Gene CBL - ENSG00000110395 | NCBI Gene ID: 867

Details for: CBL

Gene ID: 867

Symbol: CBL

Ensembl ID: ENSG00000110395

Description: Cbl proto-oncogene

Associated with

Bacterial infection pathways
(R-HSA-9824439)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by egfrviii
(R-HSA-5637810)
Constitutive signaling by ligand-responsive egfr cancer variants
(R-HSA-1236382)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Egfr downregulation
(R-HSA-182971)
Flt3 signaling
(R-HSA-9607240)
Flt3 signaling by cbl mutants
(R-HSA-9706377)
Flt3 signaling in disease
(R-HSA-9682385)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Inlb-mediated entry of listeria monocytogenes into host cell
(R-HSA-8875360)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin-6 family signaling
(R-HSA-6783589)
Interleukin-6 signaling
(R-HSA-1059683)
Listeria monocytogenes entry into host cells
(R-HSA-8876384)
Membrane trafficking
(R-HSA-199991)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of flt3
(R-HSA-9706369)
Negative regulation of met activity
(R-HSA-6807004)
Ptk6 regulates rtks and their effectors akt1 and dok1
(R-HSA-8849469)
Regulation of kit signaling
(R-HSA-1433559)
Regulation of signaling by cbl
(R-HSA-912631)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by interleukins
(R-HSA-449147)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by met
(R-HSA-6806834)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Spry regulation of fgf signaling
(R-HSA-1295596)
Tgf-beta receptor signaling activates smads
(R-HSA-2173789)
Vesicle-mediated transport
(R-HSA-5653656)
Cadherin binding
(GO:0045296)
Calcium ion binding
(GO:0005509)
Cellular response to hypoxia
(GO:0071456)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Cilium
(GO:0005929)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Entry of bacterium into host cell
(GO:0035635)
Ephrin receptor binding
(GO:0046875)
Flotillin complex
(GO:0016600)
Focal adhesion
(GO:0005925)
Golgi apparatus
(GO:0005794)
Male gonad development
(GO:0008584)
Mast cell degranulation
(GO:0043303)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of epidermal growth factor-activated receptor activity
(GO:0007175)
Negative regulation of epidermal growth factor receptor signaling pathway
(GO:0042059)
Phosphatidylinositol 3-kinase regulatory subunit binding
(GO:0036312)
Phosphotyrosine residue binding
(GO:0001784)
Plasma membrane
(GO:0005886)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Protein autoubiquitination
(GO:0051865)
Protein binding
(GO:0005515)
Protein monoubiquitination
(GO:0006513)
Protein polyubiquitination
(GO:0000209)
Protein ubiquitination
(GO:0016567)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of platelet-derived growth factor receptor-alpha signaling pathway
(GO:2000583)
Regulation of rap protein signal transduction
(GO:0032487)
Response to activity
(GO:0014823)
Response to ethanol
(GO:0045471)
Response to gamma radiation
(GO:0010332)
Response to starvation
(GO:0042594)
Response to testosterone
(GO:0033574)
Sh3 domain binding
(GO:0017124)
Signal transduction
(GO:0007165)
Ubiquitin-dependent endocytosis
(GO:0070086)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.81
Marker Score: 1998
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.75
Marker Score: 1026
Cell Name: neuron (CL0000540)
Fold Change: 1.54
Marker Score: 6262
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.53
Marker Score: 762
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.53
Marker Score: 93935
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.51
Marker Score: 22564.5
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.45
Marker Score: 6011
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.45
Marker Score: 54897
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.44
Marker Score: 53115
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.43
Marker Score: 14738
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.4
Marker Score: 13134
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.39
Marker Score: 27550
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.38
Marker Score: 13116
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.37
Marker Score: 11756
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.36
Marker Score: 2100
Cell Name: male germ cell (CL0000015)
Fold Change: 1.35
Marker Score: 388
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.31
Marker Score: 10070
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.31
Marker Score: 5048
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.25
Marker Score: 1568
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.23
Marker Score: 1415
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.17
Marker Score: 24891
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.14
Marker Score: 679
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.13
Marker Score: 2820
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.12
Marker Score: 1071.5
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.12
Marker Score: 2460
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.09
Marker Score: 36884.5
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.08
Marker Score: 1557
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.07
Marker Score: 386
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.01
Marker Score: 1358.5
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.01
Marker Score: 1418
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.01
Marker Score: 4652
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71664.5
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47889
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.99
Marker Score: 1194
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30388
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.97
Marker Score: 1167.5
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.96
Marker Score: 5053
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.96
Marker Score: 401
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2394
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.94
Marker Score: 14693
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.94
Marker Score: 454
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 479
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 434
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.91
Marker Score: 3805.5
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.91
Marker Score: 2192
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.9
Marker Score: 50221.5
Cell Name: contractile cell (CL0000183)
Fold Change: 0.89
Marker Score: 481
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.89
Marker Score: 1728.5
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.88
Marker Score: 277
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5293
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.87
Marker Score: 935
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.86
Marker Score: 916
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 306
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.84
Marker Score: 4801
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.84
Marker Score: 1360
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.82
Marker Score: 459
Cell Name: myelocyte (CL0002193)
Fold Change: 0.81
Marker Score: 351
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.81
Marker Score: 1176
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.81
Marker Score: 260
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.81
Marker Score: 1553
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.8
Marker Score: 157
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.8
Marker Score: 174
Cell Name: podocyte (CL0000653)
Fold Change: 0.8
Marker Score: 295
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.79
Marker Score: 323
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.79
Marker Score: 316
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.79
Marker Score: 472
Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.78
Marker Score: 677
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.78
Marker Score: 533
Cell Name: microglial cell (CL0000129)
Fold Change: 0.78
Marker Score: 1423
Cell Name: stellate neuron (CL0000122)
Fold Change: 0.78
Marker Score: 4192
Cell Name: fat cell (CL0000136)
Fold Change: 0.77
Marker Score: 433
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.77
Marker Score: 725
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.77
Marker Score: 1559.5
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.77
Marker Score: 240
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.76
Marker Score: 175
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.76
Marker Score: 208
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.76
Marker Score: 760
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.75
Marker Score: 767
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.75
Marker Score: 792
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.75
Marker Score: 573
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.75
Marker Score: 356
Cell Name: melanocyte (CL0000148)
Fold Change: 0.75
Marker Score: 302
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.75
Marker Score: 1054.5
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.74
Marker Score: 372
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3115.5
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.74
Marker Score: 746
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.74
Marker Score: 507
Cell Name: astrocyte (CL0000127)
Fold Change: 0.74
Marker Score: 637
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.73
Marker Score: 425
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.73
Marker Score: 2829
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.73
Marker Score: 174
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.73
Marker Score: 668
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.72
Marker Score: 354
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 373
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.72
Marker Score: 179
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.71
Marker Score: 18293
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.71
Marker Score: 308
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.71
Marker Score: 245
Cell Name: thymocyte (CL0000893)
Fold Change: 0.71
Marker Score: 739

