Details for: RUNX1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mature microglial cell (CL0002629)
Fold Change: 4.63
Marker Score: 1,675 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 3.09
Marker Score: 890 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 3.04
Marker Score: 1,513 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.81
Marker Score: 1,953 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.7
Marker Score: 10,429 - Cell Name: thymocyte (CL0000893)
Fold Change: 2.53
Marker Score: 2,653 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.49
Marker Score: 2,655 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.37
Marker Score: 1,320 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.22
Marker Score: 22,504 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.13
Marker Score: 34,185 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.04
Marker Score: 10,010 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.98
Marker Score: 1,759 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.98
Marker Score: 3,512 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.96
Marker Score: 2,894 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.95
Marker Score: 563 - Cell Name: microglial cell (CL0000129)
Fold Change: 1.89
Marker Score: 3,442 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.89
Marker Score: 4,287 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.86
Marker Score: 918 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.85
Marker Score: 585 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.73
Marker Score: 44,431 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.7
Marker Score: 808 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.7
Marker Score: 1,134 - Cell Name: lung macrophage (CL1001603)
Fold Change: 1.68
Marker Score: 1,922 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.68
Marker Score: 699 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.68
Marker Score: 1,059 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.66
Marker Score: 2,284 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.65
Marker Score: 586 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.63
Marker Score: 424 - Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.61
Marker Score: 1,100 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.61
Marker Score: 1,372 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.59
Marker Score: 13,814 - Cell Name: club cell (CL0000158)
Fold Change: 1.59
Marker Score: 1,855 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.58
Marker Score: 11,753 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.57
Marker Score: 735 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.55
Marker Score: 635 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.54
Marker Score: 564 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.54
Marker Score: 52,451 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.53
Marker Score: 3,611 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.48
Marker Score: 7,800 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.48
Marker Score: 718 - Cell Name: secretory cell (CL0000151)
Fold Change: 1.47
Marker Score: 2,683 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 1.46
Marker Score: 2,783 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.46
Marker Score: 878 - Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.46
Marker Score: 1,057 - Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 166,635 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.45
Marker Score: 543 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 1.41
Marker Score: 18,731 - Cell Name: ciliated cell (CL0000064)
Fold Change: 1.38
Marker Score: 4,749 - Cell Name: basal cell (CL0000646)
Fold Change: 1.38
Marker Score: 1,777 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.38
Marker Score: 431 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.37
Marker Score: 8,769 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.34
Marker Score: 1,615 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.34
Marker Score: 3,347 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.33
Marker Score: 872 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.32
Marker Score: 337 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.32
Marker Score: 727 - Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.31
Marker Score: 295 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.3
Marker Score: 1,370 - Cell Name: fat cell (CL0000136)
Fold Change: 1.3
Marker Score: 726 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.3
Marker Score: 755 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.28
Marker Score: 1,289 - Cell Name: pro-T cell (CL0000827)
Fold Change: 1.27
Marker Score: 5,184 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.26
Marker Score: 617 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.24
Marker Score: 69,489 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.23
Marker Score: 1,399 - Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 1.23
Marker Score: 327 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 1.23
Marker Score: 388 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.22
Marker Score: 772 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.22
Marker Score: 1,312 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.21
Marker Score: 2,327 - Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.19
Marker Score: 418 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.19
Marker Score: 10,192 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.19
Marker Score: 808 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 1.17
Marker Score: 534 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.16
Marker Score: 1,163 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.16
Marker Score: 659 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.15
Marker Score: 6,974 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.15
Marker Score: 4,439 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.14
Marker Score: 7,425 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.13
Marker Score: 752 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.13
Marker Score: 2,568 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.12
Marker Score: 388 - Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.12
Marker Score: 359 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.12
Marker Score: 736 - Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.11
Marker Score: 276 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.1
Marker Score: 2,890 - Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.1
Marker Score: 276 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.1
Marker Score: 414 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.09
Marker Score: 219 - Cell Name: inflammatory cell (CL0009002)
Fold Change: 1.07
Marker Score: 461 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.07
Marker Score: 1,511 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.06
Marker Score: 919 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.06
Marker Score: 835 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.05
Marker Score: 555 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.04
Marker Score: 2,687 - Cell Name: reticular cell (CL0000432)
Fold Change: 1.03
Marker Score: 377 - Cell Name: classical monocyte (CL0000860)
Fold Change: 1.03
Marker Score: 4,289 - Cell Name: contractile cell (CL0000183)
Fold Change: 1.03
Marker Score: 556 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.03
Marker Score: 35,520 - Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.02
Marker Score: 500
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2325961265
Symbol: RUNX1_HUMAN
Name: Runt-related transcription factor 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1720541
Title: t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.
PubMed ID: 1720541
PubMed ID: 7533526
Title: AML1 fusion transcripts in t(3;21) positive leukemia: evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts.
PubMed ID: 7533526
PubMed ID: 8490181
Title: Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis.
PubMed ID: 8490181
PubMed ID: 7835892
Title: AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.
PubMed ID: 7835892
PubMed ID: 7651838
Title: Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia.
PubMed ID: 7651838
PubMed ID: 7891692
Title: The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation.
