CAV1 | ENSG00000105974 | NCBI 857

Details for: CAV1

Gene ID: 857

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CAV1

Ensembl ID: ENSG00000105974

Description: caveolin 1

Cell Significance Landscape

Display Count:

Associated with

Basigin interactions
(R-HSA-210991)
Cdc42 gtpase cycle
(R-HSA-9013148)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-HSA-4641262)
Disease
(R-HSA-1643685)
Enos activation
(R-HSA-203615)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Foxo-mediated transcription
(R-HSA-9614085)
Foxo-mediated transcription of cell cycle genes
(R-HSA-9617828)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hemostasis
(R-HSA-109582)
Infectious disease
(R-HSA-5663205)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of nitric oxide: nos3 activation and regulation
(R-HSA-202131)
Nostrin mediated enos trafficking
(R-HSA-203641)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Rac3 gtpase cycle
(R-HSA-9013423)
Rhoa gtpase cycle
(R-HSA-8980692)
Rhob gtpase cycle
(R-HSA-9013026)
Rhoc gtpase cycle
(R-HSA-9013106)
Rhod gtpase cycle
(R-HSA-9013405)
Rhof gtpase cycle
(R-HSA-9035034)
Rhog gtpase cycle
(R-HSA-9013408)
Rho gtpase cycle
(R-HSA-9012999)
Rhoh gtpase cycle
(R-HSA-9013407)
Rhoj gtpase cycle
(R-HSA-9013409)
Rhoq gtpase cycle
(R-HSA-9013406)
Rna polymerase ii transcription
(R-HSA-73857)
Rnd1 gtpase cycle
(R-HSA-9696273)
Rnd2 gtpase cycle
(R-HSA-9696270)
Rnd3 gtpase cycle
(R-HSA-9696264)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 targets host intracellular signalling and regulatory pathways
(R-HSA-9735871)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 targets host intracellular signalling and regulatory pathways
(R-HSA-9755779)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Triglyceride catabolism
(R-HSA-163560)
Triglyceride metabolism
(R-HSA-8979227)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Viral infection pathways
(R-HSA-9824446)
Acrosomal membrane
(GO:0002080)
Angiogenesis
(GO:0001525)
Angiotensin-activated signaling pathway
(GO:0038166)
Apical plasma membrane
(GO:0016324)
Apoptotic signaling pathway
(GO:0097190)
Atpase binding
(GO:0051117)
Basement membrane organization
(GO:0071711)
Basolateral plasma membrane
(GO:0016323)
Calcium ion homeostasis
(GO:0055074)
Calcium ion transport
(GO:0006816)
Canonical wnt signaling pathway
(GO:0060070)
Caveola
(GO:0005901)
Caveola assembly
(GO:0070836)
Caveolar macromolecular signaling complex
(GO:0002095)
Caveolin-mediated endocytosis
(GO:0072584)
Cell cortex
(GO:0005938)
Cell differentiation
(GO:0030154)
Cellular response to exogenous dsrna
(GO:0071360)
Cellular response to hyperoxia
(GO:0071455)
Cellular response to misfolded protein
(GO:0071218)
Cellular response to peptide hormone stimulus
(GO:0071375)
Cellular response to starvation
(GO:0009267)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cholesterol binding
(GO:0015485)
Cholesterol homeostasis
(GO:0042632)
Cholesterol transport
(GO:0030301)
Cilium
(GO:0005929)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoplasmic vesicle
(GO:0031410)
Early endosome membrane
(GO:0031901)
Endocytic vesicle membrane
(GO:0030666)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Endosome
(GO:0005768)
Endothelial cell proliferation
(GO:0001935)
Enzyme binding
(GO:0019899)
Establishment of localization in cell
(GO:0051649)
Fibroblast proliferation
(GO:0048144)
Focal adhesion
(GO:0005925)
Glandular epithelial cell differentiation
(GO:0002067)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Identical protein binding
(GO:0042802)
Insulin receptor internalization
(GO:0038016)
Intracellular calcium ion homeostasis
(GO:0006874)
Intracellular nitric oxide homeostasis
(GO:0033484)
Inward rectifier potassium channel inhibitor activity
(GO:0070320)
Lactation
(GO:0007595)
Lipid droplet
(GO:0005811)
Lipid storage
(GO:0019915)
Maintenance of protein location in cell
(GO:0032507)
Mammary gland development
(GO:0030879)
Mammary gland involution
(GO:0060056)
Mapk cascade
(GO:0000165)
Membrane
(GO:0016020)
Membrane depolarization
(GO:0051899)
Membrane raft
(GO:0045121)
Molecular adaptor activity
(GO:0060090)
Muscle cell cellular homeostasis
(GO:0046716)
Negative regulation of anoikis
(GO:2000811)
Negative regulation of bmp signaling pathway
(GO:0030514)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cytokine-mediated signaling pathway
(GO:0001960)
Negative regulation of endothelial cell proliferation
(GO:0001937)
Negative regulation of epithelial cell differentiation
(GO:0030857)
Negative regulation of fibroblast proliferation
(GO:0048147)
Negative regulation of inward rectifier potassium channel activity
(GO:1903609)
Negative regulation of mapk cascade
(GO:0043409)
Negative regulation of necroptotic process
(GO:0060546)
Negative regulation of nitric oxide biosynthetic process
(GO:0045019)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of peptidyl-tyrosine autophosphorylation
(GO:1900085)
Negative regulation of pinocytosis
(GO:0048550)
Negative regulation of potassium ion transmembrane transport
(GO:1901380)
Negative regulation of protein tyrosine kinase activity
(GO:0061099)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of receptor signaling pathway via jak-stat
(GO:0046426)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nitric-oxide synthase binding
(GO:0050998)
Nitric oxide biosynthetic process
(GO:0006809)
Oxysterol binding
(GO:0008142)
Patched binding
(GO:0005113)
Peptidase activator activity
(GO:0016504)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of calcium ion transport into cytosol
(GO:0010524)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell adhesion molecule production
(GO:0060355)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of erad pathway
(GO:1904294)
Positive regulation of extrinsic apoptotic signaling pathway
(GO:2001238)
Positive regulation of gap junction assembly
(GO:1903598)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of intrinsic apoptotic signaling pathway
(GO:2001244)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of toll-like receptor 3 signaling pathway
(GO:0034141)
Positive regulation of vasoconstriction
(GO:0045907)
Post-transcriptional regulation of gene expression
(GO:0010608)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein kinase binding
(GO:0019901)
Protein localization
(GO:0008104)
Protein localization to basolateral plasma membrane
(GO:1903361)
Protein localization to plasma membrane raft
(GO:0044860)
Protein sequestering activity
(GO:0140311)
Protein transport
(GO:0015031)
Protein tyrosine kinase inhibitor activity
(GO:0030292)
Receptor-mediated endocytosis of virus by host cell
(GO:0019065)
Receptor internalization
(GO:0031623)
Regulation of blood coagulation
(GO:0030193)
Regulation of cardiac muscle cell action potential involved in regulation of contraction
(GO:0098909)
Regulation of cell communication by electrical coupling involved in cardiac conduction
(GO:1901844)
Regulation of cytosolic calcium ion concentration
(GO:0051480)
Regulation of entry of bacterium into host cell
(GO:2000535)
Regulation of fatty acid metabolic process
(GO:0019217)
Regulation of heart rate by cardiac conduction
(GO:0086091)
Regulation of membrane repolarization during action potential
(GO:0098903)
Regulation of ruffle assembly
(GO:1900027)
Regulation of smooth muscle contraction
(GO:0006940)
Regulation of the force of heart contraction by chemical signal
(GO:0003057)
Regulation of ventricular cardiac muscle cell action potential
(GO:0098911)
Response to bacterium
(GO:0009617)
Response to calcium ion
(GO:0051592)
Response to estrogen
(GO:0043627)
Response to hypoxia
(GO:0001666)
Response to ischemia
(GO:0002931)
Response to progesterone
(GO:0032570)
Sarcolemma
(GO:0042383)
Signaling receptor binding
(GO:0005102)
Skeletal muscle tissue development
(GO:0007519)
Small gtpase binding
(GO:0031267)
T cell costimulation
(GO:0031295)
Transmembrane transporter binding
(GO:0044325)
Triglyceride metabolic process
(GO:0006641)
Vasculogenesis
(GO:0001570)
Vasoconstriction
(GO:0042310)
Vesicle organization
(GO:0016050)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

