CAMK2B | ENSG00000058404 | NCBI 816

Details for: CAMK2B

Gene ID: 816

Symbol: CAMK2B

Ensembl ID: ENSG00000058404

Description: calcium/calmodulin dependent protein kinase II beta

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Assembly and cell surface presentation of nmda receptors
(R-HSA-9609736)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Camk iv-mediated phosphorylation of creb
(R-HSA-111932)
Cam pathway
(R-HSA-111997)
Cardiac conduction
(R-HSA-5576891)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Creb1 phosphorylation through nmda receptor-mediated activation of ras signaling
(R-HSA-442742)
Creb1 phosphorylation through the activation of camkii/camkk/camkiv cascasde
(R-HSA-442729)
Cytokine signaling in immune system
(R-HSA-1280215)
Dag and ip3 signaling
(R-HSA-1489509)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-HSA-399721)
Gpcr downstream signalling
(R-HSA-388396)
Hsf1-dependent transactivation
(R-HSA-3371571)
Immune system
(R-HSA-168256)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion channel transport
(R-HSA-983712)
Ion homeostasis
(R-HSA-5578775)
Ion transport by p-type atpases
(R-HSA-936837)
Long-term potentiation
(R-HSA-9620244)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Muscle contraction
(R-HSA-397014)
Negative regulation of nmda receptor-mediated neuronal transmission
(R-HSA-9617324)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Oncogenic mapk signaling
(R-HSA-6802957)
Opioid signalling
(R-HSA-111885)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Phase 0 - rapid depolarisation
(R-HSA-5576892)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Ras activation upon ca2+ influx through nmda receptor
(R-HSA-442982)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by gpcr
(R-HSA-372790)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling downstream of ras mutants
(R-HSA-9649948)
Trafficking of ampa receptors
(R-HSA-399719)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Unblocking of nmda receptors, glutamate binding and activation
(R-HSA-438066)
Actin binding
(GO:0003779)
Atp binding
(GO:0005524)
Calcium- and calmodulin-dependent protein kinase complex
(GO:0005954)
Calcium/calmodulin-dependent protein kinase activity
(GO:0004683)
Calmodulin binding
(GO:0005516)
Cell differentiation
(GO:0030154)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endocytic vesicle membrane
(GO:0030666)
Identical protein binding
(GO:0042802)
Nervous system development
(GO:0007399)
Neuron projection
(GO:0043005)
Nucleoplasm
(GO:0005654)
Positive regulation of dendritic spine morphogenesis
(GO:0061003)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of synapse maturation
(GO:0090129)
Postsynaptic density
(GO:0014069)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein phosphorylation
(GO:0006468)
Protein serine kinase activity
(GO:0106310)
Regulation of calcium ion transport
(GO:0051924)
Regulation of dendritic spine development
(GO:0060998)
Regulation of long-term neuronal synaptic plasticity
(GO:0048169)
Regulation of neuronal synaptic plasticity
(GO:0048168)
Regulation of neuron migration
(GO:2001222)
Regulation of protein localization to plasma membrane
(GO:1903076)
Regulation of skeletal muscle adaptation
(GO:0014733)
Regulation of synapse structural plasticity
(GO:0051823)
Sarcoplasmic reticulum membrane
(GO:0033017)
Signal transduction
(GO:0007165)
Synapse
(GO:0045202)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 256.1956
Cell Significance Index: -39.8500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 158.2537
Cell Significance Index: -40.1400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 32.3369
Cell Significance Index: -39.8700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 30.3747
Cell Significance Index: -29.0000
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 14.5020
Cell Significance Index: 111.7800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 4.7740
Cell Significance Index: 136.2400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 4.5770
Cell Significance Index: 202.4500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 4.2568
Cell Significance Index: 161.2000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 4.1868
Cell Significance Index: 281.5200
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.8380
Cell Significance Index: 35.2000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.6587
Cell Significance Index: 533.3300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.3407
Cell Significance Index: 50.7100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.3304
Cell Significance Index: 835.8600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.2029
Cell Significance Index: 115.6600
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 2.0820
Cell Significance Index: 18.3400
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 1.7539
Cell Significance Index: 21.2600
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.7158
