CBL | ENSG00000110395 | NCBI 867

Details for: CBL

Gene ID: 867

Symbol: CBL

Ensembl ID: ENSG00000110395

Description: Cbl proto-oncogene

Associated with

Bacterial infection pathways
(R-HSA-9824439)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by egfrviii
(R-HSA-5637810)
Constitutive signaling by ligand-responsive egfr cancer variants
(R-HSA-1236382)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Egfr downregulation
(R-HSA-182971)
Flt3 signaling
(R-HSA-9607240)
Flt3 signaling by cbl mutants
(R-HSA-9706377)
Flt3 signaling in disease
(R-HSA-9682385)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Inlb-mediated entry of listeria monocytogenes into host cell
(R-HSA-8875360)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin-6 family signaling
(R-HSA-6783589)
Interleukin-6 signaling
(R-HSA-1059683)
Listeria monocytogenes entry into host cells
(R-HSA-8876384)
Membrane trafficking
(R-HSA-199991)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of flt3
(R-HSA-9706369)
Negative regulation of met activity
(R-HSA-6807004)
Ptk6 regulates rtks and their effectors akt1 and dok1
(R-HSA-8849469)
Regulation of kit signaling
(R-HSA-1433559)
Regulation of signaling by cbl
(R-HSA-912631)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by interleukins
(R-HSA-449147)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by met
(R-HSA-6806834)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Spry regulation of fgf signaling
(R-HSA-1295596)
Tgf-beta receptor signaling activates smads
(R-HSA-2173789)
Vesicle-mediated transport
(R-HSA-5653656)
Cadherin binding
(GO:0045296)
Calcium ion binding
(GO:0005509)
Cellular response to hypoxia
(GO:0071456)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Cilium
(GO:0005929)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Ephrin receptor binding
(GO:0046875)
Flotillin complex
(GO:0016600)
Focal adhesion
(GO:0005925)
Golgi apparatus
(GO:0005794)
Growth cone
(GO:0030426)
Male gonad development
(GO:0008584)
Mast cell degranulation
(GO:0043303)
Membrane raft
(GO:0045121)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of epidermal growth factor receptor signaling pathway
(GO:0042059)
Phosphatidylinositol 3-kinase regulatory subunit binding
(GO:0036312)
Phosphotyrosine residue binding
(GO:0001784)
Plasma membrane
(GO:0005886)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Protein autoubiquitination
(GO:0051865)
Protein binding
(GO:0005515)
Protein monoubiquitination
(GO:0006513)
Protein polyubiquitination
(GO:0000209)
Protein ubiquitination
(GO:0016567)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of platelet-derived growth factor receptor-alpha signaling pathway
(GO:2000583)
Regulation of rap protein signal transduction
(GO:0032487)
Response to activity
(GO:0014823)
Response to ethanol
(GO:0045471)
Response to gamma radiation
(GO:0010332)
Response to starvation
(GO:0042594)
Response to testosterone
(GO:0033574)
Sh3 domain binding
(GO:0017124)
Signal transduction
(GO:0007165)
Symbiont entry into host cell
(GO:0046718)
Ubiquitin-dependent endocytosis
(GO:0070086)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 216.5930
Cell Significance Index: -33.6900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 127.3441
Cell Significance Index: -32.3000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 75.7218
Cell Significance Index: -35.7500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 72.7618
Cell Significance Index: -29.5600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 66.2344
Cell Significance Index: -34.0700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 31.0660
Cell Significance Index: -29.6600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 27.3814
Cell Significance Index: -33.7600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.2813
Cell Significance Index: -32.9000
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.2362
Cell Significance Index: -31.4400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.6044
Cell Significance Index: -21.0200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.5782
Cell Significance Index: -33.8500
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.5755
Cell Significance Index: 316.0400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.2013
Cell Significance Index: 140.0000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.0229
Cell Significance Index: 57.4000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8190
Cell Significance Index: 81.0200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7793
Cell Significance Index: 279.5200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6580
Cell Significance Index: 130.5800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.5775
Cell Significance Index: 21.8700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.5770
Cell Significance Index: 25.5200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.5468
Cell Significance Index: 7.4600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.4725
Cell Significance Index: 11.8100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.4660
Cell Significance Index: 28.6400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4445
Cell Significance Index: 307.4100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4358
Cell Significance Index: 47.4000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4245
Cell Significance Index: 52.2000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4184
Cell Significance Index: 75.4200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4102
Cell Significance Index: 66.7200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3853
Cell Significance Index: 29.5700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.3535
Cell Significance Index: 23.7700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3480
Cell Significance Index: 20.8900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3042
Cell Significance Index: 57.8900
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.3009
Cell Significance Index: 7.2200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2151
Cell Significance Index: 25.3700
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.2114
Cell Significance Index: 3.0400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2096
Cell Significance Index: 4.5400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2083
Cell Significance Index: 5.8200
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1630
Cell Significance Index: 3.5700
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1571
Cell Significance Index: 10.1400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1526
Cell Significance Index: 9.6200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1473
Cell Significance Index: 80.4600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1319
Cell Significance Index: 9.1300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1207
Cell Significance Index: 53.3500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1117
Cell Significance Index: 151.8300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0862
Cell Significance Index: 162.3800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0672