secretory cell CL0000151

CSI 38.54

rCSI 40.21%

PRS 90.15
pulmonary artery endothelial cell CL1001568

CSI 37.1

rCSI 50.49%

PRS 95.05
endothelial cell of artery CL1000413

CSI 36.88

rCSI 54.03%

PRS 93.04
keratinocyte CL0000312

CSI 35.88

rCSI 30.08%

PRS 91.21
enteric smooth muscle cell CL0002504

CSI 33.71

rCSI 48.11%

PRS 91.21
perivascular cell CL4033054

CSI 31.43

rCSI 42.97%

PRS 93.88
plasmablast CL0000980

CSI 26.68

rCSI 20.99%

PRS 93.17
capillary endothelial cell CL0002144

CSI 22.62

rCSI 41.46%

PRS 91.64
melanocyte CL0000148

CSI 20.25

rCSI 15%

PRS 87.61
extravillous trophoblast CL0008036

CSI 18.08

rCSI 22.36%

PRS 89.55
myofibroblast cell CL0000186

CSI 16.51

rCSI 22.87%

PRS 87.96
skin fibroblast CL0002620

CSI 16.39

rCSI 14.13%

PRS 90.63
retinal blood vessel endothelial cell CL0002585

CSI 15.44

rCSI 24.67%

PRS 93.13
conjunctival epithelial cell CL1000432

CSI 15.11

rCSI 23.08%

PRS 90.11
microcirculation associated smooth muscle cell CL0008035

CSI 14.9

rCSI 43.15%

PRS 90.37
pulmonary capillary endothelial cell CL4028001

CSI 14.74

rCSI 28.11%

PRS 95.88
neural crest cell CL0011012

CSI 14.48

rCSI 11.44%

PRS 84.54
stem cell CL0000034

CSI 13.79

rCSI 13.29%

PRS 87.16
vein endothelial cell CL0002543

CSI 13.23

rCSI 36.1%

PRS 93.51
epithelial cell of lung CL0000082

CSI 13

rCSI 10.78%

PRS 91.87
blood vessel endothelial cell CL0000071

CSI 12.6

rCSI 26.15%

PRS 89.51
basal-myoepithelial cell of mammary gland CL0002324

CSI 12.53

rCSI 23.68%

PRS 95.89
hepatic stellate cell CL0000632

CSI 12.24

rCSI 45.86%

PRS 86.78
endothelial cell of lymphatic vessel CL0002138

CSI 11.96

rCSI 23.7%

PRS 92.38
smooth muscle cell CL0000192

CSI 11.92

rCSI 28.42%

PRS 85.44
epithelial cell of lower respiratory tract CL0002632

CSI 11.69

rCSI 9.06%

PRS 93.28
basal cell of prostate epithelium CL0002341

CSI 11.59

rCSI 33.53%

PRS 93.17
pulmonary alveolar type 1 cell CL0002062

CSI 11.55

rCSI 66.59%

PRS 88.31
adipocyte CL0000136

CSI 11.54

rCSI 14.82%

PRS 83.36
ependymal cell CL0000065

CSI 11.52

rCSI 23.37%

PRS 74.26
lung endothelial cell CL1001567

CSI 11.18

rCSI 26.06%

PRS 96.04
fibroblast of lung CL0002553

CSI 10.79

rCSI 10.04%

PRS 92.37
bronchus fibroblast of lung CL2000093

CSI 10.56

rCSI 8.58%

PRS 90.51
multi-ciliated epithelial cell CL0005012

CSI 10.41

rCSI 10.39%

PRS 85.86
goblet cell CL0000160

CSI 10.38

rCSI 9.81%

PRS 88.98
parietal epithelial cell CL1000452

CSI 10.17

rCSI 27.18%

PRS 86
lung ciliated cell CL1000271

CSI 10.03

rCSI 11.59%

PRS 85.87
intestine goblet cell CL0019031

CSI 9.57

rCSI 8.49%

PRS 88.76
endothelial cell of placenta CL0009092

CSI 9.51

rCSI 46.85%

PRS 94.32
vascular associated smooth muscle cell CL0000359

CSI 9.5

rCSI 30.82%

PRS 89.42
placental villous trophoblast CL2000060

CSI 9.43

rCSI 14.58%

PRS 89.31
M cell of gut CL0000682

CSI 9.26

rCSI 9.84%

PRS 93.05
vein endothelial cell of respiratory system CL4033008

CSI 8.84

rCSI 60.67%

PRS 93.95
tendon cell CL0000388

CSI 8.72

rCSI 22.67%

PRS 93.65
Mueller cell CL0000636

CSI 8.6

rCSI 19.64%

PRS 84.91
alveolar type 1 fibroblast cell CL4028004

CSI 8.49

rCSI 9.3%

PRS 92.45
tracheobronchial smooth muscle cell CL0019019

CSI 8.31

rCSI 14.66%

PRS 93.52
subcutaneous adipocyte CL0002521

CSI 8.03

rCSI 41.14%

PRS 93.01
endothelial cell of uterus CL0009095

CSI 7.94

rCSI 58.08%

PRS 94.99
pancreatic stellate cell CL0002410

CSI 7.84

rCSI 45.62%

PRS 92.42
cardiac endothelial cell CL0010008

CSI 7.83

rCSI 31.58%

PRS 91.56
lung pericyte CL0009089

CSI 7.81

rCSI 20.62%

PRS 94.5
stromal cell of ovary CL0002132

CSI 7.75

rCSI 21.3%

PRS 93.93
type EC enteroendocrine cell CL0000577

CSI 7.75

rCSI 27.5%

PRS 92.24
renal interstitial pericyte CL1001318

CSI 7.68

rCSI 21.18%

PRS 88.49
interstitial cell of Cajal CL0002088

CSI 7.25

rCSI 9.23%

PRS 94.27
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 7.02

rCSI 32.19%

PRS 92.73
alveolar adventitial fibroblast CL4028006

CSI 6.71

rCSI 10.59%

PRS 91.9
cerebral cortex endothelial cell CL1001602

CSI 6.28

rCSI 10.87%

PRS 85.99
smooth muscle cell of the pulmonary artery CL0002591

CSI 6.25

rCSI 47.93%

PRS 91.67
adventitial cell CL0002503

CSI 6.07

rCSI 14.49%

PRS 93.06
respiratory basal cell CL0002633

CSI 6.07

rCSI 6.28%

PRS 92.57
endothelial cell of venule CL1000414

CSI 5.96

rCSI 52.91%

PRS 94.56
mammary gland epithelial cell CL0002327

CSI 5.58

rCSI 19.59%

PRS 94.75
mononuclear phagocyte CL0000113

