Details for: CBFA2T3

Gene ID: 863

Symbol: CBFA2T3

Ensembl ID: ENSG00000129993

Description: CBFA2/RUNX1 partner transcriptional co-repressor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.52
    Marker Score: 2874
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.39
    Marker Score: 2832
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.27
    Marker Score: 2630
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.16
    Marker Score: 1164
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.07
    Marker Score: 345.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.04
    Marker Score: 10557
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.03
    Marker Score: 3801
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.01
    Marker Score: 565
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1
    Marker Score: 682
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71790
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48015
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.98
    Marker Score: 313
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.97
    Marker Score: 462
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 493
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.95
    Marker Score: 299
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5260
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5275
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.85
    Marker Score: 3474
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.84
    Marker Score: 522
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.79
    Marker Score: 275
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1241
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.76
    Marker Score: 455
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.75
    Marker Score: 46187
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11723
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.73
    Marker Score: 789.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.72
    Marker Score: 256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 656
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.71
    Marker Score: 368
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.71
    Marker Score: 744
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 284
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7
    Marker Score: 1487
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7
    Marker Score: 537
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.69
    Marker Score: 500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2820
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.64
    Marker Score: 2659.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 376
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.6
    Marker Score: 293
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.59
    Marker Score: 911
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.57
    Marker Score: 5435
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.56
    Marker Score: 358
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.56
    Marker Score: 648
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.55
    Marker Score: 313
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.55
    Marker Score: 387
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.55
    Marker Score: 372
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.55
    Marker Score: 956
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.53
    Marker Score: 134
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.52
    Marker Score: 138
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.52
    Marker Score: 395
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.51
    Marker Score: 1389.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.51
    Marker Score: 269
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.49
    Marker Score: 240
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.48
    Marker Score: 468
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.47
    Marker Score: 224
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.46
    Marker Score: 472
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.46
    Marker Score: 1365
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.45
    Marker Score: 2726
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.45
    Marker Score: 237
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.44
    Marker Score: 418
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.43
    Marker Score: 519
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.43
    Marker Score: 297
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.42
    Marker Score: 16107
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.42
    Marker Score: 569
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.42
    Marker Score: 133
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.42
    Marker Score: 733
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.42
    Marker Score: 4304
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.41
    Marker Score: 205
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.41
    Marker Score: 1573
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.4
    Marker Score: 486.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.4
    Marker Score: 279
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.4
    Marker Score: 235
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4
    Marker Score: 22270
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.4
    Marker Score: 215
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.4
    Marker Score: 3404
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.39
    Marker Score: 240
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.38
    Marker Score: 7633
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.38
    Marker Score: 99
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.38
    Marker Score: 1278
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.38
    Marker Score: 173
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.37
    Marker Score: 1518
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.37
    Marker Score: 103
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.37
    Marker Score: 88
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.37
    Marker Score: 248
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.37
    Marker Score: 87
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.36
    Marker Score: 84
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.36
    Marker Score: 429.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.36
    Marker Score: 903
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.36
    Marker Score: 139
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.36
    Marker Score: 352
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.35
    Marker Score: 233
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.35
    Marker Score: 830

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - CBFA2T3 is a protein encoded by the ENSG00000129993 gene. - It is a transmembrane protein with a molecular weight of approximately 160 kDa. - It is expressed in various cell types, including cardiac endothelial cells, immature innate lymphoid cells, and neural cells. **Pathways and functions:** - CBFA2T3 acts as a negative regulator of cell population proliferation by interacting with RUNX1 and preventing its DNA binding. - It is involved in the regulation of hematopoiesis, where it suppresses the proliferation of blood-forming cells. - It is also involved in the regulation of neural differentiation, where it inhibits the proliferation of neural stem cells. - CBFA2T3 has been shown to play a role in the development and maintenance of cardiac endothelial cells. **Clinical significance:** - Mutations in CBFA2T3 have been linked to various human diseases, including cardiovascular diseases, cancer, and neurodegenerative disorders. - In cardiac disease, mutations in CBFA2T3 have been associated with the development of heart failure and vascular remodeling. - In cancer, mutations in CBFA2T3 have been linked to the development of various types of cancer, including breast cancer, lung cancer, and colon cancer. - CBFA2T3 is a promising target for the treatment of human diseases characterized by abnormal cell proliferation. **Additional information:** - CBFA2T3 is a member of the CBFA2 family of co-repressors. - It is also known as RUNX1-IN2. - It is a highly conserved protein with similar sequences in mammals.

Genular Protein ID: 2152887254

Symbol: MTG16_HUMAN

Name: Protein CBFA2T3

UniProtKB Accession Codes:

O75081 D3DX78 O60615 O60616 O60617 O75082 O75107 O75108 Q0P5Z6 Q6P5W6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 8 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 14 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9596646

Title: The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.