Cell Significance Index: 103.4300
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0660
Cell Significance Index: 121.6600
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0603
Cell Significance Index: 27.3600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0422
Cell Significance Index: 0.2600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0403
Cell Significance Index: 2.1000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0291
Cell Significance Index: 26.2600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0200
Cell Significance Index: 2.7500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0165
Cell Significance Index: 0.5800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0046
Cell Significance Index: 2.9400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0207
Cell Significance Index: -12.9200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0211
Cell Significance Index: -15.6200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0330
Cell Significance Index: -18.6200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0357
Cell Significance Index: -26.1700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0400
Cell Significance Index: -0.6900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0433
Cell Significance Index: -32.8000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0454
Cell Significance Index: -0.8400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0487
Cell Significance Index: -1.3000
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0578
Cell Significance Index: -1.6500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0724
Cell Significance Index: -3.2800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0877
Cell Significance Index: -14.9700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1005
Cell Significance Index: -28.9300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1195
Cell Significance Index: -13.6900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1226
Cell Significance Index: -25.8300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1233
Cell Significance Index: -12.6000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1278
Cell Significance Index: -18.5800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1369
Cell Significance Index: -9.6800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1643
Cell Significance Index: -7.7200
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1809
Cell Significance Index: -23.1900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1827
Cell Significance Index: -5.2700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.2016
Cell Significance Index: -26.0400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2093
Cell Significance Index: -21.7900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2245
Cell Significance Index: -11.6600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2987
Cell Significance Index: -34.1000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3013
Cell Significance Index: -14.0500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3264
Cell Significance Index: -24.3300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3346
Cell Significance Index: -6.9400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3397
Cell Significance Index: -20.8300
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3956
Cell Significance Index: -8.4300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4012
Cell Significance Index: -31.7800
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.4313
Cell Significance Index: -9.2200
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.4360
Cell Significance Index: -3.5600
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4415
Cell Significance Index: -9.3700
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4631
Cell Significance Index: -5.5200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5160
Cell Significance Index: -27.0900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.5525
Cell Significance Index: -16.2300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5707
Cell Significance Index: -18.6900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.5724
Cell Significance Index: -18.2300
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.5724
Cell Significance Index: -8.2000
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.6164
Cell Significance Index: -12.0300
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.6507
Cell Significance Index: -17.1100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6518
Cell Significance Index: -16.7600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6769
Cell Significance Index: -21.6800
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.7095
Cell Significance Index: -14.0300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.7178
Cell Significance Index: -19.2300
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.7208
Cell Significance Index: -25.2500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.7278
Cell Significance Index: -25.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** The CBL gene is an E3 ubiquitin-protein ligase that recognizes and targets specific protein substrates for degradation through the ubiquitin-proteasome pathway. This gene is characterized by its high degree of expression in hematopoietic cells, including T cells, B cells, and macrophages. CBL is also highly expressed in neurons, particularly in the central nervous system, where it regulates synaptic transmission and neuronal development. **Pathways and Functions** CBL is involved in various signaling pathways, including: 1. **Receptor Tyrosine Kinase (RTK) signaling**: CBL negatively regulates RTK activity, including EGFR, FGFR, and PDGFR, by ubiquitinating and degrading their phosphorylated tyrosine residues. 2. **Phosphatidylinositol 3-kinase (PI3K) signaling**: CBL positively regulates PI3K activity by ubiquitinating and stabilizing its regulatory subunit. 3. **Cytokine signaling**: CBL regulates cytokine receptor signaling, including IL-3, IL-5, and GM-CSF, by ubiquitinating and degrading their phosphorylated tyrosine residues. 4. **Apoptosis regulation**: CBL negatively regulates apoptosis by ubiquitinating and degrading pro-apoptotic proteins. **Clinical Significance** Dysregulation of CBL has been implicated in various diseases, including: 1. **Cancer**: Overexpression of CBL has been observed in several types of cancer, including leukemia, lymphoma, and solid tumors, where it can promote tumor growth and survival. 2. **Immunodeficiency**: Mutations in CBL have been associated with immunodeficiency disorders, such as Wiskott-Aldrich syndrome, where it impairs T cell function and development. 3. **Neurological disorders**: CBL has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, where it regulates synaptic transmission and neuronal survival. In conclusion, the CBL gene plays a critical role in regulating various cellular processes, including signaling pathways, protein degradation, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of CBL in maintaining tissue homeostasis and preventing disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