CSI 5.54

rCSI 12.2%

PRS 93.24
regular atrial cardiac myocyte CL0002129

CSI 5.36

rCSI 17.24%

PRS 87.7
endocardial cell CL0002350

CSI 5.27

rCSI 25.22%

PRS 87.57
vasa recta descending limb cell CL1001285

CSI 5.26

rCSI 41.98%

PRS 94.79
pericyte CL0000669

CSI 5.26

rCSI 14%

PRS 68.73
basal cell CL0000646

CSI 5.05

rCSI 6.75%

PRS 88.59
intrahepatic cholangiocyte CL0002538

CSI 4.86

rCSI 11.66%

PRS 91
myoepithelial cell CL0000185

CSI 4.48

rCSI 11.33%

PRS 93.29
fallopian tube secretory epithelial cell CL4030006

CSI 4.42

rCSI 4.26%

PRS 89.65
pancreatic ductal cell CL0002079

CSI 4.13

rCSI 8.03%

PRS 92.42
basal cell of epidermis CL0002187

CSI 3.78

rCSI 6.7%

PRS 63.06
respiratory hillock cell CL4030023

CSI 3.67

rCSI 6.54%

PRS 94.56
ciliated epithelial cell CL0000067

CSI 3.67

rCSI 3.22%

PRS 82.81
lung secretory cell CL1000272

CSI 3.64

rCSI 9%

PRS 91.65
mesenchymal cell CL0008019

CSI 3.62

rCSI 9.19%

PRS 86.33
epicardial adipocyte CL1000309

CSI 3.58

rCSI 11.64%

PRS 88.43
bronchiolar smooth muscle cell CL4033017

CSI 3.43

rCSI 51.44%

PRS 94.68
airway submucosal gland duct basal cell CL4033024

CSI 3.24

rCSI 20.71%

PRS 92.4
myeloid leukocyte CL0000766

CSI 3.2

rCSI 2.96%

PRS 92.09
cardiac blood vessel endothelial cell CL0010006

CSI 3.19

rCSI 22.58%

PRS 84.79
differentiation-committed oligodendrocyte precursor CL4023059

CSI 3.17

rCSI 5.77%

PRS 85.02
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 3.04

rCSI 9.37%

PRS 92.55
lung microvascular endothelial cell CL2000016

CSI 3.03

rCSI 58.59%

PRS 94.9
fibroblast of breast CL4006000

CSI 3.03

rCSI 12.72%

PRS 92.8
endothelial cell of vascular tree CL0002139

CSI 2.95

rCSI 16.13%

PRS 87.24
endothelial cell of arteriole CL1000412

CSI 2.83

rCSI 15.68%

PRS 95.92
IgG plasma cell CL0000985

CSI 2.82

rCSI 3.37%

PRS 94.4
mesenchymal stem cell of adipose tissue CL0002570

CSI 2.8

rCSI 15.62%

PRS 92.09
collagen secreting cell CL0000667

CSI 2.72

rCSI 15.58%

PRS 93.8
blood vessel smooth muscle cell CL0019018

CSI 2.62

rCSI 21.27%

PRS 88.59
hair follicular keratinocyte CL2000092

CSI 2.61

rCSI 45.44%

PRS 94.06
stromal cell CL0000499

CSI 2.59

rCSI 7.27%

PRS 87.4
cardiac muscle cell CL0000746

CSI 2.56

rCSI 3.67%

PRS 83.54
contractile cell CL0000183

CSI 2.54

rCSI 7.5%

PRS 90.26
smooth muscle cell of prostate CL1000487

CSI 2.48

rCSI 14.57%

PRS 93.97
skeletal muscle satellite cell CL0000594

CSI 2.43

rCSI 7.1%

PRS 95.89

Merkel cell CL0000242

CSI 0.7

rCSI 15.8%

PRS 98.0%
regular ventricular cardiac myocyte CL0002131

CSI 0.9

rCSI 5.5%

PRS 85.2%
glial cell CL0000125

CSI 1.2

rCSI 4.6%

PRS 84.9%
vasa recta ascending limb cell CL1001131

CSI 1.3

rCSI 6.1%

PRS 94.3%
mesenchymal stem cell CL0000134

CSI 1.5

rCSI 16.5%

PRS 92.9%
chondrocyte CL0000138

CSI 1.6

rCSI 2.6%

PRS 86.6%
retinal ganglion cell CL0000740

CSI 1.7

rCSI 3.8%

PRS 81.1%
syncytiotrophoblast cell CL0000525

CSI 1.7

rCSI 5.0%

PRS 92.3%
mesodermal cell CL0000222

CSI 1.8

rCSI 2.1%

PRS 90.1%
luminal epithelial cell of mammary gland CL0002326

CSI 1.8

rCSI 3.2%

PRS 95.3%
ventricular cardiac muscle cell CL2000046

CSI 2.0

rCSI 6.9%

PRS 93.6%
prostate gland microvascular endothelial cell CL2000059

CSI 2.1

rCSI 49.1%

PRS 93.9%
uterine smooth muscle cell CL0002601

CSI 2.2

rCSI 14.4%

PRS 93.2%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 2.2

rCSI 13.1%

PRS 79.2%
glycinergic amacrine cell CL4030028

CSI 2.3

rCSI 5.9%

PRS 85.5%
keratocyte CL0002363

CSI 2.3

rCSI 5.5%

PRS 92.1%
skeletal muscle satellite cell CL0000594

CSI 2.4

rCSI 7.1%

PRS 95.9%
smooth muscle cell of prostate CL1000487

CSI 2.5

rCSI 14.6%

PRS 94.0%
contractile cell CL0000183

CSI 2.5

rCSI 7.5%

PRS 90.3%
cardiac muscle cell CL0000746

CSI 2.6

rCSI 3.7%

PRS 83.5%
stromal cell CL0000499

CSI 2.6

rCSI 7.3%

PRS 87.4%
hair follicular keratinocyte CL2000092

CSI 2.6

rCSI 45.4%

PRS 94.1%
blood vessel smooth muscle cell CL0019018

CSI 2.6

rCSI 21.3%

PRS 88.6%
collagen secreting cell CL0000667

CSI 2.7

rCSI 15.6%

PRS 93.8%
mesenchymal stem cell of adipose tissue CL0002570

CSI 2.8

rCSI 15.6%

PRS 92.1%
IgG plasma cell CL0000985

CSI 2.8

rCSI 3.4%

PRS 94.4%
endothelial cell of arteriole CL1000412

CSI 2.8

rCSI 15.7%

PRS 95.9%
endothelial cell of vascular tree CL0002139

CSI 3.0

rCSI 16.1%

PRS 87.2%
fibroblast of breast CL4006000

CSI 3.0

rCSI 12.7%

PRS 92.8%
lung microvascular endothelial cell CL2000016

CSI 3.0

rCSI 58.6%

