RUNX1 | ENSG00000159216 | NCBI 861

Details for: RUNX1

Gene ID: 861

Symbol: RUNX1

Ensembl ID: ENSG00000159216

Description: RUNX family transcription factor 1

Associated with

Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Infectious disease
(R-HSA-5663205)
Organic cation/anion/zwitterion transport
(R-HSA-549132)
Organic cation transport
(R-HSA-549127)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 and foxp3 control the development of regulatory t lymphocytes (tregs)
(R-HSA-8877330)
Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
(R-HSA-8939243)
Runx1 regulates estrogen receptor mediated transcription
(R-HSA-8931987)
Runx1 regulates expression of components of tight junctions
(R-HSA-8935964)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in bcr signaling
(R-HSA-8939245)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Runx1 regulates transcription of genes involved in differentiation of keratinocytes
(R-HSA-8939242)
Runx1 regulates transcription of genes involved in differentiation of myeloid cells
(R-HSA-8939246)
Runx1 regulates transcription of genes involved in interleukin signaling
(R-HSA-8939247)
Runx1 regulates transcription of genes involved in wnt signaling
(R-HSA-8939256)
Runx2 regulates genes involved in differentiation of myeloid cells
(R-HSA-8941333)
Runx3 regulates p14-arf
(R-HSA-8951936)
Runx3 regulates runx1-mediated transcription
(R-HSA-8951911)
Sars-cov-1 activates/modulates innate immune responses
(R-HSA-9692916)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov infections
(R-HSA-9679506)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Slc-mediated transmembrane transport
(R-HSA-425407)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by runx3
(R-HSA-8878159)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-HSA-425366)
Transport of small molecules
(R-HSA-382551)
Viral infection pathways
(R-HSA-9824446)
Atp binding
(GO:0005524)
Calcium ion binding
(GO:0005509)
Cardiac muscle tissue regeneration
(GO:0061026)
Chondrocyte differentiation
(GO:0002062)
Chromatin
(GO:0000785)
Core-binding factor complex
(GO:0016513)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Hematopoietic stem cell proliferation
(GO:0071425)
Hemopoiesis
(GO:0030097)
Intracellular membrane-bounded organelle
(GO:0043231)
Myeloid cell differentiation
(GO:0030099)
Myeloid leukocyte differentiation
(GO:0002573)
Negative regulation of cd4-positive, alpha-beta t cell differentiation
(GO:0043371)
Negative regulation of granulocyte differentiation
(GO:0030853)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Ossification
(GO:0001503)
Peripheral nervous system neuron development
(GO:0048935)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cd8-positive, alpha-beta t cell differentiation
(GO:0043378)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of extracellular matrix organization
(GO:1903055)
Positive regulation of granulocyte differentiation
(GO:0030854)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of cardiac muscle cell proliferation
(GO:0060043)
Regulation of cell differentiation
(GO:0045595)
Regulation of connective tissue replacement
(GO:1905203)
Regulation of plasminogen activation
(GO:0010755)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Transcription corepressor binding
(GO:0001222)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 222.8934
Cell Significance Index: -34.6700
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 97.5385
Cell Significance Index: -24.7400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 81.8939
Cell Significance Index: -33.2700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 80.4664
Cell Significance Index: -37.9900
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 71.0168
Cell Significance Index: -36.5300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 35.0775
Cell Significance Index: -33.4900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 28.8250
Cell Significance Index: -35.5400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 16.8465
Cell Significance Index: -36.8700
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 15.8705
Cell Significance Index: 97.6700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 13.4722
Cell Significance Index: -36.0900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.3943
Cell Significance Index: -41.1400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.0090
Cell Significance Index: -35.5500
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 6.1446
Cell Significance Index: 37.9100
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 5.9844
Cell Significance Index: 60.3700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.6553
Cell Significance Index: 272.4300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 3.1978
Cell Significance Index: 43.6300
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.9880
Cell Significance Index: 24.3700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.9220
Cell Significance Index: 188.5100
Cell Name: type I muscle cell (CL0002211)
Fold Change: 2.8595
Cell Significance Index: 69.7700
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.6902
Cell Significance Index: 23.8800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.2880
Cell Significance Index: 107.5400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.1204
Cell Significance Index: 110.1500
Cell Name: preadipocyte (CL0002334)
Fold Change: 1.9578
Cell Significance Index: 38.2100
Cell Name: type II muscle cell (CL0002212)
Fold Change: 1.7412
Cell Significance Index: 28.1000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.3982
Cell Significance Index: 252.0500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3826
Cell Significance Index: 274.3900
Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: 1.1662
Cell Significance Index: 11.6700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.1257
Cell Significance Index: 32.2700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9975
Cell Significance Index: 162.2400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9715
Cell Significance Index: 119.4600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9128
Cell Significance Index: 99.2800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.8107
Cell Significance Index: 104.7400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6219
Cell Significance Index: 17.3800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.6163
Cell Significance Index: 5.6800
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6147
Cell Significance Index: 335.7200
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.5916
Cell Significance Index: 7.4500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.5876
Cell Significance Index: 22.2500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5614
Cell Significance Index: 16.1800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5200
Cell Significance Index: 23.5700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.5140
Cell Significance Index: 9.5000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.4909
Cell Significance Index: 13.1300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4839
Cell Significance Index: 29.0500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.4696
Cell Significance Index: 12.0700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4652
Cell Significance Index: 20.5800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4406
Cell Significance Index: 194.7800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4366
