Details for: SERPINA6

Gene ID: 866

Symbol: SERPINA6

Ensembl ID: ENSG00000170099

Description: serpin family A member 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 5.1761
    Cell Significance Index: 181.8800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 3.6335
    Cell Significance Index: 53.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.0097
    Cell Significance Index: 65.2100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.8878
    Cell Significance Index: 48.5700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 2.0312
    Cell Significance Index: 7.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8129
    Cell Significance Index: 359.7900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8741
    Cell Significance Index: 14.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7616
    Cell Significance Index: 16.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5283
    Cell Significance Index: 52.2600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.4741
    Cell Significance Index: 2.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4230
    Cell Significance Index: 10.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3941
    Cell Significance Index: 23.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3486
    Cell Significance Index: 37.9200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.3033
    Cell Significance Index: 0.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2910
    Cell Significance Index: 47.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2281
    Cell Significance Index: 205.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2063
    Cell Significance Index: 112.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1961
    Cell Significance Index: 4.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1742
    Cell Significance Index: 5.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1646
    Cell Significance Index: 18.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1294
    Cell Significance Index: 8.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0865
    Cell Significance Index: 1.1800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0739
    Cell Significance Index: 1.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0612
    Cell Significance Index: 11.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0183
    Cell Significance Index: 0.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0022
    Cell Significance Index: 1.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0025
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0025
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0029
    Cell Significance Index: -1.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0041
    Cell Significance Index: -7.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0059
    Cell Significance Index: -0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0060
    Cell Significance Index: -8.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0099
    Cell Significance Index: -7.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0121
    Cell Significance Index: -7.7000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0124
    Cell Significance Index: -0.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0132
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0132
    Cell Significance Index: -2.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0144
    Cell Significance Index: -0.8800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0184
    Cell Significance Index: -0.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0203
    Cell Significance Index: -0.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0210
    Cell Significance Index: -0.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0260
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0262
    Cell Significance Index: -3.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0343
    Cell Significance Index: -6.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0383
    Cell Significance Index: -3.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0407
    Cell Significance Index: -8.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0412
    Cell Significance Index: -1.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0511
    Cell Significance Index: -7.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0522
    Cell Significance Index: -7.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0524
    Cell Significance Index: -0.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0528
    Cell Significance Index: -6.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0589
    Cell Significance Index: -7.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0669
    Cell Significance Index: -7.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0704
    Cell Significance Index: -5.2500
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0858
    Cell Significance Index: -0.8500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0947
    Cell Significance Index: -1.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0968
    Cell Significance Index: -7.6700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1124
    Cell Significance Index: -1.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1261
    Cell Significance Index: -6.5700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1305
    Cell Significance Index: -1.7600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1313
    Cell Significance Index: -1.8900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1407
    Cell Significance Index: -1.8800
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1412
    Cell Significance Index: -1.5800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1415
    Cell Significance Index: -1.8200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1456
    Cell Significance Index: -2.0200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1628
    Cell Significance Index: -1.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1653
    Cell Significance Index: -4.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1658
    Cell Significance Index: -3.4400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1658
    Cell Significance Index: -1.7200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1668
    Cell Significance Index: -1.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1731
    Cell Significance Index: -8.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1733
    Cell Significance Index: -6.3600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1800
    Cell Significance Index: -3.5900
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1834
    Cell Significance Index: -1.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1883
    Cell Significance Index: -9.7800
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1885
    Cell Significance Index: -1.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1914
    Cell Significance Index: -1.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2029
    Cell Significance Index: -3.0400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.2089
    Cell Significance Index: -1.8600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2109
    Cell Significance Index: -1.4000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2226
    Cell Significance Index: -3.5800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2239
    Cell Significance Index: -3.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2244
    Cell Significance Index: -7.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2423
    Cell Significance Index: -6.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2428
    Cell Significance Index: -5.0800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2444
    Cell Significance Index: -6.1000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2510
    Cell Significance Index: -7.9400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2522
    Cell Significance Index: -6.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2547
    Cell Significance Index: -8.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2605
    Cell Significance Index: -3.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2637
    Cell Significance Index: -7.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2657
    Cell Significance Index: -8.7000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2676
    Cell Significance Index: -3.9500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2681
    Cell Significance Index: -6.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2685
    Cell Significance Index: -7.0600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2718
    Cell Significance Index: -3.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2735
    Cell Significance Index: -8.7100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2774
    Cell Significance Index: -3.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SERPINA6 belongs to the serpin family, a superfamily of protease inhibitors that regulate proteolytic processes in the body. This gene encodes for the corticosteroid-binding globulin (CBG), a protein that binds to glucocorticoids, facilitating their transport and metabolism. SERPINA6 is characterized by its ability to inhibit serine-type endopeptidases, which are involved in various physiological and pathological processes. **Pathways and Functions:** SERPINA6 is involved in several key pathways, including: 1. **Glucocorticoid biosynthesis and metabolism:** SERPINA6 binds to glucocorticoids, such as prednisone, facilitating their transport and metabolism. This process is essential for maintaining glucocorticoid homeostasis and regulating various physiological processes. 2. **Negative regulation of endopeptidase activity:** SERPINA6 inhibits serine-type endopeptidases, which are involved in the degradation of various proteins. This inhibition is crucial for maintaining protein homeostasis and regulating cellular processes. 3. **Extracellular space and glucocorticoid adme:** SERPINA6 is involved in the regulation of glucocorticoid metabolism and transport in the extracellular space. **Clinical Significance:** SERPINA6 has implications in various clinical contexts, including: 1. **Glucocorticoid resistance:** Alterations in SERPINA6 expression or function may contribute to glucocorticoid resistance, a condition characterized by impaired glucocorticoid metabolism and binding. 2. **Steroid hormone metabolism disorders:** SERPINA6 plays a critical role in regulating steroid hormone metabolism, and alterations in this gene may contribute to disorders such as Cushing's syndrome or Addison's disease. 3. **Neoplastic processes:** SERPINA6 is overexpressed in various neoplastic cells, suggesting its potential role in tumorigenesis and cancer progression. In conclusion, SERPINA6 is a serpin family member with significant implications in glucocorticoid metabolism and regulation. Its involvement in various pathways, including glucocorticoid biosynthesis, negative regulation of endopeptidase activity, and extracellular space, highlights its importance in maintaining physiological homeostasis. Further research is needed to fully elucidate the clinical significance of SERPINA6 and its potential applications in treating glucocorticoid-related disorders.