PRS 94.9%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 3.0

rCSI 9.4%

PRS 92.6%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 3.2

rCSI 5.8%

PRS 85.0%
cardiac blood vessel endothelial cell CL0010006

CSI 3.2

rCSI 22.6%

PRS 84.8%
myeloid leukocyte CL0000766

CSI 3.2

rCSI 3.0%

PRS 92.1%
airway submucosal gland duct basal cell CL4033024

CSI 3.2

rCSI 20.7%

PRS 92.4%
bronchiolar smooth muscle cell CL4033017

CSI 3.4

rCSI 51.4%

PRS 94.7%
epicardial adipocyte CL1000309

CSI 3.6

rCSI 11.6%

PRS 88.4%
mesenchymal cell CL0008019

CSI 3.6

rCSI 9.2%

PRS 86.3%
lung secretory cell CL1000272

CSI 3.6

rCSI 9.0%

PRS 91.7%
ciliated epithelial cell CL0000067

CSI 3.7

rCSI 3.2%

PRS 82.8%
respiratory hillock cell CL4030023

CSI 3.7

rCSI 6.5%

PRS 94.6%
basal cell of epidermis CL0002187

CSI 3.8

rCSI 6.7%

PRS 63.1%
pancreatic ductal cell CL0002079

CSI 4.1

rCSI 8.0%

PRS 92.4%
fallopian tube secretory epithelial cell CL4030006

CSI 4.4

rCSI 4.3%

PRS 89.7%
myoepithelial cell CL0000185

CSI 4.5

rCSI 11.3%

PRS 93.3%
intrahepatic cholangiocyte CL0002538

CSI 4.9

rCSI 11.7%

PRS 91.0%
basal cell CL0000646

CSI 5.1

rCSI 6.8%

PRS 88.6%
pericyte CL0000669

CSI 5.3

rCSI 14.0%

PRS 68.7%
vasa recta descending limb cell CL1001285

CSI 5.3

rCSI 42.0%

PRS 94.8%
endocardial cell CL0002350

CSI 5.3

rCSI 25.2%

PRS 87.6%
regular atrial cardiac myocyte CL0002129

CSI 5.4

rCSI 17.2%

PRS 87.7%
mononuclear phagocyte CL0000113

CSI 5.5

rCSI 12.2%

PRS 93.2%
mammary gland epithelial cell CL0002327

CSI 5.6

rCSI 19.6%

PRS 94.8%
endothelial cell of venule CL1000414

CSI 6.0

rCSI 52.9%

PRS 94.6%
respiratory basal cell CL0002633

CSI 6.1

rCSI 6.3%

PRS 92.6%
adventitial cell CL0002503

CSI 6.1

rCSI 14.5%

PRS 93.1%
smooth muscle cell of the pulmonary artery CL0002591

CSI 6.3

rCSI 47.9%

PRS 91.7%
cerebral cortex endothelial cell CL1001602

CSI 6.3

rCSI 10.9%

PRS 86.0%
alveolar adventitial fibroblast CL4028006

CSI 6.7

rCSI 10.6%

PRS 91.9%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 7.0

rCSI 32.2%

PRS 92.7%
interstitial cell of Cajal CL0002088

CSI 7.3

rCSI 9.2%

PRS 94.3%
renal interstitial pericyte CL1001318

CSI 7.7

rCSI 21.2%

PRS 88.5%
type EC enteroendocrine cell CL0000577

CSI 7.8

rCSI 27.5%

PRS 92.2%
stromal cell of ovary CL0002132

CSI 7.8

rCSI 21.3%

PRS 93.9%
lung pericyte CL0009089

CSI 7.8

rCSI 20.6%

PRS 94.5%
cardiac endothelial cell CL0010008

CSI 7.8

rCSI 31.6%

PRS 91.6%
pancreatic stellate cell CL0002410

CSI 7.8

rCSI 45.6%

PRS 92.4%
endothelial cell of uterus CL0009095

CSI 7.9

rCSI 58.1%

PRS 95.0%
subcutaneous adipocyte CL0002521

CSI 8.0

rCSI 41.1%

PRS 93.0%
tracheobronchial smooth muscle cell CL0019019

CSI 8.3

rCSI 14.7%

PRS 93.5%
alveolar type 1 fibroblast cell CL4028004

CSI 8.5

rCSI 9.3%

PRS 92.5%
Mueller cell CL0000636

CSI 8.6

rCSI 19.6%

PRS 84.9%
tendon cell CL0000388

CSI 8.7

rCSI 22.7%

PRS 93.7%
vein endothelial cell of respiratory system CL4033008

CSI 8.8

rCSI 60.7%

PRS 94.0%
M cell of gut CL0000682

CSI 9.3

rCSI 9.8%

PRS 93.1%
placental villous trophoblast CL2000060

CSI 9.4

rCSI 14.6%

PRS 89.3%
vascular associated smooth muscle cell CL0000359

CSI 9.5

rCSI 30.8%

PRS 89.4%
endothelial cell of placenta CL0009092

CSI 9.5

rCSI 46.9%

PRS 94.3%
intestine goblet cell CL0019031

CSI 9.6

rCSI 8.5%

PRS 88.8%
lung ciliated cell CL1000271

CSI 10.0

rCSI 11.6%

PRS 85.9%
parietal epithelial cell CL1000452

CSI 10.2

rCSI 27.2%

PRS 86.0%
goblet cell CL0000160

CSI 10.4

rCSI 9.8%

PRS 89.0%
multi-ciliated epithelial cell CL0005012

CSI 10.4

rCSI 10.4%

PRS 85.9%
bronchus fibroblast of lung CL2000093

CSI 10.6

rCSI 8.6%

PRS 90.5%
fibroblast of lung CL0002553

CSI 10.8

rCSI 10.0%

PRS 92.4%
lung endothelial cell CL1001567

CSI 11.2

rCSI 26.1%

PRS 96.0%
ependymal cell CL0000065

CSI 11.5

rCSI 23.4%

PRS 74.3%
adipocyte CL0000136

CSI 11.5

rCSI 14.8%

PRS 83.4%
pulmonary alveolar type 1 cell CL0002062

CSI 11.6

rCSI 66.6%

PRS 88.3%
basal cell of prostate epithelium CL0002341

CSI 11.6

rCSI 33.5%

PRS 93.2%
epithelial cell of lower respiratory tract CL0002632

CSI 11.7

rCSI 9.1%

PRS 93.3%
smooth muscle cell CL0000192

CSI 11.9

rCSI 28.4%

PRS 85.4%
endothelial cell of lymphatic vessel CL0002138

CSI 12.0

rCSI 23.7%

PRS 92.4%
hepatic stellate cell CL0000632

CSI 12.2

rCSI 45.9%

PRS 86.8%
basal-myoepithelial cell of mammary gland CL0002324

CSI 12.5

rCSI 23.7%

PRS 95.9%
blood vessel endothelial cell CL0000071

CSI 12.6

rCSI 26.2%

PRS 89.5%
