CAMK2B | ENSG00000058404 | NCBI 816

Details for: CAMK2B

Gene ID: 816

Symbol: CAMK2B

Ensembl ID: ENSG00000058404

Description: calcium/calmodulin dependent protein kinase II beta

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Assembly and cell surface presentation of nmda receptors
(R-HSA-9609736)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Camk iv-mediated phosphorylation of creb
(R-HSA-111932)
Cam pathway
(R-HSA-111997)
Cardiac conduction
(R-HSA-5576891)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Creb1 phosphorylation through nmda receptor-mediated activation of ras signaling
(R-HSA-442742)
Creb1 phosphorylation through the activation of camkii/camkk/camkiv cascasde
(R-HSA-442729)
Cytokine signaling in immune system
(R-HSA-1280215)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-HSA-399721)
Gpcr downstream signalling
(R-HSA-388396)
Hsf1-dependent transactivation
(R-HSA-3371571)
Immune system
(R-HSA-168256)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion channel transport
(R-HSA-983712)
Ion homeostasis
(R-HSA-5578775)
Ion transport by p-type atpases
(R-HSA-936837)
Long-term potentiation
(R-HSA-9620244)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Muscle contraction
(R-HSA-397014)
Negative regulation of nmda receptor-mediated neuronal transmission
(R-HSA-9617324)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Oncogenic mapk signaling
(R-HSA-6802957)
Opioid signalling
(R-HSA-111885)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Phase 0 - rapid depolarisation
(R-HSA-5576892)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Ras activation upon ca2+ influx through nmda receptor
(R-HSA-442982)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by gpcr
(R-HSA-372790)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling downstream of ras mutants
(R-HSA-9649948)
Trafficking of ampa receptors
(R-HSA-399719)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Unblocking of nmda receptors, glutamate binding and activation
(R-HSA-438066)
Actin binding
(GO:0003779)
Atp binding
(GO:0005524)
Calcium- and calmodulin-dependent protein kinase complex
(GO:0005954)
Calcium-dependent protein serine/threonine kinase activity
(GO:0009931)
Calmodulin-dependent protein kinase activity
(GO:0004683)
Calmodulin binding
(GO:0005516)
Cell differentiation
(GO:0030154)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endocytic vesicle membrane
(GO:0030666)
Identical protein binding
(GO:0042802)
Nervous system development
(GO:0007399)
Neuron projection
(GO:0043005)
Nucleoplasm
(GO:0005654)
Peptidyl-serine phosphorylation
(GO:0018105)
Positive regulation of dendritic spine morphogenesis
(GO:0061003)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of synapse maturation
(GO:0090129)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein phosphorylation
(GO:0006468)
Protein serine kinase activity
(GO:0106310)
Regulation of calcium ion transport
(GO:0051924)
Regulation of dendritic spine development
(GO:0060998)
Regulation of long-term neuronal synaptic plasticity
(GO:0048169)
Regulation of neuron migration
(GO:2001222)
Regulation of skeletal muscle adaptation
(GO:0014733)
Regulation of synapse structural plasticity
(GO:0051823)
Sarcoplasmic reticulum membrane
(GO:0033017)
Signal transduction
(GO:0007165)
Synapse
(GO:0045202)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.61
Marker Score: 7,432
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.53
Marker Score: 4,256
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.51
Marker Score: 19,236
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.44
Marker Score: 4,962
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.44
Marker Score: 36,479
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.4
Marker Score: 47,725
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.4
Marker Score: 91,034
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.39
Marker Score: 9,891
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.22
Marker Score: 82,018
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.21
Marker Score: 47,246
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 2.2
Marker Score: 1,151
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.2
Marker Score: 7,825
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.17
Marker Score: 8,406
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.02
Marker Score: 18,979
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.01
Marker Score: 123,356
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.95
Marker Score: 20,153
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.91
Marker Score: 18,147
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.85
Marker Score: 15,921
Cell Name: endocrine cell (CL0000163)
Fold Change: 1.77
Marker Score: 914
Cell Name: neuron (CL0000540)
Fold Change: 1.7
Marker Score: 6,925
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.7
Marker Score: 711
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.67
Marker Score: 2,020
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.66
Marker Score: 619
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.66
Marker Score: 3,136
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.65
Marker Score: 1,085
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.64
Marker Score: 2,537
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.64
Marker Score: 55,489
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.63
Marker Score: 1,537
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.63
Marker Score: 6,790
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.61
Marker Score: 36,063
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1,167
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.58
Marker Score: 7,313
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168,792
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.34
Marker Score: 20,909
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.32
Marker Score: 362
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.28
Marker Score: 405
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 1.23
Marker Score: 407
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.17
Marker Score: 449
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,811
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.14
Marker Score: 1,606
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.13
Marker Score: 715
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.12
Marker Score: 2,276
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 501
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.08
Marker Score: 436
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.04
Marker Score: 707
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 793
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,815
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1
Marker Score: 414
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,040
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 507
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408
Cell Name: stellate neuron (CL0000122)
Fold Change: 0.97
Marker Score: 5,233
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 460
Cell Name: astrocyte (CL0000127)
Fold Change: 0.97
Marker Score: 839
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,345
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 372
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,739
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: granule cell (CL0000120)
Fold Change: 0.88
Marker Score: 6,663
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,287
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.86
Marker Score: 288
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.83
Marker Score: 1,948
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.82
Marker Score: 4,311
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.79
Marker Score: 473
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,261
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 708
Cell Name: macroglial cell (CL0000126)
Fold Change: 0.77
Marker Score: 1,772
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.76
Marker Score: 239
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.75
Marker Score: 564
Cell Name: male germ cell (CL0000015)
Fold Change: 0.73
Marker Score: 209
Cell Name: PP cell (CL0000696)
Fold Change: 0.72
Marker Score: 163
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 460
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.71
Marker Score: 183
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.7
Marker Score: 361
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.69
Marker Score: 777
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.69
Marker Score: 402
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.67
Marker Score: 1,951
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.67
Marker Score: 612
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.66
Marker Score: 2,201
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.66
Marker Score: 313
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.65
Marker Score: 6,629
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.63
Marker Score: 218
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.6
Marker Score: 194
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 442
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 174
Cell Name: epithelial cell of thymus (CL0002293)
Fold Change: 0.54
Marker Score: 173
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.53
Marker Score: 863
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.5
Marker Score: 486
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.49
Marker Score: 276
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.48
Marker Score: 1,415
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.45
Marker Score: 516
Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.45
Marker Score: 215
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.44
Marker Score: 1,319
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.44
Marker Score: 159
Cell Name: centrocyte (CL0009111)
Fold Change: 0.43
Marker Score: 102
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.42
Marker Score: 412