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**Key characteristics:** * CBL is a ubiquitin-protein ligase that plays a crucial role in the regulation of cell growth and survival. * It is a highly conserved protein with homologs in other species. * CBL is a key regulator of cell cycle progression and apoptosis. * It is involved in the regulation of immune responses, including the activation of immune cells. **Pathways and functions:** * CBL is involved in the clathrin-mediated endocytosis pathway, which is a major mechanism for the internalization of growth factors and other extracellular signals. * It is also involved in the cytokine signaling pathway in the immune system. * CBL is a key regulator of the growth and development of neurons. * It is involved in the regulation of epithelial cell migration and differentiation. * CBL is also involved in the regulation of immune responses, including the activation of immune cells. **Clinical significance:** * Mutations in the CBL gene have been linked to a number of human cancers. * CBL inhibitors are being investigated as potential cancer drugs. * Understanding the role of CBL in cancer and other diseases involving cell growth and survival could lead to the development of new therapeutic strategies. **Additional notes:** * CBL is a multi-domain protein that has been shown to interact with a variety of proteins. * It is a highly regulated protein that is often dysregulated in cancer. * CBL is a promising target for cancer therapy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

E3 ubiquitin-protein ligase CBL

Genular Protein ID: 51023601

Symbol: CBL_HUMAN

Name: E3 ubiquitin-protein ligase CBL

UniProtKB Accession Codes:

P22681 A3KMP8

Database IDs:

Citations:

PubMed ID: 2030914

Title: The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.

PubMed ID: 2030914

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8083187

Title: The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.

PubMed ID: 8083187

DOI: 10.1016/s0021-9258(17)31595-8

PubMed ID: 7657591

Title: Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.

PubMed ID: 7657591

DOI: 10.1074/jbc.270.35.20242

PubMed ID: 9407100

Title: The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

PubMed ID: 9407100

DOI: 10.1074/jbc.272.52.33140

PubMed ID: 9535867

Title: Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.

PubMed ID: 9535867

DOI: 10.1074/jbc.273.15.8867

PubMed ID: 10092522

Title: The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.

PubMed ID: 10092522

DOI: 10.1006/bbrc.1999.0427

PubMed ID: 10374881

Title: APS, an adaptor protein containing pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl.

PubMed ID: 10374881

DOI: 10.1038/sj.leu.2401397

PubMed ID: 9989826

Title: APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis.

PubMed ID: 9989826

DOI: 10.1038/sj.onc.1202326

PubMed ID: 10449770

Title: SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.

