Details for: CAMLG
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 58.68rCSI 39%PRS 22.87
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CSI 53.11rCSI 47.96%PRS 17.13
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CSI 42.94rCSI 58.51%PRS 16.89
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CSI 26.63rCSI 36.41%PRS 29.91
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CSI 25.91rCSI 39.5%PRS 17.72
-
CSI 24.78rCSI 25.9%PRS 19.89
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CSI 21.73rCSI 59.72%PRS 31.23
-
CSI 21.64rCSI 16.37%PRS 26.11
-
CSI 18.48rCSI 40.92%PRS 17.64
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CSI 15.11rCSI 43.73%PRS 21.55
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CSI 13.38rCSI 11.22%PRS 22.73
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CSI 12.45rCSI 81.68%PRS 47.56
-
CSI 9.95rCSI 77.99%PRS 38.19
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CSI 9.4rCSI 9.05%PRS 19.73
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CSI 8.32rCSI 9.98%PRS 18.64
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CSI 8.04rCSI 8.42%PRS 20.33
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CSI 7.9rCSI 10.14%PRS 18.42
-
CSI 7.79rCSI 41.54%PRS 61.98
-
CSI 7.67rCSI 24.61%PRS 27.39
-
CSI 7.46rCSI 29.7%PRS 32.65
-
CSI 7.28rCSI 5.89%PRS 19.07
-
CSI 7.14rCSI 41.57%PRS 28.31
-
CSI 6.54rCSI 9.34%PRS 21.44
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CSI 6.4rCSI 18.88%PRS 22.96
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CSI 6.31rCSI 12.17%PRS 42.57
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CSI 6.25rCSI 6.03%PRS 13.74
-
CSI 6.24rCSI 6.42%PRS 30.9
-
CSI 5.4rCSI 7.36%PRS 44.34
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CSI 5.06rCSI 11.55%PRS 16.38
-
CSI 4.93rCSI 4.85%PRS 20.62
-
CSI 4.78rCSI 7.3%PRS 21.85
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CSI 4.71rCSI 10.4%PRS 13.67
-
CSI 4.08rCSI 2.72%PRS 45.89
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CSI 4.03rCSI 2.8%PRS 22.77
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CSI 3.91rCSI 7.11%PRS 29.05
-
CSI 3.72rCSI 54.92%PRS 45.6
-
CSI 3.62rCSI 4.61%PRS 22.14
-
CSI 3.61rCSI 6.88%PRS 30.17
-
CSI 3.47rCSI 9.02%PRS 47.69
-
CSI 3.4rCSI 4.73%PRS 19.5
-
CSI 3.25rCSI 5.2%PRS 51.73
-
CSI 3.1rCSI 4.73%PRS 24.58
-
CSI 2.97rCSI 14.89%PRS 25.2
-
CSI 2.94rCSI 8.04%PRS 61.42
-
CSI 2.83rCSI 2.36%PRS 49.04
-
CSI 2.78rCSI 10.58%PRS 18.59
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CSI 2.59rCSI 1.8%PRS 27.02
-
CSI 2.57rCSI 5.34%PRS 19.01
-
CSI 2.55rCSI 2.66%PRS 19.53
-
CSI 2.53rCSI 2.13%PRS 30.25
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CSI 2.51rCSI 11.16%PRS 18.69
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CSI 2.5rCSI 3.9%PRS 43.64
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CSI 2.45rCSI 3.39%PRS 26.94
-
CSI 2.4rCSI 3.87%PRS 14.63
-
CSI 2.37rCSI 16.28%PRS 36.81
-
CSI 2.34rCSI 8.23%PRS 33.13
-
CSI 2.31rCSI 42.29%PRS 52.73
-
CSI 2.31rCSI 1.88%PRS 20.15
-
CSI 2.3rCSI 3.53%PRS 26.2
-
CSI 2.29rCSI 2.58%PRS 30.4
-
CSI 2.27rCSI 18.48%PRS 19.29
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CSI 2.25rCSI 4.46%PRS 20.07
-
CSI 2.24rCSI 2.58%PRS 16.7
-
CSI 2.19rCSI 5.01%PRS 18.54
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CSI 2.18rCSI 1.61%PRS 16.61
-
CSI 2.18rCSI 1.53%PRS 44.84
-