epithelial cell of lung CL0000082

CSI 13.0

rCSI 10.8%

PRS 91.9%
vein endothelial cell CL0002543

CSI 13.2

rCSI 36.1%

PRS 93.5%
stem cell CL0000034

CSI 13.8

rCSI 13.3%

PRS 87.2%
neural crest cell CL0011012

CSI 14.5

rCSI 11.4%

PRS 84.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [CAV1](/details-gene/857) (Caveolin-1) is a protein-coding gene located on chromosome 7q31.2 that encodes the principal structural component of caveolae, which are small invaginations of the plasma membrane involved in endocytosis, cholesterol homeostasis, and signal transduction. Functionally, [CAV1](/details-gene/857) acts as a scaffolding protein to organize and concentrate signaling molecules, playing a critical role in numerous cellular processes including angiogenesis, lipid metabolism, and the regulation of signaling cascades such as Wnt and MAPK pathways. Expression data indicates that [CAV1](/details-gene/857) is a highly significant marker for a variety of structural and barrier cells, most notably endothelial cells of the vasculature, secretory cells, smooth muscle cells, and keratinocytes. Clinically, mutations in [CAV1](/details-gene/857) are associated with congenital lipodystrophy and hypertriglyceridemia ([601047](https://omim.org/entry/601047)). ## Cellular Roles and Expression Landscape The expression profile of [CAV1](/details-gene/857) highlights its fundamental role in structural, secretory, and endothelial cell types. **Overall**, the gene shows the highest significance in [secretory cell](/details-cell/CL0000151) (CSI: 38.54), suggesting a key function in vesicle trafficking and secretion. A predominant role for [CAV1](/details-gene/857) is observed within the vascular endothelium. It is a defining marker for multiple endothelial subtypes, including [pulmonary artery endothelial cell](/details-cell/CL1001568) (CSI: 37.10), [endothelial cell of artery](/details-cell/CL1000413) (CSI: 36.88), [capillary endothelial cell](/details-cell/CL0002144) (CSI: 22.62), and [retinal blood vessel endothelial cell](/details-cell/CL0002585) (CSI: 15.44). This widespread and high significance is consistent with its established role in regulating vascular permeability, angiogenesis, and nitric oxide signaling. Beyond the endothelium, [CAV1](/details-gene/857) is highly significant in cells that form structural barriers or contractile tissues. This includes high significance in [keratinocyte](/details-cell/CL0000312) (CSI: 35.88) of the skin, [enteric smooth muscle cell](/details-cell/CL0002504) (CSI: 33.71), and stromal cells such as [myofibroblast cell](/details-cell/CL0000186) (CSI: 16.51) and [skin fibroblast](/details-cell/CL0002620) (CSI: 16.39). Its presence in [perivascular cell](/details-cell/CL4033054) (CSI: 31.43) further underscores its importance in the architecture and function of the circulatory system. The notable significance in [plasmablast](/details-cell/CL0000980) (CSI: 26.68) suggests a potential role in the extensive protein secretion apparatus of these antibody-producing cells. ## Pathways and Molecular Function The functional annotations for [CAV1](/details-gene/857) are extensive, reflecting its role as a master regulator of membrane organization and signaling. Its primary molecular function is to serve as a scaffolding protein within [Caveola (GO:0005901)](https://www.ebi.ac.uk/QuickGO/term/GO:0005901) and [Membrane raft (GO:0045121)](https://www.ebi.ac.uk/QuickGO/term/GO:0045121). This role is facilitated by its ability to bind a wide array of proteins, including signaling receptors, enzymes, and other structural components, as indicated by its annotation for [Protein binding (GO:0005515)](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) and [Enzyme binding (GO:0019899)](https://www.ebi.ac.uk/QuickGO/term/GO:0019899). Biologically, [CAV1](/details-gene/857) is integral to several key processes: * **Vesicular Transport:** It is a central player in [Caveolin-mediated endocytosis (GO:0072584)](https://www.ebi.ac.uk/QuickGO/term/GO:0072584) and is involved in [Receptor internalization (GO:0031623)](https://www.ebi.ac.uk/QuickGO/term/GO:0031623), which aligns with its high expression in secretory and endothelial cells that require active membrane trafficking. * **Signal Transduction:** [CAV1](/details-gene/857) acts as a potent regulator of multiple signaling pathways. It is involved in the negative regulation of the [Mapk cascade (GO:0043409)](https://www.ebi.ac.uk/QuickGO/term/GO:0043409) and [Canonical wnt signaling pathway (GO:0090090)](https://www.ebi.ac.uk/QuickGO/term/GO:0090090). Its role in vascular biology is underscored by its participation in the [Vegfa-vegfr2 pathway (R-HSA-4420097)](https://reactome.org/content/detail/R-HSA-4420097) and [Metabolism of nitric oxide: nos3 activation and regulation (R-HSA-202131)](https://reactome.org/content/detail/R-HSA-202131). The gene's connection to T-cell biology is supported by evidence that it triggers T-cell activation [Link](https://doi.org/10.1074/jbc.m609157200). * **Lipid Metabolism:** It plays a crucial role in [Cholesterol homeostasis (GO:0042632)](https://www.ebi.ac.uk/QuickGO/term/GO:0042632) and [Triglyceride metabolic process (GO:0006641)](https://www.ebi.ac.uk/QuickGO/term/GO:0006641). This is highly consistent with its clinical association with lipodystrophies, where mutations in [CAV1](/details-gene/857) lead to abnormal fat distribution [Link](https://doi.org/10.1210/jc.2007-1328). * **Angiogenesis and Vascular Function:** [CAV1](/details-gene/857) is directly implicated in [Angiogenesis (GO:0001525)](https://www.ebi.ac.uk/QuickGO/term/GO:0001525) and [Vasoconstriction (GO:0042310)](https://www.ebi.ac.uk/QuickGO/term/GO:0042310), functions that are directly linked to its high significance in the various endothelial and smooth muscle cell types. ## Research Directions The widespread expression of [CAV1](/details-gene/857) in fundamental cell types, coupled with its role as a signaling hub, presents several avenues for future research, particularly in understanding its context-dependent functions in health and disease. Based on the available data, several testable hypotheses can be proposed: 1. Given the high significance of [CAV1](/details-gene/857) across diverse endothelial subtypes ([pulmonary artery endothelial cell](/details-cell/CL1001568), [capillary endothelial cell](/details-cell/CL0002144)), we hypothesize that the composition of [CAV1](/details-gene/857)-associated protein complexes varies between these vascular beds, thereby dictating tissue-specific endothelial responses to systemic signals like inflammation or hypoxia. 2. The high CSI score of [CAV1](/details-gene/857) in [plasmablast](/details-cell/CL0000980) suggests a critical role in large-scale protein secretion. We hypothesize that [CAV1](/details-gene/857) is essential for the efficient trafficking and fusion of immunoglobulin-containing vesicles with the plasma membrane, and its disruption would impair antibody secretion. 3. Considering its role in both promoting and inhibiting proliferation in different contexts ([Fibroblast proliferation (GO:0048144)](https://www.ebi.ac.uk/QuickGO/term/GO:0048144) and [Negative regulation of endothelial cell proliferation (GO:0001937)](https://www.ebi.ac.uk/QuickGO/term/GO:0001937)), we hypothesize that the function of [CAV1](/details-gene/857) as a pro- or anti-proliferative factor is determined by the specific protein kinase and phosphatase partners it recruits to caveolae in a given cell type. To test the first hypothesis regarding tissue-specific endothelial functions, a compelling experimental approach would be to employ proximity-labeling proteomics (e.g., BioID or TurboID) using [CAV1](/details-gene/857) as bait in primary cultures of different human endothelial cells, such as pulmonary artery versus dermal microvascular endothelial cells. Mass spectrometry analysis of the labeled proteins would reveal differential interactomes, which could then be validated by co-immunoprecipitation. Functional follow-up could involve siRNA-mediated knockdown of specific, differentially-interacting partners to assess their impact on key endothelial functions like permeability or tube formation in response to VEGF. From a therapeutic perspective, [CAV1](/details-gene/857) presents a complex profile. Its integral role in angiogenesis makes it a potential target for anti-cancer therapies aimed at disrupting tumor vasculature. However, its widespread and critical function in normal tissues, particularly the entire vascular system, makes systemic inhibition a high-risk strategy likely to cause significant toxicity. A more viable therapeutic approach may involve developing agents that disrupt specific pathogenic protein-protein interactions involving [CAV1](/details-gene/857) rather than inhibiting the protein itself, thereby offering greater specificity for diseased cells or tissues.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 978574568

