CAV2 | ENSG00000105971 | NCBI 858

Details for: CAV2

Gene ID: 858

Symbol: CAV2

Ensembl ID: ENSG00000105971

Description: caveolin 2

Associated with

Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Acrosomal membrane
(GO:0002080)
Basement membrane organization
(GO:0071711)
Caveola
(GO:0005901)
Caveola assembly
(GO:0070836)
Caveolar macromolecular signaling complex
(GO:0002095)
Cell differentiation
(GO:0030154)
Cytoplasmic vesicle
(GO:0031410)
Endoplasmic reticulum organization
(GO:0007029)
Endothelial cell proliferation
(GO:0001935)
Focal adhesion
(GO:0005925)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Insulin receptor signaling pathway
(GO:0008286)
Membrane raft
(GO:0045121)
Mitochondrion organization
(GO:0007005)
Molecular adaptor activity
(GO:0060090)
Negative regulation of endothelial cell proliferation
(GO:0001937)
Negative regulation of skeletal muscle cell proliferation
(GO:0014859)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Plasma membrane raft
(GO:0044853)
Positive regulation by host of viral process
(GO:0044794)
Positive regulation of dopamine receptor signaling pathway
(GO:0060161)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of mapk cascade
(GO:0043410)
Protein-containing complex
(GO:0032991)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Receptor-mediated endocytosis of virus by host cell
(GO:0019065)
Regulation of cytosolic calcium ion concentration
(GO:0051480)
Regulation of mitotic nuclear division
(GO:0007088)
Sarcolemma
(GO:0042383)
Scaffold protein binding
(GO:0097110)
Skeletal muscle cell proliferation
(GO:0014856)
Skeletal muscle fiber development
(GO:0048741)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Transport vesicle
(GO:0030133)
Vesicle docking
(GO:0048278)
Vesicle fusion
(GO:0006906)
Vesicle organization
(GO:0016050)
Viral release from host cell
(GO:0019076)

Other Information

Proteins

Caveolin-2

Genular Protein ID: 2558931515

Symbol: CAV2_HUMAN

Name: Caveolin-2

UniProtKB Accession Codes:

P51636 A4D0U2 Q9UGM7

Database IDs:

Citations:

PubMed ID: 8552590

Title: Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.

PubMed ID: 8552590

DOI: 10.1073/pnas.93.1.131

PubMed ID: 9361015

Title: Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo.

PubMed ID: 9361015

DOI: 10.1074/jbc.272.46.29337

PubMed ID: 10218480

Title: Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines.

PubMed ID: 10218480

DOI: 10.1016/s0014-5793(99)00365-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9738464

Title: Mutational analysis of caveolin-induced vesicle formation. Expression of caveolin-1 recruits caveolin-2 to caveolae membranes.

PubMed ID: 9738464

DOI: 10.1016/s0014-5793(98)00945-4

PubMed ID: 12091389

Title: Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.

PubMed ID: 12091389

DOI: 10.1074/jbc.m204367200

PubMed ID: 15504032

Title: Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).

PubMed ID: 15504032

DOI: 10.1021/bi049295+

PubMed ID: 18081315

Title: Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells.

PubMed ID: 18081315

DOI: 10.1021/bi701709s

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 162
Mass: 18291
Checksum: 89FDEDA861330B87
Sequence:

MGLETEKADV QLFMDDDSYS HHSGLEYADP EKFADSDQDR DPHRLNSHLK LGFEDVIAEP 
VTTHSFDKVW ICSHALFEIS KYVMYKFLTV FLAIPLAFIA GILFATLSCL HIWILMPFVK 
TCLMVLPSVQ TIWKSVTDVI IAPLCTSVGR CFSSVSLQLS QD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CAV2

Associated with

Other Information

Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. PubMed ID: 8552590

Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. PubMed ID: 9361015

Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines. PubMed ID: 10218480

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mutational analysis of caveolin-induced vesicle formation. Expression of caveolin-1 recruits caveolin-2 to caveolae membranes. PubMed ID: 9738464

Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. PubMed ID: 12091389

Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27). PubMed ID: 15504032

Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells. PubMed ID: 18081315

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569