E3 ubiquitin-protein ligase CBL

Genular Protein ID: 51023601

Symbol: CBL_HUMAN

Name: E3 ubiquitin-protein ligase CBL

UniProtKB Accession Codes:

P22681 A3KMP8

Database IDs:

Citations:

PubMed ID: 2030914

Title: The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.

PubMed ID: 2030914

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8083187

Title: The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.

PubMed ID: 8083187

DOI: 10.1016/s0021-9258(17)31595-8

PubMed ID: 7657591

Title: Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.

PubMed ID: 7657591

DOI: 10.1074/jbc.270.35.20242

PubMed ID: 9407100

Title: The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

PubMed ID: 9407100

DOI: 10.1074/jbc.272.52.33140

PubMed ID: 9535867

Title: Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.

PubMed ID: 9535867

DOI: 10.1074/jbc.273.15.8867

PubMed ID: 10092522

Title: The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.

PubMed ID: 10092522

DOI: 10.1006/bbrc.1999.0427

PubMed ID: 10374881

Title: APS, an adaptor protein containing pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl.

PubMed ID: 10374881

DOI: 10.1038/sj.leu.2401397

PubMed ID: 9989826

Title: APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis.

PubMed ID: 9989826

DOI: 10.1038/sj.onc.1202326

PubMed ID: 10449770

Title: SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.

PubMed ID: 10449770

DOI: 10.1073/pnas.96.17.9775

PubMed ID: 10514377

Title: The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.

PubMed ID: 10514377

DOI: 10.1126/science.286.5438.309

PubMed ID: 11067845

Title: The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction.

PubMed ID: 11067845

DOI: 10.1074/jbc.m005784200

PubMed ID: 11696592

Title: Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling.

PubMed ID: 11696592

DOI: 10.1084/jem.194.9.1263

PubMed ID: 12486104

Title: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.

PubMed ID: 12486104

DOI: 10.1084/jem.20021405

PubMed ID: 11997497

Title: APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes.

PubMed ID: 11997497

DOI: 10.1128/mcb.22.11.3599-3609.2002

PubMed ID: 11896602

Title: Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation.

PubMed ID: 11896602

DOI: 10.1038/sj.onc.1205228

PubMed ID: 11850825

Title: C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus.

PubMed ID: 11850825

DOI: 10.1038/sj.onc.1205166

PubMed ID: 12504111

Title: The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2.

PubMed ID: 12504111

DOI: 10.1016/s0006-291x(02)02894-2

PubMed ID: 12435267

Title: Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils.

PubMed ID: 12435267

DOI: 10.1042/bj20021201

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 15556646

Title: Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl.

PubMed ID: 15556646

DOI: 10.1016/j.febslet.2004.10.054

PubMed ID: 15190072

Title: Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation.

PubMed ID: 15190072

DOI: 10.1074/jbc.m402469200

PubMed ID: 14739300

Title: Src kinase activity is essential for osteoclast function.

PubMed ID: 14739300

DOI: 10.1074/jbc.m311032200

PubMed ID: 15226403

Title: ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.

