Details for: CAMK2B

Gene ID: 816

Symbol: CAMK2B

Ensembl ID: ENSG00000058404

Description: calcium/calmodulin dependent protein kinase II beta

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.61
    Marker Score: 7,432
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.53
    Marker Score: 4,256
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.51
    Marker Score: 19,236
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.44
    Marker Score: 4,962
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.44
    Marker Score: 36,479
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.4
    Marker Score: 47,725
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.4
    Marker Score: 91,034
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.39
    Marker Score: 9,891
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.22
    Marker Score: 82,018
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.21
    Marker Score: 47,246
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.2
    Marker Score: 1,151
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.2
    Marker Score: 7,825
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.17
    Marker Score: 8,406
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.02
    Marker Score: 18,979
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.01
    Marker Score: 123,356
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.95
    Marker Score: 20,153
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18,147
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.85
    Marker Score: 15,921
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.77
    Marker Score: 914
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.7
    Marker Score: 6,925
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.7
    Marker Score: 711
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.67
    Marker Score: 2,020
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.66
    Marker Score: 619
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.66
    Marker Score: 3,136
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.65
    Marker Score: 1,085
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.64
    Marker Score: 2,537
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.64
    Marker Score: 55,489
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.63
    Marker Score: 1,537
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.63
    Marker Score: 6,790
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.61
    Marker Score: 36,063
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,167
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.58
    Marker Score: 7,313
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,792
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.34
    Marker Score: 20,909
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.32
    Marker Score: 362
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.28
    Marker Score: 405
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.23
    Marker Score: 407
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.17
    Marker Score: 449
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,811
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.14
    Marker Score: 1,606
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.13
    Marker Score: 715
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.12
    Marker Score: 2,276
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 501
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.08
    Marker Score: 436
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 707
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,815
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1
    Marker Score: 414
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,040
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.97
    Marker Score: 5,233
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.97
    Marker Score: 839
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,345
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.88
    Marker Score: 6,663
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.86
    Marker Score: 288
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.83
    Marker Score: 1,948
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.82
    Marker Score: 4,311
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.79
    Marker Score: 473
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.77
    Marker Score: 1,772
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.76
    Marker Score: 239
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.75
    Marker Score: 564
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.73
    Marker Score: 209
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.72
    Marker Score: 163
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.71
    Marker Score: 183
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.7
    Marker Score: 361
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.69
    Marker Score: 777
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.69
    Marker Score: 402
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.67
    Marker Score: 1,951
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.67
    Marker Score: 612
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.66
    Marker Score: 2,201
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.66
    Marker Score: 313
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.65
    Marker Score: 6,629
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.63
    Marker Score: 218
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.6
    Marker Score: 194
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.54
    Marker Score: 173
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.53
    Marker Score: 863
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.5
    Marker Score: 486
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.49
    Marker Score: 276
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.48
    Marker Score: 1,415
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.45
    Marker Score: 516
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.45
    Marker Score: 215
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.44
    Marker Score: 1,319
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.44
    Marker Score: 159
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.43
    Marker Score: 102
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.42
    Marker Score: 412

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CAMK2B is a member of the calcium/calmodulin-dependent protein kinase (CaMK) family, which consists of four distinct isoforms (CaMK II, CaMK IV, CaMK IIα, and CaMK IIβ). CAMK2B is the beta subunit of CaMK II, which is a tetrameric enzyme consisting of two catalytic subunits (α and β) and two regulatory subunits (γ and δ). The beta subunit of CaMK II is highly conserved across species and is essential for the enzyme's activity. **Pathways and Functions** CAMK2B is involved in multiple signaling pathways, including: 1. **Synaptic Plasticity**: CAMK2B regulates the phosphorylation of NMDA receptors, AMPA receptors, and other synaptic proteins, modulating synaptic transmission and plasticity. 2. **Neuronal Development**: CAMK2B is involved in the regulation of neuronal migration, differentiation, and synaptogenesis. 3. **Immune Response**: CAMK2B plays a role in the regulation of cytokine signaling and the activation of immune cells. 4. **Long-term Potentiation**: CAMK2B is involved in the regulation of long-term potentiation, a form of synaptic plasticity that underlies learning and memory. **Clinical Significance** Mutations in the CAMK2B gene have been associated with several neurological disorders, including: 1. **Autism Spectrum Disorder**: Studies have shown that mutations in CAMK2B are more common in individuals with autism spectrum disorder than in the general population. 2. **Schizophrenia**: CAMK2B has been implicated in the pathophysiology of schizophrenia, with some studies suggesting that mutations in the gene may contribute to the development of the disorder. 3. **Epilepsy**: CAMK2B has been associated with a subset of epilepsy disorders, particularly those characterized by abnormal synaptic plasticity. In conclusion, CAMK2B is a critical component of the neuronal signaling pathway, playing a key role in regulating synaptic plasticity, neuronal development, and immune response. Mutations in the CAMK2B gene have been associated with several neurological disorders, highlighting the importance of this gene in human health and disease. Further research is needed to fully elucidate the mechanisms by which CAMK2B regulates cellular processes and to develop therapeutic strategies for the treatment of CAMK2B-related disorders.

