Details for: CAV2

Gene ID: 858

Symbol: CAV2

Ensembl ID: ENSG00000105971

Description: caveolin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 246.7289
    Cell Significance Index: -38.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 151.8471
    Cell Significance Index: -38.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 78.0518
    Cell Significance Index: -36.8500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 12.3823
    Cell Significance Index: 36.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6806
    Cell Significance Index: -38.2000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 6.1490
    Cell Significance Index: 77.4300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 4.3579
    Cell Significance Index: 77.0100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 2.7549
    Cell Significance Index: 12.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.0184
    Cell Significance Index: 22.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9934
    Cell Significance Index: 152.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5581
    Cell Significance Index: 42.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5110
    Cell Significance Index: 668.0400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.2782
    Cell Significance Index: 9.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2480
    Cell Significance Index: 153.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2405
    Cell Significance Index: 87.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9532
    Cell Significance Index: 860.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9352
    Cell Significance Index: 120.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.7620
    Cell Significance Index: 11.2500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.7076
    Cell Significance Index: 6.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6604
    Cell Significance Index: 17.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5528
    Cell Significance Index: 89.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4253
    Cell Significance Index: 46.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4244
    Cell Significance Index: 41.9800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.3989
    Cell Significance Index: 2.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3961
    Cell Significance Index: 54.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3870
    Cell Significance Index: 211.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.3398
    Cell Significance Index: 38.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3223
    Cell Significance Index: 16.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2956
    Cell Significance Index: 53.2900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2896
    Cell Significance Index: 4.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2620
    Cell Significance Index: 49.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2423
    Cell Significance Index: 11.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1336
    Cell Significance Index: 8.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1306
    Cell Significance Index: 16.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1088
    Cell Significance Index: 12.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0706
    Cell Significance Index: 12.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0684
    Cell Significance Index: 1.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0579
    Cell Significance Index: 3.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0208
    Cell Significance Index: 39.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0170
    Cell Significance Index: 7.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0097
    Cell Significance Index: 14.9300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0060
    Cell Significance Index: 0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0039
    Cell Significance Index: -2.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0050
    Cell Significance Index: -1.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0052
    Cell Significance Index: -0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0071
    Cell Significance Index: -9.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0077
    Cell Significance Index: -14.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0132
    Cell Significance Index: -0.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0164
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0205
    Cell Significance Index: -15.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0212
    Cell Significance Index: -14.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0258
    Cell Significance Index: -16.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0264
    Cell Significance Index: -16.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0265
    Cell Significance Index: -9.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0288
    Cell Significance Index: -21.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0398
    Cell Significance Index: -7.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0486
    Cell Significance Index: -2.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0521
    Cell Significance Index: -29.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0808
    Cell Significance Index: -2.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1078
    Cell Significance Index: -11.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1101
    Cell Significance Index: -7.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1194
    Cell Significance Index: -34.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1219
    Cell Significance Index: -25.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1227
    Cell Significance Index: -14.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1496
    Cell Significance Index: -5.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1602
    Cell Significance Index: -3.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1847
    Cell Significance Index: -2.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2101
    Cell Significance Index: -4.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2186
    Cell Significance Index: -31.7700
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2205
    Cell Significance Index: -0.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2462
    Cell Significance Index: -6.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2664
    Cell Significance Index: -12.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2873
    Cell Significance Index: -4.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2890
    Cell Significance Index: -21.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3207
    Cell Significance Index: -33.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4126
    Cell Significance Index: -32.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4559
    Cell Significance Index: -7.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4671
    Cell Significance Index: -28.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4795
    Cell Significance Index: -30.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4957
    Cell Significance Index: -30.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5033
    Cell Significance Index: -10.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5052
    Cell Significance Index: -16.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5285
    Cell Significance Index: -35.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5740
    Cell Significance Index: -12.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5837
    Cell Significance Index: -37.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7199
    Cell Significance Index: -36.3800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7200
    Cell Significance Index: -26.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7282
    Cell Significance Index: -40.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7458
    Cell Significance Index: -32.9900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.7595
    Cell Significance Index: -11.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7706
    Cell Significance Index: -29.1800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7813
    Cell Significance Index: -24.7100
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.7834
    Cell Significance Index: -3.8100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.8288
    Cell Significance Index: -5.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8551
    Cell Significance Index: -21.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8590
    Cell Significance Index: -17.9800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.8742
    Cell Significance Index: -11.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8857
    Cell Significance Index: -28.2100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.9220
    Cell Significance Index: -6.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9566
    Cell Significance Index: -33.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CAV2 is a 18-kDa protein that belongs to the caveolin family, which consists of three isoforms: CAV1, CAV2, and CAV3. Unlike CAV1, which is highly expressed in most tissues, CAV2 is predominantly found in endothelial cells and epithelial cells. CAV2 has a unique structure, consisting of four transmembrane domains and a hydrophobic C-terminal tail. This tail is essential for the formation of caveolae and the interaction with other proteins. CAV2 has been shown to be involved in various signaling pathways, including those mediated by the insulin receptor, dopamine receptor, and transforming growth factor-beta receptor. It also regulates the activity of small GTPases, such as RhoA and Rac1, which are involved in cell signaling and cytoskeletal organization. **Pathways and Functions** CAV2 is a multifunctional protein that regulates various cellular processes, including: 1. **Endothelial cell proliferation and survival**: CAV2 negatively regulates endothelial cell proliferation and survival, which is essential for maintaining vascular homeostasis. 2. **Cell differentiation**: CAV2 regulates the differentiation of epithelial cells and endothelial cells, ensuring proper tissue development and maintenance. 3. **Signaling by nuclear receptors**: CAV2 interacts with nuclear receptors, such as estrogen receptors, to modulate gene expression and cell growth. 4. **GTPase activity regulation**: CAV2 regulates the activity of small GTPases, such as RhoA and Rac1, which are involved in cell signaling and cytoskeletal organization. 5. **Receptor-mediated endocytosis**: CAV2 is involved in the internalization of receptors, such as the insulin receptor, which regulates cell growth and metabolism. **Clinical Significance** Dysregulation of CAV2 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of CAV2 has been observed in various types of cancer, including breast, lung, and prostate cancer. 2. **Cardiovascular disease**: CAV2 has been shown to play a role in the development of cardiovascular disease, including atherosclerosis and hypertension. 3. **Neurological disorders**: CAV2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Respiratory disease**: CAV2 has been shown to play a role in the development of respiratory diseases, including chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. In conclusion, CAV2 is a multifunctional protein that plays a crucial role in various cellular processes, including cell growth, differentiation, and survival. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying CAV2 function and its role in human disease.

