Details for: CAMP

Gene ID: 820

Symbol: CAMP

Ensembl ID: ENSG00000164047

Description: cathelicidin antimicrobial peptide

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8277
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.36
    Marker Score: 2375
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.24
    Marker Score: 5104
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.92
    Marker Score: 2321
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1172
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4819
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.82
    Marker Score: 5448
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.81
    Marker Score: 348
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 586.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.76
    Marker Score: 357
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 694
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.66
    Marker Score: 404
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.66
    Marker Score: 1335
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.62
    Marker Score: 677
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.55
    Marker Score: 285
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.52
    Marker Score: 259
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.52
    Marker Score: 979
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.5
    Marker Score: 305
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.49
    Marker Score: 243
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.47
    Marker Score: 12047
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 293
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.44
    Marker Score: 6849
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.38
    Marker Score: 1142
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.35
    Marker Score: 264
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.31
    Marker Score: 760
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.28
    Marker Score: 443
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.27
    Marker Score: 177
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.27
    Marker Score: 72
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.26
    Marker Score: 109
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.24
    Marker Score: 255
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.24
    Marker Score: 297
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.23
    Marker Score: 141
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.23
    Marker Score: 108
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: 0.23
    Marker Score: 78
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.22
    Marker Score: 212
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.22
    Marker Score: 123
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.22
    Marker Score: 97
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 101
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.2
    Marker Score: 227
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.19
    Marker Score: 62
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.19
    Marker Score: 335
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.19
    Marker Score: 192
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.19
    Marker Score: 117.5
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.18
    Marker Score: 265
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.18
    Marker Score: 88
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.17
    Marker Score: 301
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.17
    Marker Score: 126
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.16
    Marker Score: 79.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.16
    Marker Score: 46
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.16
    Marker Score: 325
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.16
    Marker Score: 54
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.15
    Marker Score: 64
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.15
    Marker Score: 234
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.15
    Marker Score: 246
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.14
    Marker Score: 45
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.14
    Marker Score: 855
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.14
    Marker Score: 251
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.13
    Marker Score: 28
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.13
    Marker Score: 159
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.13
    Marker Score: 54
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.12
    Marker Score: 110
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.12
    Marker Score: 120
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.11
    Marker Score: 107
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 73
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.11
    Marker Score: 77
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1
    Marker Score: 876
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.1
    Marker Score: 124
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.09
    Marker Score: 388
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.09
    Marker Score: 240
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.09
    Marker Score: 53

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Other Information

**Key characteristics:** - CAMP is a 34-kD secreted peptide that belongs to the cathelicidin family of antimicrobial peptides. - It is produced by various cell types in response to bacterial infections. - It has potent antibacterial activity against a wide range of bacteria, including Gram-positive and Gram-negative bacteria. - It exerts its antimicrobial effects by binding to lipopolysaccharide (LPS) on the surface of bacteria and triggering the activation of immune cells. - It also modulates angiogenesis, cell population proliferation, protein phosphorylation, and cell survival. **Pathways and functions:** - CAMP is primarily produced in response to bacterial infections and is released into the extracellular space. - It binds to LPS on the surface of bacteria, triggering a cascade of intracellular events that lead to the activation of immune cells. - It promotes the differentiation and activation of neutrophils, macrophages, and dendritic cells, leading to the initiation of the inflammatory response. - It also suppresses the production of inflammatory cytokines and promotes the production of anti-inflammatory cytokines. - It plays a role in innate immunity against bacterial infections by protecting tissues from infection and promoting tissue repair. **Clinical significance:** - Mutations in the CAMP gene have been linked to the development of some bacterial infections, such as pneumonia, sepsis, and meningitis. - Targeting the CAMP signaling pathway has been investigated as a potential therapeutic strategy for these infections. - In some cases, high levels of CAMP have been associated with increased susceptibility to bacterial infections.

Genular Protein ID: 544523925

Symbol: CAMP_HUMAN

Name: N/A

UniProtKB Accession Codes:

P49913 Q71SN9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 11 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 20 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7529412

Title: FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis.

PubMed ID: 7529412

DOI: 10.1073/pnas.92.1.195

PubMed ID: 7615076

Title: hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules.

PubMed ID: 7615076

DOI: 10.1016/0014-5793(95)00634-l

PubMed ID: 7890387

Title: Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein.

PubMed ID: 7890387

DOI: 10.1128/iai.63.4.1291-1297.1995

PubMed ID: 8946956

Title: Structural, functional analysis and localization of the human CAP18 gene.

PubMed ID: 8946956

DOI: 10.1016/s0014-5793(96)01199-4

PubMed ID: 8681941

Title: The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes.