PubMed ID: 10449770

DOI: 10.1073/pnas.96.17.9775

PubMed ID: 10514377

Title: The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.

PubMed ID: 10514377

DOI: 10.1126/science.286.5438.309

PubMed ID: 11067845

Title: The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction.

PubMed ID: 11067845

DOI: 10.1074/jbc.m005784200

PubMed ID: 11696592

Title: Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling.

PubMed ID: 11696592

DOI: 10.1084/jem.194.9.1263

PubMed ID: 12486104

Title: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.

PubMed ID: 12486104

DOI: 10.1084/jem.20021405

PubMed ID: 11997497

Title: APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes.

PubMed ID: 11997497

DOI: 10.1128/mcb.22.11.3599-3609.2002

PubMed ID: 11896602

Title: Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation.

PubMed ID: 11896602

DOI: 10.1038/sj.onc.1205228

PubMed ID: 11850825

Title: C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus.

PubMed ID: 11850825

DOI: 10.1038/sj.onc.1205166

PubMed ID: 12504111

Title: The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2.

PubMed ID: 12504111

DOI: 10.1016/s0006-291x(02)02894-2

PubMed ID: 12435267

Title: Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils.

PubMed ID: 12435267

DOI: 10.1042/bj20021201

PubMed ID: 12522270

Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

PubMed ID: 12522270

DOI: 10.1073/pnas.2436191100

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 15556646

Title: Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl.

PubMed ID: 15556646

DOI: 10.1016/j.febslet.2004.10.054

PubMed ID: 15190072

Title: Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation.

PubMed ID: 15190072

DOI: 10.1074/jbc.m402469200

PubMed ID: 14739300

Title: Src kinase activity is essential for osteoclast function.

PubMed ID: 14739300

DOI: 10.1074/jbc.m311032200

PubMed ID: 15226403

Title: ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.

PubMed ID: 15226403

DOI: 10.1242/jcs.01183

PubMed ID: 14661060

Title: Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.

PubMed ID: 14661060

DOI: 10.1038/sj.onc.1207298

PubMed ID: 16129412

Title: Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.

PubMed ID: 16129412

DOI: 10.1016/j.bbrc.2005.08.055

PubMed ID: 15958209

Title: Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation.

PubMed ID: 15958209

DOI: 10.1016/j.bbrc.2005.05.086

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17094949

Title: Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination.

PubMed ID: 17094949

DOI: 10.1016/j.bbrc.2006.10.150

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17509076

Title: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor.

PubMed ID: 17509076

DOI: 10.1111/j.1742-4658.2007.05835.x

PubMed ID: 17620338

Title: Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.

PubMed ID: 17620338

DOI: 10.1074/jbc.m701797200

PubMed ID: 18235045

Title: Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.

PubMed ID: 18235045

DOI: 10.1182/blood-2007-08-109330

PubMed ID: 18374639

Title: FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival.

PubMed ID: 18374639

DOI: 10.1016/j.bone.2008.02.009

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18034775

Title: Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.

PubMed ID: 18034775

DOI: 10.1111/j.1600-0854.2007.00679.x

PubMed ID: 19689429

Title: Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.

PubMed ID: 19689429

DOI: 10.1042/bj20091010

PubMed ID: 19836242

Title: An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.

PubMed ID: 19836242

DOI: 10.1016/j.cub.2009.09.048

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20494825

Title: Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.

PubMed ID: 20494825

DOI: 10.1016/j.cellsig.2010.05.004

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21596750

Title: The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination.

PubMed ID: 21596750

DOI: 10.1074/jbc.m110.197525

PubMed ID: 23774213

Title: CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation.

PubMed ID: 23774213

DOI: 10.1158/0008-5472.can-12-4441

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29237719

Title: IFT20 modulates ciliary PDGFRalpha signaling by regulating the stability of Cbl E3 ubiquitin ligases.

PubMed ID: 29237719

DOI: 10.1083/jcb.201611050

PubMed ID: 30118682

Title: An Mtb-human protein-protein interaction map identifies a switch between host antiviral and antibacterial responses.

PubMed ID: 30118682

DOI: 10.1016/j.molcel.2018.07.010

PubMed ID: 10078535

Title: Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.

PubMed ID: 10078535

DOI: 10.1038/18050

PubMed ID: 10966114

Title: Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.

PubMed ID: 10966114

DOI: 10.1016/s0092-8674(00)00057-x

PubMed ID: 20619386

Title: Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype.

PubMed ID: 20619386

DOI: 10.1016/j.ajhg.2010.06.015

PubMed ID: 20622007

Title: Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism.

PubMed ID: 20622007

DOI: 10.1074/jbc.m110.106161

PubMed ID: 25178484

Title: RASopathy-associated CBL germline mutations cause aberrant ubiquitylation and trafficking of EGFR.