Symbol: CAV1_HUMAN

Name: Caveolin-1

UniProtKB Accession Codes:

Q03135 Q9UGP1 Q9UNG1 Q9UQH6

Database IDs:

Citations:

PubMed ID: 1360410

Title: The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles.

PubMed ID: 1360410

DOI: 10.1016/0014-5793(92)81458-x

PubMed ID: 10086342

Title: Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines.

PubMed ID: 10086342

DOI: 10.1038/sj.onc.1202491

PubMed ID: 10218480

Title: Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines.

PubMed ID: 10218480

DOI: 10.1016/s0014-5793(99)00365-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15219854

Title: N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes.

PubMed ID: 15219854

DOI: 10.1016/j.bbrc.2004.05.196

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 8632005

Title: Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo.

PubMed ID: 8632005

DOI: 10.1074/jbc.271.7.3863

PubMed ID: 11751885

Title: Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx.

PubMed ID: 11751885

DOI: 10.1074/jbc.m108537200

PubMed ID: 11865038

Title: Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex.

PubMed ID: 11865038

DOI: 10.1242/jcs.115.4.827

PubMed ID: 12531427

Title: c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14.

PubMed ID: 12531427

DOI: 10.1016/s0898-6568(02)00090-6

PubMed ID: 16807357

Title: Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN.

PubMed ID: 16807357

DOI: 10.1091/mbc.e05-08-0709

PubMed ID: 16501093

Title: The rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1.

PubMed ID: 16501093

DOI: 10.1128/jvi.80.6.2842-2854.2006

PubMed ID: 17287217

Title: Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.

PubMed ID: 17287217

DOI: 10.1074/jbc.m609157200

PubMed ID: 18211975

Title: Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy.

