Details for: CAST

Gene ID: 831

Symbol: CAST

Ensembl ID: ENSG00000153113

Description: calpastatin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.38
    Marker Score: 188800.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.27
    Marker Score: 7989
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.24
    Marker Score: 3460
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.14
    Marker Score: 3309
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.06
    Marker Score: 68302
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.04
    Marker Score: 2595
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.98
    Marker Score: 6280.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.97
    Marker Score: 10215
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.96
    Marker Score: 9280
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.94
    Marker Score: 25504
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.93
    Marker Score: 2309.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.92
    Marker Score: 22805
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.86
    Marker Score: 3686
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.84
    Marker Score: 21130
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.81
    Marker Score: 1878
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.74
    Marker Score: 1867
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.72
    Marker Score: 11391.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.66
    Marker Score: 90485.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.64
    Marker Score: 8339
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.63
    Marker Score: 22633.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.61
    Marker Score: 6511
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.58
    Marker Score: 1112
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.56
    Marker Score: 4671
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.55
    Marker Score: 820
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.53
    Marker Score: 3484
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.53
    Marker Score: 730
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.51
    Marker Score: 4454
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.51
    Marker Score: 2888.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.5
    Marker Score: 2192
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.47
    Marker Score: 3637
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.47
    Marker Score: 4808.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.46
    Marker Score: 1026
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.46
    Marker Score: 85335
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.45
    Marker Score: 28486
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.43
    Marker Score: 8647
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.42
    Marker Score: 38838
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.41
    Marker Score: 1410
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.41
    Marker Score: 15708
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.4
    Marker Score: 2901
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.39
    Marker Score: 2123.5
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.39
    Marker Score: 1365
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.39
    Marker Score: 61149.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.38
    Marker Score: 3505.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.37
    Marker Score: 1124
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.36
    Marker Score: 4494
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.35
    Marker Score: 560.5
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 2.34
    Marker Score: 529.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.34
    Marker Score: 2519
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.32
    Marker Score: 857
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.32
    Marker Score: 2650
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.31
    Marker Score: 12163
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.31
    Marker Score: 1344
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.31
    Marker Score: 11065
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.3
    Marker Score: 1119
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.28
    Marker Score: 2519
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.28
    Marker Score: 1325
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.27
    Marker Score: 1059
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 2.25
    Marker Score: 913
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.25
    Marker Score: 558
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.25
    Marker Score: 1109.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.25
    Marker Score: 2141
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.24
    Marker Score: 1064
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.22
    Marker Score: 512
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.21
    Marker Score: 546
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.21
    Marker Score: 697
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.2
    Marker Score: 3505
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2
    Marker Score: 5020
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.2
    Marker Score: 5748
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.19
    Marker Score: 14002.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.19
    Marker Score: 1226
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.19
    Marker Score: 2558
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.19
    Marker Score: 2481
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.18
    Marker Score: 2622
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.17
    Marker Score: 1356.5
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.17
    Marker Score: 2362
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.17
    Marker Score: 3155
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.17
    Marker Score: 623
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.17
    Marker Score: 24402
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.15
    Marker Score: 750
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.15
    Marker Score: 2011
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.15
    Marker Score: 963
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.14
    Marker Score: 1787
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.14
    Marker Score: 2660
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.13
    Marker Score: 10483
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.13
    Marker Score: 21123.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.13
    Marker Score: 614
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.13
    Marker Score: 9167
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.12
    Marker Score: 1181
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.12
    Marker Score: 740
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.12
    Marker Score: 4228
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.11
    Marker Score: 1653.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.1
    Marker Score: 1932
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.1
    Marker Score: 1460.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.1
    Marker Score: 1266
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.1
    Marker Score: 2823.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.1
    Marker Score: 907
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.09
    Marker Score: 110604
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.09
    Marker Score: 8966
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.09
    Marker Score: 1871
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.08
    Marker Score: 1955

