Details for: CAPG

Gene ID: 822

Symbol: CAPG

Ensembl ID: ENSG00000042493

Description: capping actin protein, gelsolin like

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 4
    Marker Score: 24308
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.73
    Marker Score: 10296
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.34
    Marker Score: 1589
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.3
    Marker Score: 184637
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.97
    Marker Score: 7499
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.89
    Marker Score: 4791
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.88
    Marker Score: 73778
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.81
    Marker Score: 3218
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.72
    Marker Score: 6782.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.71
    Marker Score: 21159
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.6
    Marker Score: 10641
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.51
    Marker Score: 21669
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.44
    Marker Score: 9407
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.4
    Marker Score: 6223.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.39
    Marker Score: 2658
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.37
    Marker Score: 24037
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.31
    Marker Score: 3396
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.3
    Marker Score: 1030
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.29
    Marker Score: 14612
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.29
    Marker Score: 953
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.28
    Marker Score: 1797
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.24
    Marker Score: 2105
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.21
    Marker Score: 25678
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.16
    Marker Score: 3057
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.04
    Marker Score: 15161
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.04
    Marker Score: 3609
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.98
    Marker Score: 704
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.93
    Marker Score: 1939
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.87
    Marker Score: 997.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.85
    Marker Score: 3598
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.81
    Marker Score: 7507
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.79
    Marker Score: 4373
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.74
    Marker Score: 1457
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.72
    Marker Score: 701
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.71
    Marker Score: 16926
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.7
    Marker Score: 524
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.69
    Marker Score: 1021
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.68
    Marker Score: 2025
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.67
    Marker Score: 831
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.65
    Marker Score: 970
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.64
    Marker Score: 322
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.64
    Marker Score: 2860
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.64
    Marker Score: 1663
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.59
    Marker Score: 2903
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.55
    Marker Score: 855
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.54
    Marker Score: 5482
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.54
    Marker Score: 1202
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.53
    Marker Score: 1558
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.53
    Marker Score: 2426
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.51
    Marker Score: 737
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.51
    Marker Score: 4038
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.49
    Marker Score: 7166
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.48
    Marker Score: 1853.5
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.48
    Marker Score: 724
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.47
    Marker Score: 4608
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.45
    Marker Score: 1524
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.44
    Marker Score: 417
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.44
    Marker Score: 348
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.41
    Marker Score: 1026
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.41
    Marker Score: 325
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.41
    Marker Score: 825
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.4
    Marker Score: 445
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.4
    Marker Score: 1483
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.4
    Marker Score: 328
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.36
    Marker Score: 1642
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.34
    Marker Score: 8562
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.33
    Marker Score: 573
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.32
    Marker Score: 1403
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.32
    Marker Score: 466
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.32
    Marker Score: 902
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.31
    Marker Score: 865
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.31
    Marker Score: 1524
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.3
    Marker Score: 1162
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.3
    Marker Score: 982
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.29
    Marker Score: 425
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.28
    Marker Score: 6733
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.27
    Marker Score: 1522.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.26
    Marker Score: 2070
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.25
    Marker Score: 1080
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.24
    Marker Score: 1601
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.23
    Marker Score: 2927
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.23
    Marker Score: 888
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.22
    Marker Score: 640
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.2
    Marker Score: 560
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.2
    Marker Score: 659
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.19
    Marker Score: 824
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 1.19
    Marker Score: 873
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.19
    Marker Score: 811
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.19
    Marker Score: 403
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.18
    Marker Score: 2683
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.17
    Marker Score: 1527
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.17
    Marker Score: 1166.5
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.17
    Marker Score: 733
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.16
    Marker Score: 296
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.15
    Marker Score: 233
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.15
    Marker Score: 2102
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.15
    Marker Score: 591
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.15
    Marker Score: 397
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.14
    Marker Score: 655
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.14
    Marker Score: 563

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Other Information

**Key characteristics:** - CAPG is a protein of the Actin family. - It is a capping protein that binds to the C-terminus of actin filaments and prevents them from polymerizing. - CAPG is also involved in the disassembly of the extracellular matrix. **Pathways and functions:** - CAPG is involved in the regulation of actin filament dynamics. - It is expressed in cells that are undergoing cell migration or cell adhesion. - CAPG prevents the polymerization of actin filaments, which is important for their proper function. - It also plays a role in the disassembly of the extracellular matrix, which is essential for cell migration and cell adhesion. **Clinical significance:** - Mutations in the CAPG gene have been linked to a number of human diseases, including cancer, fibrosis, and vascular disease. - CAPG is a potential target for cancer immunotherapy. - Targeting CAPG could provide a new treatment for these diseases. **Additional information:** - CAPG is a highly conserved protein. - It is found in all eukaryotic cells. - CAPG is a multifunctional protein that has a variety of cellular functions.

Genular Protein ID: 3195570818

Symbol: CAPG_HUMAN

Name: Macrophage-capping protein

UniProtKB Accession Codes:

P40121 B8ZZS7 D6W5K8 Q53SA7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 7 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1322908

Title: Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.

PubMed ID: 1322908

DOI: 10.1016/s0021-9258(18)42037-6

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7851883

Title: The human actin-regulatory protein cap G: gene structure and chromosome location.

PubMed ID: 7851883

DOI: 10.1006/geno.1994.1543

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18266911

Title: A new role for nuclear transport factor 2 and Ran: nuclear import of CapG.

PubMed ID: 18266911

DOI: 10.1111/j.1600-0854.2008.00720.x

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 7814409

Title: Gain-of-function mutations conferring actin-severing activity to human macrophage cap G.

PubMed ID: 7814409

DOI: 10.1074/jbc.270.1.45

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 348
  • Mass: 38499
  • Checksum: BE6E5641D15E9C07
  • Sequence:
    • MYTAIPQSGS PFPGSVQDPG LHVWRVEKLK PVPVAQENQG VFFSGDSYLV LHNGPEEVSH 
LHLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG NESDLFMSYF PRGLKYQEGG 
VESAFHKTST GAPAAIKKLY QVKGKKNIRA TERALNWDSF NTGDCFILDL GQNIFAWCGG 
KSNILERNKA RDLALAIRDS ERQGKAQVEI VTDGEEPAEM IQVLGPKPAL KEGNPEEDLT 
ADKANAQAAA LYKVSDATGQ MNLTKVADSS PFALELLISD DCFVLDNGLC GKIYIWKGRK 
ANEKERQAAL QVAEGFISRM QYAPNTQVEI LPQGHESPIF KQFFKDWK

Genular Protein ID: 4145676554

Symbol: B2R9S4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R9S4

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 Pfam 2 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 348
  • Mass: 38498
  • Checksum: BE60B8A1D15E960D
  • Sequence:
    • MYTAIPQSGS PFPGSVQDPG LHVWRVEKLK PVPVAQENQG VFFSGDSYLV LHNGPEEVSH 
LHLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG NESDLFMSYF PRGLKYQEGG 
VESAFHKTST GAPAAIKKLY QVKGKKNIRA TERALNWDSF NTGDCFILDL GQNIFAWCGG 
KSNILERNKA RDLALAIRDS ERQGKAQVEI VTDGEEPAEM IQVLGPKPAL KEGNPEEDLT 
ADKANAQAAA LYKVSDATGQ MNLTKVADSS PFALELLISD DCFVLNNGLC GKIYIWKGRK 
ANEKERQAAL QVAEGFISRM QYAPNTQVEI LPQGHESPIF KQFFKDWK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.