Cell Significance Index: 30.1900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3324
Cell Significance Index: 15.5000
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2285
Cell Significance Index: 29.2900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2004
Cell Significance Index: 5.0100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1923
Cell Significance Index: 68.9900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1848
Cell Significance Index: 5.0300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1593
Cell Significance Index: 30.3200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1256
Cell Significance Index: 12.4200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1196
Cell Significance Index: 23.9900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0977
Cell Significance Index: 11.5200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0711
Cell Significance Index: 2.5000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0575
Cell Significance Index: 51.9200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0451
Cell Significance Index: 61.3200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0418
Cell Significance Index: 78.6600
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0410
Cell Significance Index: 75.6200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0252
Cell Significance Index: 15.9900
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.0184
Cell Significance Index: 0.1200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0144
Cell Significance Index: 22.1000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0035
Cell Significance Index: 0.0600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0124
Cell Significance Index: -9.3600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0160
Cell Significance Index: -7.2600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0216
Cell Significance Index: -14.9100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0223
Cell Significance Index: -16.5200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0270
Cell Significance Index: -2.0700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0333
Cell Significance Index: -18.7800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0334
Cell Significance Index: -4.5900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0338
Cell Significance Index: -21.1100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0429
Cell Significance Index: -31.4200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0532
Cell Significance Index: -9.0900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0626
Cell Significance Index: -18.0100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0666
Cell Significance Index: -6.8000
Cell Name: mature microglial cell (CL0002629)
Fold Change: -0.0980
Cell Significance Index: -1.0700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1080
Cell Significance Index: -15.7100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1172
Cell Significance Index: -7.8800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1248
Cell Significance Index: -26.2900
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.1631
Cell Significance Index: -0.7100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1795
Cell Significance Index: -20.5600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1872
Cell Significance Index: -21.8200
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1944
Cell Significance Index: -22.1900
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.2068
Cell Significance Index: -2.9700
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2327
Cell Significance Index: -6.1200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2743
Cell Significance Index: -8.0600
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2940
Cell Significance Index: -4.2100
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3013
Cell Significance Index: -6.2500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3014
Cell Significance Index: -7.7000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3182
Cell Significance Index: -33.1300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3675
Cell Significance Index: -18.5700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3895
Cell Significance Index: -5.8700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4016
Cell Significance Index: -28.4000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4472
Cell Significance Index: -35.4200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.4528
Cell Significance Index: -9.8100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4576
Cell Significance Index: -25.6800
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.4719
Cell Significance Index: -6.9700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4881
Cell Significance Index: -30.0000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4963
Cell Significance Index: -10.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** RUNX1 is a transcription factor that binds to specific DNA sequences and regulates the expression of target genes through the recruitment of co-factors and chromatin-modifying enzymes. It possesses a unique DNA-binding domain, which allows it to recognize and bind to specific sequences, such as the CTCF binding site. RUNX1 is also capable of dimerizing with other transcription factors, such as CBFβ, to form a heterodimeric complex that enhances its transcriptional activity. **Pathways and Functions** RUNX1 is involved in multiple signaling pathways and cellular processes, including: 1. **Hematopoiesis**: RUNX1 regulates the expression of genes involved in hematopoiesis, including those involved in the development of lymphoid and myeloid cells. 2. **Immune responses**: RUNX1 is essential for the development and function of lymphoid cells, including T cells, B cells, and natural killer cells. 3. **Cell differentiation**: RUNX1 regulates the expression of genes involved in cell differentiation, including those involved in the development of epithelial cells, keratinocytes, and myeloid cells. 4. **Angiogenesis**: RUNX1 promotes angiogenesis by regulating the expression of genes involved in vascular endothelial cell proliferation and migration. 5. **Wnt signaling**: RUNX1 interacts with the Wnt/β-catenin signaling pathway to regulate the expression of target genes involved in cell proliferation and differentiation. **Clinical Significance** RUNX1 mutations are associated with several human diseases, including: 1. **Acute myeloid leukemia (AML)**: RUNX1 mutations are commonly found in AML patients and are associated with a poor prognosis. 2. **Thrombocytopenia**: RUNX1 mutations are associated with thrombocytopenia, a condition characterized by low platelet counts. 3. **Immune dysregulation**: RUNX1 mutations are also associated with immune dysregulation, including autoimmune diseases and immunodeficiency disorders. 4. **Cancer**: RUNX1 is also involved in the development of various cancers, including leukemia, lymphoma, and solid tumors. In conclusion, RUNX1 is a critical transcription factor involved in multiple biological processes, including hematopoiesis, immune responses, and cell differentiation. Its dysregulation is associated with several human diseases, highlighting the importance of RUNX1 in maintaining tissue homeostasis and preventing disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Runt-related transcription factor 1