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Other Information

## Summary The CAST gene encodes a calcium-dependent cysteine-type endopeptidase inhibitor, which plays a crucial role in maintaining cellular homeostasis and preventing excessive cell death. It is highly expressed in various cell types, including monocytic, epithelial, and stem cells. ## Key characteristics * **Function:** Inhibits the activity of cysteine-type endopeptidases, which are enzymes that break down proteins. * **Location:** Found in the cytoplasm, cytosol, and extracellular matrix. * **Expression:** Highly expressed in cells expressing CD14, CD16, or beta-catenin. * **Protein structure:** A protein composed of 137 amino acids, with a conserved cysteine-rich domain. ## Pathways and functions * **Cadherin binding:** CAST inhibits the binding of cadherins, which are cell adhesion molecules, to their receptors on endothelial cells. This prevents the formation of cell-cell contacts, disrupting cell-cell communication and migration. * **Calcium-dependent cysteine-type endopeptidase inhibitor activity:** CAST acts as an endopeptidase inhibitor, preventing the proteolytic cleavage of various substrates involved in cell cycle regulation, apoptosis, and extracellular matrix remodeling. * **Regulation of cell death:** CAST inhibits the cdk5 pathway, a major regulator of cell cycle progression and apoptosis. By preventing the proteolytic cleavage of cdk5 substrates, CAST ensures the stability and activity of this critical regulator. * **Neurodegenerative diseases:** CAST has been implicated in several neurodegenerative diseases, including Alzheimer's disease, where it promotes neuronal survival and protects against neurotoxic insults. ## Clinical significance * **Cancer therapy:** Studies have shown that targeting CAST can inhibit cancer cell growth and metastasis. * **Cardiovascular disease:** CAST is expressed in cardiac cells and may contribute to the development of cardiovascular diseases by promoting plaque formation and inflammation. * **Neurological disorders:** The role of CAST in neurodegenerative diseases suggests that targeting it could be a potential therapeutic strategy. Overall, CAST is a critical regulator of cellular homeostasis, cell death, and angiogenesis. Its dysregulation is implicated in various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders.

Genular Protein ID: 1058318670

Symbol: ICAL_HUMAN

Name: Calpastatin

UniProtKB Accession Codes:

P20810 B7Z468 G5E946 G5E9D3 O95360 Q05DE8 Q7Z4K0 Q96D08 Q9H1Z5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 EMBL 27 EPD 1 Ensembl 10 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MEROPS 4 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 10 Pumba 1 RNAct 1 Reactome 2 RefSeq 14 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2577276

Title: cDNA cloning of human calpastatin: sequence homology among human, pig, and rabbit calpastatins.

PubMed ID: 2577276

DOI: 10.3109/14756368909030363

PubMed ID: 11978196

Title: Cloning and characterization of a novel isoform of calpastatin in human adult testis.

PubMed ID: 11978196

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 1569094

Title: Molecular diversity in amino-terminal domains of human calpastatin by exon skipping.

PubMed ID: 1569094

DOI: 10.1016/s0021-9258(18)42463-5

PubMed ID: 2553724

Title: Inhibition of calpain by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene.

PubMed ID: 2553724

DOI: 10.1016/s0021-9258(19)47235-9

PubMed ID: 2407243

Title: Characterization of a functional domain of human calpastatin.

PubMed ID: 2407243

DOI: 10.1016/0006-291x(90)91035-q

PubMed ID: 7951045

Title: Calpastatin gene in human testis.

PubMed ID: 7951045

PubMed ID: 7706496

Title: Detection and expression of a cDNA clone that encodes a polypeptide containing two inhibitory domains of human calpastatin and its recognition by rheumatoid arthritis sera.

PubMed ID: 7706496

DOI: 10.1172/jci117870

PubMed ID: 1995645

Title: Phosphorylation and subcellular distribution of calpastatin in human hematopoietic system cells.

PubMed ID: 1995645

DOI: 10.1016/s0021-9258(19)67888-9

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25683118

Title: Loss-of-function mutations in CAST cause peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads.

PubMed ID: 25683118

DOI: 10.1016/j.ajhg.2014.12.026

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 708
  • Mass: 76573
  • Checksum: 2DB0C14B860E89C7
  • Sequence:
    • MNPTETKAIP VSQQMEGPHL PNKKKHKKQA VKTEPEKKSQ STKLSVVHEK KSQEGKPKEH 
TEPKSLPKQA SDTGSNDAHN KKAVSRSAEQ QPSEKSTEPK TKPQDMISAG GESVAGITAI 
SGKPGDKKKE KKSLTPAVPV ESKPDKPSGK SGMDAALDDL IDTLGGPEET EEENTTYTGP 
EVSDPMSSTY IEELGKREVT IPPKYRELLA KKEGITGPPA DSSKPIGPDD AIDALSSDFT 
CGSPTAAGKK TEKEESTEVL KAQSAGTVRS AAPPQEKKRK VEKDTMSDQA LEALSASLGT 
RQAEPELDLR SIKEVDEAKA KEEKLEKCGE DDETIPSEYR LKPATDKDGK PLLPEPEEKP 
KPRSESELID ELSEDFDRSE CKEKPSKPTE KTEESKAAAP APVSEAVCRT SMCSIQSAPP 
EPATLKGTVP DDAVEALADS LGKKEADPED GKPVMDKVKE KAKEEDREKL GEKEETIPPD 
YRLEEVKDKD GKPLLPKESK EQLPPMSEDF LLDALSEDFS GPQNASSLKF EDAKLAAAIS 
EVVSQTPAST TQAGAPPRDT SQSDKDLDDA LDKLSDSLGQ RQPDPDENKP MEDKVKEKAK 
AEHRDKLGER DDTIPPEYRH LLDDNGQDKP VKPPTKKSED SKKPADDQDP IDALSGDLDS 
CPSTTETSQN TAKDKCKKAA SSSKAPKNGG KAKDSAKTTE ETSKPKDD

