Details for: SERPINA6
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 5.1761
Cell Significance Index: 181.8800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 3.6335
Cell Significance Index: 53.6300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 3.0097
Cell Significance Index: 65.2100 - Cell Name: hepatoblast (CL0005026)
Fold Change: 2.8878
Cell Significance Index: 48.5700 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 2.0312
Cell Significance Index: 7.6500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.8129
Cell Significance Index: 359.7900 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.8741
Cell Significance Index: 14.7300 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7616
Cell Significance Index: 16.2200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5283
Cell Significance Index: 52.2600 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.4741
Cell Significance Index: 2.7300 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.4230
Cell Significance Index: 10.2500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3941
Cell Significance Index: 23.6600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3486
Cell Significance Index: 37.9200 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 0.3033
Cell Significance Index: 0.8000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2910
Cell Significance Index: 47.3300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2281
Cell Significance Index: 205.9700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2063
Cell Significance Index: 112.6700 - Cell Name: peg cell (CL4033014)
Fold Change: 0.1961
Cell Significance Index: 4.5300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1742
Cell Significance Index: 5.5800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.1646
Cell Significance Index: 18.8600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1294
Cell Significance Index: 8.9500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0865
Cell Significance Index: 1.1800 - Cell Name: helper T cell (CL0000912)
Fold Change: 0.0739
Cell Significance Index: 1.0500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0612
Cell Significance Index: 11.6600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0183
Cell Significance Index: 0.8300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0022
Cell Significance Index: 1.6000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0025
Cell Significance Index: -1.3900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0025
Cell Significance Index: -0.4200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0029
Cell Significance Index: -1.8100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0041
Cell Significance Index: -7.6600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0046
Cell Significance Index: -8.4400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0054
Cell Significance Index: -8.3000 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0059
Cell Significance Index: -0.2400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0060
Cell Significance Index: -8.1500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0099
Cell Significance Index: -7.2700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0121
Cell Significance Index: -7.7000 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0124
Cell Significance Index: -0.5400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0132
Cell Significance Index: -0.3800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0132
Cell Significance Index: -2.7800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0144
Cell Significance Index: -0.8800 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.0184
Cell Significance Index: -0.3000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0203
Cell Significance Index: -0.5700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0210
Cell Significance Index: -0.5400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0260
Cell Significance Index: -0.6500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0262
Cell Significance Index: -3.0000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0343
Cell Significance Index: -6.1800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0383
Cell Significance Index: -3.9100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0407
Cell Significance Index: -8.1700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0412
Cell Significance Index: -1.9200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0511
Cell Significance Index: -7.4400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0522
Cell Significance Index: -7.1700 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0524
Cell Significance Index: -0.7900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0528
Cell Significance Index: -6.4900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0589
Cell Significance Index: -7.6100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0669
Cell Significance Index: -7.8000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0704
Cell Significance Index: -5.2500 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: -0.0858
Cell Significance Index: -0.8500 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.0947
Cell Significance Index: -1.3100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0968
Cell Significance Index: -7.6700 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.1124
Cell Significance Index: -1.5600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1261
Cell Significance Index: -6.5700 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.1305
Cell Significance Index: -1.7600 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1313
Cell Significance Index: -1.8900 - Cell Name: adipocyte (CL0000136)
Fold Change: -0.1407
Cell Significance Index: -1.8800 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: -0.1412
Cell Significance Index: -1.5800 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.1415
Cell Significance Index: -1.8200 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.1456
Cell Significance Index: -2.0200 - Cell Name: pro-B cell (CL0000826)
Fold Change: -0.1628
Cell Significance Index: -1.7500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1653
Cell Significance Index: -4.4300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1658
Cell Significance Index: -3.4400 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.1658
Cell Significance Index: -1.7200 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.1668
Cell Significance Index: -1.6500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1731
Cell Significance Index: -8.1400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1733
Cell Significance Index: -6.3600 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.1800
Cell Significance Index: -3.5900 - Cell Name: myelocyte (CL0002193)
Fold Change: -0.1834
Cell Significance Index: -1.9600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1883
Cell Significance Index: -9.7800 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: -0.1885
Cell Significance Index: -1.9500 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.1914
Cell Significance Index: -1.8400 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.2029
Cell Significance Index: -3.0400 - Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.2089
Cell Significance Index: -1.8600 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.2109
Cell Significance Index: -1.4000 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.2226
Cell Significance Index: -3.5800 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.2239
Cell Significance Index: -3.6900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2244
Cell Significance Index: -7.8600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2423
Cell Significance Index: -6.4700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2428
Cell Significance Index: -5.0800 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2444
Cell Significance Index: -6.1000 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.2510
Cell Significance Index: -7.9400 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2522
Cell Significance Index: -6.3000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2547
Cell Significance Index: -8.8500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2605
Cell Significance Index: -3.7300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2637
Cell Significance Index: -7.5600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2657
Cell Significance Index: -8.7000 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2676
Cell Significance Index: -3.9500 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.2681
Cell Significance Index: -6.8300 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2685
Cell Significance Index: -7.0600 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.2718
Cell Significance Index: -3.8100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2735
Cell Significance Index: -8.7100 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.2774
Cell Significance Index: -3.9800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1134463714
Symbol: CBG_HUMAN
Name: Corticosteroid-binding globulin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3299377
Title: Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors.
