Details for: RUNX3

Gene ID: 864

Symbol: RUNX3

Ensembl ID: ENSG00000020633

Description: RUNX family transcription factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 89.0416
    Cell Significance Index: -13.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.0670
    Cell Significance Index: -17.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.9092
    Cell Significance Index: -10.6300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 35.1682
    Cell Significance Index: -18.0900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 22.8755
    Cell Significance Index: -15.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.2656
    Cell Significance Index: -13.8900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 7.8746
    Cell Significance Index: 21.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.0237
    Cell Significance Index: -15.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6087
    Cell Significance Index: -14.2400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3851
    Cell Significance Index: -5.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7672
    Cell Significance Index: 38.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.5193
    Cell Significance Index: -4.0700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.3127
    Cell Significance Index: 8.3800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.0084
    Cell Significance Index: 10.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9999
    Cell Significance Index: 190.3000
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.9991
    Cell Significance Index: 10.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8472
    Cell Significance Index: 24.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7714
    Cell Significance Index: 76.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6658
    Cell Significance Index: 601.1700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.5105
    Cell Significance Index: 8.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4115
    Cell Significance Index: 48.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3976
    Cell Significance Index: 50.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3600
    Cell Significance Index: 75.8300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.3540
    Cell Significance Index: 3.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3236
    Cell Significance Index: 52.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2803
    Cell Significance Index: 5.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2475
    Cell Significance Index: 26.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2108
    Cell Significance Index: 115.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1772
    Cell Significance Index: 4.7400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1380
    Cell Significance Index: 2.0800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1192
    Cell Significance Index: 0.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0647
    Cell Significance Index: 4.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0576
    Cell Significance Index: 36.0000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0554
    Cell Significance Index: 0.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0147
    Cell Significance Index: 0.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0031
    Cell Significance Index: -0.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0063
    Cell Significance Index: -0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0071
    Cell Significance Index: -13.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0086
    Cell Significance Index: -15.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0096
    Cell Significance Index: -14.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0099
    Cell Significance Index: -5.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0117
    Cell Significance Index: -15.8500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0137
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0160
    Cell Significance Index: -12.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0164
    Cell Significance Index: -0.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0185
    Cell Significance Index: -8.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0231
    Cell Significance Index: -16.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0261
    Cell Significance Index: -16.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0304
    Cell Significance Index: -1.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0324
    Cell Significance Index: -14.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0370
    Cell Significance Index: -13.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0403
    Cell Significance Index: -2.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0404
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0435
    Cell Significance Index: -7.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0495
    Cell Significance Index: -14.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0581
    Cell Significance Index: -11.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0628
    Cell Significance Index: -7.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0650
    Cell Significance Index: -1.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0674
    Cell Significance Index: -12.1500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0680
    Cell Significance Index: -1.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0713
    Cell Significance Index: -14.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0767
    Cell Significance Index: -9.9200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0818
    Cell Significance Index: -1.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0846
    Cell Significance Index: -2.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0869
    Cell Significance Index: -3.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0923
    Cell Significance Index: -9.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0939
    Cell Significance Index: -6.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0952
    Cell Significance Index: -13.0800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0967
    Cell Significance Index: -11.0400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1002
    Cell Significance Index: -1.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1003
    Cell Significance Index: -12.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1012
    Cell Significance Index: -3.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1067
    Cell Significance Index: -12.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1090
    Cell Significance Index: -15.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1254
    Cell Significance Index: -7.5300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1266
    Cell Significance Index: -0.8400
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.1394
    Cell Significance Index: -0.5800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1479
    Cell Significance Index: -6.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1627
    Cell Significance Index: -3.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1718
    Cell Significance Index: -2.4600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1764
    Cell Significance Index: -2.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1992
    Cell Significance Index: -15.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2030
    Cell Significance Index: -14.3600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2198
    Cell Significance Index: -1.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2205
    Cell Significance Index: -16.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2268
    Cell Significance Index: -15.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2375
    Cell Significance Index: -14.6000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2405
    Cell Significance Index: -2.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2634
    Cell Significance Index: -12.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2798
    Cell Significance Index: -15.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2927
    Cell Significance Index: -15.2100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2941
    Cell Significance Index: -3.0500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2989
    Cell Significance Index: -2.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3237
    Cell Significance Index: -5.5500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.3252
    Cell Significance Index: -2.3400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3277
    Cell Significance Index: -4.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3279
    Cell Significance Index: -17.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3310
    Cell Significance Index: -9.2500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.3347
    Cell Significance Index: -2.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RUNX3 is a transcription factor that belongs to the Runt-related family of proteins. It is characterized by its ability to bind to specific DNA sequences and regulate the expression of target genes. RUNX3 contains a conserved Runt domain, which is essential for its transcriptional activity. The gene is highly expressed in cells involved in immune responses, such as natural killer cells and T cells. RUNX3 has been shown to interact with other transcription factors and signaling molecules, including β-catenin, NF-κB, and TGF-β receptors. **Pathways and Functions** RUNX3 is involved in various cellular pathways, including: 1. **Immune Response**: RUNX3 regulates the expression of genes involved in immune responses, such as the transcription of cytokines and chemokines. 2. **Cell Differentiation**: RUNX3 is involved in the regulation of cell differentiation, particularly in the development of natural killer cells and T cells. 3. **Cell Migration**: RUNX3 regulates the expression of genes involved in cell migration, such as the transcription of chemokines and adhesion molecules. 4. **Apoptosis**: RUNX3 has been shown to regulate the expression of anti-apoptotic genes, such as Bcl-2 family members. 5. **Cancer**: RUNX3 has been implicated in the regulation of cancer cell growth and survival. RUNX3's functions can be broadly categorized into: 1. **Positive Regulation**: RUNX3 regulates the expression of genes involved in immune responses, cell migration, and cancer. 2. **Negative Regulation**: RUNX3 regulates the expression of genes involved in cell proliferation, apoptosis, and cancer. **Clinical Significance** RUNX3 has been implicated in various autoimmune and inflammatory disorders, including: 1. **Rheumatoid Arthritis**: RUNX3 has been shown to be a key regulator of the immune response in rheumatoid arthritis. 2. **Multiple Sclerosis**: RUNX3 has been implicated in the regulation of immune responses in multiple sclerosis. 3. **Autoimmune Diseases**: RUNX3 has been shown to regulate the expression of genes involved in autoimmune diseases, such as lupus and type 1 diabetes. 4. **Cancer**: RUNX3 has been implicated in the regulation of cancer cell growth and survival, particularly in hematological malignancies. In conclusion, RUNX3 is a critical transcription factor involved in regulating various cellular processes, including immune responses, cell differentiation, and cancer. Its dysregulation has been implicated in various autoimmune and inflammatory disorders, highlighting the importance of RUNX3 in maintaining immune homeostasis.