PubMed ID: 9596646

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9790752

Title: CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family.

PubMed ID: 9790752

DOI: 10.1006/geno.1998.5429

PubMed ID: 10995019

Title: AML1-MTG16 fusion gene in therapy-related acute leukemia with t(16;21)(q24;q22): two new cases.

PubMed ID: 10995019

DOI: 10.1038/sj.leu.2401885

PubMed ID: 11224496

Title: AML1/MTG16 fusion gene from a t(16;21)(q24;q22) translocation in treatment-induced leukemia after breast cancer.

PubMed ID: 11224496

PubMed ID: 11533236

Title: ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.

PubMed ID: 11533236

DOI: 10.1128/mcb.21.19.6470-6483.2001

PubMed ID: 12183414

Title: CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3.

PubMed ID: 12183414

PubMed ID: 11823486

Title: Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes.

PubMed ID: 11823486

DOI: 10.4049/jimmunol.168.4.1590

PubMed ID: 12242670

Title: The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t(16; 21)-positive myeloid malignancies.

PubMed ID: 12242670

DOI: 10.1038/sj.onc.1205882

PubMed ID: 12559562

Title: The ETO (MTG8) gene family.

PubMed ID: 12559562

DOI: 10.1016/s0378-1119(02)01172-1

PubMed ID: 15231665

Title: AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation.

PubMed ID: 15231665

DOI: 10.1158/0008-5472.can-03-3689

PubMed ID: 15203199

Title: The MTG proteins: chromatin repression players with a passion for networking.

PubMed ID: 15203199

DOI: 10.1016/j.ygeno.2004.02.011

PubMed ID: 15470020

Title: A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines.

PubMed ID: 15470020

DOI: 10.4049/jimmunol.173.8.4806

PubMed ID: 15676213

Title: The leukemia-associated ETO homologues are differently expressed during hematopoietic differentiation.

PubMed ID: 15676213

DOI: 10.1016/j.exphem.2004.10.011

PubMed ID: 16616331

Title: The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity.

PubMed ID: 16616331

DOI: 10.1016/j.ccr.2006.03.012

PubMed ID: 16815842

Title: ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression.

PubMed ID: 16815842

DOI: 10.1074/jbc.m603998200

PubMed ID: 16966434

Title: ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription.

PubMed ID: 16966434

DOI: 10.1158/1541-7786.mcr-05-0249

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20138877

Title: Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner.

PubMed ID: 20138877

DOI: 10.1016/j.febslet.2010.02.007

PubMed ID: 23251453

Title: Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters.

PubMed ID: 23251453

DOI: 10.1371/journal.pone.0051205

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23840896

Title: The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration.

PubMed ID: 23840896

DOI: 10.1371/journal.pone.0068502

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25974097

Title: Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1.

PubMed ID: 25974097

DOI: 10.1371/journal.pone.0123725

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 653
  • Mass: 71192
  • Checksum: 0B72B602120FA5DE
  • Sequence:
    • MPASRLRDRA ASSASGSTCG SMSQTHPVLE SGLLASAGCS APRGPRKGGP APVDRKAKAS 
AMPDSPAEVK TQPRSTPPSM PPPPPAASQG ATRPPSFTPH THREDGPATL PHGRFHGCLK 
WSMVCLLMNG SSHSPTAING APCTPNGFSN GPATSSTASL STQHLPPACG ARQLSKLKRF 
LTTLQQFGSD ISPEIGERVR TLVLGLVNST LTIEEFHSKL QEATNFPLRP FVIPFLKANL 
PLLQRELLHC ARLAKQTPAQ YLAQHEQLLL DASASSPIDS SELLLEVNEN GKRRTPDRTK 
ENGSDRDPLH PEHLSKRPCT LNPAQRYSPS NGPPQPTPPP HYRLEDIAMA HHFRDAYRHP 
DPRELRERHR PLVVPGSRQE EVIDHKLTER EWAEEWKHLN NLLNCIMDMV EKTRRSLTVL 
RRCQEADREE LNHWARRYSD AEDTKKGPAP AAARPRSSSA GPEGPQLDVP REFLPRTLTG 
YVPEDIWRKA EEAVNEVKRQ AMSELQKAVS DAERKAHELI TTERAKMERA LAEAKRQASE 
DALTVINQQE DSSESCWNCG RKASETCSGC NAARYCGSFC QHRDWEKHHH VCGQSLQGPT 
AVVADPVPGP PEAAHSLGPS LPVGAASPSE AGSAGPSRPG SPSPPGPLDT VPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.