CAMK2B | ENSG00000058404 | NCBI 816

Details for: CAMK2B

Gene ID: 816

Symbol: CAMK2B

Ensembl ID: ENSG00000058404

Description: calcium/calmodulin dependent protein kinase II beta

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Assembly and cell surface presentation of nmda receptors
(R-HSA-9609736)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Camk iv-mediated phosphorylation of creb
(R-HSA-111932)
Cam pathway
(R-HSA-111997)
Cardiac conduction
(R-HSA-5576891)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Creb1 phosphorylation through nmda receptor-mediated activation of ras signaling
(R-HSA-442742)
Creb1 phosphorylation through the activation of camkii/camkk/camkiv cascasde
(R-HSA-442729)
Cytokine signaling in immune system
(R-HSA-1280215)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-HSA-399721)
Gpcr downstream signalling
(R-HSA-388396)
Hsf1-dependent transactivation
(R-HSA-3371571)
Immune system
(R-HSA-168256)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion channel transport
(R-HSA-983712)
Ion homeostasis
(R-HSA-5578775)
Ion transport by p-type atpases
(R-HSA-936837)
Long-term potentiation
(R-HSA-9620244)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Muscle contraction
(R-HSA-397014)
Negative regulation of nmda receptor-mediated neuronal transmission
(R-HSA-9617324)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Oncogenic mapk signaling
(R-HSA-6802957)
Opioid signalling
(R-HSA-111885)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Phase 0 - rapid depolarisation
(R-HSA-5576892)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Ras activation upon ca2+ influx through nmda receptor
(R-HSA-442982)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by gpcr
(R-HSA-372790)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling downstream of ras mutants
(R-HSA-9649948)
Trafficking of ampa receptors
(R-HSA-399719)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Unblocking of nmda receptors, glutamate binding and activation
(R-HSA-438066)
Actin binding
(GO:0003779)
Atp binding
(GO:0005524)
Calcium- and calmodulin-dependent protein kinase complex
(GO:0005954)
Calcium-dependent protein serine/threonine kinase activity
(GO:0009931)
Calmodulin-dependent protein kinase activity
(GO:0004683)
Calmodulin binding
(GO:0005516)
Cell differentiation
(GO:0030154)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endocytic vesicle membrane
(GO:0030666)
Identical protein binding
(GO:0042802)
Nervous system development
(GO:0007399)
Neuron projection
(GO:0043005)
Nucleoplasm
(GO:0005654)
Peptidyl-serine phosphorylation
(GO:0018105)
Positive regulation of dendritic spine morphogenesis
(GO:0061003)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of synapse maturation
(GO:0090129)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein phosphorylation
(GO:0006468)
Protein serine kinase activity
(GO:0106310)
Regulation of calcium ion transport
(GO:0051924)
Regulation of dendritic spine development
(GO:0060998)
Regulation of long-term neuronal synaptic plasticity
(GO:0048169)
Regulation of neuron migration
(GO:2001222)
Regulation of skeletal muscle adaptation
(GO:0014733)
Regulation of synapse structural plasticity
(GO:0051823)
Sarcoplasmic reticulum membrane
(GO:0033017)
Signal transduction
(GO:0007165)
Synapse
(GO:0045202)

Other Information

Proteins

Calcium/calmodulin-dependent protein kinase type II subunit beta
B7Z1Z6_HUMAN

Genular Protein ID: 3454572469

Symbol: KCC2B_HUMAN

Name: Calcium/calmodulin-dependent protein kinase type II subunit beta

UniProtKB Accession Codes:

Q13554 A4D2K0 A4D2K1 A4D2K2 A4D2K3 A4D2K4 A4D2K5 A4D2K6 O95437 O95438 O95599 Q9UGH7 Q9UGH8 Q9UGH9 Q9UNX0 Q9UNX7 Q9UP00 Q9Y5N4 Q9Y6F4

Database IDs:

Citations:

PubMed ID: 10858498

Title: Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities.

PubMed ID: 10858498

DOI: 10.1016/s0014-5793(00)01634-3

PubMed ID: 10819240

Title: Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells.

PubMed ID: 10819240

DOI: 10.1007/s001250051330

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9060999

Title: Identification of novel human tumor cell-specific CaMK-II variants.