PubMed ID: 3299377
PubMed ID: 3386241
Title: Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors.
PubMed ID: 3386241
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3347061
Title: Comparative structural analyses of corticosteroid binding globulin.
PubMed ID: 3347061
PubMed ID: 14760718
Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
PubMed ID: 14760718
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 18513745
Title: The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release.
PubMed ID: 18513745
PubMed ID: 1504007
Title: A Leu-->His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol.
PubMed ID: 1504007
PubMed ID: 8212073
Title: Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93.
PubMed ID: 8212073
PubMed ID: 10634411
Title: Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity.
PubMed ID: 10634411
PubMed ID: 17245537
Title: Haploinsufficiency of the SERPINA6 gene is associated with severe muscle fatigue: A de novo mutation in corticosteroid-binding globulin deficiency.
PubMed ID: 17245537
Sequence Information:
- Length: 405
- Mass: 45141
- Checksum: F0E36EFC3B3C08A1
- Sequence:
MPLLLYTCLL WLPTSGLWTV QAMDPNAAYV NMSNHHRGLA SANVDFAFSL YKHLVALSPK KNIFISPVSI SMALAMLSLG TCGHTRAQLL QGLGFNLTER SETEIHQGFQ HLHQLFAKSD TSLEMTMGNA LFLDGSLELL ESFSADIKHY YESEVLAMNF QDWATASRQI NSYVKNKTQG KIVDLFSGLD SPAILVLVNY IFFKGTWTQP FDLASTREEN FYVDETTVVK VPMMLQSSTI SYLHDSELPC QLVQMNYVGN GTVFFILPDK GKMNTVIAAL SRDTINRWSA GLTSSQVDLY IPKVTISGVY DLGDVLEEMG IADLFTNQAN FSRITQDAQL KSSKVVHKAV LQLNEEGVDT AGSTGVTLNL TSKPIILRFN QPFIIMIFDH FTWSSLFLAR VMNPV
Genular Protein ID: 2962218331
Symbol: A0A2Z4LCH4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 29922157
Title: Opposite Expression of Hepatic and Pulmonary Corticosteroid-Binding Globulin in Cystic Fibrosis Patients.
PubMed ID: 29922157
Sequence Information:
- Length: 405
- Mass: 45125
- Checksum: 1BBF93625B25EF35
- Sequence:
MPLLLYTCLL WLPTSGLWTV QAMDPNAAYV NMSNHHRGLA SANVDFAFSL YKHLVALSPK KNIFISPVSI SMALAMLSLG TCGHTRAQLL QGLGFNLTER SETEIHQGFQ HLHQLFAKSD TSLEMTMGNA LFLDGSLELL ESFSADIKHY YESEVLAMNF QDWATASRQI NSYVKNKTQG KIVDLFSGLD SPAILVLVNY IFFKGTWTQP FDLASTREEN FYVDETTVVK VPMMLQSSTI SYLHDAELPC QLVQMNYVGN GTVFFILPDK GKMNTVIAAL SRDTINRWSA GLTSSQVDLY IPKVTISGVY DLGDVLEEMG IADLFTNQAN FSRITQDAQL KSSKVVHKAV LQLNEEGVDT AGSTGVTLNL TSKPIILRFN QPFIIMIFDH FTWSSLFLAR VMNPV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.