Details for: RUNX3

Gene ID: 864

Symbol: RUNX3

Ensembl ID: ENSG00000020633

Description: RUNX family transcription factor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.91
    Marker Score: 8029.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.89
    Marker Score: 3207
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.76
    Marker Score: 1192
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.76
    Marker Score: 7732
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.72
    Marker Score: 1972
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.45
    Marker Score: 2058
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.35
    Marker Score: 1012
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.28
    Marker Score: 708
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.22
    Marker Score: 1143
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.22
    Marker Score: 732
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.09
    Marker Score: 20702
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.06
    Marker Score: 6500
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.94
    Marker Score: 5667.5
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.76
    Marker Score: 386
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.69
    Marker Score: 1578
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.69
    Marker Score: 2326
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.59
    Marker Score: 1717.5
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.58
    Marker Score: 873
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.56
    Marker Score: 941
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.56
    Marker Score: 1133
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.48
    Marker Score: 2183
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.42
    Marker Score: 854
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.42
    Marker Score: 2686
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.41
    Marker Score: 506
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.39
    Marker Score: 1388.5
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.37
    Marker Score: 686
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.32
    Marker Score: 760
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.3
    Marker Score: 2317
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.29
    Marker Score: 292
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.25
    Marker Score: 842
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.23
    Marker Score: 2001
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.23
    Marker Score: 399
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.22
    Marker Score: 827.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.15
    Marker Score: 408
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.15
    Marker Score: 902
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.14
    Marker Score: 1002.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4752
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.13
    Marker Score: 468
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.1
    Marker Score: 709
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.09
    Marker Score: 1415
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.09
    Marker Score: 2657
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.06
    Marker Score: 868.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.05
    Marker Score: 2172
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.05
    Marker Score: 1133
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.02
    Marker Score: 258
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.01
    Marker Score: 53357
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71733.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47960
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.99
    Marker Score: 748
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30401
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.97
    Marker Score: 220
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.97
    Marker Score: 488
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.96
    Marker Score: 2490.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.96
    Marker Score: 697
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.96
    Marker Score: 811.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.95
    Marker Score: 557
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.95
    Marker Score: 1342
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.94
    Marker Score: 828
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.92
    Marker Score: 5887
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.92
    Marker Score: 2073
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2720
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5161
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 361
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13866
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5257
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.86
    Marker Score: 624
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.85
    Marker Score: 839
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.85
    Marker Score: 296
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.83
    Marker Score: 640
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.8
    Marker Score: 776
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.8
    Marker Score: 1395
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.8
    Marker Score: 490
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.79
    Marker Score: 703
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.79
    Marker Score: 1539
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.78
    Marker Score: 1346
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.78
    Marker Score: 537
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 589
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.77
    Marker Score: 8928
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.76
    Marker Score: 246
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1232
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.75
    Marker Score: 347
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.75
    Marker Score: 3050.5
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.74
    Marker Score: 1797
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 383
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 675
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.73
    Marker Score: 40566
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.7
    Marker Score: 242
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.69
    Marker Score: 2050
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.68
    Marker Score: 286
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.68
    Marker Score: 461.5
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.68
    Marker Score: 310.5
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.67
    Marker Score: 1316
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.67
    Marker Score: 203
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.67
    Marker Score: 489
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.65
    Marker Score: 493

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Other Information

**Key characteristics:** - The RUNX3 gene is located on chromosome 17q21.1. - It is a highly conserved gene with similar sequences in mammals. - It belongs to the RUNX family of transcription factors, which are characterized by their ability to bind to DNA and regulate gene expression through the formation of the beta-catenin:tcf transactivating complex. **Pathways and functions:** - RUNX3 regulates various cellular processes, including cell cycle regulation, proliferation, differentiation, migration, and apoptosis. - It interacts with other transcription factors to control gene expression and cell fate. - In the developing embryo, RUNX3 is expressed in various cell types, including endothelial cells, epithelial cells, and immune cells. - In adult tissues, RUNX3 is expressed in various cell types, including endothelial cells, epithelial cells, and immune cells. - It is involved in the regulation of stem cell differentiation, tissue homeostasis, and inflammation. **Clinical significance:** - Mutations in the RUNX3 gene have been linked to human diseases, including cancer, cardiovascular disease, and autoimmune disorders. - Targeting RUNX3 has emerged as a potential therapeutic approach for these diseases. - The development of RUNX3 inhibitors is an active area of research for the treatment of cancer and other diseases. **Additional notes:** - RUNX3 is a key regulator of the beta-catenin:tcf transactivating complex, which is essential for the transcriptional regulation of various genes. - It is also involved in the regulation of the Notch signaling pathway, which is important for cell survival and proliferation. - RUNX3 is a highly versatile transcription factor that plays a critical role in maintaining tissue homeostasis and preventing cancer.

Genular Protein ID: 1359048561

Symbol: RUNX3_HUMAN

Name: Runt-related transcription factor 3

UniProtKB Accession Codes:

Q13761 B1AJV5 Q12969 Q13760

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 10 RefSeq 4 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7622058

Title: Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain.

PubMed ID: 7622058

DOI: 10.1016/0378-1119(95)00060-j

PubMed ID: 7835892

Title: AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization.

PubMed ID: 7835892

DOI: 10.1006/geno.1994.1519

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7607690

Title: Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter.

PubMed ID: 7607690

DOI: 10.1016/0888-7543(95)80185-o

PubMed ID: 9751710

Title: Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.

PubMed ID: 9751710

DOI: 10.1073/pnas.95.20.11590

PubMed ID: 16652147

Title: RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription.

PubMed ID: 16652147

DOI: 10.1038/sj.onc.1209591

PubMed ID: 17377532

Title: Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.

PubMed ID: 17377532

DOI: 10.1038/nature05673

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 20599712

Title: Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction.

PubMed ID: 20599712

DOI: 10.1016/j.bbrc.2010.06.090

PubMed ID: 20100835

Title: Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.

PubMed ID: 20100835

DOI: 10.1074/jbc.m109.071381

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 415
  • Mass: 44356
  • Checksum: 593FBFB3C4639BBD
  • Sequence:
    • MRIPVDPSTS RRFTPPSPAF PCGGGGGKMG ENSGALSAQA AVGPGGRARP EVRSMVDVLA 
DHAGELVRTD SPNFLCSVLP SHWRCNKTLP VAFKVVALGD VPDGTVVTVM AGNDENYSAE 
LRNASAVMKN QVARFNDLRF VGRSGRGKSF TLTITVFTNP TQVATYHRAI KVTVDGPREP 
RRHRQKLEDQ TKPFPDRFGD LERLRMRVTP STPSPRGSLS TTSHFSSQPQ TPIQGTSELN 
PFSDPRQFDR SFPTLPTLTE SRFPDPRMHY PGAMSAAFPY SATPSGTSIS SLSVAGMPAT 
SRFHHTYLPP PYPGAPQNQS GPFQANPSPY HLYYGTSSGS YQFSMVAGSS SGGDRSPTRM 
LASCTSSAAS VAAGNLMNPS LGGQSDGVEA DGSHSNSPTA LSTPGRMDEA VWRPY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.