Genular Protein ID: 2325961265

Symbol: RUNX1_HUMAN

Name: Runt-related transcription factor 1

UniProtKB Accession Codes:

Q01196 A8MV94 B2RMS4 D3DSG1 O60472 O60473 O76047 O76089 Q13081 Q13755 Q13756 Q13757 Q13758 Q13759 Q15341 Q15343 Q16122 Q16284 Q16285 Q16286 Q16346 Q16347 Q92479

Database IDs:

Citations:

PubMed ID: 1720541

Title: t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

PubMed ID: 1720541

DOI: 10.1073/pnas.88.23.10431

PubMed ID: 7533526

Title: AML1 fusion transcripts in t(3;21) positive leukemia: evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts.

PubMed ID: 7533526

DOI: 10.1002/gcc.2870110405

PubMed ID: 8490181

Title: Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis.

PubMed ID: 8490181

PubMed ID: 7835892

Title: AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.

PubMed ID: 7835892

DOI: 10.1006/geno.1994.1519

PubMed ID: 7651838

Title: Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia.

PubMed ID: 7651838

DOI: 10.1093/nar/23.14.2762

PubMed ID: 7891692

Title: The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation.

PubMed ID: 7891692

DOI: 10.1128/mcb.15.4.1974

PubMed ID: 9199349

Title: A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells.

PubMed ID: 9199349

DOI: 10.1128/mcb.17.7.4133

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8313895

Title: Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.

PubMed ID: 8313895

DOI: 10.1002/j.1460-2075.1994.tb06288.x

PubMed ID: 8700862

Title: Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions.

PubMed ID: 8700862

DOI: 10.1073/pnas.93.5.1935

PubMed ID: 8634147

Title: A large variety of alternatively spliced and differentially expressed mRNAs are encoded by the human acute myeloid leukemia gene AML1.

PubMed ID: 8634147

DOI: 10.1089/dna.1996.15.175

PubMed ID: 1560822

Title: Leukaemia/Drosophila homology.

PubMed ID: 1560822

DOI: 10.1038/356484b0

PubMed ID: 8413232

Title: Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.

PubMed ID: 8413232

DOI: 10.1128/mcb.13.10.6336-6345.1993

PubMed ID: 9119228

Title: ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function.

PubMed ID: 9119228

DOI: 10.1101/gad.11.5.640

PubMed ID: 9596646

Title: The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.

PubMed ID: 9596646

PubMed ID: 9751710

Title: Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.