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics** CAMK2B is a member of the calcium/calmodulin-dependent protein kinase (CaMK) family, which consists of four distinct isoforms (CaMK II, CaMK IV, CaMK IIα, and CaMK IIβ). CAMK2B is the beta subunit of CaMK II, which is a tetrameric enzyme consisting of two catalytic subunits (α and β) and two regulatory subunits (γ and δ). The beta subunit of CaMK II is highly conserved across species and is essential for the enzyme's activity. **Pathways and Functions** CAMK2B is involved in multiple signaling pathways, including: 1. **Synaptic Plasticity**: CAMK2B regulates the phosphorylation of NMDA receptors, AMPA receptors, and other synaptic proteins, modulating synaptic transmission and plasticity. 2. **Neuronal Development**: CAMK2B is involved in the regulation of neuronal migration, differentiation, and synaptogenesis. 3. **Immune Response**: CAMK2B plays a role in the regulation of cytokine signaling and the activation of immune cells. 4. **Long-term Potentiation**: CAMK2B is involved in the regulation of long-term potentiation, a form of synaptic plasticity that underlies learning and memory. **Clinical Significance** Mutations in the CAMK2B gene have been associated with several neurological disorders, including: 1. **Autism Spectrum Disorder**: Studies have shown that mutations in CAMK2B are more common in individuals with autism spectrum disorder than in the general population. 2. **Schizophrenia**: CAMK2B has been implicated in the pathophysiology of schizophrenia, with some studies suggesting that mutations in the gene may contribute to the development of the disorder. 3. **Epilepsy**: CAMK2B has been associated with a subset of epilepsy disorders, particularly those characterized by abnormal synaptic plasticity. In conclusion, CAMK2B is a critical component of the neuronal signaling pathway, playing a key role in regulating synaptic plasticity, neuronal development, and immune response. Mutations in the CAMK2B gene have been associated with several neurological disorders, highlighting the importance of this gene in human health and disease. Further research is needed to fully elucidate the mechanisms by which CAMK2B regulates cellular processes and to develop therapeutic strategies for the treatment of CAMK2B-related disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Calcium/calmodulin-dependent protein kinase type II subunit beta
B7Z1Z6_HUMAN

Genular Protein ID: 3454572469

Symbol: KCC2B_HUMAN

Name: Calcium/calmodulin-dependent protein kinase type II subunit beta

UniProtKB Accession Codes:

Q13554 A4D2K0 A4D2K1 A4D2K2 A4D2K3 A4D2K4 A4D2K5 A4D2K6 O95437 O95438 O95599 Q9UGH7 Q9UGH8 Q9UGH9 Q9UNX0 Q9UNX7 Q9UP00 Q9Y5N4 Q9Y6F4

Database IDs:

Citations:

PubMed ID: 10858498

Title: Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities.

