Details for: CAV2

Gene ID: 858

Symbol: CAV2

Ensembl ID: ENSG00000105971

Description: caveolin 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 4.24
    Marker Score: 5102
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.88
    Marker Score: 5619
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.62
    Marker Score: 9203
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.72
    Marker Score: 6650
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.57
    Marker Score: 868.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.55
    Marker Score: 2197
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.45
    Marker Score: 54813
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.45
    Marker Score: 8717
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.38
    Marker Score: 11710
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.32
    Marker Score: 1815
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.3
    Marker Score: 2196
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.17
    Marker Score: 3158
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.14
    Marker Score: 1521
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.13
    Marker Score: 4253
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.11
    Marker Score: 21209
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.01
    Marker Score: 3786
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.95
    Marker Score: 5301
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.9
    Marker Score: 1073
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.89
    Marker Score: 535
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.88
    Marker Score: 3179
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.87
    Marker Score: 1757
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.86
    Marker Score: 598
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.84
    Marker Score: 540
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.83
    Marker Score: 1904
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.79
    Marker Score: 1411
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.72
    Marker Score: 652
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.7
    Marker Score: 1119
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.69
    Marker Score: 757
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.68
    Marker Score: 908
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.64
    Marker Score: 26263
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.62
    Marker Score: 1742
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.62
    Marker Score: 592
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.57
    Marker Score: 610
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.56
    Marker Score: 870
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.53
    Marker Score: 326
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.52
    Marker Score: 2774.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.51
    Marker Score: 538
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.51
    Marker Score: 1519
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.47
    Marker Score: 2036
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167635
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.43
    Marker Score: 837
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.43
    Marker Score: 1280
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.41
    Marker Score: 339
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.4
    Marker Score: 18877
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.4
    Marker Score: 1638
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.39
    Marker Score: 1258
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.38
    Marker Score: 1488
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.37
    Marker Score: 330
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.35
    Marker Score: 1740
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.33
    Marker Score: 6997
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.33
    Marker Score: 11453
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.3
    Marker Score: 342
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.29
    Marker Score: 20185
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.29
    Marker Score: 372
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.29
    Marker Score: 533
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.24
    Marker Score: 2716
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.23
    Marker Score: 1292
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.17
    Marker Score: 299
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.17
    Marker Score: 11104
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.17
    Marker Score: 9115
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.16
    Marker Score: 2197
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.16
    Marker Score: 1427
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.16
    Marker Score: 729
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.14
    Marker Score: 2027
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.13
    Marker Score: 717
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.13
    Marker Score: 371
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.12
    Marker Score: 1651
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.1
    Marker Score: 516
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.08
    Marker Score: 2553
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.08
    Marker Score: 8071
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.06
    Marker Score: 258
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.06
    Marker Score: 424
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.05
    Marker Score: 1442
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.04
    Marker Score: 2618
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.04
    Marker Score: 325
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.04
    Marker Score: 241
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.03
    Marker Score: 35064
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.01
    Marker Score: 2653
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.01
    Marker Score: 257
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.01
    Marker Score: 601
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1
    Marker Score: 417
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71745
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47968
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.98
    Marker Score: 1621
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.98
    Marker Score: 243
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.97
    Marker Score: 605
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.97
    Marker Score: 243
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.95
    Marker Score: 1940.5
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.95
    Marker Score: 596
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.95
    Marker Score: 459
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.94
    Marker Score: 4060
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.94
    Marker Score: 1328
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.94
    Marker Score: 205
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.93
    Marker Score: 263
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.93
    Marker Score: 988
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.93
    Marker Score: 1477

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Other Information

**Key characteristics:** * Type: Protein * Ensembl ID: ENSG00000105971 * Protein length: 1,271 amino acids * Domain: Transmembrane domain * Tissue expression: Endothelial cells of the lungs, blood vessels, and other tissues * Functional domains: * Extra-nuclear estrogen signaling domain * Endoplasmic reticulum organization domain * Negative regulation of endothelial cell proliferation domain * Positive regulation of endothelial cell proliferation domain **Pathways and functions:** * Endoplasmic reticulum organization: Caveolin-2 is a key component of the endoplasmic reticulum (ER), where it is involved in the transport of proteins and lipids. * Endothelial cell proliferation: Caveolin-2 is essential for the proliferation of endothelial cells. It is a key regulator of vascularization and tumor growth. * Esr-mediated signaling: Caveolin-2 is a downstream target of estrogen receptors. It is involved in the regulation of angiogenesis and breast development. * Extra-nuclear estrogen signaling: Caveolin-2 is also a downstream target of the extra-nuclear estrogen receptor (ER). It is involved in the regulation of cell growth and differentiation. * Insulin receptor signaling pathway: Caveolin-2 is a downstream target of the insulin receptor. It is involved in the regulation of vascular permeability. * Mitochondrial organization: Caveolin-2 is involved in the organization and stability of mitochondria in endothelial cells. **Clinical significance:** * Mutations in the CAV2 gene have been linked to a number of human diseases, including pulmonary hypertension, heart failure, and cancer. * Caveolin-2 inhibitors are being investigated as potential treatments for these diseases. **Additional notes:** * Caveolin-2 is a highly conserved protein that is found in organisms from yeast to humans. * It is a member of the CAV family of proteins, which are involved in the organization and function of the endoplasmic reticulum. * Caveolin-2 is a multifunctional protein that plays a critical role in the regulation of endothelial cell growth, migration, and survival.

Genular Protein ID: 2558931515

Symbol: CAV2_HUMAN

Name: Caveolin-2

UniProtKB Accession Codes:

P51636 A4D0U2 Q9UGM7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 46 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8552590

Title: Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.

PubMed ID: 8552590

DOI: 10.1073/pnas.93.1.131

PubMed ID: 9361015

Title: Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo.

PubMed ID: 9361015

DOI: 10.1074/jbc.272.46.29337

PubMed ID: 10218480

Title: Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines.

PubMed ID: 10218480

DOI: 10.1016/s0014-5793(99)00365-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9738464

Title: Mutational analysis of caveolin-induced vesicle formation. Expression of caveolin-1 recruits caveolin-2 to caveolae membranes.

PubMed ID: 9738464

DOI: 10.1016/s0014-5793(98)00945-4

PubMed ID: 12091389

Title: Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.

PubMed ID: 12091389

DOI: 10.1074/jbc.m204367200

PubMed ID: 15504032

Title: Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).

PubMed ID: 15504032

DOI: 10.1021/bi049295+

PubMed ID: 18081315

Title: Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells.

PubMed ID: 18081315

DOI: 10.1021/bi701709s

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 162
  • Mass: 18291
  • Checksum: 89FDEDA861330B87
  • Sequence:
    • MGLETEKADV QLFMDDDSYS HHSGLEYADP EKFADSDQDR DPHRLNSHLK LGFEDVIAEP 
VTTHSFDKVW ICSHALFEIS KYVMYKFLTV FLAIPLAFIA GILFATLSCL HIWILMPFVK 
TCLMVLPSVQ TIWKSVTDVI IAPLCTSVGR CFSSVSLQLS QD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.