Details for: CAPN1

Gene ID: 823

Symbol: CAPN1

Ensembl ID: ENSG00000014216

Description: calpain 1

Associated with

Other Information

Genular Protein ID: 3003816363

Symbol: CAN1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3017764

Title: Complete amino acid sequence of the large subunit of the low-Ca2+-requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence.

PubMed ID: 3017764

DOI: 10.1016/0014-5793(86)80919-x

PubMed ID: 2400579

Title: A novel member of the calcium-dependent cysteine protease family.

PubMed ID: 2400579

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8954105

Title: Modulation of the calpain autoproteolysis by calpastatin and phospholipids.

PubMed ID: 8954105

DOI: 10.1006/bbrc.1996.1779

PubMed ID: 8769305

Title: Autolysis of human erythrocyte calpain produces two active enzyme forms with different cell localization.

PubMed ID: 8769305

DOI: 10.1016/0014-5793(96)00775-2

PubMed ID: 9271093

Title: Calcium-binding properties of human erythrocyte calpain.

PubMed ID: 9271093

DOI: 10.1042/bj3250721

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19617626

Title: Calpain-1 cleaves and activates caspase-7.

PubMed ID: 19617626

DOI: 10.1074/jbc.m109.038174

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21531719

Title: Deimination of human filaggrin-2 promotes its proteolysis by calpain 1.

PubMed ID: 21531719

DOI: 10.1074/jbc.m110.197400

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23707407

Title: PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.

PubMed ID: 23707407

DOI: 10.1016/j.jmb.2013.05.009

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27153400

Title: Mutations in CAPN1 cause autosomal-recessive hereditary spastic paraplegia.

PubMed ID: 27153400

DOI: 10.1016/j.ajhg.2016.04.002

PubMed ID: 16411745

Title: Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core.

PubMed ID: 16411745

DOI: 10.1021/bi052077b

Sequence Information:

  • Length: 714
  • Mass: 81890
  • Checksum: 1CB6D7C56D063498
  • Sequence:
  • MSEEIITPVY CTGVSAQVQK QRARELGLGR HENAIKYLGQ DYEQLRVRCL QSGTLFRDEA 
    FPPVPQSLGY KDLGPNSSKT YGIKWKRPTE LLSNPQFIVD GATRTDICQG ALGDCWLLAA 
    IASLTLNDTL LHRVVPHGQS FQNGYAGIFH FQLWQFGEWV DVVVDDLLPI KDGKLVFVHS 
    AEGNEFWSAL LEKAYAKVNG SYEALSGGST SEGFEDFTGG VTEWYELRKA PSDLYQIILK 
    ALERGSLLGC SIDISSVLDM EAITFKKLVK GHAYSVTGAK QVNYRGQVVS LIRMRNPWGE 
    VEWTGAWSDS SSEWNNVDPY ERDQLRVKME DGEFWMSFRD FMREFTRLEI CNLTPDALKS 
    RTIRKWNTTL YEGTWRRGST AGGCRNYPAT FWVNPQFKIR LDETDDPDDY GDRESGCSFV 
    LALMQKHRRR ERRFGRDMET IGFAVYEVPP ELVGQPAVHL KRDFFLANAS RARSEQFINL 
    REVSTRFRLP PGEYVVVPST FEPNKEGDFV LRFFSEKSAG TVELDDQIQA NLPDEQVLSE 
    EEIDENFKAL FRQLAGEDME ISVKELRTIL NRIISKHKDL RTKGFSLESC RSMVNLMDRD 
    GNGKLGLVEF NILWNRIRNY LSIFRKFDLD KSGSMSAYEM RMAIESAGFK LNKKLYELII 
    TRYSEPDLAV DFDNFVCCLV RLETMFRFFK TLDTDLDGVV TFDLFKWLQL TMFA

Genular Protein ID: 3087462350

Symbol: B4DWH5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 660
  • Mass: 75835
  • Checksum: D7BE7773AC75929D
  • Sequence:
  • MRMPSSTWAR IMSSCGCDAC RVGPSSVMRP SPRYPRAWVT RTWVPIPPRP MASSGSVPRN 
    CWLLAAIASL TLNDTLLHRV VPHGQSFQNG YAGIFHFQLW QFGEWVDVVV DDLLPIKDGK 
    LVFVHSAEGN EFWSALLEKA YAKVNGSYEA LSGGSTSEGF EDFTGGVTEW YELRKAPSDL 
    YQIILKALER GSLLGCSIDI SSVLDMEAIT FKKLVKGHAY SVTGAKQVNY RGQVVSLIRM 
    RNPWGEVEWT GAWSDSSSEW NNVDPYERDQ LRVKMEDGEF WMSFRDFMRE FTRLEICNLT 
    PDALKSRTIR KWNTTLYEGT WRRGSTAGGC RNYPATFWVN PQFKIRLDET DDPDDYGDRE 
    SGCSFVLALM QKHRRRERRF GRDMETIGFA VYEVPPELVG QPAVHLKRDF FLANASRARS 
    EQFINLREVS TRFRLPPGEY VVVPSTFEPN KEGDFVLRFF SEKSAGTVEL DDQIQANLPD 
    EQVLSEEEID ENFKALFRQL AGEDMEISVK ELRTILNRII SKHKDLRTKG FSLESCRSMV 
    NLMDRDGNGK LGLVEFNILW NRIRNYLSIF RKFDLDKSGS MSAYEMRMAI ESAGFKLNKK 
    LYELIITRYS EPDLAVDFDN FVCCLVRLET MFRFFKTLDT DLDGVVTFDL FKWLQLTMFA

Genular Protein ID: 1092034388

Symbol: B2RDI5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 714
  • Mass: 81897
  • Checksum: C583A49958C137CE
  • Sequence:
  • MSEEIITPVY CTGVSAQVQK QRARELGLGR HENAIKYLGQ DYEQLRVRCL QSGTLFRDEA 
    FPPVPQSLGY KDLGPNSSKT YGIKWKRPTE LLSNPQFIVD GATRTDICQG ALGDCWLLAA 
    IASLTLNDTL LHRVVPHGQS FQNGYAGIFH FQLWQFGEWV DVVVDDLLPI KDGKLVFVHS 
    AEGNEFWSAL LEKAYAKVNG SYEALSGGST SEGFEDFTGG VTEWYELRKA PSDLYQIILK 
    ALERGSLLGC SIDISSVLDM EAITFKKLVK GHAYSVTGAK QVNYRGQVVS LIRMRNPWGE 
    VEWTGAWSDS SSEWNNVDPY ERDQLRVKME DGEFWMSFRD FMREFTRLEI CNLTPDALKS 
    RTIRKWNTTL YEGTWRRGST AGGCRNYPAT FWVNPQFKIR LDETDDPDDY GDRESGCSFV 
    LALMQKHRRR ERRFGCDMET IGFTVYEVPP ELVGQPAVHL KRDFFLANAS RARSEQFINL 
    REVSTRFRLP PGEYVVVPST FEPNKEGDFV LRFFSEKSAG TVELDDQIQA NLPDEQVLSE 
    EEIDENFKAL FRQLAGEDME ISVKELRTIL NRIISKHKDL RTKGFSLESC RSMVNLMDRD 
    GNGKLGLVEF NILWNRIWNY LSIFRKFDLD KSGSMSAYEM RMAIESAGFK LNKKLYELII 
    TRYSEPDLAV DFDNFVCCLV RLETMFRFFK TLDTDLDGVV TFDLFKWLQL TMFA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.