Details for: CBL
Associated with
Other Information
Genular Protein ID: 51023601
Symbol: CBL_HUMAN
Name: E3 ubiquitin-protein ligase CBL
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2030914
Title: The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.
PubMed ID: 2030914
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8083187
Title: The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.
PubMed ID: 8083187
PubMed ID: 7657591
Title: Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.
PubMed ID: 7657591
PubMed ID: 9407100
Title: The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.
PubMed ID: 9407100
PubMed ID: 9535867
Title: Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.
PubMed ID: 9535867
PubMed ID: 10092522
Title: The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.
PubMed ID: 10092522
PubMed ID: 10374881
Title: APS, an adaptor protein containing pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl.
PubMed ID: 10374881
PubMed ID: 9989826
Title: APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis.
PubMed ID: 9989826
PubMed ID: 10449770
Title: SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling.
PubMed ID: 10449770
PubMed ID: 10514377
Title: The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
PubMed ID: 10514377
PubMed ID: 11067845
Title: The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction.
PubMed ID: 11067845
PubMed ID: 11696592
Title: Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling.
PubMed ID: 11696592
PubMed ID: 12486104
Title: Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.
PubMed ID: 12486104
DOI: 10.1084/jem.20021405
PubMed ID: 11997497
Title: APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes.
PubMed ID: 11997497
PubMed ID: 11896602
Title: Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation.
PubMed ID: 11896602
PubMed ID: 11850825
Title: C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus.
PubMed ID: 11850825
PubMed ID: 12504111
Title: The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2.
PubMed ID: 12504111
PubMed ID: 12435267
Title: Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils.
PubMed ID: 12435267
DOI: 10.1042/bj20021201
PubMed ID: 12522270
Title: Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.
PubMed ID: 12522270
PubMed ID: 15144186
Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
PubMed ID: 15144186
DOI: 10.1021/ac035352d
PubMed ID: 15526160
Title: Signal transduction via the stem cell factor receptor/c-Kit.
PubMed ID: 15526160
PubMed ID: 15556646
Title: Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl.
PubMed ID: 15556646
PubMed ID: 15190072
Title: Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation.
PubMed ID: 15190072
PubMed ID: 14739300
Title: Src kinase activity is essential for osteoclast function.
PubMed ID: 14739300
PubMed ID: 15226403
Title: ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.
PubMed ID: 15226403
DOI: 10.1242/jcs.01183
PubMed ID: 14661060
Title: Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.
PubMed ID: 14661060
PubMed ID: 16129412
Title: Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.
PubMed ID: 16129412
PubMed ID: 15958209
Title: Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation.
PubMed ID: 15958209
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 17094949
Title: Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination.
PubMed ID: 17094949
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17509076
Title: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor.
PubMed ID: 17509076
PubMed ID: 17620338
Title: Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.
PubMed ID: 17620338
PubMed ID: 18235045
Title: Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.
PubMed ID: 18235045
PubMed ID: 18374639
Title: FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival.
PubMed ID: 18374639
PubMed ID: 17974561
Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.
PubMed ID: 17974561
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18034775
Title: Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.
PubMed ID: 18034775
PubMed ID: 19689429
Title: Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation.
PubMed ID: 19689429
DOI: 10.1042/bj20091010
PubMed ID: 19836242
Title: An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.
PubMed ID: 19836242
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20494825
Title: Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.
PubMed ID: 20494825
PubMed ID: 20094046
Title: Fibroblast growth factor signalling: from development to cancer.
PubMed ID: 20094046
DOI: 10.1038/nrc2780
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21596750
Title: The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination.
PubMed ID: 21596750
PubMed ID: 23774213
Title: CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation.
PubMed ID: 23774213
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 29237719
Title: IFT20 modulates ciliary PDGFRalpha signaling by regulating the stability of Cbl E3 ubiquitin ligases.
PubMed ID: 29237719
PubMed ID: 30118682
Title: An Mtb-human protein-protein interaction map identifies a switch between host antiviral and antibacterial responses.
PubMed ID: 30118682
PubMed ID: 10078535
Title: Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
PubMed ID: 10078535
DOI: 10.1038/18050
PubMed ID: 10966114
Title: Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
PubMed ID: 10966114
PubMed ID: 20619386
Title: Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype.
PubMed ID: 20619386
PubMed ID: 20622007
Title: Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism.
PubMed ID: 20622007
PubMed ID: 25178484
Title: RASopathy-associated CBL germline mutations cause aberrant ubiquitylation and trafficking of EGFR.
PubMed ID: 25178484
DOI: 10.1002/humu.22682
Sequence Information:
- Length: 906
- Mass: 99633
- Checksum: 1AA6BF67377322CA
- Sequence:
MAGNVKKSSG AGGGSGSGGS GSGGLIGLMK DAFQPHHHHH HHLSPHPPGT VDKKMVEKCW KLMDKVVRLC QNPKLALKNS PPYILDLLPD TYQHLRTILS RYEGKMETLG ENEYFRVFME NLMKKTKQTI SLFKEGKERM YEENSQPRRN LTKLSLIFSH MLAELKGIFP SGLFQGDTFR ITKADAAEFW RKAFGEKTIV PWKSFRQALH EVHPISSGLE AMALKSTIDL TCNDYISVFE FDIFTRLFQP WSSLLRNWNS LAVTHPGYMA FLTYDEVKAR LQKFIHKPGS YIFRLSCTRL GQWAIGYVTA DGNILQTIPH NKPLFQALID GFREGFYLFP DGRNQNPDLT GLCEPTPQDH IKVTQEQYEL YCEMGSTFQL CKICAENDKD VKIEPCGHLM CTSCLTSWQE SEGQGCPFCR CEIKGTEPIV VDPFDPRGSG SLLRQGAEGA PSPNYDDDDD ERADDTLFMM KELAGAKVER PPSPFSMAPQ ASLPPVPPRL DLLPQRVCVP SSASALGTAS KAASGSLHKD KPLPVPPTLR DLPPPPPPDR PYSVGAESRP QRRPLPCTPG DCPSRDKLPP VPSSRLGDSW LPRPIPKVPV SAPSSSDPWT GRELTNRHSL PFSLPSQMEP RPDVPRLGST FSLDTSMSMN SSPLVGPECD HPKIKPSSSA NAIYSLAARP LPVPKLPPGE QCEGEEDTEY MTPSSRPLRP LDTSQSSRAC DCDQQIDSCT YEAMYNIQSQ APSITESSTF GEGNLAAAHA NTGPEESENE DDGYDVPKPP VPAVLARRTL SDISNASSSF GWLSLDGDPT TNVTEGSQVP ERPPKPFPRR INSERKAGSC QQGSGPAASA ATASPQLSSE IENLMSQGYS YQDIQKALVI AQNNIEMAKN ILREFVSISS PAHVAT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.