Details for: SERPINA6

Gene ID: 866

Symbol: SERPINA6

Ensembl ID: ENSG00000170099

Description: serpin family A member 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.13
    Marker Score: 6967
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.88
    Marker Score: 2102
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7660
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4820
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.14
    Marker Score: 1180
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.08
    Marker Score: 6546
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.02
    Marker Score: 4381
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.01
    Marker Score: 686
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5337
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 481
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.79
    Marker Score: 4254
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1163
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.72
    Marker Score: 4618
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.67
    Marker Score: 1572
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.62
    Marker Score: 234
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 387
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 457
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.48
    Marker Score: 326
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.41
    Marker Score: 1453
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.37
    Marker Score: 367
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.36
    Marker Score: 389
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.35
    Marker Score: 538
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.34
    Marker Score: 342
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.32
    Marker Score: 127
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.31
    Marker Score: 121
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.31
    Marker Score: 314
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.29
    Marker Score: 184
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.29
    Marker Score: 161
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.28
    Marker Score: 9757
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.27
    Marker Score: 100
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.27
    Marker Score: 504
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.26
    Marker Score: 108
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.24
    Marker Score: 73
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.23
    Marker Score: 224
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.22
    Marker Score: 102.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.22
    Marker Score: 753
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.22
    Marker Score: 158
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.18
    Marker Score: 85
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.17
    Marker Score: 74
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.17
    Marker Score: 167
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.17
    Marker Score: 46
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.16
    Marker Score: 382
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.14
    Marker Score: 75
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.14
    Marker Score: 38
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.14
    Marker Score: 1249
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 37
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.11
    Marker Score: 225
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.1
    Marker Score: 203
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.1
    Marker Score: 92
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 86
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.09
    Marker Score: 19
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.09
    Marker Score: 95
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.09
    Marker Score: 156
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.09
    Marker Score: 46
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.09
    Marker Score: 65.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.08
    Marker Score: 124
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.08
    Marker Score: 125
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.07
    Marker Score: 80
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.07
    Marker Score: 190
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.07
    Marker Score: 120
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.07
    Marker Score: 85
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.07
    Marker Score: 142
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 73
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.07
    Marker Score: 69
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.07
    Marker Score: 94
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.06
    Marker Score: 43

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Other Information

**Key characteristics:** - SERPINA6 is a secreted protein that is expressed in high levels in the plasma and is also present in the extracellular space. - It is a serpin, which is a family of enzymes that catalyze the hydrolysis of peptide bonds. - SERPINA6 is a potent inhibitor of serine-type endopeptidase, which is an enzyme that cleaves proteins at specific amino acid residues. - It is involved in the regulation of inflammation and immune responses. **Pathways and functions:** - SERPINA6 is involved in the regulation of inflammation and immune responses. - It is a key regulator of the production of glucocorticoids, which are hormones that are produced by the adrenal glands. - SERPINA6 is involved in the negative regulation of endopeptidase activity, which is an enzyme that cleaves proteins at specific amino acid residues. - It is involved in the metabolism of steroids, including cortisol. - It is also involved in the regulation of lipid metabolism. **Clinical significance:** - SERPINA6 is a potential therapeutic target for a variety of diseases, including autoimmune disorders, inflammatory diseases, and cancer. - By targeting SERPINA6, it is possible to inhibit the production of glucocorticoids and reduce inflammation. - This could lead to the treatment of a variety of diseases, including asthma, rheumatoid arthritis, and inflammatory bowel disease.

Genular Protein ID: 1134463714

Symbol: CBG_HUMAN

Name: Corticosteroid-binding globulin

UniProtKB Accession Codes:

P08185 A8K456 Q7Z2Q9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 3 CPTC 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 43 DrugCentral 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3299377

Title: Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors.

PubMed ID: 3299377

DOI: 10.1073/pnas.84.15.5153

PubMed ID: 3386241

Title: Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors.

PubMed ID: 3386241

DOI: 10.1016/0022-4731(88)90085-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3347061

Title: Comparative structural analyses of corticosteroid binding globulin.

PubMed ID: 3347061

DOI: 10.1016/0022-4731(88)90268-3

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 18513745

Title: The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release.

PubMed ID: 18513745

DOI: 10.1016/j.jmb.2008.05.012

PubMed ID: 1504007

Title: A Leu-->His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol.

PubMed ID: 1504007

DOI: 10.1016/0960-0760(92)90107-t

PubMed ID: 8212073

Title: Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93.

PubMed ID: 8212073

DOI: 10.1016/0039-128x(93)90072-u

PubMed ID: 10634411

Title: Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity.

PubMed ID: 10634411

DOI: 10.1210/jcem.85.1.6315

PubMed ID: 17245537

Title: Haploinsufficiency of the SERPINA6 gene is associated with severe muscle fatigue: A de novo mutation in corticosteroid-binding globulin deficiency.

PubMed ID: 17245537

DOI: 10.1007/s00702-006-0620-5

Sequence Information:

  • Length: 405
  • Mass: 45141
  • Checksum: F0E36EFC3B3C08A1
  • Sequence:
    • MPLLLYTCLL WLPTSGLWTV QAMDPNAAYV NMSNHHRGLA SANVDFAFSL YKHLVALSPK 
KNIFISPVSI SMALAMLSLG TCGHTRAQLL QGLGFNLTER SETEIHQGFQ HLHQLFAKSD 
TSLEMTMGNA LFLDGSLELL ESFSADIKHY YESEVLAMNF QDWATASRQI NSYVKNKTQG 
KIVDLFSGLD SPAILVLVNY IFFKGTWTQP FDLASTREEN FYVDETTVVK VPMMLQSSTI 
SYLHDSELPC QLVQMNYVGN GTVFFILPDK GKMNTVIAAL SRDTINRWSA GLTSSQVDLY 
IPKVTISGVY DLGDVLEEMG IADLFTNQAN FSRITQDAQL KSSKVVHKAV LQLNEEGVDT 
AGSTGVTLNL TSKPIILRFN QPFIIMIFDH FTWSSLFLAR VMNPV

Genular Protein ID: 2962218331

Symbol: A0A2Z4LCH4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2Z4LCH4

Database IDs:

ARBA 9 AlphaFoldDB 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 29922157

Title: Opposite Expression of Hepatic and Pulmonary Corticosteroid-Binding Globulin in Cystic Fibrosis Patients.

PubMed ID: 29922157

Sequence Information:

  • Length: 405
  • Mass: 45125
  • Checksum: 1BBF93625B25EF35
  • Sequence:
    • MPLLLYTCLL WLPTSGLWTV QAMDPNAAYV NMSNHHRGLA SANVDFAFSL YKHLVALSPK 
KNIFISPVSI SMALAMLSLG TCGHTRAQLL QGLGFNLTER SETEIHQGFQ HLHQLFAKSD 
TSLEMTMGNA LFLDGSLELL ESFSADIKHY YESEVLAMNF QDWATASRQI NSYVKNKTQG 
KIVDLFSGLD SPAILVLVNY IFFKGTWTQP FDLASTREEN FYVDETTVVK VPMMLQSSTI 
SYLHDAELPC QLVQMNYVGN GTVFFILPDK GKMNTVIAAL SRDTINRWSA GLTSSQVDLY 
IPKVTISGVY DLGDVLEEMG IADLFTNQAN FSRITQDAQL KSSKVVHKAV LQLNEEGVDT 
AGSTGVTLNL TSKPIILRFN QPFIIMIFDH FTWSSLFLAR VMNPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.