Details for: CAPG

Gene ID: 822

Symbol: CAPG

Ensembl ID: ENSG00000042493

Description: capping actin protein, gelsolin like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 208.4281
    Cell Significance Index: -32.4200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 87.8753
    Cell Significance Index: -36.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 86.6965
    Cell Significance Index: -21.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 76.2079
    Cell Significance Index: -30.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 72.1635
    Cell Significance Index: -34.0700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 67.4203
    Cell Significance Index: -34.6800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 50.5796
    Cell Significance Index: -33.9400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.6585
    Cell Significance Index: -33.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.1871
    Cell Significance Index: -32.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.1413
    Cell Significance Index: -34.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3729
    Cell Significance Index: -33.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.3329
    Cell Significance Index: -13.8600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 5.5555
    Cell Significance Index: 102.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 5.4856
    Cell Significance Index: 50.5200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.7537
    Cell Significance Index: 29.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.7369
    Cell Significance Index: 241.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.6114
    Cell Significance Index: 187.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.3972
    Cell Significance Index: 92.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7568
    Cell Significance Index: 205.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.0112
    Cell Significance Index: 27.4400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.7357
    Cell Significance Index: 14.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6992
    Cell Significance Index: 79.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4305
    Cell Significance Index: 85.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3971
    Cell Significance Index: 41.0300
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.3450
    Cell Significance Index: 5.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1439
    Cell Significance Index: 17.1400
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.0980
    Cell Significance Index: 4.5700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.0960
    Cell Significance Index: 6.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0242
    Cell Significance Index: 132.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9977
    Cell Significance Index: 441.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9477
    Cell Significance Index: 170.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9060
    Cell Significance Index: 47.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8631
    Cell Significance Index: 106.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7318
    Cell Significance Index: 33.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6024
    Cell Significance Index: 13.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4279
    Cell Significance Index: 11.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4037
    Cell Significance Index: 8.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3390
    Cell Significance Index: 64.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2829
    Cell Significance Index: 36.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2644
    Cell Significance Index: 144.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2518
    Cell Significance Index: 17.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1733
    Cell Significance Index: 17.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1418
    Cell Significance Index: 6.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1274
    Cell Significance Index: 3.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0924
    Cell Significance Index: 15.0200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.0769
    Cell Significance Index: 0.5100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0703
    Cell Significance Index: 0.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0478
    Cell Significance Index: 1.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0393
    Cell Significance Index: 4.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0289
    Cell Significance Index: 4.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0265
    Cell Significance Index: 0.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0230
    Cell Significance Index: 17.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0228
    Cell Significance Index: 0.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0227
    Cell Significance Index: 16.6700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0172
    Cell Significance Index: 10.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0046
    Cell Significance Index: -8.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0123
    Cell Significance Index: -22.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0125
    Cell Significance Index: -19.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0200
    Cell Significance Index: -14.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0277
    Cell Significance Index: -37.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0395
    Cell Significance Index: -22.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0467
    Cell Significance Index: -13.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0508
    Cell Significance Index: -1.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0509
    Cell Significance Index: -1.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0510
    Cell Significance Index: -32.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0545
    Cell Significance Index: -1.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0693
    Cell Significance Index: -9.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0730
    Cell Significance Index: -1.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0769
    Cell Significance Index: -34.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0807
    Cell Significance Index: -9.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0853
    Cell Significance Index: -10.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0877
    Cell Significance Index: -31.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0944
    Cell Significance Index: -10.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1021
    Cell Significance Index: -21.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1137
    Cell Significance Index: -5.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1410
    Cell Significance Index: -28.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1470
    Cell Significance Index: -29.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1521
    Cell Significance Index: -3.2400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1626
    Cell Significance Index: -1.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1792
    Cell Significance Index: -26.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1945
    Cell Significance Index: -3.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2389
    Cell Significance Index: -18.9200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2503
    Cell Significance Index: -10.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2785
    Cell Significance Index: -31.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3051
    Cell Significance Index: -8.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3062
    Cell Significance Index: -31.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3168
    Cell Significance Index: -11.0100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3771
    Cell Significance Index: -5.8400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.4444
    Cell Significance Index: -3.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4563
    Cell Significance Index: -35.0200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4623
    Cell Significance Index: -5.9200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4680
    Cell Significance Index: -4.8500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4693
    Cell Significance Index: -6.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4782
    Cell Significance Index: -29.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4919
    Cell Significance Index: -14.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5244
    Cell Significance Index: -35.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5271
    Cell Significance Index: -32.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5509
    Cell Significance Index: -34.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5607
    Cell Significance Index: -6.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6325
    Cell Significance Index: -35.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The CAPG protein exhibits several key characteristics that distinguish it from other actin-binding proteins: * **Barbed-end actin filament capping**: CAPG is specifically involved in capping barbed-end actin filaments, preventing their extension and promoting filament severing. * **Gelsolin-like activity**: CAPG shares structural and functional similarities with gelsolin, another actin-binding protein that regulates actin filament dynamics. * **High expression in immune cells**: CAPG is highly expressed in immune cells, including macrophages, natural killer cells, and monocytes, suggesting its importance in immune function and cellular regulation. * **Cellular localization**: CAPG is localized to the cytoskeleton, where it regulates actin filament dynamics and interacts with other cytoskeletal proteins. **Pathways and Functions** The CAPG protein is involved in several cellular pathways and functions, including: * **Actin cytoskeleton regulation**: CAPG regulates actin filament dynamics, including capping, severing, and polymerization/depolymerization. * **Cell migration and adhesion**: CAPG contributes to cell migration and adhesion by regulating the actin cytoskeleton and interacting with adhesion molecules. * **Immune cell function**: CAPG is essential for the regulation of immune cell function, including phagocytosis, antigen presentation, and cytokine production. * **Cell signaling**: CAPG interacts with other signaling proteins, including those involved in cell growth, differentiation, and survival. **Clinical Significance** The CAPG gene and protein have implications for various diseases and disorders, including: * **Immune-related disorders**: Dysregulation of CAPG has been implicated in immune-related disorders, such as autoimmune diseases and cancer. * **Neurological disorders**: CAPG has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. * **Cancer**: CAPG has been shown to play a role in cancer progression and metastasis. * **Infectious diseases**: CAPG has been implicated in the regulation of immune responses to infectious diseases, including HIV and tuberculosis. In conclusion, the CAPG gene and protein play a crucial role in regulating the actin cytoskeleton and immune cell function. Further studies are necessary to fully elucidate the mechanisms by which CAPG contributes to disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3195570818