Cell Significance Index: 37.5700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.6373
Cell Significance Index: 125.6500
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.1115
Cell Significance Index: 8.5200
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.9475
Cell Significance Index: 12.6400
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.8370
Cell Significance Index: 10.8600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.7773
Cell Significance Index: 537.5900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.6296
Cell Significance Index: 10.7900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6236
Cell Significance Index: 563.0600
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 0.5986
Cell Significance Index: 8.3700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5464
Cell Significance Index: 54.0600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3251
Cell Significance Index: 61.8700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.3022
Cell Significance Index: 9.6800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2945
Cell Significance Index: 47.9000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2793
Cell Significance Index: 17.1700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1769
Cell Significance Index: 19.2400
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.1451
Cell Significance Index: 3.5400
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.1138
Cell Significance Index: 1.6800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0912
Cell Significance Index: 10.7600
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.0841
Cell Significance Index: 0.8000
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0809
Cell Significance Index: 1.9400
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.0294
Cell Significance Index: 0.3200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0080
Cell Significance Index: 0.2800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0079
Cell Significance Index: 5.8400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0023
Cell Significance Index: -4.2500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0054
Cell Significance Index: -0.3300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0088
Cell Significance Index: -4.9600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0106
Cell Significance Index: -6.6500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0156
Cell Significance Index: -0.4500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0171
Cell Significance Index: -31.4800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0207
Cell Significance Index: -31.9200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0228
Cell Significance Index: -30.9800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0258
Cell Significance Index: -16.3900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0315
Cell Significance Index: -0.8100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0370
Cell Significance Index: -27.1300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0372
Cell Significance Index: -7.8300
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0452
Cell Significance Index: -0.9600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0460
Cell Significance Index: -20.3400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0461
Cell Significance Index: -20.9400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0551
Cell Significance Index: -41.6700
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0577
Cell Significance Index: -31.4900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0624
Cell Significance Index: -10.6600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0780
Cell Significance Index: -5.3900
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0837
Cell Significance Index: -1.6800
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: -0.0956
Cell Significance Index: -1.0800
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0961
Cell Significance Index: -5.7700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1017
Cell Significance Index: -4.6100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1065
Cell Significance Index: -30.6400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1442
Cell Significance Index: -25.9900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1580
Cell Significance Index: -22.9700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1789
Cell Significance Index: -18.2700
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.1805
Cell Significance Index: -1.4900
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1863
Cell Significance Index: -36.9700
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1881
Cell Significance Index: -3.7200
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1908
Cell Significance Index: -24.6500
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1941
Cell Significance Index: -2.7800
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1995
Cell Significance Index: -4.3100