Genular Protein ID: 280642240

Symbol: E9PDE4_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PDE4

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 636
  • Mass: 69008
  • Checksum: 35C4E6EE462503F1
  • Sequence:
    • MNPTETKAVK TEPEKKSQST KLSVVHEKKS QEGKPKEHTE PKSLPKQASD TGSNDAHNKK 
AVSRSAEQQP SEKSTEPKSG MDAALDDLID TLGGPEETEE ENTTYTGPEV SDPMSSTYIE 
ELGKREVTIP PKYRELLAKK EGITGPPADS SKPIGPDDAI DALSSDFTCG SPTAAGKKTE 
KEESTEVLKA QSAGTVRSAA PPQEKKRKVE KDTMSDQALE ALSASLGTRQ AEPELDLRSI 
KEVDEAKAKE EKLEKCGEDD ETIPSEYRLK PATDKDGKPL LPEPEEKPKP RSESELIDEL 
SEDFDRSECK EKPSKPTEKT EESKAAAPAP VSEAVCRTSM CSIQSAPPEP ATLKGTVPDD 
AVEALADSLG KKEADPEDGK PVMDKVKEKA KEEDREKLGE KEETIPPDYR LEEVKDKDGK 
PLLPKESKEQ LPPMSEDFLL DALSEDFSGP QNASSLKFED AKLAAAISEV VSQTPASTTQ 
AGAPPRDTSQ SDKDLDDALD KLSDSLGQRQ PDPDENKPME DKVKEKAKAE HRDKLGERDD 
TIPPEYRHLL DDNGQDKPVK PPTKKSEDSK KPADDQDPID ALSGDLDSCP STTETSQNTA 
KDKCKKAASS SKAPKNGGKA KDSAKTTEET SKPKDD

Genular Protein ID: 1636886090

Symbol: Q86YM9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86YM9

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Genevisible 1 GenomeRNAi 1 InterPro 2 MEROPS 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 RefSeq 2 SAM 1

Sequence Information:

  • Length: 435
  • Mass: 47714
  • Checksum: 19B858ACA46A336D
  • Sequence:
    • KTEKEESTEV LKAQSAGTVR SAAPPQEKKR KVEKDTMSDQ ALEALSASLG TRQAEPELDL 
RSIKEVDEAK AKEEKLEKCG EDDETIPSEY RLKPATDKDG KPLLPEPEEK PKPRSESELI 
DELSEDFDRS ECKEKPSKPT EKTEESKAAA PAPVSEAVCR TSMCSIQSAP PEPATLKGTV 
PDDAVEALAD SLGKKEADPE DGKPVMDKVK EKAKEEDREK LGEKEETIPP DYRLEEVKDK 
DGKPLLPKES KEQLPPMSED FLLDALSEDF SGPQNASSLK FEDAKLAAAI SEVVSQTPAS 
TTQAGAPPRD TSQSDKDLDD ALDKLSDSLG QRQPDPDENK PMEDKVKEKA KAEHRDKLGE 
RDDTIPPEYR HLLDDNGQDK PVKPPTKKSE DSKKPADDQD PIDALSGDLD SCPSTTETSQ 
NTAKTTEETS KPKDD

Genular Protein ID: 2582212969

Symbol: Q59HE3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59HE3

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 Genevisible 1 GenomeRNAi 1 InterPro 2 MEROPS 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 784
  • Mass: 84228
  • Checksum: 545694098E6C32CF
  • Sequence:
    • SGHRRRNAAT SNPFFLTNRD QSSAGAGAGH RHVSEKTSES PSKPGEKKGS DEKKAASLGS 
SQSSRTYAGG TASATKVSAS SGATSKSSSM NPTETKAIPV SQQMEGPHLP NKKKHKKQAV 
KTEPEKKSQS TKLSVVHEKK SQEGKPKEHT EPKSLPKQAS DTGSNDAHNK KAVSRSAEQQ 
PSEKSTEPKT KPQDMISAGG ESVAGITAIS GKPGDKKKEK KSLTPAVPVE SKPDKPSGKS 
GMDAALDDLI DTLGGPEETE EENTTYTGPE VSDPMSSTYI EELGKREVTI PPKYRELLAK 
PIGPDDAIDA LSSDFTCGSP TAAGKKTEKE ESTEVLKAQS AGTVRSAAPP QEKKRKVEKD 
TMSDQALEAL SASLGTRQAE PELDLRSIKE VDEAKAKEEK LEKCGEDDET IPSEYRLKPA 
TDKDGKPLLP EPEEKPKPRS ESELIDELSE DFDRSECKEK PSKPTEKTEE SKAAAPAPVS 
EAVSRTSMCS IQSAPPEPAT LKGTVPDDAV EALADSLGKK EADPEDGKPV MDKVKEKAKE 
EDREKLGEKE ETIPPDYRLE EVKDKDGKPL LPKESKEQLP PMSEDFLLDA LSEDFSGPQN 
ASSLKFEDAK LAAAISEVVS QTPASTTQAG APPRDTSQSD KDLDDALDKL SDSLGQRQPD 
PDENKPMEDK VKEKAKAEHR DKLGERDDTI PPEYRHLLDD NGQDKPVKPP TKKSEDSKKP 
ADDQDPIDAL SGDLDSCPST TETSQNTAKD KCKKAASSSK APKNGGKAKD SAKTTEETSK 
PKDD