Symbol: CAPG_HUMAN

Name: Macrophage-capping protein

UniProtKB Accession Codes:

P40121 B8ZZS7 D6W5K8 Q53SA7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 7 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1322908

Title: Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.

PubMed ID: 1322908

DOI: 10.1016/s0021-9258(18)42037-6

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7851883

Title: The human actin-regulatory protein cap G: gene structure and chromosome location.

PubMed ID: 7851883

DOI: 10.1006/geno.1994.1543

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18266911

Title: A new role for nuclear transport factor 2 and Ran: nuclear import of CapG.

PubMed ID: 18266911

DOI: 10.1111/j.1600-0854.2008.00720.x

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 7814409

Title: Gain-of-function mutations conferring actin-severing activity to human macrophage cap G.

PubMed ID: 7814409

DOI: 10.1074/jbc.270.1.45

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 348
  • Mass: 38499
  • Checksum: BE6E5641D15E9C07
  • Sequence:
    • MYTAIPQSGS PFPGSVQDPG LHVWRVEKLK PVPVAQENQG VFFSGDSYLV LHNGPEEVSH 
LHLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG NESDLFMSYF PRGLKYQEGG 
VESAFHKTST GAPAAIKKLY QVKGKKNIRA TERALNWDSF NTGDCFILDL GQNIFAWCGG 
KSNILERNKA RDLALAIRDS ERQGKAQVEI VTDGEEPAEM IQVLGPKPAL KEGNPEEDLT 
ADKANAQAAA LYKVSDATGQ MNLTKVADSS PFALELLISD DCFVLDNGLC GKIYIWKGRK 
ANEKERQAAL QVAEGFISRM QYAPNTQVEI LPQGHESPIF KQFFKDWK

Genular Protein ID: 4145676554

Symbol: B2R9S4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R9S4

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 Pfam 2 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 348
  • Mass: 38498
  • Checksum: BE60B8A1D15E960D
  • Sequence:
    • MYTAIPQSGS PFPGSVQDPG LHVWRVEKLK PVPVAQENQG VFFSGDSYLV LHNGPEEVSH 
LHLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG NESDLFMSYF PRGLKYQEGG 
VESAFHKTST GAPAAIKKLY QVKGKKNIRA TERALNWDSF NTGDCFILDL GQNIFAWCGG 
KSNILERNKA RDLALAIRDS ERQGKAQVEI VTDGEEPAEM IQVLGPKPAL KEGNPEEDLT 
ADKANAQAAA LYKVSDATGQ MNLTKVADSS PFALELLISD DCFVLNNGLC GKIYIWKGRK 
ANEKERQAAL QVAEGFISRM QYAPNTQVEI LPQGHESPIF KQFFKDWK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.