Details for: RUNX1

Gene ID: 861

Symbol: RUNX1

Ensembl ID: ENSG00000159216

Description: RUNX family transcription factor 1

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Disease
    (R-HSA-1643685)
  • Esr-mediated signaling
    (R-HSA-8939211)
  • Estrogen-dependent gene expression
    (R-HSA-9018519)
  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Infectious disease
    (R-HSA-5663205)
  • Organic cation/anion/zwitterion transport
    (R-HSA-549132)
  • Organic cation transport
    (R-HSA-549127)
  • Pre-notch expression and processing
    (R-HSA-1912422)
  • Pre-notch transcription and translation
    (R-HSA-1912408)
  • Regulation of runx1 expression and activity
    (R-HSA-8934593)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Runx1 and foxp3 control the development of regulatory t lymphocytes (tregs)
    (R-HSA-8877330)
  • Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
    (R-HSA-8939243)
  • Runx1 regulates estrogen receptor mediated transcription
    (R-HSA-8931987)
  • Runx1 regulates expression of components of tight junctions
    (R-HSA-8935964)
  • Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
    (R-HSA-8936459)
  • Runx1 regulates transcription of genes involved in bcr signaling
    (R-HSA-8939245)
  • Runx1 regulates transcription of genes involved in differentiation of hscs
    (R-HSA-8939236)
  • Runx1 regulates transcription of genes involved in differentiation of keratinocytes
    (R-HSA-8939242)
  • Runx1 regulates transcription of genes involved in differentiation of myeloid cells
    (R-HSA-8939246)
  • Runx1 regulates transcription of genes involved in interleukin signaling
    (R-HSA-8939247)
  • Runx1 regulates transcription of genes involved in wnt signaling
    (R-HSA-8939256)
  • Runx2 regulates genes involved in differentiation of myeloid cells
    (R-HSA-8941333)
  • Runx3 regulates p14-arf
    (R-HSA-8951936)
  • Runx3 regulates runx1-mediated transcription
    (R-HSA-8951911)
  • Sars-cov-1 activates/modulates innate immune responses
    (R-HSA-9692916)
  • Sars-cov-1 infection
    (R-HSA-9678108)
  • Sars-cov-1-host interactions
    (R-HSA-9692914)
  • Sars-cov infections
    (R-HSA-9679506)
  • Signaling by notch
    (R-HSA-157118)
  • Signaling by nuclear receptors
    (R-HSA-9006931)
  • Signal transduction
    (R-HSA-162582)
  • Slc-mediated transmembrane transport
    (R-HSA-425407)
  • Transcriptional regulation by runx1
    (R-HSA-8878171)
  • Transcriptional regulation by runx2
    (R-HSA-8878166)
  • Transcriptional regulation by runx3
    (R-HSA-8878159)
  • Transcriptional regulation of granulopoiesis
    (R-HSA-9616222)
  • Transport of bile salts and organic acids, metal ions and amine compounds
    (R-HSA-425366)
  • Transport of small molecules
    (R-HSA-382551)
  • Viral infection pathways
    (R-HSA-9824446)
  • Atp binding
    (GO:0005524)
  • Cardiac muscle tissue regeneration
    (GO:0061026)
  • Chondrocyte differentiation
    (GO:0002062)
  • Chromatin
    (GO:0000785)
  • Core-binding factor complex
    (GO:0016513)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Hematopoietic stem cell proliferation
    (GO:0071425)
  • Hemopoiesis
    (GO:0030097)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Myeloid leukocyte differentiation
    (GO:0002573)
  • Negative regulation of cd4-positive, alpha-beta t cell differentiation
    (GO:0043371)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Ossification
    (GO:0001503)
  • Peripheral nervous system neuron development
    (GO:0048935)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of cd8-positive, alpha-beta t cell differentiation
    (GO:0043378)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of extracellular matrix organization
    (GO:1903055)
  • Positive regulation of granulocyte differentiation
    (GO:0030854)
  • Positive regulation of interleukin-2 production
    (GO:0032743)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of cardiac muscle cell proliferation
    (GO:0060043)
  • Regulation of cell differentiation
    (GO:0045595)
  • Regulation of connective tissue replacement
    (GO:1905203)
  • Regulation of plasminogen activation
    (GO:0010755)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 4.63
    Marker Score: 1,675
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 3.09
    Marker Score: 890
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.04
    Marker Score: 1,513
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.81
    Marker Score: 1,953
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7
    Marker Score: 10,429
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.53
    Marker Score: 2,653
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.49
    Marker Score: 2,655
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.37
    Marker Score: 1,320
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.22
    Marker Score: 22,504
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.13
    Marker Score: 34,185
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.04
    Marker Score: 10,010
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.98
    Marker Score: 1,759
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.98
    Marker Score: 3,512
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.96
    Marker Score: 2,894
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.95
    Marker Score: 563
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.89
    Marker Score: 3,442
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.89
    Marker Score: 4,287
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.86
    Marker Score: 918
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.85
    Marker Score: 585
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.73
    Marker Score: 44,431
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.7
    Marker Score: 808
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.7
    Marker Score: 1,134
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.68
    Marker Score: 1,922
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.68
    Marker Score: 699
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.68
    Marker Score: 1,059
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.66
    Marker Score: 2,284
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.65
    Marker Score: 586
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.63
    Marker Score: 424
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.61
    Marker Score: 1,100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.61
    Marker Score: 1,372
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.59
    Marker Score: 13,814
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.59
    Marker Score: 1,855
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.58
    Marker Score: 11,753
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.57
    Marker Score: 735
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.55
    Marker Score: 635
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.54
    Marker Score: 564
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.54
    Marker Score: 52,451
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.53
    Marker Score: 3,611
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.48
