CBFB | ENSG00000067955 | NCBI 865

Details for: CBFB

Gene ID: 865

Symbol: CBFB

Ensembl ID: ENSG00000067955

Description: core-binding factor subunit beta

Associated with

Developmental biology
(R-HSA-1266738)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Regulation of runx1 expression and activity
(R-HSA-8934593)
Regulation of runx2 expression and activity
(R-HSA-8939902)
Regulation of runx3 expression and activity
(R-HSA-8941858)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 and foxp3 control the development of regulatory t lymphocytes (tregs)
(R-HSA-8877330)
Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
(R-HSA-8939243)
Runx1 regulates estrogen receptor mediated transcription
(R-HSA-8931987)
Runx1 regulates expression of components of tight junctions
(R-HSA-8935964)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-HSA-8936459)
Runx1 regulates transcription of genes involved in bcr signaling
(R-HSA-8939245)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
Runx1 regulates transcription of genes involved in differentiation of keratinocytes
(R-HSA-8939242)
Runx1 regulates transcription of genes involved in differentiation of myeloid cells
(R-HSA-8939246)
Runx1 regulates transcription of genes involved in interleukin signaling
(R-HSA-8939247)
Runx1 regulates transcription of genes involved in wnt signaling
(R-HSA-8939256)
Runx2 regulates bone development
(R-HSA-8941326)
Runx2 regulates chondrocyte maturation
(R-HSA-8941284)
Runx2 regulates genes involved in cell migration
(R-HSA-8941332)
Runx2 regulates genes involved in differentiation of myeloid cells
(R-HSA-8941333)
Runx2 regulates osteoblast differentiation
(R-HSA-8940973)
Runx3 regulates immune response and cell migration
(R-HSA-8949275)
Runx3 regulates p14-arf
(R-HSA-8951936)
Runx3 regulates runx1-mediated transcription
(R-HSA-8951911)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transcriptional regulation by runx3
(R-HSA-8878159)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Cell maturation
(GO:0048469)
Core-binding factor complex
(GO:0016513)
Definitive hemopoiesis
(GO:0060216)
Lymphocyte differentiation
(GO:0030098)
Membrane
(GO:0016020)
Myeloid cell differentiation
(GO:0030099)
Negative regulation of cd4-positive, alpha-beta t cell differentiation
(GO:0043371)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Osteoblast differentiation
(GO:0001649)
Positive regulation of cd8-positive, alpha-beta t cell differentiation
(GO:0043378)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein polyubiquitination
(GO:0000209)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Sequence-specific dna binding
(GO:0043565)
Transcription by rna polymerase ii
(GO:0006366)
Transcription coactivator activity
(GO:0003713)

Other Information

Proteins

Core-binding factor subunit beta

Genular Protein ID: 1594943014

Symbol: PEBB_HUMAN

Name: Core-binding factor subunit beta

UniProtKB Accession Codes:

Q13951 A8K347 Q13124 Q9HCT2

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8351518

Title: Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia.

PubMed ID: 8351518

DOI: 10.1126/science.8351518

PubMed ID: 7607682

Title: Structure of the leukemia-associated human CBFB gene.

PubMed ID: 7607682

DOI: 10.1016/0888-7543(95)80177-n

PubMed ID: 9064279

Title:

PubMed ID: 9064279

DOI: 10.1006/geno.1996.0603

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 10856244

Title: Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta.

PubMed ID: 10856244

DOI: 10.1093/emboj/19.12.3004

PubMed ID: 11276260

Title: The leukemia-associated AML1 (Runx1) -- CBF beta complex functions as a DNA-induced molecular clamp.

PubMed ID: 11276260

DOI: 10.1038/86264

PubMed ID: 10404215

Title: Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta.

PubMed ID: 10404215

DOI: 10.1038/10664

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 36241386

Title: Heterozygous pathogenic variants involving CBFB cause a new skeletal disorder resembling cleidocranial dysplasia.

PubMed ID: 36241386

DOI: 10.1136/jmg-2022-108739

Sequence Information:

Length: 182
Mass: 21508
Checksum: 20FB1CC05FBFE4FB
Sequence:

MPRVVPDQRS KFENEEFFRK LSRECEIKYT GFRDRPHEER QARFQNACRD GRSEIAFVAT 
GTNLSLQFFP ASWQGEQRQT PSREYVDLER EAGKVYLKAP MILNGVCVIW KGWIDLQRLD 
GMGCLEFDEE RAQQEDALAQ QAFEEARRRT REFEDRDRSH REEMEVRVSQ LLAVTGKKTT 
RP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CBFB

Associated with

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. PubMed ID: 8351518

Structure of the leukemia-associated human CBFB gene. PubMed ID: 7607682

PubMed ID: 9064279

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta. PubMed ID: 10856244

The leukemia-associated AML1 (Runx1) -- CBF beta complex functions as a DNA-induced molecular clamp. PubMed ID: 11276260

Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta. PubMed ID: 10404215

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Heterozygous pathogenic variants involving CBFB cause a new skeletal disorder resembling cleidocranial dysplasia. PubMed ID: 36241386