PubMed ID: 10858498

DOI: 10.1016/s0014-5793(00)01634-3

PubMed ID: 10819240

Title: Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells.

PubMed ID: 10819240

DOI: 10.1007/s001250051330

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9060999

Title: Identification of novel human tumor cell-specific CaMK-II variants.

PubMed ID: 9060999

DOI: 10.1016/s0167-4889(96)00141-3

PubMed ID: 14722083

Title: Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II.

PubMed ID: 14722083

DOI: 10.1074/jbc.m313597200

PubMed ID: 15312654

Title: SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.

PubMed ID: 15312654

DOI: 10.1016/j.neuron.2004.08.003

PubMed ID: 16690701

Title: Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise.

PubMed ID: 16690701

DOI: 10.1113/jphysiol.2006.111757

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21529938

Title: Analysis of CaM-kinase signaling in cells.

PubMed ID: 21529938

DOI: 10.1016/j.ceca.2011.02.007

PubMed ID: 15294044

Title: The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis.

PubMed ID: 15294044

DOI: 10.1079/pns2004335

PubMed ID: 18817731

Title: Calmodulin-kinases: modulators of neuronal development and plasticity.

PubMed ID: 18817731

DOI: 10.1016/j.neuron.2008.08.021

PubMed ID: 19996366

Title: The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag?

PubMed ID: 19996366

DOI: 10.1152/physiol.00029.2009

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31930741

Title: FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy.

PubMed ID: 31930741

DOI: 10.15252/embj.2019102608

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 29100089

Title: De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.

PubMed ID: 29100089

DOI: 10.1016/j.ajhg.2017.10.003

PubMed ID: 29560374

Title: De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders.

PubMed ID: 29560374

DOI: 10.1002/acn3.528

Sequence Information:

Length: 666
Mass: 72678
Checksum: 8CACFC3E392C3857
Sequence:

MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 
EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 
LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 
LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 
VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 
KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD GVKPQTNSTK 
NSAAATSPKG TLPPAALEPQ TTVIHNPVDG IKESSDSANT TIEDEDAKAP RVPDILSSVR 
RGSGAPEAEG PLPCPSPAPF SPLPAPSPRI SDILNSVRRG SGTPEAEGPL SAGPPPCLSP 
ALLGPLSSPS PRISDILNSV RRGSGTPEAE GPSPVGPPPC PSPTIPGPLP TPSRKQEIIK 
TTEQLIEAVN NGDFEAYAKI CDPGLTSFEP EALGNLVEGM DFHRFYFENL LAKNSKPIHT 
TILNPHVHVI GEDAACIAYI RLTQYIDGQG RPRTSQSEET RVWHRRDGKW QNVHFHCSGA 
PVAPLQ

Genular Protein ID: 2641500323

Symbol: B7Z1Z6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1Z6

Database IDs:

Sequence Information:

Length: 305
Mass: 33295
Checksum: D5587FCFDD28E56E
Sequence:

MGVVHRDLKP ENLLLASKCK GAAVKLADFG LAIEVQGDQQ AWFGFAGTPG YLSPEVLRKE 
AYGKPVDIWA CGVILYILLV GYPPFWDEDQ HKLYQQIKAG AYDFPSPEWD TVTPEAKNLI 
NQMLTINPAK RITAHEALKH PWVCQRSTVA SMMHRQETVE CLKKFNARRK LKGAILTTML 
ATRNFSVGRQ TTAPATMSTA ASGTTMGLVE QAKSLLNKKA DGVKPQTNST KNSAAATSPK 
GTLPPAALEP QTTVIHNPVD GIKESSDSAN TTIEDEDAKA RKQEIIKTTE QLIEAVNNGD 
FEAYA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CAMK2B

Associated with

Cells (max top 100)

Other Information

Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities. PubMed ID: 10858498

Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells. PubMed ID: 10819240

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of novel human tumor cell-specific CaMK-II variants. PubMed ID: 9060999

Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. PubMed ID: 14722083

SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. PubMed ID: 15312654

Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise. PubMed ID: 16690701

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Analysis of CaM-kinase signaling in cells. PubMed ID: 21529938

The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis. PubMed ID: 15294044

Calmodulin-kinases: modulators of neuronal development and plasticity. PubMed ID: 18817731

The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag? PubMed ID: 19996366

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy. PubMed ID: 31930741

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. PubMed ID: 29100089

De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders. PubMed ID: 29560374