    Marker Score: 7,800
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.48
    Marker Score: 718
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.47
    Marker Score: 2,683
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.46
    Marker Score: 2,783
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.46
    Marker Score: 878
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.46
    Marker Score: 1,057
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,635
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.45
    Marker Score: 543
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.41
    Marker Score: 18,731
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.38
    Marker Score: 4,749
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.38
    Marker Score: 1,777
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.38
    Marker Score: 431
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.37
    Marker Score: 8,769
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.34
    Marker Score: 1,615
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.34
    Marker Score: 3,347
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.33
    Marker Score: 872
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.32
    Marker Score: 337
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.32
    Marker Score: 727
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.31
    Marker Score: 295
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3
    Marker Score: 1,370
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.3
    Marker Score: 726
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.3
    Marker Score: 755
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.28
    Marker Score: 1,289
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.27
    Marker Score: 5,184
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.26
    Marker Score: 617
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.24
    Marker Score: 69,489
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.23
    Marker Score: 1,399
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.23
    Marker Score: 327
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.23
    Marker Score: 388
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.22
    Marker Score: 772
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.22
    Marker Score: 1,312
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.21
    Marker Score: 2,327
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.19
    Marker Score: 418
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.19
    Marker Score: 10,192
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.19
    Marker Score: 808
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.17
    Marker Score: 534
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.16
    Marker Score: 1,163
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.16
    Marker Score: 659
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.15
    Marker Score: 6,974
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.15
    Marker Score: 4,439
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.14
    Marker Score: 7,425
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.13
    Marker Score: 752
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.13
    Marker Score: 2,568
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.12
    Marker Score: 388
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.12
    Marker Score: 359
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.12
    Marker Score: 736
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.11
    Marker Score: 276
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.1
    Marker Score: 2,890
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.1
    Marker Score: 276
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.1
    Marker Score: 414
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.09
    Marker Score: 219
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.07
    Marker Score: 461
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.07
    Marker Score: 1,511
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.06
    Marker Score: 919
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.06
    Marker Score: 835
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.05
    Marker Score: 555
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.04
    Marker Score: 2,687
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.03
    Marker Score: 377
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.03
    Marker Score: 4,289
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.03
    Marker Score: 556
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.03
    Marker Score: 35,520
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.02
    Marker Score: 500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RUNX1 is a transcription factor that binds to specific DNA sequences and regulates the expression of target genes through the recruitment of co-factors and chromatin-modifying enzymes. It possesses a unique DNA-binding domain, which allows it to recognize and bind to specific sequences, such as the CTCF binding site. RUNX1 is also capable of dimerizing with other transcription factors, such as CBFβ, to form a heterodimeric complex that enhances its transcriptional activity. **Pathways and Functions** RUNX1 is involved in multiple signaling pathways and cellular processes, including: 1. **Hematopoiesis**: RUNX1 regulates the expression of genes involved in hematopoiesis, including those involved in the development of lymphoid and myeloid cells. 2. **Immune responses**: RUNX1 is essential for the development and function of lymphoid cells, including T cells, B cells, and natural killer cells. 3. **Cell differentiation**: RUNX1 regulates the expression of genes involved in cell differentiation, including those involved in the development of epithelial cells, keratinocytes, and myeloid cells. 4. **Angiogenesis**: RUNX1 promotes angiogenesis by regulating the expression of genes involved in vascular endothelial cell proliferation and migration. 5. **Wnt signaling**: RUNX1 interacts with the Wnt/β-catenin signaling pathway to regulate the expression of target genes involved in cell proliferation and differentiation. **Clinical Significance** RUNX1 mutations are associated with several human diseases, including: 1. **Acute myeloid leukemia (AML)**: RUNX1 mutations are commonly found in AML patients and are associated with a poor prognosis. 2. **Thrombocytopenia**: RUNX1 mutations are associated with thrombocytopenia, a condition characterized by low platelet counts. 3. **Immune dysregulation**: RUNX1 mutations are also associated with immune dysregulation, including autoimmune diseases and immunodeficiency disorders. 4. **Cancer**: RUNX1 is also involved in the development of various cancers, including leukemia, lymphoma, and solid tumors. In conclusion, RUNX1 is a critical transcription factor involved in multiple biological processes, including hematopoiesis, immune responses, and cell differentiation. Its dysregulation is associated with several human diseases, highlighting the importance of RUNX1 in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 2325961265

