Details for: CBLB

Gene ID: 868

Symbol: CBLB

Ensembl ID: ENSG00000114423

Description: Cbl proto-oncogene B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 5.04
    Marker Score: 3,319
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.53
    Marker Score: 101,163
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.45
    Marker Score: 2,476
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.51
    Marker Score: 11,775
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.22
    Marker Score: 7,072
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 3.16
    Marker Score: 819
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.05
    Marker Score: 12,781
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.97
    Marker Score: 5,717
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.68
    Marker Score: 9,544
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.68
    Marker Score: 782
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.62
    Marker Score: 3,016
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.41
    Marker Score: 6,756
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.4
    Marker Score: 2,560
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.39
    Marker Score: 755
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.35
    Marker Score: 2,599
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.34
    Marker Score: 674
  • Cell Name: interneuron (CL0000099)
    Fold Change: 2.31
    Marker Score: 1,053
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.3
    Marker Score: 1,105
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.29
    Marker Score: 1,239
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.25
    Marker Score: 11,804
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.2
    Marker Score: 813
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.03
    Marker Score: 1,179
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.03
    Marker Score: 68,507
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2
    Marker Score: 73,902
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2
    Marker Score: 1,903
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.99
    Marker Score: 3,473
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.99
    Marker Score: 832
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.97
    Marker Score: 35,021
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.95
    Marker Score: 1,137
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.93
    Marker Score: 2,801
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.88
    Marker Score: 709
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.87
    Marker Score: 5,903
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.84
    Marker Score: 2,292
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.82
    Marker Score: 1,022
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.82
    Marker Score: 1,038
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.82
    Marker Score: 4,354
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.77
    Marker Score: 988
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.75
    Marker Score: 34,872
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.75
    Marker Score: 1,874
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.75
    Marker Score: 754
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.74
    Marker Score: 626
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.71
    Marker Score: 1,480
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.69
    Marker Score: 64,356
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.69
    Marker Score: 1,303
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.69
    Marker Score: 6,869
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.67
    Marker Score: 569
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.67
    Marker Score: 17,250
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.66
    Marker Score: 2,295
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.66
    Marker Score: 1,247
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.63
    Marker Score: 55,576
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.62
    Marker Score: 99,853
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.61
    Marker Score: 6,656
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.6
    Marker Score: 580
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.6
    Marker Score: 1,720
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.58
    Marker Score: 33,741
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.57
    Marker Score: 6,554
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.56
    Marker Score: 14,637
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.55
    Marker Score: 480
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.54
    Marker Score: 594
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.53
    Marker Score: 15,184
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.51
    Marker Score: 413
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.51
    Marker Score: 11,394
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.5
    Marker Score: 893
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.49
    Marker Score: 893
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.47
    Marker Score: 5,668
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.46
    Marker Score: 335
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.45
    Marker Score: 21,722
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.45
    Marker Score: 732
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.45
    Marker Score: 13,758
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.43
    Marker Score: 6,635
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.43
    Marker Score: 22,958
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.43
    Marker Score: 692
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.4
    Marker Score: 697
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.39
    Marker Score: 1,667
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.38
    Marker Score: 13,871
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.37
    Marker Score: 791
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.37
    Marker Score: 349
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.37
    Marker Score: 1,940
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.37
    Marker Score: 10,485
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.37
    Marker Score: 1,122
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.37
    Marker Score: 387
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.36
    Marker Score: 1,687
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.36
    Marker Score: 2,430
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.35
    Marker Score: 1,631
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.34
    Marker Score: 408
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.34
    Marker Score: 1,098
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.33
    Marker Score: 20,835
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.33
    Marker Score: 921
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.32
    Marker Score: 326
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.31
    Marker Score: 1,390
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.31
    Marker Score: 3,012
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.31
    Marker Score: 2,017
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.31
    Marker Score: 947
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.3
    Marker Score: 11,205
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.3
    Marker Score: 1,751
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.3
    Marker Score: 1,100
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.29
    Marker Score: 425
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.28
    Marker Score: 3,133
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.28
    Marker Score: 549
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.27
    Marker Score: 335