PubMed ID: 9751710

DOI: 10.1073/pnas.95.20.11590

PubMed ID: 10207087

Title: Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.

PubMed ID: 10207087

DOI: 10.1128/mcb.19.5.3635

PubMed ID: 11742995

Title: Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein.

PubMed ID: 11742995

DOI: 10.1093/emboj/20.24.7184

PubMed ID: 11965546

Title: MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2.

PubMed ID: 11965546

DOI: 10.1038/sj.onc.1205367

PubMed ID: 12917624

Title: SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo.

PubMed ID: 12917624

DOI: 10.1038/sj.onc.1206600

PubMed ID: 14970218

Title: Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.

PubMed ID: 14970218

DOI: 10.1074/jbc.m309074200

PubMed ID: 16652147

Title: RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription.

PubMed ID: 16652147

DOI: 10.1038/sj.onc.1209591

PubMed ID: 17431401

Title: Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction.

PubMed ID: 17431401

DOI: 10.1038/sj.emboj.7601675

PubMed ID: 17532767

Title: LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22).

PubMed ID: 17532767

DOI: 10.1111/j.1600-0609.2007.00858.x

PubMed ID: 17377532

Title: Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.

PubMed ID: 17377532

DOI: 10.1038/nature05673

PubMed ID: 18695000

Title: PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis.

PubMed ID: 18695000

DOI: 10.1182/blood-2008-01-134122

PubMed ID: 18280240

Title: Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage.

PubMed ID: 18280240

DOI: 10.1016/j.molcel.2007.12.022

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19202074

Title: Transforming activity of AML1-ETO is independent of CBFbeta and ETO interaction but requires formation of homo-oligomeric complexes.

PubMed ID: 19202074

DOI: 10.1073/pnas.0810558106

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20520637

Title: CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia.

PubMed ID: 20520637

DOI: 10.1038/leu.2010.106

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25134913

Title: Novel function of PITH domain-containing 1 as an activator of internal ribosomal entry site to enhance RUNX1 expression and promote megakaryocyte differentiation.

PubMed ID: 25134913

DOI: 10.1007/s00018-014-1704-2

PubMed ID: 10856244

Title: Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta.

PubMed ID: 10856244

DOI: 10.1093/emboj/19.12.3004

PubMed ID: 11276260

Title: The leukemia-associated AML1 (Runx1) -- CBF beta complex functions as a DNA-induced molecular clamp.

PubMed ID: 11276260

DOI: 10.1038/86264

PubMed ID: 12377125

Title: DNA recognition by the RUNX1 transcription factor is mediated by an allosteric transition in the RUNT domain and by DNA bending.

PubMed ID: 12377125

DOI: 10.1016/s0969-2126(02)00853-5

PubMed ID: 10404214

Title: Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain.

PubMed ID: 10404214

DOI: 10.1038/10658

PubMed ID: 10545320

Title: The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains.

PubMed ID: 10545320

DOI: 10.1016/s0969-2126(00)80058-1

PubMed ID: 12217689

Title: The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding.

PubMed ID: 12217689

DOI: 10.1016/s0022-2836(02)00702-7

PubMed ID: 7795214

Title: AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia.

PubMed ID: 7795214

PubMed ID: 1423235

Title: Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells.

PubMed ID: 1423235

DOI: 10.1016/0165-4608(92)90384-k

PubMed ID: 8353289

Title: Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction.

PubMed ID: 8353289

PubMed ID: 8334990

Title: The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript.

PubMed ID: 8334990

DOI: 10.1002/j.1460-2075.1993.tb05933.x

PubMed ID: 8395054

Title: The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1.

PubMed ID: 8395054

DOI: 10.1073/pnas.90.16.7784

PubMed ID: 7919324

Title: Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2.

PubMed ID: 7919324

PubMed ID: 7780150

Title: The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

PubMed ID: 7780150

PubMed ID: 7541640

Title: Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells.

PubMed ID: 7541640

DOI: 10.1002/gcc.2870130105

PubMed ID: 7761424

Title: Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

PubMed ID: 7761424

DOI: 10.1073/pnas.92.11.4917

PubMed ID: 10508512

Title: Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.