Symbol: RUNX1_HUMAN

Name: Runt-related transcription factor 1

UniProtKB Accession Codes:

Q01196 A8MV94 B2RMS4 D3DSG1 O60472 O60473 O76047 O76089 Q13081 Q13755 Q13756 Q13757 Q13758 Q13759 Q15341 Q15343 Q16122 Q16284 Q16285 Q16286 Q16346 Q16347 Q92479

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 40 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 5 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 11 Pumba 1 RNAct 1 Reactome 19 RefSeq 5 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1720541

Title: t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

PubMed ID: 1720541

DOI: 10.1073/pnas.88.23.10431

PubMed ID: 7533526

Title: AML1 fusion transcripts in t(3;21) positive leukemia: evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts.

PubMed ID: 7533526

DOI: 10.1002/gcc.2870110405

PubMed ID: 8490181

Title: Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis.

PubMed ID: 8490181

PubMed ID: 7835892

Title: AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.

PubMed ID: 7835892

DOI: 10.1006/geno.1994.1519

PubMed ID: 7651838

Title: Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia.

PubMed ID: 7651838

DOI: 10.1093/nar/23.14.2762

PubMed ID: 7891692

Title: The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation.

PubMed ID: 7891692

DOI: 10.1128/mcb.15.4.1974

PubMed ID: 9199349

Title: A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells.

PubMed ID: 9199349

DOI: 10.1128/mcb.17.7.4133

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8313895

Title: Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia.

PubMed ID: 8313895

DOI: 10.1002/j.1460-2075.1994.tb06288.x

PubMed ID: 8700862

Title: Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions.

PubMed ID: 8700862

DOI: 10.1073/pnas.93.5.1935

PubMed ID: 8634147

Title: A large variety of alternatively spliced and differentially expressed mRNAs are encoded by the human acute myeloid leukemia gene AML1.

PubMed ID: 8634147

DOI: 10.1089/dna.1996.15.175

PubMed ID: 1560822

Title: Leukaemia/Drosophila homology.

PubMed ID: 1560822

DOI: 10.1038/356484b0

PubMed ID: 8413232

Title: Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.

PubMed ID: 8413232

DOI: 10.1128/mcb.13.10.6336-6345.1993

PubMed ID: 9119228

Title: ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function.

PubMed ID: 9119228

DOI: 10.1101/gad.11.5.640

PubMed ID: 9596646

Title: The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.

PubMed ID: 9596646

PubMed ID: 9751710

Title: Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.

PubMed ID: 9751710

DOI: 10.1073/pnas.95.20.11590

PubMed ID: 10207087

Title: Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.

PubMed ID: 10207087

DOI: 10.1128/mcb.19.5.3635

PubMed ID: 11742995

Title: Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein.

PubMed ID: 11742995

DOI: 10.1093/emboj/20.24.7184

PubMed ID: 11965546

Title: MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2.

PubMed ID: 11965546

DOI: 10.1038/sj.onc.1205367

PubMed ID: 12917624

Title: SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo.

PubMed ID: 12917624

DOI: 10.1038/sj.onc.1206600

PubMed ID: 14970218

Title: Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.

PubMed ID: 14970218

DOI: 10.1074/jbc.m309074200

PubMed ID: 16652147

Title: RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription.

PubMed ID: 16652147

DOI: 10.1038/sj.onc.1209591

PubMed ID: 17431401

Title: Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction.

PubMed ID: 17431401

DOI: 10.1038/sj.emboj.7601675

PubMed ID: 17532767

Title: LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22).

PubMed ID: 17532767

DOI: 10.1111/j.1600-0609.2007.00858.x

PubMed ID: 17377532

Title: Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.