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.2037
Cell Significance Index: -2.5400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.2208
Cell Significance Index: -27.1500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2251
Cell Significance Index: -7.3700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2280
Cell Significance Index: -7.2600
Cell Name: neural cell (CL0002319)
Fold Change: -0.2662
Cell Significance Index: -3.1100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.2833
Cell Significance Index: -38.9100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2993
Cell Significance Index: -34.1700
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.3225
Cell Significance Index: -4.0700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3377
Cell Significance Index: -38.6900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3447
Cell Significance Index: -40.1700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3722
Cell Significance Index: -23.4600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3879
Cell Significance Index: -40.3900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4069
Cell Significance Index: -32.2300
Cell Name: neuron (CL0000540)
Fold Change: -0.4093
Cell Significance Index: -3.8800
Cell Name: odontoblast (CL0000060)
Fold Change: -0.4101
Cell Significance Index: -52.5700
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.4160
Cell Significance Index: -5.2500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4208
Cell Significance Index: -11.7600
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.4448
Cell Significance Index: -19.3400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4473
Cell Significance Index: -33.3400
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.4867
Cell Significance Index: -12.1400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5128
Cell Significance Index: -36.2700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5327
Cell Significance Index: -29.8900
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.5409
Cell Significance Index: -34.9000
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.5442
Cell Significance Index: -9.4100
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5472
Cell Significance Index: -19.1700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5558
Cell Significance Index: -28.9500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.5579
Cell Significance Index: -15.1900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.5606
Cell Significance Index: -29.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** CAMK2B is a member of the calcium/calmodulin-dependent protein kinase (CaMK) family, which consists of four distinct isoforms (CaMK II, CaMK IV, CaMK IIα, and CaMK IIβ). CAMK2B is the beta subunit of CaMK II, which is a tetrameric enzyme consisting of two catalytic subunits (α and β) and two regulatory subunits (γ and δ). The beta subunit of CaMK II is highly conserved across species and is essential for the enzyme's activity. **Pathways and Functions** CAMK2B is involved in multiple signaling pathways, including: 1. **Synaptic Plasticity**: CAMK2B regulates the phosphorylation of NMDA receptors, AMPA receptors, and other synaptic proteins, modulating synaptic transmission and plasticity. 2. **Neuronal Development**: CAMK2B is involved in the regulation of neuronal migration, differentiation, and synaptogenesis. 3. **Immune Response**: CAMK2B plays a role in the regulation of cytokine signaling and the activation of immune cells. 4. **Long-term Potentiation**: CAMK2B is involved in the regulation of long-term potentiation, a form of synaptic plasticity that underlies learning and memory. **Clinical Significance** Mutations in the CAMK2B gene have been associated with several neurological disorders, including: 1. **Autism Spectrum Disorder**: Studies have shown that mutations in CAMK2B are more common in individuals with autism spectrum disorder than in the general population. 2. **Schizophrenia**: CAMK2B has been implicated in the pathophysiology of schizophrenia, with some studies suggesting that mutations in the gene may contribute to the development of the disorder. 3. **Epilepsy**: CAMK2B has been associated with a subset of epilepsy disorders, particularly those characterized by abnormal synaptic plasticity. In conclusion, CAMK2B is a critical component of the neuronal signaling pathway, playing a key role in regulating synaptic plasticity, neuronal development, and immune response. Mutations in the CAMK2B gene have been associated with several neurological disorders, highlighting the importance of this gene in human health and disease. Further research is needed to fully elucidate the mechanisms by which CAMK2B regulates cellular processes and to develop therapeutic strategies for the treatment of CAMK2B-related disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Calcium/calmodulin-dependent protein kinase type II subunit beta
B7Z1Z6_HUMAN