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The CBLB gene exhibits the following characteristics: 1. **Ubiquitination**: CBL-B is an E3 ubiquitin ligase, which means it catalyzes the transfer of ubiquitin molecules to target proteins, marking them for degradation. 2. **Phosphotyrosine binding**: CBL-B binds to phosphotyrosine residues on target proteins, facilitating the recruitment of other proteins and the initiation of downstream signaling cascades. 3. **Sh3 domain binding**: CBL-B contains a Src homology 3 (Sh3) domain, which interacts with other proteins and regulates its activity. 4. **Negative regulation of T cell signaling**: CBL-B negatively regulates T cell receptor signaling, preventing excessive activation and promoting tolerance. 5. **Positive regulation of protein catabolic process**: CBL-B promotes the degradation of proteins, which is essential for maintaining cellular homeostasis. **Pathways and Functions** The CBLB gene is involved in several signaling pathways, including: 1. **Adaptive immune system**: CBL-B regulates T cell activation, proliferation, and anergy, ensuring proper immune responses. 2. **Antigen processing and presentation**: CBL-B interacts with MHC class I molecules, facilitating the presentation of antigens to CD8+ T cells. 3. **Intracellular signal transduction**: CBL-B regulates various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. 4. **Negative regulation of epidermal growth factor (EGF)-activated receptor activity**: CBL-B inhibits EGF signaling, preventing excessive cell growth and proliferation. **Clinical Significance** Dysregulation of the CBLB gene has been implicated in several diseases, including: 1. **Cancer**: Overexpression of CBL-B has been observed in various cancers, including leukemia, lymphoma, and breast cancer. 2. **Autoimmune disorders**: CBL-B dysfunction contributes to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Immunodeficiency**: CBL-B deficiency has been linked to impaired immune function and increased susceptibility to infections. 4. **Cardiovascular disease**: CBL-B regulates platelet-derived growth factor receptor-alpha signaling, which is essential for cardiovascular health. In conclusion, the CBLB gene plays a critical role in regulating T cell signaling, ubiquitination, and protein degradation. Its dysregulation has significant implications for various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease. Further research is needed to fully elucidate the functions and clinical significance of the CBLB gene.

Genular Protein ID: 2587945829

Symbol: CBLB_HUMAN

Name: E3 ubiquitin-protein ligase CBL-B

UniProtKB Accession Codes:

Q13191 A8K9S7 B7WNM4 Q13192 Q13193 Q3LIC0 Q63Z43 Q8IVC5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 14 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 12 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7784085

Title: Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene.

PubMed ID: 7784085

PubMed ID: 9399639

Title: Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.

PubMed ID: 9399639

DOI: 10.1038/sj.onc.1201430

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12880961

Title: Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma.

PubMed ID: 12880961

DOI: 10.1016/s0304-3835(03)00085-5

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10022120

Title: Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.

PubMed ID: 10022120

DOI: 10.1038/sj.onc.1202411

PubMed ID: 10086340

Title: cbl-b inhibits epidermal growth factor receptor signaling.

PubMed ID: 10086340

DOI: 10.1038/sj.onc.1202499

PubMed ID: 11087752

Title: Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

PubMed ID: 11087752

DOI: 10.1074/jbc.m008901200

PubMed ID: 11375397

Title: Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex.

PubMed ID: 11375397

DOI: 10.1074/jbc.m102641200

PubMed ID: 11526404

Title: Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

PubMed ID: 11526404

DOI: 10.1038/ni0901-870

PubMed ID: 12177062

Title: CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.

PubMed ID: 12177062

DOI: 10.1074/jbc.m205535200

PubMed ID: 14661060

Title: Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.

PubMed ID: 14661060

DOI: 10.1038/sj.onc.1207298

PubMed ID: 15273720

Title: Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b.

PubMed ID: 15273720

DOI: 10.1038/sj.onc.1207952

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19549985

Title: PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation.

PubMed ID: 19549985

DOI: 10.1126/scisignal.2000046

PubMed ID: 20525694

Title: The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.

PubMed ID: 20525694

DOI: 10.1074/jbc.m109.091157

PubMed ID: 29237719

Title: IFT20 modulates ciliary PDGFRalpha signaling by regulating the stability of Cbl E3 ubiquitin ligases.

PubMed ID: 29237719

DOI: 10.1083/jcb.201611050

PubMed ID: 16228008

Title: Cbl promotes clustering of endocytic adaptor proteins.

PubMed ID: 16228008

DOI: 10.1038/nsmb1000

PubMed ID: 17020880

Title: Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain.

PubMed ID: 17020880

DOI: 10.1074/jbc.m606411200

PubMed ID: 17679095

Title: Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b.