PubMed ID: 7891692
PubMed ID: 9199349
Title: A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells.
PubMed ID: 9199349
PubMed ID: 10830953
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8313895
Title: Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.
PubMed ID: 8313895
PubMed ID: 8700862
Title: Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions.
PubMed ID: 8700862
PubMed ID: 8634147
Title: A large variety of alternatively spliced and differentially expressed mRNAs are encoded by the human acute myeloid leukemia gene AML1.
PubMed ID: 8634147
PubMed ID: 1560822
PubMed ID: 8413232
Title: Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.
PubMed ID: 8413232
PubMed ID: 9119228
Title: ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function.
PubMed ID: 9119228
DOI: 10.1101/gad.11.5.640
PubMed ID: 9596646
Title: The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.
PubMed ID: 9596646
PubMed ID: 9751710
Title: Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.
PubMed ID: 9751710
PubMed ID: 10207087
Title: Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.
PubMed ID: 10207087
PubMed ID: 11742995
Title: Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein.
PubMed ID: 11742995
PubMed ID: 11965546
Title: MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2.
PubMed ID: 11965546
PubMed ID: 12917624
Title: SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo.
PubMed ID: 12917624
PubMed ID: 14970218
Title: Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.
PubMed ID: 14970218
PubMed ID: 16652147
Title: RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription.
PubMed ID: 16652147
PubMed ID: 17431401
Title: Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction.
PubMed ID: 17431401
PubMed ID: 17532767
Title: LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22).
PubMed ID: 17532767
PubMed ID: 17377532
Title: Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.
PubMed ID: 17377532
DOI: 10.1038/nature05673
PubMed ID: 18695000
Title: PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis.
PubMed ID: 18695000
PubMed ID: 18280240
Title: Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage.
PubMed ID: 18280240
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19202074
Title: Transforming activity of AML1-ETO is independent of CBFbeta and ETO interaction but requires formation of homo-oligomeric complexes.
PubMed ID: 19202074
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20520637
Title: CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia.
PubMed ID: 20520637
DOI: 10.1038/leu.2010.106
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25134913
Title: Novel function of PITH domain-containing 1 as an activator of internal ribosomal entry site to enhance RUNX1 expression and promote megakaryocyte differentiation.
PubMed ID: 25134913
PubMed ID: 10856244
Title: Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta.
PubMed ID: 10856244
PubMed ID: 11276260
Title: The leukemia-associated AML1 (Runx1) -- CBF beta complex functions as a DNA-induced molecular clamp.
PubMed ID: 11276260
DOI: 10.1038/86264
PubMed ID: 12377125
Title: DNA recognition by the RUNX1 transcription factor is mediated by an allosteric transition in the RUNT domain and by DNA bending.
PubMed ID: 12377125
PubMed ID: 10404214
Title: Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain.
PubMed ID: 10404214
DOI: 10.1038/10658
PubMed ID: 10545320
Title: The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains.
PubMed ID: 10545320
PubMed ID: 12217689
Title: The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding.
PubMed ID: 12217689
PubMed ID: 7795214
Title: AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia.
PubMed ID: 7795214
PubMed ID: 1423235
Title: Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells.
PubMed ID: 1423235
PubMed ID: 8353289
Title: Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction.
PubMed ID: 8353289
PubMed ID: 8334990
Title: The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript.
PubMed ID: 8334990
PubMed ID: 8395054
Title: The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1.
PubMed ID: 8395054
PubMed ID: 7919324
Title: Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2.
PubMed ID: 7919324
PubMed ID: 7780150
Title: The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.
PubMed ID: 7780150
PubMed ID: 7541640
Title: Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells.
PubMed ID: 7541640
PubMed ID: 7761424
Title: Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.
PubMed ID: 7761424
PubMed ID: 10508512
Title: Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.
PubMed ID: 10508512
DOI: 10.1038/13793
PubMed ID: 18925961
Title: Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes.
PubMed ID: 18925961
PubMed ID: 28533407
Title: Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.
PubMed ID: 28533407
Sequence Information:
- Length: 453
- Mass: 48737
- Checksum: 4F1F193A7CADDBAB
- Sequence:
MRIPVDASTS RRFTPPSTAL SPGKMSEALP LGAPDAGAAL AGKLRSGDRS MVEVLADHPG ELVRTDSPNF LCSVLPTHWR CNKTLPIAFK VVALGDVPDG TLVTVMAGND ENYSAELRNA TAAMKNQVAR FNDLRFVGRS GRGKSFTLTI TVFTNPPQVA TYHRAIKITV DGPREPRRHR QKLDDQTKPG SLSFSERLSE LEQLRRTAMR VSPHHPAPTP NPRASLNHST AFNPQPQSQM QDTRQIQPSP PWSYDQSYQY LGSIASPSVH PATPISPGRA SGMTTLSAEL SSRLSTAPDL TAFSDPRQFP ALPSISDPRM HYPGAFTYSP TPVTSGIGIG MSAMGSATRY HTYLPPPYPG SSQAQGGPFQ ASSPSYHLYY GASAGSYQFS MVGGERSPPR ILPPCTNAST GSALLNPSLP NQSDVVEAEG SHSNSPTNMA PSARLEEAVW RPY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.