PubMed ID: 10508512

DOI: 10.1038/13793

PubMed ID: 18925961

Title: Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes.

PubMed ID: 18925961

DOI: 10.1186/1471-2407-8-299

PubMed ID: 28533407

Title: Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.

PubMed ID: 28533407

DOI: 10.1073/pnas.1700328114

Sequence Information:

Length: 453
Mass: 48737
Checksum: 4F1F193A7CADDBAB
Sequence:

MRIPVDASTS RRFTPPSTAL SPGKMSEALP LGAPDAGAAL AGKLRSGDRS MVEVLADHPG 
ELVRTDSPNF LCSVLPTHWR CNKTLPIAFK VVALGDVPDG TLVTVMAGND ENYSAELRNA 
TAAMKNQVAR FNDLRFVGRS GRGKSFTLTI TVFTNPPQVA TYHRAIKITV DGPREPRRHR 
QKLDDQTKPG SLSFSERLSE LEQLRRTAMR VSPHHPAPTP NPRASLNHST AFNPQPQSQM 
QDTRQIQPSP PWSYDQSYQY LGSIASPSVH PATPISPGRA SGMTTLSAEL SSRLSTAPDL 
TAFSDPRQFP ALPSISDPRM HYPGAFTYSP TPVTSGIGIG MSAMGSATRY HTYLPPPYPG 
SSQAQGGPFQ ASSPSYHLYY GASAGSYQFS MVGGERSPPR ILPPCTNAST GSALLNPSLP 
NQSDVVEAEG SHSNSPTNMA PSARLEEAVW RPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RUNX1

Associated with

Cells (max top 100)

Other Information

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. PubMed ID: 1720541

AML1 fusion transcripts in t(3;21) positive leukemia: evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts. PubMed ID: 7533526

Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. PubMed ID: 8490181

AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. PubMed ID: 7835892

Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia. PubMed ID: 7651838

The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. PubMed ID: 7891692

A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells. PubMed ID: 9199349

The DNA sequence of human chromosome 21. PubMed ID: 10830953

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. PubMed ID: 8313895

Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions. PubMed ID: 8700862

A large variety of alternatively spliced and differentially expressed mRNAs are encoded by the human acute myeloid leukemia gene AML1. PubMed ID: 8634147

Leukaemia/Drosophila homology. PubMed ID: 1560822

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. PubMed ID: 8413232

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. PubMed ID: 9119228

The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. PubMed ID: 9596646

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. PubMed ID: 9751710

Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias. PubMed ID: 10207087

Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein. PubMed ID: 11742995

MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2. PubMed ID: 11965546

SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo. PubMed ID: 12917624

Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. PubMed ID: 14970218

RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription. PubMed ID: 16652147

Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction. PubMed ID: 17431401

LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). PubMed ID: 17532767

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. PubMed ID: 17377532

PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis. PubMed ID: 18695000

Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. PubMed ID: 18280240

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Transforming activity of AML1-ETO is independent of CBFbeta and ETO interaction but requires formation of homo-oligomeric complexes. PubMed ID: 19202074

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia. PubMed ID: 20520637

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Novel function of PITH domain-containing 1 as an activator of internal ribosomal entry site to enhance RUNX1 expression and promote megakaryocyte differentiation. PubMed ID: 25134913

Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta. PubMed ID: 10856244

The leukemia-associated AML1 (Runx1) -- CBF beta complex functions as a DNA-induced molecular clamp. PubMed ID: 11276260

DNA recognition by the RUNX1 transcription factor is mediated by an allosteric transition in the RUNT domain and by DNA bending. PubMed ID: 12377125

Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain. PubMed ID: 10404214

The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains. PubMed ID: 10545320

The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding. PubMed ID: 12217689

AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia. PubMed ID: 7795214

Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells. PubMed ID: 1423235

Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction. PubMed ID: 8353289

The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. PubMed ID: 8334990

The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1. PubMed ID: 8395054

Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2. PubMed ID: 7919324

The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. PubMed ID: 7780150

Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells. PubMed ID: 7541640

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. PubMed ID: 7761424

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. PubMed ID: 10508512

Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes. PubMed ID: 18925961

Histone-binding of DPF2 mediates its repressive role in myeloid differentiation. PubMed ID: 28533407