Genular Protein ID: 3454572469

Symbol: KCC2B_HUMAN

Name: Calcium/calmodulin-dependent protein kinase type II subunit beta

UniProtKB Accession Codes:

Q13554 A4D2K0 A4D2K1 A4D2K2 A4D2K3 A4D2K4 A4D2K5 A4D2K6 O95437 O95438 O95599 Q9UGH7 Q9UGH8 Q9UGH9 Q9UNX0 Q9UNX7 Q9UP00 Q9Y5N4 Q9Y6F4

Database IDs:

Citations:

PubMed ID: 10858498

Title: Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities.

PubMed ID: 10858498

DOI: 10.1016/s0014-5793(00)01634-3

PubMed ID: 10819240

Title: Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells.

PubMed ID: 10819240

DOI: 10.1007/s001250051330

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9060999

Title: Identification of novel human tumor cell-specific CaMK-II variants.

PubMed ID: 9060999

DOI: 10.1016/s0167-4889(96)00141-3

PubMed ID: 14722083

Title: Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II.

PubMed ID: 14722083

DOI: 10.1074/jbc.m313597200

PubMed ID: 15312654

Title: SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.

PubMed ID: 15312654

DOI: 10.1016/j.neuron.2004.08.003

PubMed ID: 16690701

Title: Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise.

PubMed ID: 16690701

DOI: 10.1113/jphysiol.2006.111757

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21529938

Title: Analysis of CaM-kinase signaling in cells.

PubMed ID: 21529938

DOI: 10.1016/j.ceca.2011.02.007

PubMed ID: 15294044

Title: The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis.

PubMed ID: 15294044

DOI: 10.1079/pns2004335

PubMed ID: 18817731

Title: Calmodulin-kinases: modulators of neuronal development and plasticity.

PubMed ID: 18817731

DOI: 10.1016/j.neuron.2008.08.021

PubMed ID: 19996366

Title: The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag?

PubMed ID: 19996366

DOI: 10.1152/physiol.00029.2009

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31930741

Title: FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy.

PubMed ID: 31930741

DOI: 10.15252/embj.2019102608

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 29100089

Title: De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.

PubMed ID: 29100089

DOI: 10.1016/j.ajhg.2017.10.003

PubMed ID: 29560374

Title: De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders.

PubMed ID: 29560374

DOI: 10.1002/acn3.528

Sequence Information:

Length: 666
Mass: 72678
Checksum: 8CACFC3E392C3857
Sequence:

MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 
EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 
LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 
LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 
VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 
KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD GVKPQTNSTK 
NSAAATSPKG TLPPAALEPQ TTVIHNPVDG IKESSDSANT TIEDEDAKAP RVPDILSSVR 
RGSGAPEAEG PLPCPSPAPF SPLPAPSPRI SDILNSVRRG SGTPEAEGPL SAGPPPCLSP 
ALLGPLSSPS PRISDILNSV RRGSGTPEAE GPSPVGPPPC PSPTIPGPLP TPSRKQEIIK 
TTEQLIEAVN NGDFEAYAKI CDPGLTSFEP EALGNLVEGM DFHRFYFENL LAKNSKPIHT 
TILNPHVHVI GEDAACIAYI RLTQYIDGQG RPRTSQSEET RVWHRRDGKW QNVHFHCSGA 
PVAPLQ

Genular Protein ID: 2641500323

Symbol: B7Z1Z6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1Z6

Database IDs:

Sequence Information:

Length: 305
Mass: 33295
Checksum: D5587FCFDD28E56E
Sequence:

MGVVHRDLKP ENLLLASKCK GAAVKLADFG LAIEVQGDQQ AWFGFAGTPG YLSPEVLRKE 
AYGKPVDIWA CGVILYILLV GYPPFWDEDQ HKLYQQIKAG AYDFPSPEWD TVTPEAKNLI 
NQMLTINPAK RITAHEALKH PWVCQRSTVA SMMHRQETVE CLKKFNARRK LKGAILTTML 
ATRNFSVGRQ TTAPATMSTA ASGTTMGLVE QAKSLLNKKA DGVKPQTNST KNSAAATSPK 
GTLPPAALEP QTTVIHNPVD GIKESSDSAN TTIEDEDAKA RKQEIIKTTE QLIEAVNNGD 
FEAYA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CAMK2B

Associated with

Cells (max top 100)

Other Information

Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities. PubMed ID: 10858498

Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells. PubMed ID: 10819240

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of novel human tumor cell-specific CaMK-II variants. PubMed ID: 9060999

Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. PubMed ID: 14722083

SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. PubMed ID: 15312654

Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise. PubMed ID: 16690701

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Analysis of CaM-kinase signaling in cells. PubMed ID: 21529938

The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis. PubMed ID: 15294044

Calmodulin-kinases: modulators of neuronal development and plasticity. PubMed ID: 18817731

The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag? PubMed ID: 19996366

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy. PubMed ID: 31930741

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. PubMed ID: 29100089

De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders. PubMed ID: 29560374