PubMed ID: 9060999

DOI: 10.1016/s0167-4889(96)00141-3

PubMed ID: 14722083

Title: Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II.

PubMed ID: 14722083

DOI: 10.1074/jbc.m313597200

PubMed ID: 15312654

Title: SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.

PubMed ID: 15312654

DOI: 10.1016/j.neuron.2004.08.003

PubMed ID: 16690701

Title: Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise.

PubMed ID: 16690701

DOI: 10.1113/jphysiol.2006.111757

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21529938

Title: Analysis of CaM-kinase signaling in cells.

PubMed ID: 21529938

DOI: 10.1016/j.ceca.2011.02.007

PubMed ID: 15294044

Title: The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis.

PubMed ID: 15294044

DOI: 10.1079/pns2004335

PubMed ID: 18817731

Title: Calmodulin-kinases: modulators of neuronal development and plasticity.

PubMed ID: 18817731

DOI: 10.1016/j.neuron.2008.08.021

PubMed ID: 19996366

Title: The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag?

PubMed ID: 19996366

DOI: 10.1152/physiol.00029.2009

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31930741

Title: FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy.

PubMed ID: 31930741

DOI: 10.15252/embj.2019102608

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 29100089

Title: De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.

PubMed ID: 29100089

DOI: 10.1016/j.ajhg.2017.10.003

PubMed ID: 29560374

Title: De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders.

PubMed ID: 29560374

DOI: 10.1002/acn3.528

Sequence Information:

Length: 666
Mass: 72678
Checksum: 8CACFC3E392C3857
Sequence:

MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 
EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 
LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 
LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 
VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 
KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD GVKPQTNSTK 
NSAAATSPKG TLPPAALEPQ TTVIHNPVDG IKESSDSANT TIEDEDAKAP RVPDILSSVR 
RGSGAPEAEG PLPCPSPAPF SPLPAPSPRI SDILNSVRRG SGTPEAEGPL SAGPPPCLSP 
ALLGPLSSPS PRISDILNSV RRGSGTPEAE GPSPVGPPPC PSPTIPGPLP TPSRKQEIIK 
TTEQLIEAVN NGDFEAYAKI CDPGLTSFEP EALGNLVEGM DFHRFYFENL LAKNSKPIHT 
TILNPHVHVI GEDAACIAYI RLTQYIDGQG RPRTSQSEET RVWHRRDGKW QNVHFHCSGA 
PVAPLQ

Genular Protein ID: 2641500323

Symbol: B7Z1Z6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1Z6

Database IDs:

Sequence Information:

Length: 305
Mass: 33295
Checksum: D5587FCFDD28E56E
Sequence:

MGVVHRDLKP ENLLLASKCK GAAVKLADFG LAIEVQGDQQ AWFGFAGTPG YLSPEVLRKE 
AYGKPVDIWA CGVILYILLV GYPPFWDEDQ HKLYQQIKAG AYDFPSPEWD TVTPEAKNLI 
NQMLTINPAK RITAHEALKH PWVCQRSTVA SMMHRQETVE CLKKFNARRK LKGAILTTML 
ATRNFSVGRQ TTAPATMSTA ASGTTMGLVE QAKSLLNKKA DGVKPQTNST KNSAAATSPK 
GTLPPAALEP QTTVIHNPVD GIKESSDSAN TTIEDEDAKA RKQEIIKTTE QLIEAVNNGD 
FEAYA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CAMK2B

Associated with

Other Information

Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities. PubMed ID: 10858498

Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells. PubMed ID: 10819240

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of novel human tumor cell-specific CaMK-II variants. PubMed ID: 9060999

Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. PubMed ID: 14722083

SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. PubMed ID: 15312654

Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise. PubMed ID: 16690701

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Analysis of CaM-kinase signaling in cells. PubMed ID: 21529938

The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis. PubMed ID: 15294044

Calmodulin-kinases: modulators of neuronal development and plasticity. PubMed ID: 18817731

The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag? PubMed ID: 19996366

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy. PubMed ID: 31930741

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. PubMed ID: 29100089

De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders. PubMed ID: 29560374