PubMed ID: 17377532

DOI: 10.1038/nature05673

PubMed ID: 18695000

Title: PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis.

PubMed ID: 18695000

DOI: 10.1182/blood-2008-01-134122

PubMed ID: 18280240

Title: Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage.

PubMed ID: 18280240

DOI: 10.1016/j.molcel.2007.12.022

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19202074

Title: Transforming activity of AML1-ETO is independent of CBFbeta and ETO interaction but requires formation of homo-oligomeric complexes.

PubMed ID: 19202074

DOI: 10.1073/pnas.0810558106

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20520637

Title: CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia.

PubMed ID: 20520637

DOI: 10.1038/leu.2010.106

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25134913

Title: Novel function of PITH domain-containing 1 as an activator of internal ribosomal entry site to enhance RUNX1 expression and promote megakaryocyte differentiation.

PubMed ID: 25134913

DOI: 10.1007/s00018-014-1704-2

PubMed ID: 10856244

Title: Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta.

PubMed ID: 10856244

DOI: 10.1093/emboj/19.12.3004

PubMed ID: 11276260

Title: The leukemia-associated AML1 (Runx1) -- CBF beta complex functions as a DNA-induced molecular clamp.

PubMed ID: 11276260

DOI: 10.1038/86264

PubMed ID: 12377125

Title: DNA recognition by the RUNX1 transcription factor is mediated by an allosteric transition in the RUNT domain and by DNA bending.

PubMed ID: 12377125

DOI: 10.1016/s0969-2126(02)00853-5

PubMed ID: 10404214

Title: Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain.

PubMed ID: 10404214

DOI: 10.1038/10658

PubMed ID: 10545320

Title: The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains.

PubMed ID: 10545320

DOI: 10.1016/s0969-2126(00)80058-1

PubMed ID: 12217689

Title: The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding.

PubMed ID: 12217689

DOI: 10.1016/s0022-2836(02)00702-7

PubMed ID: 7795214

Title: AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia.

PubMed ID: 7795214

PubMed ID: 1423235

Title: Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells.

PubMed ID: 1423235

DOI: 10.1016/0165-4608(92)90384-k

PubMed ID: 8353289

Title: Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction.

PubMed ID: 8353289

PubMed ID: 8334990

Title: The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript.

PubMed ID: 8334990

DOI: 10.1002/j.1460-2075.1993.tb05933.x

PubMed ID: 8395054

Title: The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1.

PubMed ID: 8395054

DOI: 10.1073/pnas.90.16.7784

PubMed ID: 7919324

Title: Alternative, out-of-frame runt/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2.

PubMed ID: 7919324

PubMed ID: 7780150

Title: The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

PubMed ID: 7780150

PubMed ID: 7541640

Title: Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells.

PubMed ID: 7541640

DOI: 10.1002/gcc.2870130105

PubMed ID: 7761424

Title: Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

PubMed ID: 7761424

DOI: 10.1073/pnas.92.11.4917

PubMed ID: 10508512

Title: Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.

PubMed ID: 10508512

DOI: 10.1038/13793

PubMed ID: 18925961

Title: Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes.

PubMed ID: 18925961

DOI: 10.1186/1471-2407-8-299

PubMed ID: 28533407

Title: Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.

PubMed ID: 28533407

DOI: 10.1073/pnas.1700328114

Sequence Information:

  • Length: 453
  • Mass: 48737
  • Checksum: 4F1F193A7CADDBAB
  • Sequence:
    • MRIPVDASTS RRFTPPSTAL SPGKMSEALP LGAPDAGAAL AGKLRSGDRS MVEVLADHPG 
ELVRTDSPNF LCSVLPTHWR CNKTLPIAFK VVALGDVPDG TLVTVMAGND ENYSAELRNA 
TAAMKNQVAR FNDLRFVGRS GRGKSFTLTI TVFTNPPQVA TYHRAIKITV DGPREPRRHR 
QKLDDQTKPG SLSFSERLSE LEQLRRTAMR VSPHHPAPTP NPRASLNHST AFNPQPQSQM 
QDTRQIQPSP PWSYDQSYQY LGSIASPSVH PATPISPGRA SGMTTLSAEL SSRLSTAPDL 
TAFSDPRQFP ALPSISDPRM HYPGAFTYSP TPVTSGIGIG MSAMGSATRY HTYLPPPYPG 
SSQAQGGPFQ ASSPSYHLYY GASAGSYQFS MVGGERSPPR ILPPCTNAST GSALLNPSLP 
NQSDVVEAEG SHSNSPTNMA PSARLEEAVW RPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.