Genular Protein ID: 3952738036

Symbol: B7Z6N0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6N0

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 GenomeRNAi 1 InterPro 2 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 636
  • Mass: 69010
  • Checksum: D0870AA0ED21ECA0
  • Sequence:
    • MNPTETKAVK TEPEKKSQST KLSVVHEKKS QEGKPKEHTE PKSLPKQASD TGSNDAHNKK 
AVSRSAEQQP SEKSTEPKSG MDAALDDLID TLGGPEETEE ENTTYTGPEV SDPMSSTYIE 
ELGKREVTIP PKYRELLAKK EGITGPPADS SKPIGPDDAI DALSSDFTCG SPTAAGKKTE 
KEESTEVLKA QSAGTVRSAA PPQEKKRKVE KDTMSDQALE ALSASLGTRQ AEPELDLRSI 
KEVDEAKAKE EKLEKCGEDD ETIPSEYRLK PAMDKDGKPL LPEPEEKPKP RSESELIDEL 
SEDFDRSECK EKPSKPTEKT EESKAAAPAP VSEAVCRTSM CSIQSAPPEP ATLKGTVPDD 
AVEALADSLG KKEADPEDGK PVMDKVKEKA KEEDREKLGE KEETIPPDYR LEEVKDKDGK 
PLLPKESKEQ LPPMSEDFLL DALSEDFSGP QNASSLKFED AKLAAAISEV VSQTPASTTQ 
AGAPPRDTSQ SDKDLDDALD KLSDSLGQRQ PDPDENKPME DKVKEKAKAE HRDKLGERDD 
TIPPEYKHLL DDNGQDKPVK PPTKKSEDSK KPADDQDPID ALSGDLDSCP STTETSQNTA 
KDKCKKAASS SKAPKNGGKA KDSAKTTEET SKPKDD

Genular Protein ID: 2219310373

Symbol: E9PCH5_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PCH5

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1 iPTMnet 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 673
  • Mass: 72798
  • Checksum: C93014A2FDCDBFBF
  • Sequence:
    • MNPTETKAVK TEPEKKSQST KLSVVHEKKS QEGKPKEHTE PKSLPKQASD TGSNDAHNKK 
AVSRSAEQQP SEKSTEPKTK PQDMISAGGE SVAGITAISG KPGDKKKEKK SLTPAVPVES 
KPDKPSGKSG MDAALDDLID TLGGPEETEE ENTTYTGPEV SDPMSSTYIE ELGKREVTIP 
PKYRELLAKP IGPDDAIDAL SSDFTCGSPT AAGKKTEKEE STEVLKAQSA GTVRSAAPPQ 
EKKRKVEKDT MSDQALEALS ASLGTRQAEP ELDLRSIKEV DEAKAKEEKL EKCGEDDETI 
PSEYRLKPAT DKDGKPLLPE PEEKPKPRSE SELIDELSED FDRSECKEKP SKPTEKTEES 
KAAAPAPVSE AVCRTSMCSI QSAPPEPATL KGTVPDDAVE ALADSLGKKE ADPEDGKPVM 
DKVKEKAKEE DREKLGEKEE TIPPDYRLEE VKDKDGKPLL PKESKEQLPP MSEDFLLDAL 
SEDFSGPQNA SSLKFEDAKL AAAISEVVSQ TPASTTQAGA PPRDTSQSDK DLDDALDKLS 
DSLGQRQPDP DENKPMEDKV KEKAKAEHRD KLGERDDTIP PEYRHLLDDN GQDKPVKPPT 
KKSEDSKKPA DDQDPIDALS GDLDSCPSTT ETSQNTAKDK CKKAASSSKA PKNGGKAKDS 
AKTTEETSKP KDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.