Genular Protein ID: 3454572469

Symbol: KCC2B_HUMAN

Name: Calcium/calmodulin-dependent protein kinase type II subunit beta

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10858498

Title: Identification of alternative splicing variants of the beta subunit of human Ca(2+)/calmodulin-dependent protein kinase II with different activities.

PubMed ID: 10858498

DOI: 10.1016/s0014-5793(00)01634-3

PubMed ID: 10819240

Title: Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells.

PubMed ID: 10819240

DOI: 10.1007/s001250051330

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9060999

Title: Identification of novel human tumor cell-specific CaMK-II variants.

PubMed ID: 9060999

DOI: 10.1016/s0167-4889(96)00141-3

PubMed ID: 14722083

Title: Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II.

PubMed ID: 14722083

DOI: 10.1074/jbc.m313597200

PubMed ID: 15312654

Title: SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.

PubMed ID: 15312654

DOI: 10.1016/j.neuron.2004.08.003

PubMed ID: 16690701

Title: Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise.

PubMed ID: 16690701

DOI: 10.1113/jphysiol.2006.111757

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21529938

Title: Analysis of CaM-kinase signaling in cells.

PubMed ID: 21529938

DOI: 10.1016/j.ceca.2011.02.007

PubMed ID: 15294044

Title: The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis.

PubMed ID: 15294044

DOI: 10.1079/pns2004335

PubMed ID: 18817731

Title: Calmodulin-kinases: modulators of neuronal development and plasticity.

PubMed ID: 18817731

DOI: 10.1016/j.neuron.2008.08.021

PubMed ID: 19996366

Title: The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: a potential molecular identity of a synaptic tag?

PubMed ID: 19996366

DOI: 10.1152/physiol.00029.2009

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31930741

Title: FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy.

PubMed ID: 31930741

DOI: 10.15252/embj.2019102608

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 29100089

Title: De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.

PubMed ID: 29100089

DOI: 10.1016/j.ajhg.2017.10.003

PubMed ID: 29560374

Title: De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders.

PubMed ID: 29560374

DOI: 10.1002/acn3.528

Sequence Information:

  • Length: 666
  • Mass: 72678
  • Checksum: 8CACFC3E392C3857
  • Sequence:
  • MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER 
    EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI 
    LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY 
    LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT 
    VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL 
    KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD GVKPQTNSTK 
    NSAAATSPKG TLPPAALEPQ TTVIHNPVDG IKESSDSANT TIEDEDAKAP RVPDILSSVR 
    RGSGAPEAEG PLPCPSPAPF SPLPAPSPRI SDILNSVRRG SGTPEAEGPL SAGPPPCLSP 
    ALLGPLSSPS PRISDILNSV RRGSGTPEAE GPSPVGPPPC PSPTIPGPLP TPSRKQEIIK 
    TTEQLIEAVN NGDFEAYAKI CDPGLTSFEP EALGNLVEGM DFHRFYFENL LAKNSKPIHT 
    TILNPHVHVI GEDAACIAYI RLTQYIDGQG RPRTSQSEET RVWHRRDGKW QNVHFHCSGA 
    PVAPLQ

Genular Protein ID: 2641500323

Symbol: B7Z1Z6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 305
  • Mass: 33295
  • Checksum: D5587FCFDD28E56E
  • Sequence:
  • MGVVHRDLKP ENLLLASKCK GAAVKLADFG LAIEVQGDQQ AWFGFAGTPG YLSPEVLRKE 
    AYGKPVDIWA CGVILYILLV GYPPFWDEDQ HKLYQQIKAG AYDFPSPEWD TVTPEAKNLI 
    NQMLTINPAK RITAHEALKH PWVCQRSTVA SMMHRQETVE CLKKFNARRK LKGAILTTML 
    ATRNFSVGRQ TTAPATMSTA ASGTTMGLVE QAKSLLNKKA DGVKPQTNST KNSAAATSPK 
    GTLPPAALEP QTTVIHNPVD GIKESSDSAN TTIEDEDAKA RKQEIIKTTE QLIEAVNNGD 
    FEAYA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.