PubMed ID: 25178484

DOI: 10.1002/humu.22682

Sequence Information:

Length: 906
Mass: 99633
Checksum: 1AA6BF67377322CA
Sequence:

MAGNVKKSSG AGGGSGSGGS GSGGLIGLMK DAFQPHHHHH HHLSPHPPGT VDKKMVEKCW 
KLMDKVVRLC QNPKLALKNS PPYILDLLPD TYQHLRTILS RYEGKMETLG ENEYFRVFME 
NLMKKTKQTI SLFKEGKERM YEENSQPRRN LTKLSLIFSH MLAELKGIFP SGLFQGDTFR 
ITKADAAEFW RKAFGEKTIV PWKSFRQALH EVHPISSGLE AMALKSTIDL TCNDYISVFE 
FDIFTRLFQP WSSLLRNWNS LAVTHPGYMA FLTYDEVKAR LQKFIHKPGS YIFRLSCTRL 
GQWAIGYVTA DGNILQTIPH NKPLFQALID GFREGFYLFP DGRNQNPDLT GLCEPTPQDH 
IKVTQEQYEL YCEMGSTFQL CKICAENDKD VKIEPCGHLM CTSCLTSWQE SEGQGCPFCR 
CEIKGTEPIV VDPFDPRGSG SLLRQGAEGA PSPNYDDDDD ERADDTLFMM KELAGAKVER 
PPSPFSMAPQ ASLPPVPPRL DLLPQRVCVP SSASALGTAS KAASGSLHKD KPLPVPPTLR 
DLPPPPPPDR PYSVGAESRP QRRPLPCTPG DCPSRDKLPP VPSSRLGDSW LPRPIPKVPV 
SAPSSSDPWT GRELTNRHSL PFSLPSQMEP RPDVPRLGST FSLDTSMSMN SSPLVGPECD 
HPKIKPSSSA NAIYSLAARP LPVPKLPPGE QCEGEEDTEY MTPSSRPLRP LDTSQSSRAC 
DCDQQIDSCT YEAMYNIQSQ APSITESSTF GEGNLAAAHA NTGPEESENE DDGYDVPKPP 
VPAVLARRTL SDISNASSSF GWLSLDGDPT TNVTEGSQVP ERPPKPFPRR INSERKAGSC 
QQGSGPAASA ATASPQLSSE IENLMSQGYS YQDIQKALVI AQNNIEMAKN ILREFVSISS 
PAHVAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CBL

Associated with

Cells (max top 100)

Other Information

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. PubMed ID: 2030914

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. PubMed ID: 8083187

Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation. PubMed ID: 7657591

The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. PubMed ID: 9407100

Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases. PubMed ID: 9535867

The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase. PubMed ID: 10092522

APS, an adaptor protein containing pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl. PubMed ID: 10374881

APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis. PubMed ID: 9989826

SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling. PubMed ID: 10449770

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. PubMed ID: 10514377

The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. PubMed ID: 11067845

Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. PubMed ID: 11696592

Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. PubMed ID: 12486104

APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. PubMed ID: 11997497

Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation. PubMed ID: 11896602

C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus. PubMed ID: 11850825

The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2. PubMed ID: 12504111

Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils. PubMed ID: 12435267

Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. PubMed ID: 12522270

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. PubMed ID: 15144186

Signal transduction via the stem cell factor receptor/c-Kit. PubMed ID: 15526160

Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl. PubMed ID: 15556646

Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. PubMed ID: 15190072

Src kinase activity is essential for osteoclast function. PubMed ID: 14739300

ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth. PubMed ID: 15226403

Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation. PubMed ID: 14661060

Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor. PubMed ID: 16129412

Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation. PubMed ID: 15958209

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. PubMed ID: 17094949

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor. PubMed ID: 17509076

Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation. PubMed ID: 17620338

Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. PubMed ID: 18235045

FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival. PubMed ID: 18374639

Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. PubMed ID: 17974561

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway. PubMed ID: 18034775

Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation. PubMed ID: 19689429

An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. PubMed ID: 19836242

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration. PubMed ID: 20494825

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination. PubMed ID: 21596750

CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation. PubMed ID: 23774213

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

IFT20 modulates ciliary PDGFRalpha signaling by regulating the stability of Cbl E3 ubiquitin ligases. PubMed ID: 29237719

An Mtb-human protein-protein interaction map identifies a switch between host antiviral and antibacterial responses. PubMed ID: 30118682

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. PubMed ID: 10078535

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. PubMed ID: 10966114

Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype. PubMed ID: 20619386

Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism. PubMed ID: 20622007

RASopathy-associated CBL germline mutations cause aberrant ubiquitylation and trafficking of EGFR. PubMed ID: 25178484