Genular Protein ID: 1359048561

Symbol: RUNX3_HUMAN

Name: Runt-related transcription factor 3

UniProtKB Accession Codes:

Q13761 B1AJV5 Q12969 Q13760

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 10 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7622058

Title: Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain.

PubMed ID: 7622058

DOI: 10.1016/0378-1119(95)00060-j

PubMed ID: 7835892

Title: AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.

PubMed ID: 7835892

DOI: 10.1006/geno.1994.1519

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7607690

Title: Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter.

PubMed ID: 7607690

DOI: 10.1016/0888-7543(95)80185-o

PubMed ID: 9751710

Title: Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.

PubMed ID: 9751710

DOI: 10.1073/pnas.95.20.11590

PubMed ID: 16652147

Title: RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription.

PubMed ID: 16652147

DOI: 10.1038/sj.onc.1209591

PubMed ID: 17377532

Title: Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.

PubMed ID: 17377532

DOI: 10.1038/nature05673

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 20599712

Title: Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.

PubMed ID: 20599712

DOI: 10.1016/j.bbrc.2010.06.090

PubMed ID: 20100835

Title: Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.

PubMed ID: 20100835

DOI: 10.1074/jbc.m109.071381

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 415
  • Mass: 44356
  • Checksum: 593FBFB3C4639BBD
  • Sequence:
    • MRIPVDPSTS RRFTPPSPAF PCGGGGGKMG ENSGALSAQA AVGPGGRARP EVRSMVDVLA 
DHAGELVRTD SPNFLCSVLP SHWRCNKTLP VAFKVVALGD VPDGTVVTVM AGNDENYSAE 
LRNASAVMKN QVARFNDLRF VGRSGRGKSF TLTITVFTNP TQVATYHRAI KVTVDGPREP 
RRHRQKLEDQ TKPFPDRFGD LERLRMRVTP STPSPRGSLS TTSHFSSQPQ TPIQGTSELN 
PFSDPRQFDR SFPTLPTLTE SRFPDPRMHY PGAMSAAFPY SATPSGTSIS SLSVAGMPAT 
SRFHHTYLPP PYPGAPQNQS GPFQANPSPY HLYYGTSSGS YQFSMVAGSS SGGDRSPTRM 
LASCTSSAAS VAAGNLMNPS LGGQSDGVEA DGSHSNSPTA LSTPGRMDEA VWRPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.