03BA9264
Sequence:

MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARDHQKLERE 
ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL 
EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGFAGTPGYL 
SPEVLRKDPY GKPVDLWACG VILYILLVGY PPFWDEDQHR LYKQIKAGAY DFPSPEWDTV 
TPEAKDLINK MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK 
GAILTTMLAT RNFSGGKSGG NKKSDGVKES SESTNTTIED EDTKVRKQEI IKVTEQLIEA 
ISNGDFESYT KMCDPGMTAF EPEALGNLVE GLDFHRFYFE NLWSRNSKPV HTTILNPHIH 
LMGDESACIA YIRITQYLDA GGIPRTAQSE ETRVWHRRDG KWQIVHFHRS GAPSVLPH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CAMK2A

Associated with

Cells (max top 100)

Other Information

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10231032

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma. PubMed ID: 11972023

Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. PubMed ID: 14722083

SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. PubMed ID: 15312654

CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16. PubMed ID: 23805378

Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. PubMed ID: 28130356

Large-scale discovery of novel genetic causes of developmental disorders. PubMed ID: 25533962

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. PubMed ID: 29100089

De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders. PubMed ID: 29560374

A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability. PubMed ID: 29784083

A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling. PubMed ID: 35568036

The sequence of the human genome. PubMed ID: 11181995

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Database document:

PubMed ID: 10231032

PubMed ID: 15372022

PubMed ID: 11972023

PubMed ID: 14722083

PubMed ID: 15312654

PubMed ID: 23805378

PubMed ID: 28130356

PubMed ID: 25533962

PubMed ID: 29100089

PubMed ID: 29560374

PubMed ID: 29784083

PubMed ID: 35568036

PubMed ID: 11181995

PubMed ID: 15489334