RUNX3 | ENSG00000020633 | NCBI 864

Details for: RUNX3

Gene ID: 864

Symbol: RUNX3

Ensembl ID: ENSG00000020633

Description: RUNX family transcription factor 3

Associated with

Binding of tcf/lef:ctnnb1 to target gene promoters
(R-HSA-4411364)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Regulation of runx3 expression and activity
(R-HSA-8941858)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates bcl2l11 (bim) transcription
(R-HSA-8952158)
Runx3 regulates cdkn1a transcription
(R-HSA-8941855)
Runx3 regulates immune response and cell migration
(R-HSA-8949275)
Runx3 regulates notch signaling
(R-HSA-8941856)
Runx3 regulates p14-arf
(R-HSA-8951936)
Runx3 regulates runx1-mediated transcription
(R-HSA-8951911)
Runx3 regulates wnt signaling
(R-HSA-8951430)
Runx3 regulates yap1-mediated transcription
(R-HSA-8951671)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation by runx3
(R-HSA-8878159)
Atp binding
(GO:0005524)
Chondrocyte differentiation
(GO:0002062)
Chromatin
(GO:0000785)
Core-binding factor complex
(GO:0016513)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Hemopoiesis
(GO:0030097)
Intracellular membrane-bounded organelle
(GO:0043231)
Negative regulation of cd4-positive, alpha-beta t cell differentiation
(GO:0043371)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Ossification
(GO:0001503)
Peripheral nervous system neuron development
(GO:0048935)
Positive regulation of cd8-positive, alpha-beta t cell differentiation
(GO:0043378)
Positive regulation of dna-templated transcription
(GO:0045893)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Regulation of cell differentiation
(GO:0045595)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to transforming growth factor beta
(GO:0071559)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription corepressor binding
(GO:0001222)

Other Information

Proteins

Runt-related transcription factor 3

Genular Protein ID: 1359048561

Symbol: RUNX3_HUMAN

Name: Runt-related transcription factor 3

UniProtKB Accession Codes:

Q13761 B1AJV5 Q12969 Q13760

Database IDs:

Citations:

PubMed ID: 7622058

Title: Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain.

PubMed ID: 7622058

DOI: 10.1016/0378-1119(95)00060-j

PubMed ID: 7835892

Title: AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.

PubMed ID: 7835892

DOI: 10.1006/geno.1994.1519

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7607690

Title: Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter.

PubMed ID: 7607690

DOI: 10.1016/0888-7543(95)80185-o

PubMed ID: 9751710

Title: Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.

PubMed ID: 9751710

DOI: 10.1073/pnas.95.20.11590

PubMed ID: 16652147

Title: RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription.

PubMed ID: 16652147

DOI: 10.1038/sj.onc.1209591

PubMed ID: 17377532

Title: Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.

PubMed ID: 17377532

DOI: 10.1038/nature05673

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 20599712

Title: Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.

PubMed ID: 20599712

DOI: 10.1016/j.bbrc.2010.06.090

PubMed ID: 20100835

Title: Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.

PubMed ID: 20100835

DOI: 10.1074/jbc.m109.071381

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

Length: 415
Mass: 44356
Checksum: 593FBFB3C4639BBD
Sequence:

MRIPVDPSTS RRFTPPSPAF PCGGGGGKMG ENSGALSAQA AVGPGGRARP EVRSMVDVLA 
DHAGELVRTD SPNFLCSVLP SHWRCNKTLP VAFKVVALGD VPDGTVVTVM AGNDENYSAE 
LRNASAVMKN QVARFNDLRF VGRSGRGKSF TLTITVFTNP TQVATYHRAI KVTVDGPREP 
RRHRQKLEDQ TKPFPDRFGD LERLRMRVTP STPSPRGSLS TTSHFSSQPQ TPIQGTSELN 
PFSDPRQFDR SFPTLPTLTE SRFPDPRMHY PGAMSAAFPY SATPSGTSIS SLSVAGMPAT 
SRFHHTYLPP PYPGAPQNQS GPFQANPSPY HLYYGTSSGS YQFSMVAGSS SGGDRSPTRM 
LASCTSSAAS VAAGNLMNPS LGGQSDGVEA DGSHSNSPTA LSTPGRMDEA VWRPY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RUNX3

Associated with

Other Information

Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain. PubMed ID: 7622058

AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. PubMed ID: 7835892

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter. PubMed ID: 7607690

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. PubMed ID: 9751710

RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription. PubMed ID: 16652147

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. PubMed ID: 17377532

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction. PubMed ID: 20599712

Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm. PubMed ID: 20100835

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733