Details for: CAMLG

Gene ID: 819

Symbol: CAMLG

Ensembl ID: ENSG00000164615

Description: calcium modulating ligand

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.4
    Marker Score: 81741
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.31
    Marker Score: 30532.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.23
    Marker Score: 2503
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.19
    Marker Score: 4120
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.15
    Marker Score: 4366
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.12
    Marker Score: 2262
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.12
    Marker Score: 9127
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1
    Marker Score: 23596
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.07
    Marker Score: 71598
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2
    Marker Score: 2417
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.9
    Marker Score: 1797
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.9
    Marker Score: 640
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.9
    Marker Score: 3363
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.89
    Marker Score: 2021
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.89
    Marker Score: 12286.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.86
    Marker Score: 7767.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.83
    Marker Score: 412
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.83
    Marker Score: 1154
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.79
    Marker Score: 1121
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.78
    Marker Score: 1018
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.78
    Marker Score: 4184.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.77
    Marker Score: 3528
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.76
    Marker Score: 3679
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.75
    Marker Score: 1650
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.72
    Marker Score: 1822
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.71
    Marker Score: 812
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7
    Marker Score: 6568
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.7
    Marker Score: 392
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.7
    Marker Score: 848
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.7
    Marker Score: 1803
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.68
    Marker Score: 1214
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.66
    Marker Score: 2562.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.65
    Marker Score: 6764
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.65
    Marker Score: 981
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.64
    Marker Score: 2419
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.64
    Marker Score: 773
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.63
    Marker Score: 4260
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.62
    Marker Score: 781.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.61
    Marker Score: 16335.5
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.61
    Marker Score: 516
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.61
    Marker Score: 1881
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.6
    Marker Score: 382
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.6
    Marker Score: 2713
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.59
    Marker Score: 663
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.59
    Marker Score: 1490
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.59
    Marker Score: 548
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.58
    Marker Score: 1593
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.58
    Marker Score: 1900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.58
    Marker Score: 1055
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.57
    Marker Score: 1034
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.56
    Marker Score: 1330
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.56
    Marker Score: 2031.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.55
    Marker Score: 4223.5
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.54
    Marker Score: 821
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.53
    Marker Score: 2513
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.53
    Marker Score: 578
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.52
    Marker Score: 1091
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.52
    Marker Score: 5625
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.5
    Marker Score: 426
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.5
    Marker Score: 3410
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5
    Marker Score: 3668
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.5
    Marker Score: 2613
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.5
    Marker Score: 4077
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.49
    Marker Score: 2114
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.48
    Marker Score: 2650
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.48
    Marker Score: 892
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.48
    Marker Score: 517
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.47
    Marker Score: 77580
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.47
    Marker Score: 3482.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.45
    Marker Score: 361.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.44
    Marker Score: 489
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.44
    Marker Score: 9217
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 165358
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.44
    Marker Score: 560
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.44
    Marker Score: 361.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.44
    Marker Score: 508
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.44
    Marker Score: 1772
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.43
    Marker Score: 336
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.43
    Marker Score: 12289
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.43
    Marker Score: 352
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.42
    Marker Score: 287
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.42
    Marker Score: 374
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.42
    Marker Score: 376
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.41
    Marker Score: 1945
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.41
    Marker Score: 316
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.4
    Marker Score: 955
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4
    Marker Score: 3189
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.39
    Marker Score: 718
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.39
    Marker Score: 415
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.39
    Marker Score: 319
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.38
    Marker Score: 2344
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.38
    Marker Score: 477.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.38
    Marker Score: 1487
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.37
    Marker Score: 364
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.37
    Marker Score: 1156
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.37
    Marker Score: 756
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.37
    Marker Score: 13802.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.37
    Marker Score: 516
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.37
    Marker Score: 1489
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.37
    Marker Score: 4061

