Details for: CAMLG

Gene ID: 819

Symbol: CAMLG

Ensembl ID: ENSG00000164615

Description: calcium modulating ligand

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 378.9252
    Cell Significance Index: -58.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 166.7794
    Cell Significance Index: -42.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 135.4627
    Cell Significance Index: -63.9600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 120.7072
    Cell Significance Index: -62.0900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 95.5632
    Cell Significance Index: -64.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.8047
    Cell Significance Index: -62.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.9260
    Cell Significance Index: -50.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.1427
    Cell Significance Index: -63.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.7101
    Cell Significance Index: -42.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.3700
    Cell Significance Index: -16.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5149
    Cell Significance Index: 345.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1550
    Cell Significance Index: 350.4900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.9850
    Cell Significance Index: 15.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.8288
    Cell Significance Index: 38.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5848
    Cell Significance Index: 45.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5636
    Cell Significance Index: 853.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5078
    Cell Significance Index: 41.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.4224
    Cell Significance Index: 74.6800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4009
    Cell Significance Index: 15.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2609
    Cell Significance Index: 252.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2239
    Cell Significance Index: 156.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2220
    Cell Significance Index: 150.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2090
    Cell Significance Index: 56.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1755
    Cell Significance Index: 519.7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1607
    Cell Significance Index: 74.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0411
    Cell Significance Index: 77.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0347
    Cell Significance Index: 186.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9833
    Cell Significance Index: 127.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9577
    Cell Significance Index: 10.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9415
    Cell Significance Index: 66.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9216
    Cell Significance Index: 42.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7637
    Cell Significance Index: 90.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7591
    Cell Significance Index: 26.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7105
    Cell Significance Index: 254.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4772
    Cell Significance Index: 24.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4463
    Cell Significance Index: 76.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3970
    Cell Significance Index: 25.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3808
    Cell Significance Index: 8.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3472
    Cell Significance Index: 9.1300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2948
    Cell Significance Index: 5.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2924
    Cell Significance Index: 55.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2884
    Cell Significance Index: 8.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2713
    Cell Significance Index: 26.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2653
    Cell Significance Index: 52.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1813
    Cell Significance Index: 125.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1681
    Cell Significance Index: 7.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1651
    Cell Significance Index: 10.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1556
    Cell Significance Index: 140.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1493
    Cell Significance Index: 3.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0308
    Cell Significance Index: 0.5200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0262
    Cell Significance Index: 0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0250
    Cell Significance Index: 47.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0128
    Cell Significance Index: 0.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0176
    Cell Significance Index: -13.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0181
    Cell Significance Index: -11.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0247
    Cell Significance Index: -45.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0258
    Cell Significance Index: -18.9300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0260
    Cell Significance Index: -0.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0269
    Cell Significance Index: -41.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0307
    Cell Significance Index: -41.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0328
    Cell Significance Index: -0.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0489
    Cell Significance Index: -31.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0541
    Cell Significance Index: -5.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0693
    Cell Significance Index: -39.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0918
    Cell Significance Index: -41.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1151
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1312
    Cell Significance Index: -27.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1748
    Cell Significance Index: -20.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1797
    Cell Significance Index: -26.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1803
    Cell Significance Index: -51.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2081
    Cell Significance Index: -13.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2233
    Cell Significance Index: -6.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2630
    Cell Significance Index: -8.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2932
    Cell Significance Index: -33.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3557
    Cell Significance Index: -19.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3858
    Cell Significance Index: -10.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4161
    Cell Significance Index: -10.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5087
    Cell Significance Index: -58.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5658
    Cell Significance Index: -43.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5834
    Cell Significance Index: -60.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6161
    Cell Significance Index: -15.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6327
    Cell Significance Index: -50.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7148
    Cell Significance Index: -12.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7583
    Cell Significance Index: -33.5400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.8826
    Cell Significance Index: -5.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8891
    Cell Significance Index: -12.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9108
    Cell Significance Index: -34.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9515
    Cell Significance Index: -22.8200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9633
    Cell Significance Index: -5.8200
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.9651
    Cell Significance Index: -5.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9735
    Cell Significance Index: -27.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0359
    Cell Significance Index: -63.5100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.1776
    Cell Significance Index: -20.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2761
    Cell Significance Index: -23.5900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.2774
    Cell Significance Index: -10.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2781
    Cell Significance Index: -37.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.3017
    Cell Significance Index: -13.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3130
    Cell Significance Index: -48.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3175
    Cell Significance Index: -33.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CAMLG is a calcium-modulating ligand, a protein that interacts with calcium ions to regulate its activity. It is primarily expressed in various cell types, including fibroblasts of the mammary gland, mesodermal cells, peripheral nervous system neurons, and supporting cells. The protein's expression is also found in cells of the ovary, and it is significantly expressed in cell cultures. **Pathways and Functions:** CAMLG is involved in multiple cellular pathways, including: 1. **B cell homeostasis**: CAMLG plays a crucial role in regulating the number and activity of B cells, which are essential for the adaptive immune response. 2. **Endoplasmic reticulum (ER) function**: CAMLG is involved in the insertion of tail-anchored proteins into the ER membrane, which is critical for protein folding and quality control. 3. **Signal transduction**: CAMLG interacts with various signaling pathways, including the epidermal growth factor receptor (EGFR) pathway, to regulate cellular responses to external stimuli. 4. **Protein regulation**: CAMLG modulates the activity of ubiquitin ligases, which are involved in protein degradation and modification. 5. **Vesicle-mediated transport**: CAMLG is involved in the regulation of vesicle-mediated transport, which is essential for the movement of proteins and lipids within cells. **Clinical Significance:** The dysregulation of CAMLG has been implicated in various diseases, including: 1. **Immunological disorders**: Alterations in CAMLG expression have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: CAMLG has been shown to play a role in the development and progression of certain types of cancer, including breast cancer and leukemia. 3. **Neurological disorders**: CAMLG has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, CAMLG is a multifunctional protein that plays a critical role in maintaining cellular homeostasis and regulating various cellular processes. Further research is needed to fully understand the function of CAMLG and its implications in human health and disease. **Recommendations:** 1. **Further research**: Investigate the specific mechanisms by which CAMLG regulates B cell homeostasis and ER function. 2. **Cancer research**: Explore the role of CAMLG in the development and progression of cancer, and identify potential therapeutic targets. 3. **Neurological disorders**: Investigate the involvement of CAMLG in neurodegenerative diseases and explore potential therapeutic strategies. By continuing to study CAMLG, we can gain a deeper understanding of its role in maintaining cellular homeostasis and developing new therapeutic strategies for various diseases.