CSI 2.09rCSI 3.37%PRS 29.42
-
CSI 2.07rCSI 1.88%PRS 29.06
-
CSI 2.07rCSI 2.56%PRS 16.72
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CSI 2.06rCSI 4.54%PRS 28.93
-
CSI 2.06rCSI 2.21%PRS 17.57
-
CSI 2.05rCSI 4.88%PRS 48.43
-
CSI 2.04rCSI 4.04%PRS 50.87
-
CSI 2.04rCSI 10.04%PRS 25.84
-
CSI 2.02rCSI 1.77%PRS 21.9
-
CSI 2.01rCSI 8.18%PRS 19.44
-
CSI 2.01rCSI 4.14%PRS 28.43
-
CSI 2rCSI 2.51%PRS 67.09
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CSI 2rCSI 2.93%PRS 25.04
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CSI 1.99rCSI 4.29%PRS 65.5
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CSI 1.97rCSI 7.39%PRS 16.11
-
CSI 1.96rCSI 3.11%PRS 24.52
-
CSI 1.92rCSI 1.46%PRS 25.2
-
CSI 1.91rCSI 3.27%PRS 38.28
-
CSI 1.88rCSI 1.51%PRS 34.05
-
CSI 1.86rCSI 2.27%PRS 23.96
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CSI 1.83rCSI 1.36%PRS 28.17
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CSI 1.83rCSI 8.52%PRS 42.29
-
CSI 1.8rCSI 1.55%PRS 29.79
-
CSI 1.79rCSI 3.36%PRS 37.15
-
CSI 1.77rCSI 9.15%PRS 36.93
-
CSI 1.74rCSI 2.37%PRS 21.13
-
CSI 1.72rCSI 2.08%PRS 22.81
-
CSI 1.72rCSI 4.92%PRS 32.38
-
CSI 1.69rCSI 1.98%PRS 22.07
-
CSI 1.69rCSI 1.62%PRS 38.56
-
CSI 1.66rCSI 1.53%PRS 34.26
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CSI 1.65rCSI 1.43%PRS 21.43
-
CSI 1.62rCSI 2.17%PRS 20.92
-
CSI 1.61rCSI 2.15%PRS 36.21
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CSI -3.3rCSI -5.1%PRS 28.5%
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CSI -0.6rCSI -1.6%PRS 17.6%
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CSI -0.6rCSI -1.9%PRS 23.0%
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CSI -0.5rCSI -0.6%PRS 33.2%
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CSI 0.1rCSI 0.1%PRS 15.9%
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CSI 0.1rCSI 0.7%PRS 11.0%
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CSI 0.1rCSI 2.6%PRS 9.6%
-
CSI 0.1rCSI 2.7%PRS 85.0%
-
CSI 0.1rCSI 0.5%PRS 35.1%
-
CSI 0.1rCSI 0.8%PRS 28.7%
-
CSI 0.1rCSI 3.2%PRS 10.5%
-
CSI 0.2rCSI 0.4%PRS 19.7%
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CSI 0.2rCSI 0.7%PRS 33.1%
-
CSI 0.2rCSI 0.3%PRS 24.1%
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CSI 0.2rCSI 0.8%PRS 47.2%
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CSI 0.2rCSI 0.3%PRS 28.6%
-
CSI 0.2rCSI 0.3%PRS 11.2%
-
CSI 0.2rCSI 0.3%PRS 17.5%
-
CSI 0.2rCSI 5.0%PRS 65.9%
-
CSI 0.2rCSI 0.2%PRS 20.2%
-
CSI 0.2rCSI 2.6%PRS 36.2%
-
CSI 0.2rCSI 3.1%PRS 56.9%
-
CSI 0.2rCSI 1.1%PRS 18.0%
-
CSI 0.3rCSI 0.3%PRS 38.5%
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CSI 0.3rCSI 2.8%PRS 45.5%
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CSI 0.3rCSI 0.4%PRS 37.2%
-
CSI 0.3rCSI 2.4%PRS 61.3%
-
CSI 0.3rCSI 0.4%PRS 11.1%
-
CSI 0.3rCSI 1.7%PRS 48.0%
-
CSI 0.3rCSI 3.1%PRS 49.4%
-
CSI 0.4rCSI 0.5%PRS 27.2%
-
CSI 0.4rCSI 2.6%PRS 34.7%
-
CSI 0.4rCSI 1.4%PRS 32.7%
-
CSI 0.4rCSI 0.6%PRS 20.2%
-
CSI 0.4rCSI 1.2%PRS 43.6%
-
CSI 0.4rCSI 0.5%PRS 10.3%
-
CSI 0.4rCSI 0.4%PRS 22.3%
-
CSI 0.4rCSI 1.4%PRS 30.9%
-
CSI 0.4rCSI 0.6%PRS 21.6%
-
CSI 0.4rCSI 1.0%PRS 51.0%
-
CSI 0.4rCSI 0.8%PRS 13.7%
-
CSI 0.4rCSI 3.9%PRS 49.3%
-
CSI 0.4rCSI 2.6%PRS 47.0%
-
CSI 0.4rCSI 10.1%PRS 35.4%
-
CSI 0.4rCSI 0.5%PRS 27.7%
-
CSI 0.5rCSI 1.0%PRS 21.5%
-
CSI 0.5rCSI 0.5%PRS 11.0%
-
CSI 0.5rCSI 1.4%PRS 12.0%
-
