Details for: CBFA2T3

Gene ID: 863

Symbol: CBFA2T3

Ensembl ID: ENSG00000129993

Description: CBFA2/RUNX1 partner transcriptional co-repressor 3

Associated with

Other Information

Genular Protein ID: 2152887254

Symbol: MTG16_HUMAN

Name: Protein CBFA2T3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9596646

Title: The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.

PubMed ID: 9596646

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9790752

Title: CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family.

PubMed ID: 9790752

DOI: 10.1006/geno.1998.5429

PubMed ID: 10995019

Title: AML1-MTG16 fusion gene in therapy-related acute leukemia with t(16;21)(q24;q22): two new cases.

PubMed ID: 10995019

DOI: 10.1038/sj.leu.2401885

PubMed ID: 11224496

Title: AML1/MTG16 fusion gene from a t(16;21)(q24;q22) translocation in treatment-induced leukemia after breast cancer.

PubMed ID: 11224496

PubMed ID: 11533236

Title: ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.

PubMed ID: 11533236

DOI: 10.1128/mcb.21.19.6470-6483.2001

PubMed ID: 12183414

Title: CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3.

PubMed ID: 12183414

PubMed ID: 11823486

Title: Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes.

PubMed ID: 11823486

DOI: 10.4049/jimmunol.168.4.1590

PubMed ID: 12242670

Title: The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t(16; 21)-positive myeloid malignancies.

PubMed ID: 12242670

DOI: 10.1038/sj.onc.1205882

PubMed ID: 12559562

Title: The ETO (MTG8) gene family.

PubMed ID: 12559562

DOI: 10.1016/s0378-1119(02)01172-1

PubMed ID: 15231665

Title: AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation.

PubMed ID: 15231665

DOI: 10.1158/0008-5472.can-03-3689

PubMed ID: 15203199

Title: The MTG proteins: chromatin repression players with a passion for networking.

PubMed ID: 15203199

DOI: 10.1016/j.ygeno.2004.02.011

PubMed ID: 15470020

Title: A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines.

PubMed ID: 15470020

DOI: 10.4049/jimmunol.173.8.4806

PubMed ID: 15676213

Title: The leukemia-associated ETO homologues are differently expressed during hematopoietic differentiation.

PubMed ID: 15676213

DOI: 10.1016/j.exphem.2004.10.011

PubMed ID: 16616331

Title: The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity.

PubMed ID: 16616331

DOI: 10.1016/j.ccr.2006.03.012

PubMed ID: 16815842

Title: ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression.

PubMed ID: 16815842

DOI: 10.1074/jbc.m603998200

PubMed ID: 16966434

Title: ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription.

PubMed ID: 16966434

DOI: 10.1158/1541-7786.mcr-05-0249

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20138877

Title: Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner.

PubMed ID: 20138877

DOI: 10.1016/j.febslet.2010.02.007

PubMed ID: 23251453

Title: Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters.

PubMed ID: 23251453

DOI: 10.1371/journal.pone.0051205

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23840896

Title: The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration.

PubMed ID: 23840896

DOI: 10.1371/journal.pone.0068502

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25974097

Title: Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1.

PubMed ID: 25974097

DOI: 10.1371/journal.pone.0123725

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 653
  • Mass: 71192
  • Checksum: 0B72B602120FA5DE
  • Sequence:
  • MPASRLRDRA ASSASGSTCG SMSQTHPVLE SGLLASAGCS APRGPRKGGP APVDRKAKAS 
    AMPDSPAEVK TQPRSTPPSM PPPPPAASQG ATRPPSFTPH THREDGPATL PHGRFHGCLK 
    WSMVCLLMNG SSHSPTAING APCTPNGFSN GPATSSTASL STQHLPPACG ARQLSKLKRF 
    LTTLQQFGSD ISPEIGERVR TLVLGLVNST LTIEEFHSKL QEATNFPLRP FVIPFLKANL 
    PLLQRELLHC ARLAKQTPAQ YLAQHEQLLL DASASSPIDS SELLLEVNEN GKRRTPDRTK 
    ENGSDRDPLH PEHLSKRPCT LNPAQRYSPS NGPPQPTPPP HYRLEDIAMA HHFRDAYRHP 
    DPRELRERHR PLVVPGSRQE EVIDHKLTER EWAEEWKHLN NLLNCIMDMV EKTRRSLTVL 
    RRCQEADREE LNHWARRYSD AEDTKKGPAP AAARPRSSSA GPEGPQLDVP REFLPRTLTG 
    YVPEDIWRKA EEAVNEVKRQ AMSELQKAVS DAERKAHELI TTERAKMERA LAEAKRQASE 
    DALTVINQQE DSSESCWNCG RKASETCSGC NAARYCGSFC QHRDWEKHHH VCGQSLQGPT 
    AVVADPVPGP PEAAHSLGPS LPVGAASPSE AGSAGPSRPG SPSPPGPLDT VPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.