Genular Protein ID: 2474699802

Symbol: CAMLG_HUMAN

Name: N/A

UniProtKB Accession Codes:

P49069 A1L3Y3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7522304

Title: Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.

PubMed ID: 7522304

DOI: 10.1038/371355a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9311921

Title: NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.

PubMed ID: 9311921

DOI: 10.1126/science.278.5335.138

PubMed ID: 12388711

Title: Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis.

PubMed ID: 12388711

DOI: 10.1128/jvi.76.22.11491-11504.2002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23041287

Title: Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.

PubMed ID: 23041287

DOI: 10.1016/j.molcel.2012.08.028

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24392163

Title: WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.

PubMed ID: 24392163

DOI: 10.1371/journal.pone.0085033

PubMed ID: 27226539

Title: Tail-anchored protein insertion in mammals: function and reciprocal interactions of the two subunits of the TRC40 receptor.

PubMed ID: 27226539

DOI: 10.1074/jbc.m115.707752

PubMed ID: 31417168

Title: The WRB Subunit of the Get3 Receptor is Required for the Correct Integration of its Partner CAML into the ER.

PubMed ID: 31417168

DOI: 10.1038/s41598-019-48363-2

PubMed ID: 32187542

Title: Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex.

PubMed ID: 32187542

DOI: 10.1016/j.celrep.2020.02.084

PubMed ID: 35262690

Title: CAMLG-CDG: a novel congenital disorder of glycosylation linked to defective membrane trafficking.

PubMed ID: 35262690

DOI: 10.1093/hmg/ddac055

PubMed ID: 32910895

Title: Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.

PubMed ID: 32910895

DOI: 10.1016/j.molcel.2020.08.012

Sequence Information:

  • Length: 296
  • Mass: 32953
  • Checksum: 22DCD8CF022FEF09
  • Sequence:
    • MESMAVATDG GERPGVPAGS GLSASQRRAE LRRRKLLMNS EQRINRIMGF HRPGSGAEEE 
SQTKSKQQDS DKLNSLSVPS VSKRVVLGDS VSTGTTDQQG GVAEVKGTQL GDKLDSFIKP 
PECSSDVNLE LRQRNRGDLT ADSVQRGSRH GLEQYLSRFE EAMKLRKQLI SEKPSQEDGN 
TTEEFDSFRI FRLVGCALLA LGVRAFVCKY LSIFAPFLTL QLAYMGLYKY FPKSEKKIKT 
TVLTAALLLS GIPAEVINRS MDTYSKMGEV FTDLCVYFFT FIFCHELLDY WGSEVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.