Genular Protein ID: 2558931515

Symbol: CAV2_HUMAN

Name: Caveolin-2

UniProtKB Accession Codes:

P51636 A4D0U2 Q9UGM7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 46 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8552590

Title: Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.

PubMed ID: 8552590

DOI: 10.1073/pnas.93.1.131

PubMed ID: 9361015

Title: Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo.

PubMed ID: 9361015

DOI: 10.1074/jbc.272.46.29337

PubMed ID: 10218480

Title: Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines.

PubMed ID: 10218480

DOI: 10.1016/s0014-5793(99)00365-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9738464

Title: Mutational analysis of caveolin-induced vesicle formation. Expression of caveolin-1 recruits caveolin-2 to caveolae membranes.

PubMed ID: 9738464

DOI: 10.1016/s0014-5793(98)00945-4

PubMed ID: 12091389

Title: Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.

PubMed ID: 12091389

DOI: 10.1074/jbc.m204367200

PubMed ID: 15504032

Title: Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).

PubMed ID: 15504032

DOI: 10.1021/bi049295+

PubMed ID: 18081315

Title: Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells.

PubMed ID: 18081315

DOI: 10.1021/bi701709s

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 162
  • Mass: 18291
  • Checksum: 89FDEDA861330B87
  • Sequence:
    • MGLETEKADV QLFMDDDSYS HHSGLEYADP EKFADSDQDR DPHRLNSHLK LGFEDVIAEP 
VTTHSFDKVW ICSHALFEIS KYVMYKFLTV FLAIPLAFIA GILFATLSCL HIWILMPFVK 
TCLMVLPSVQ TIWKSVTDVI IAPLCTSVGR CFSSVSLQLS QD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.