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Other Information

**Key characteristics:** - CAMLG is a transmembrane protein with a predicted molecular weight of approximately 130 kDa. - It belongs to the CAMLG family of calcium-regulated proteins. - It is expressed in a wide range of cell types, including epithelial cells, fibroblasts, mesodermal cells, neurons, and stem cells. - CAMLG is a key regulator of cell growth and differentiation, and its expression is often upregulated in cancer cells. **Pathways and functions:** - CAMLG is involved in B cell homeostasis and regulation of the cytoplasm. - It interacts with the cytoplasm and endoplasmic reticulum (ER) and modulates the activity of various proteins involved in cell growth, survival, and differentiation. - It plays a role in the negative regulation of the proteasomal ubiquitin-dependent protein catabolic process. - CAMLG also regulates protein ubiquitination, preventing the degradation of proteins that are not correctly folded or that are misfolded. - It is involved in the insertion of tail-anchored proteins into the endoplasmic reticulum (ER) membrane. - It is a key regulator of the negative regulation of protein ubiquitination and is often upregulated in cancer cells. **Clinical significance:** - CAMLG is a potential therapeutic target for cancer and other diseases characterized by abnormal cell growth and survival. - Inhibition of CAMLG has been shown to inhibit cancer cell growth and metastasis. - CAMLG is a promising target for the development of novel cancer therapies. **Additional information:** - CAMLG is also known as CD90 or CD90.1. - It is a transmembrane protein that is expressed on the surface of epithelial cells, where it is involved in cell-cell interactions. - It is also expressed in some immune cells, where it plays a role in regulating immune responses.

Genular Protein ID: 2474699802

Symbol: CAMLG_HUMAN

Name: N/A

UniProtKB Accession Codes:

P49069 A1L3Y3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 EMDB 1 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7522304

Title: Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.

PubMed ID: 7522304

DOI: 10.1038/371355a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9311921

Title: NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.

PubMed ID: 9311921

DOI: 10.1126/science.278.5335.138

PubMed ID: 12388711

Title: Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis.

PubMed ID: 12388711

DOI: 10.1128/jvi.76.22.11491-11504.2002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23041287

Title: Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.

PubMed ID: 23041287

DOI: 10.1016/j.molcel.2012.08.028

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24392163

Title: WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.

PubMed ID: 24392163

DOI: 10.1371/journal.pone.0085033

PubMed ID: 27226539

Title: Tail-anchored protein insertion in mammals: function and reciprocal interactions of the two subunits of the TRC40 receptor.

PubMed ID: 27226539

DOI: 10.1074/jbc.m115.707752

PubMed ID: 31417168

Title: The WRB Subunit of the Get3 Receptor is Required for the Correct Integration of its Partner CAML into the ER.

PubMed ID: 31417168

DOI: 10.1038/s41598-019-48363-2

PubMed ID: 32187542

Title: Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex.

PubMed ID: 32187542

DOI: 10.1016/j.celrep.2020.02.084

PubMed ID: 35262690

Title: CAMLG-CDG: a novel congenital disorder of glycosylation linked to defective membrane trafficking.

PubMed ID: 35262690

DOI: 10.1093/hmg/ddac055

PubMed ID: 32910895

Title: Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.

PubMed ID: 32910895

DOI: 10.1016/j.molcel.2020.08.012

Sequence Information:

  • Length: 296
  • Mass: 32953
  • Checksum: 22DCD8CF022FEF09
  • Sequence:
    • MESMAVATDG GERPGVPAGS GLSASQRRAE LRRRKLLMNS EQRINRIMGF HRPGSGAEEE 
SQTKSKQQDS DKLNSLSVPS VSKRVVLGDS VSTGTTDQQG GVAEVKGTQL GDKLDSFIKP 
PECSSDVNLE LRQRNRGDLT ADSVQRGSRH GLEQYLSRFE EAMKLRKQLI SEKPSQEDGN 
TTEEFDSFRI FRLVGCALLA LGVRAFVCKY LSIFAPFLTL QLAYMGLYKY FPKSEKKIKT 
TVLTAALLLS GIPAEVINRS MDTYSKMGEV FTDLCVYFFT FIFCHELLDY WGSEVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.