PubMed ID: 8681941

DOI: 10.1111/j.1432-1033.1996.0325z.x

PubMed ID: 11238224

Title: Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules.

PubMed ID: 11238224

DOI: 10.1128/cdli.8.2.370-375.2001

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9736536

Title: Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils.

PubMed ID: 9736536

DOI: 10.1128/aac.42.9.2206

PubMed ID: 10417311

Title: Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity.

PubMed ID: 10417311

DOI: 10.1042/bj3410501

PubMed ID: 11389039

Title: Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3.

PubMed ID: 11389039

DOI: 10.1182/blood.v97.12.3951

PubMed ID: 14978112

Title: Postsecretory processing generates multiple cathelicidins for enhanced topical antimicrobial defense.

PubMed ID: 14978112

DOI: 10.4049/jimmunol.172.5.3070

PubMed ID: 15778390

Title: Structure-function relationships among human cathelicidin peptides: dissociation of antimicrobial properties from host immunostimulatory activities.

PubMed ID: 15778390

DOI: 10.4049/jimmunol.174.7.4271

PubMed ID: 21463582

Title: Transmembrane pores formed by human antimicrobial peptide LL-37.

PubMed ID: 21463582

DOI: 10.1016/j.bpj.2011.02.018

PubMed ID: 22879591

Title: Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions.

PubMed ID: 22879591

DOI: 10.1074/jbc.m112.394452

PubMed ID: 34708076

Title: Quorum Sensing Pseudomonas Quinolone Signal Forms Chiral Supramolecular Assemblies With the Host Defense Peptide LL-37.

PubMed ID: 34708076

DOI: 10.3389/fmolb.2021.742023

PubMed ID: 16637646

Title: Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region.

PubMed ID: 16637646

DOI: 10.1021/ja0584875

PubMed ID: 18818205

Title: Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles.

PubMed ID: 18818205

DOI: 10.1074/jbc.m805533200

PubMed ID: 22185690

Title: Structure, dynamics, and antimicrobial and immune modulatory activities of human LL-23 and its single-residue variants mutated on the basis of homologous primate cathelicidins.

PubMed ID: 22185690

DOI: 10.1021/bi2016266

PubMed ID: 23406372

Title: Structural and functional analysis of the pro-domain of human cathelicidin, LL-37.

PubMed ID: 23406372

DOI: 10.1021/bi301008r

PubMed ID: 29087182

Title: Conformational Aspects of High Content Packing of Antimicrobial Peptides in Polymer Microgels.

PubMed ID: 29087182

DOI: 10.1021/acsami.7b13714

PubMed ID: 29133814

Title: Structural remodeling and oligomerization of human cathelicidin on membranes suggest fibril-like structures as active species.

PubMed ID: 29133814

DOI: 10.1038/s41598-017-14206-1

PubMed ID: 29317506

Title: The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.

PubMed ID: 29317506

DOI: 10.1074/jbc.ra117.001013

PubMed ID: 32753597

Title: The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure.

PubMed ID: 32753597

DOI: 10.1038/s41467-020-17736-x

PubMed ID: 33060695

Title: The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics.

PubMed ID: 33060695

DOI: 10.1038/s41598-020-74401-5

PubMed ID: 35061360

Title: Rare by Natural Selection: Disulfide-Bonded Supramolecular Antimicrobial Peptides.

PubMed ID: 35061360

DOI: 10.1021/acs.biomac.1c01353

Sequence Information:

  • Length: 170
  • Mass: 19301
  • Checksum: 055B07DCA95A7D16
  • Sequence:
    • MKTQRDGHSL GRWSLVLLLL GLVMPLAIIA QVLSYKEAVL RAIDGINQRS SDANLYRLLD 
LDPRPTMDGD PDTPKPVSFT VKETVCPRTT QQSPEDCDFK KDGLVKRCMG TVTLNQARGS 
FDISCDKDNK RFALLGDFFR KSKEKIGKEF KRIVQRIKDF LRNLVPRTES

Genular Protein ID: 261572625

Symbol: J3KNB4_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KNB4

Database IDs:

ARBA 12 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 3 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 Proteomes 2 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 173
  • Mass: 19591
  • Checksum: 5D1D86D6A0038858
  • Sequence:
    • MGTMKTQRDG HSLGRWSLVL LLLGLVMPLA IIAQVLSYKE AVLRAIDGIN QRSSDANLYR 
LLDLDPRPTM DGDPDTPKPV SFTVKETVCP RTTQQSPEDC DFKKDGLVKR CMGTVTLNQA 
RGSFDISCDK DNKRFALLGD FFRKSKEKIG KEFKRIVQRI KDFLRNLVPR TES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.