Genular Protein ID: 1134463714

Symbol: CBG_HUMAN

Name: Corticosteroid-binding globulin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3299377

Title: Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors.

PubMed ID: 3299377

DOI: 10.1073/pnas.84.15.5153

PubMed ID: 3386241

Title: Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors.

PubMed ID: 3386241

DOI: 10.1016/0022-4731(88)90085-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3347061

Title: Comparative structural analyses of corticosteroid binding globulin.

PubMed ID: 3347061

DOI: 10.1016/0022-4731(88)90268-3

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 18513745

Title: The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release.

PubMed ID: 18513745

DOI: 10.1016/j.jmb.2008.05.012

PubMed ID: 1504007

Title: A Leu-->His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol.

PubMed ID: 1504007

DOI: 10.1016/0960-0760(92)90107-t

PubMed ID: 8212073

Title: Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93.

PubMed ID: 8212073

DOI: 10.1016/0039-128x(93)90072-u

PubMed ID: 10634411

Title: Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity.

PubMed ID: 10634411

DOI: 10.1210/jcem.85.1.6315

PubMed ID: 17245537

Title: Haploinsufficiency of the SERPINA6 gene is associated with severe muscle fatigue: A de novo mutation in corticosteroid-binding globulin deficiency.

PubMed ID: 17245537

DOI: 10.1007/s00702-006-0620-5

Sequence Information:

  • Length: 405
  • Mass: 45141
  • Checksum: F0E36EFC3B3C08A1
  • Sequence:
  • MPLLLYTCLL WLPTSGLWTV QAMDPNAAYV NMSNHHRGLA SANVDFAFSL YKHLVALSPK 
    KNIFISPVSI SMALAMLSLG TCGHTRAQLL QGLGFNLTER SETEIHQGFQ HLHQLFAKSD 
    TSLEMTMGNA LFLDGSLELL ESFSADIKHY YESEVLAMNF QDWATASRQI NSYVKNKTQG 
    KIVDLFSGLD SPAILVLVNY IFFKGTWTQP FDLASTREEN FYVDETTVVK VPMMLQSSTI 
    SYLHDSELPC QLVQMNYVGN GTVFFILPDK GKMNTVIAAL SRDTINRWSA GLTSSQVDLY 
    IPKVTISGVY DLGDVLEEMG IADLFTNQAN FSRITQDAQL KSSKVVHKAV LQLNEEGVDT 
    AGSTGVTLNL TSKPIILRFN QPFIIMIFDH FTWSSLFLAR VMNPV

Genular Protein ID: 2962218331

Symbol: A0A2Z4LCH4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 29922157

Title: Opposite Expression of Hepatic and Pulmonary Corticosteroid-Binding Globulin in Cystic Fibrosis Patients.

PubMed ID: 29922157

Sequence Information:

  • Length: 405
  • Mass: 45125
  • Checksum: 1BBF93625B25EF35
  • Sequence:
  • MPLLLYTCLL WLPTSGLWTV QAMDPNAAYV NMSNHHRGLA SANVDFAFSL YKHLVALSPK 
    KNIFISPVSI SMALAMLSLG TCGHTRAQLL QGLGFNLTER SETEIHQGFQ HLHQLFAKSD 
    TSLEMTMGNA LFLDGSLELL ESFSADIKHY YESEVLAMNF QDWATASRQI NSYVKNKTQG 
    KIVDLFSGLD SPAILVLVNY IFFKGTWTQP FDLASTREEN FYVDETTVVK VPMMLQSSTI 
    SYLHDAELPC QLVQMNYVGN GTVFFILPDK GKMNTVIAAL SRDTINRWSA GLTSSQVDLY 
    IPKVTISGVY DLGDVLEEMG IADLFTNQAN FSRITQDAQL KSSKVVHKAV LQLNEEGVDT 
    AGSTGVTLNL TSKPIILRFN QPFIIMIFDH FTWSSLFLAR VMNPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.