PubMed ID: 15226403

DOI: 10.1242/jcs.01183

PubMed ID: 14661060

Title: Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.

PubMed ID: 14661060

DOI: 10.1038/sj.onc.1207298

PubMed ID: 16129412

Title: Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.

PubMed ID: 16129412

DOI: 10.1016/j.bbrc.2005.08.055

PubMed ID: 15958209

Title: Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation.

PubMed ID: 15958209

DOI: 10.1016/j.bbrc.2005.05.086

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17094949

Title: Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination.

PubMed ID: 17094949

DOI: 10.1016/j.bbrc.2006.10.150

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17509076

Title: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor.

PubMed ID: 17509076

DOI: 10.1111/j.1742-4658.2007.05835.x

PubMed ID: 17620338

Title: Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.

PubMed ID: 17620338

DOI: 10.1074/jbc.m701797200

PubMed ID: 18235045

Title: Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.

PubMed ID: 18235045

DOI: 10.1182/blood-2007-08-109330

PubMed ID: 18374639

Title: FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival.

PubMed ID: 18374639

DOI: 10.1016/j.bone.2008.02.009

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18034775

Title: Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.

PubMed ID: 18034775

DOI: 10.1111/j.1600-0854.2007.00679.x

PubMed ID: 19689429

Title: Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.

PubMed ID: 19689429

DOI: 10.1042/bj20091010

PubMed ID: 19836242

Title: An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.

PubMed ID: 19836242

DOI: 10.1016/j.cub.2009.09.048

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20494825

Title: Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.

PubMed ID: 20494825

DOI: 10.1016/j.cellsig.2010.05.004

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21596750

Title: The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination.

PubMed ID: 21596750

DOI: 10.1074/jbc.m110.197525

PubMed ID: 23774213

Title: CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation.

PubMed ID: 23774213

DOI: 10.1158/0008-5472.can-12-4441

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23376399

Title: The carboxy-terminal region of CD5 is required for c-CBL mediated TCR signaling downmodulation in thymocytes.

PubMed ID: 23376399

DOI: 10.1016/j.bbrc.2013.01.086

PubMed ID: 26848865

Title: CD93 and dystroglycan cooperation in human endothelial cell adhesion and migration adhesion and migration.

PubMed ID: 26848865

DOI: 10.18632/oncotarget.7136

PubMed ID: 29237719

Title: IFT20 modulates ciliary PDGFRalpha signaling by regulating the stability of Cbl E3 ubiquitin ligases.

PubMed ID: 29237719

DOI: 10.1083/jcb.201611050

PubMed ID: 30118682

Title: An Mtb-human protein-protein interaction map identifies a switch between host antiviral and antibacterial responses.

PubMed ID: 30118682

DOI: 10.1016/j.molcel.2018.07.010

PubMed ID: 10078535

Title: Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.

PubMed ID: 10078535

DOI: 10.1038/18050

PubMed ID: 10966114

Title: Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.

PubMed ID: 10966114

DOI: 10.1016/s0092-8674(00)00057-x

PubMed ID: 20619386

Title: Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype.

PubMed ID: 20619386

DOI: 10.1016/j.ajhg.2010.06.015

PubMed ID: 20622007

Title: Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism.

PubMed ID: 20622007

DOI: 10.1074/jbc.m110.106161

PubMed ID: 25178484

Title: RASopathy-associated CBL germline mutations cause aberrant ubiquitylation and trafficking of EGFR.

PubMed ID: 25178484

DOI: 10.1002/humu.22682

Sequence Information:

Length: 906
Mass: 99633
Checksum: 1AA6BF67377322CA
Sequence:

MAGNVKKSSG AGGGSGSGGS GSGGLIGLMK DAFQPHHHHH HHLSPHPPGT VDKKMVEKCW 
KLMDKVVRLC QNPKLALKNS PPYILDLLPD TYQHLRTILS RYEGKMETLG ENEYFRVFME 
NLMKKTKQTI SLFKEGKERM YEENSQPRRN LTKLSLIFSH MLAELKGIFP SGLFQGDTFR 
ITKADAAEFW RKAFGEKTIV PWKSFRQALH EVHPISSGLE AMALKSTIDL TCNDYISVFE 
FDIFTRLFQP WSSLLRNWNS LAVTHPGYMA FLTYDEVKAR LQKFIHKPGS YIFRLSCTRL 
GQWAIGYVTA DGNILQTIPH NKPLFQALID GFREGFYLFP DGRNQNPDLT GLCEPTPQDH 
IKVTQEQYEL YCEMGSTFQL CKICAENDKD VKIEPCGHLM CTSCLTSWQE SEGQGCPFCR 
CEIKGTEPIV VDPFDPRGSG SLLRQGAEGA PSPNYDDDDD ERADDTLFMM KELAGAKVER 
PPSPFSMAPQ ASLPPVPPRL DLLPQRVCVP SSASALGTAS KAASGSLHKD KPLPVPPTLR 
DLPPPPPPDR PYSVGAESRP QRRPLPCTPG DCPSRDKLPP VPSSRLGDSW LPRPIPKVPV 
SAPSSSDPWT GRELTNRHSL PFSLPSQMEP RPDVPRLGST FSLDTSMSMN SSPLVGPECD 
HPKIKPSSSA NAIYSLAARP LPVPKLPPGE QCEGEEDTEY MTPSSRPLRP LDTSQSSRAC 
DCDQQIDSCT YEAMYNIQSQ APSITESSTF GEGNLAAAHA NTGPEESENE DDGYDVPKPP 
VPAVLARRTL SDISNASSSF GWLSLDGDPT TNVTEGSQVP ERPPKPFPRR INSERKAGSC 
QQGSGPAASA ATASPQLSSE IENLMSQGYS YQDIQKALVI AQNNIEMAKN ILREFVSISS 
PAHVAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CBL

Associated with

Cells (max top 100)

Other Information

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. PubMed ID: 2030914

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. PubMed ID: 8083187

Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation. PubMed ID: 7657591

The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. PubMed ID: 9407100

Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases. PubMed ID: 9535867

The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase. PubMed ID: 10092522

APS, an adaptor protein containing pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl. PubMed ID: 10374881

APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis. PubMed ID: 9989826

SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling. PubMed ID: 10449770

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. PubMed ID: 10514377

The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. PubMed ID: 11067845

Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. PubMed ID: 11696592

Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. PubMed ID: 12486104

APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. PubMed ID: 11997497

Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation. PubMed ID: 11896602

C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus. PubMed ID: 11850825

The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2. PubMed ID: 12504111

Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils. PubMed ID: 12435267

Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. PubMed ID: 12522270

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. PubMed ID: 15144186

Signal transduction via the stem cell factor receptor/c-Kit. PubMed ID: 15526160

Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl. PubMed ID: 15556646

Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. PubMed ID: 15190072

Src kinase activity is essential for osteoclast function. PubMed ID: 14739300

ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth. PubMed ID: 15226403

Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation. PubMed ID: 14661060

Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor. PubMed ID: 16129412

Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation. PubMed ID: 15958209

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. PubMed ID: 17094949

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor. PubMed ID: 17509076

Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation. PubMed ID: 17620338

Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. PubMed ID: 18235045

FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival. PubMed ID: 18374639

Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. PubMed ID: 17974561

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway. PubMed ID: 18034775

Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation. PubMed ID: 19689429

An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. PubMed ID: 19836242

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration. PubMed ID: 20494825

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination. PubMed ID: 21596750

CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation. PubMed ID: 23774213

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The carboxy-terminal region of CD5 is required for c-CBL mediated TCR signaling downmodulation in thymocytes. PubMed ID: 23376399

CD93 and dystroglycan cooperation in human endothelial cell adhesion and migration adhesion and migration. PubMed ID: 26848865

IFT20 modulates ciliary PDGFRalpha signaling by regulating the stability of Cbl E3 ubiquitin ligases. PubMed ID: 29237719

An Mtb-human protein-protein interaction map identifies a switch between host antiviral and antibacterial responses. PubMed ID: 30118682

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. PubMed ID: 10078535

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. PubMed ID: 10966114

Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype. PubMed ID: 20619386

Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism. PubMed ID: 20622007

RASopathy-associated CBL germline mutations cause aberrant ubiquitylation and trafficking of EGFR. PubMed ID: 25178484