PubMed ID: 18211975

DOI: 10.1210/jc.2007-1328

PubMed ID: 18237401

Title: Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia.

PubMed ID: 18237401

DOI: 10.1186/1476-511x-7-3

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19262564

Title: SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function.

PubMed ID: 19262564

DOI: 10.1038/emboj.2009.46

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20345844

Title: Decreased caveolin-1 levels contribute to fibrosis and deposition of extracellular IGFBP-5.

PubMed ID: 20345844

DOI: 10.1111/j.1582-4934.2010.01063.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22474227

Title: Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension.

PubMed ID: 22474227

DOI: 10.1161/circgenetics.111.961888

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24576892

Title: Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux.

PubMed ID: 24576892

DOI: 10.1016/j.bbalip.2014.02.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25588833

Title: Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae.

PubMed ID: 25588833

DOI: 10.1242/jcs.161463

PubMed ID: 25893292

Title: Syntenin regulates TGF-beta1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-beta type I receptor internalization.

PubMed ID: 25893292

DOI: 10.1038/onc.2015.100

PubMed ID: 28593998

Title: The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation.

PubMed ID: 28593998

DOI: 10.1038/ncomms15502

PubMed ID: 12368209

Title: Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia.

PubMed ID: 12368209

DOI: 10.1016/s0002-9440(10)64412-4

PubMed ID: 21822278

Title: Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations.

PubMed ID: 21822278

DOI: 10.1038/ncb2301

PubMed ID: 23335559

Title: Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase.

PubMed ID: 23335559

DOI: 10.1074/jbc.m112.429076

PubMed ID: 25556234

Title: New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.

PubMed ID: 25556234

DOI: 10.1074/mcp.m114.044107

Sequence Information:

Length: 178
Mass: 20472
Checksum: 2424DE9B5E6521D5
Sequence:

MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADELSEKQ VYDAHTKEID LVNRDPKHLN 
DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSALFGIP MALIWGIYFA 
ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTVCDPLF EAVGKIFSNV RINLQKEI

Genular Protein ID: 4004908550

Symbol: A9XTE5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A9XTE5

Database IDs:

Sequence Information:

Length: 176
Mass: 20068
Checksum: 39A8184FA6C3A71B
Sequence:

HGAVAVGAGH LYTVPIREQG NIYKPNNKAM ADELSEKQVY DAHTKEIDLV NRDPKHLNDD 
VVKIDFEDVI AEPEGTHSFD GIWKASFTTF TVTKYWFYRL LSALFGIPMA LIWGIYFAIL 
SFLHIWAVVP CIKSFLIEIQ CTSRVYSIYV HTVCDPLFEA VGKIFSNVRI NLQKEI

Genular Protein ID: 4202660448

Symbol: Q7Z4F3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z4F3

Database IDs:

Sequence Information:

Length: 147
Mass: 17011
Checksum: 1A7D908D1C072A47
Sequence:

MADELSEKQV YDAHTKEIDL VNRDPKHLND DVVKIDFEDV IAEPEGTHSF DGIWKASFTT 
FTVTKYWFYR LLSALFGIPM ALIWGIYFAI LSFLHIWAVV PCIKSFLIEI QCTSRVYSIY 
VHTVCDPLFE AVGKIFSNVR INLQKEI

Genular Protein ID: 2883065047

Symbol: Q59E85_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59E85

Database IDs:

Sequence Information:

Length: 217
Mass: 25069
Checksum: 220BFA69EEDE7BF2
Sequence:

LSERLVRFRA RGFPRRQADF SSLVFLFAFF LPPPLPPSPS WPSALRPLQG HLYTVPIREQ 
GNIYKPNNKA MADELSEKQV YDAHTKEIDL VNRDPKHLND DVVKIDFEDV IAEPEGTHSF 
DGIWKASFTT FTVTKYWFYR LLSALFGIPM ALIWGIYFAI LSFLHIWAVV PCIKSFLIEI 
QCISRVYSIY VHTVCDPLFE AVGKIFSNVR INLQKEI

Details for: CAV1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles. PubMed ID: 1360410

Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines. PubMed ID: 10086342

Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines. PubMed ID: 10218480

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes. PubMed ID: 15219854

Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. PubMed ID: 15242332

Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo. PubMed ID: 8632005

Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx. PubMed ID: 11751885

Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex. PubMed ID: 11865038

c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14. PubMed ID: 12531427

Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. PubMed ID: 16807357

The rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1. PubMed ID: 16501093

Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1. PubMed ID: 17287217

Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy. PubMed ID: 18211975

Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia. PubMed ID: 18237401

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function. PubMed ID: 19262564

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Decreased caveolin-1 levels contribute to fibrosis and deposition of extracellular IGFBP-5. PubMed ID: 20345844

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension. PubMed ID: 22474227

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux. PubMed ID: 24576892

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae. PubMed ID: 25588833

Syntenin regulates TGF-beta1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-beta type I receptor internalization. PubMed ID: 25893292

The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation. PubMed ID: 28593998

Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia. PubMed ID: 12368209

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations. PubMed ID: 21822278

Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase. PubMed ID: 23335559

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein. PubMed ID: 25556234

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PubMed ID: 19608861

PubMed ID: 20068231

PubMed ID: 20345844

PubMed ID: 21269460

PubMed ID: 21406692

PubMed ID: 22474227

PubMed ID: 22814378

PubMed ID: 23186163

PubMed ID: 24576892

PubMed ID: 24275569

PubMed ID: 25588833

PubMed ID: 25893292

PubMed ID: 28593998

PubMed ID: 12368209

PubMed ID: 21822278

PubMed ID: 23335559

PubMed ID: 25556234