CSI 0.5rCSI 1.7%PRS 55.8%
-
CSI 0.5rCSI 3.0%PRS 42.0%
-
CSI 0.5rCSI 1.9%PRS 11.5%
-
CSI 0.5rCSI 2.9%PRS 55.5%
-
CSI 0.5rCSI 0.7%PRS 26.3%
-
CSI 0.5rCSI 1.1%PRS 30.3%
-
CSI 0.5rCSI 0.9%PRS 25.9%
-
CSI 0.5rCSI 0.8%PRS 33.4%
-
CSI 0.5rCSI 1.6%PRS 33.5%
-
CSI 0.6rCSI 0.8%PRS 19.3%
-
CSI 0.6rCSI 1.5%PRS 24.7%
-
CSI 0.6rCSI 3.4%PRS 11.8%
-
CSI 0.6rCSI 0.6%PRS 21.5%
-
CSI 0.6rCSI 0.6%PRS 22.5%
-
CSI 0.6rCSI 0.8%PRS 30.1%
-
CSI 0.6rCSI 1.0%PRS 18.8%
-
CSI 0.6rCSI 0.5%PRS 17.6%
-
CSI 0.6rCSI 0.5%PRS 23.9%
-
CSI 0.6rCSI 1.9%PRS 12.9%
-
CSI 0.6rCSI 3.6%PRS 59.6%
-
CSI 0.6rCSI 0.9%PRS 26.7%
-
CSI 0.6rCSI 15.1%PRS 55.8%
-
CSI 0.6rCSI 1.1%PRS 25.1%
-
CSI 0.6rCSI 3.4%PRS 33.4%
-
CSI 0.7rCSI 0.8%PRS 14.0%
-
CSI 0.7rCSI 1.6%PRS 11.0%
-
CSI 0.7rCSI 1.4%PRS 38.0%
-
CSI 0.7rCSI 1.0%PRS 21.9%
-
CSI 0.7rCSI 1.1%PRS 14.7%
-
CSI 0.7rCSI 1.6%PRS 28.2%
-
CSI 0.7rCSI 1.3%PRS 40.1%
-
CSI 0.7rCSI 4.9%PRS 49.6%
-
CSI 0.7rCSI 10.2%PRS 52.4%
-
CSI 0.7rCSI 2.9%PRS 45.8%
-
CSI 0.7rCSI 0.8%PRS 23.8%
-
CSI 0.7rCSI 3.1%PRS 35.2%
-
CSI 0.7rCSI 1.0%PRS 37.8%
-
CSI 0.7rCSI 2.9%PRS 31.4%
-
CSI 0.7rCSI 1.9%PRS 14.5%
-
CSI 0.7rCSI 1.7%PRS 25.8%
-
CSI 0.7rCSI 0.6%PRS 18.3%
-
CSI 0.8rCSI 1.9%PRS 23.6%
-
CSI 0.8rCSI 1.2%PRS 16.3%
-
CSI 0.8rCSI 1.4%PRS 46.4%
-
CSI 0.8rCSI 4.8%PRS 59.9%
-
CSI 0.8rCSI 2.3%PRS 35.5%
-
CSI 0.8rCSI 1.7%PRS 30.3%
-
CSI 0.8rCSI 1.0%PRS 29.3%
-
CSI 0.8rCSI 1.3%PRS 20.9%
-
CSI 0.8rCSI 0.8%PRS 16.3%
-
CSI 0.8rCSI 10.9%PRS 69.9%
-
CSI 0.9rCSI 1.1%PRS 24.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2474699802
Symbol: CAMLG_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7522304
Title: Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.
PubMed ID: 7522304
DOI: 10.1038/371355a0
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9311921
Title: NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily.
PubMed ID: 9311921
PubMed ID: 12388711
Title: Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis.
PubMed ID: 12388711
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23041287
Title: Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.
PubMed ID: 23041287
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24392163
Title: WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.
PubMed ID: 24392163
PubMed ID: 27226539
Title: Tail-anchored protein insertion in mammals: function and reciprocal interactions of the two subunits of the TRC40 receptor.
PubMed ID: 27226539
PubMed ID: 31417168
Title: The WRB Subunit of the Get3 Receptor is Required for the Correct Integration of its Partner CAML into the ER.
PubMed ID: 31417168
PubMed ID: 32187542
Title: Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex.
PubMed ID: 32187542
PubMed ID: 35262690
Title: CAMLG-CDG: a novel congenital disorder of glycosylation linked to defective membrane trafficking.
PubMed ID: 35262690
DOI: 10.1093/hmg/ddac055
PubMed ID: 32910895
Title: Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex.
PubMed ID: 32910895
Sequence Information:
- Length: 296
- Mass: 32953
- Checksum: 22DCD8CF022FEF09
- Sequence:
MESMAVATDG GERPGVPAGS GLSASQRRAE LRRRKLLMNS EQRINRIMGF HRPGSGAEEE SQTKSKQQDS DKLNSLSVPS VSKRVVLGDS VSTGTTDQQG GVAEVKGTQL GDKLDSFIKP PECSSDVNLE LRQRNRGDLT ADSVQRGSRH GLEQYLSRFE EAMKLRKQLI SEKPSQEDGN TTEEFDSFRI FRLVGCALLA LGVRAFVCKY LSIFAPFLTL QLAYMGLYKY FPKSEKKIKT TVLTAALLLS GIPAEVINRS MDTYSKMGEV FTDLCVYFFT FIFCHELLDY WGSEVP