PubMed ID: 17679095

DOI: 10.1016/j.molcel.2007.06.023

Sequence Information:

  • Length: 982
  • Mass: 109450
  • Checksum: B4E307D31B9F0779
  • Sequence:
    • MANSMNGRNP GGRGGNPRKG RILGIIDAIQ DAVGPPKQAA ADRRTVEKTW KLMDKVVRLC 
QNPKLQLKNS PPYILDILPD TYQHLRLILS KYDDNQKLAQ LSENEYFKIY IDSLMKKSKR 
AIRLFKEGKE RMYEEQSQDR RNLTKLSLIF SHMLAEIKAI FPNGQFQGDN FRITKADAAE 
FWRKFFGDKT IVPWKVFRQC LHEVHQISSG LEAMALKSTI DLTCNDYISV FEFDIFTRLF 
QPWGSILRNW NFLAVTHPGY MAFLTYDEVK ARLQKYSTKP GSYIFRLSCT RLGQWAIGYV 
TGDGNILQTI PHNKPLFQAL IDGSREGFYL YPDGRSYNPD LTGLCEPTPH DHIKVTQEQY 
ELYCEMGSTF QLCKICAEND KDVKIEPCGH LMCTSCLTAW QESDGQGCPF CRCEIKGTEP 
IIVDPFDPRD EGSRCCSIID PFGMPMLDLD DDDDREESLM MNRLANVRKC TDRQNSPVTS 
PGSSPLAQRR KPQPDPLQIP HLSLPPVPPR LDLIQKGIVR SPCGSPTGSP KSSPCMVRKQ 
DKPLPAPPPP LRDPPPPPPE RPPPIPPDNR LSRHIHHVES VPSRDPPMPL EAWCPRDVFG 
TNQLVGCRLL GEGSPKPGIT ASSNVNGRHS RVGSDPVLMR KHRRHDLPLE GAKVFSNGHL 
GSEEYDVPPR LSPPPPVTTL LPSIKCTGPL ANSLSEKTRD PVEEDDDEYK IPSSHPVSLN 
SQPSHCHNVK PPVRSCDNGH CMLNGTHGPS SEKKSNIPDL SIYLKGDVFD SASDPVPLPP 
ARPPTRDNPK HGSSLNRTPS DYDLLIPPLG EDAFDALPPS LPPPPPPARH SLIEHSKPPG 
SSSRPSSGQD LFLLPSDPFV DLASGQVPLP PARRLPGENV KTNRTSQDYD QLPSCSDGSQ 
APARPPKPRP RRTAPEIHHR KPHGPEAALE NVDAKIAKLM GEGYAFEEVK RALEIAQNNV 
EVARSILREF AFPPPVSPRL NL

Genular Protein ID: 1373687835

Symbol: B4DYP3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DYP3

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 DNASU 1 EC 1 EMBL 2 GO 6 Gene3D 5 GenomeRNAi 1 InterPro 14 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 4 UniPathway 1

Sequence Information:

  • Length: 960
  • Mass: 107083
  • Checksum: 330B04D6638D0BBD
  • Sequence:
    • MALAPGSDAH AHLPPLIELK FQMANSMNGR NPGGRGGNPR KGRILGIIDA IQDAVGPPKQ 
AAADRRTVEK TWKLMDKVVR LCQNPKLQLK NSPPYILDIL PDTYQHLRLI LSKYDDNQKL 
AQLSENEYFK IYIDSLMKKS KRAIRLFKEG KERMYEEQSQ DRRNLTKLSL IFSHMLAEIK 
AIFPNGQFQG DNFRITKADA AEFWRKFFGD KTIVPWKVFR QCLHEVHQIS SGLEAMALKS 
TIDLTCNDYI SVFEFDIFTR LFQPWGSILR NWNFLAVTHP GYMAFLTYDE VKARLQKYST 
KPGSYIFRLS CTRLGQWAIG YVTGDGNILQ TIPHNKPLFQ ALIDGSREGF YLYPDGRSYN 
PDLTGLCEPT PHDHIKVTQE QYELYCEMGS TFQLCKICAE NDKDVKIEPC GHLMCTSCLT 
AWQESDGQGC PFCRCEIKGT EPIIVDPFDP RDEGSRCCSI IDPFGMPMLD LDDDDDREES 
LMMNRLANVR KCTDRQNSPV TSPGSSPLAQ RRKPQPDPLQ IPHLSLPPVP PRLDLIQKGI 
VRSPCGSPTG SPKSSPCMVR KQDKPLPAPP PPLRDPPPPP PERPPPIPPD NRLSRHIHHV 
ESVPSRDPPM PLEAWCPRDV FGTNQLVGCR LLGEGSPKPG ITASSNVNGR HSRVGSDPVL 
MRKHRRHDLP LEGAKVFSNG HLGSEEYDVP PRLSPPPPVT TLLPSIKCTG PLANSLSEKT 
RDPVEEDDDE YKIPSSHPVS LNSQPSHCHN VKPPVRSCDN GHCMLNGTHG PSSEKKSNIP 
DLSIYLKGED AFDALPPSLP PPPPPARHSL IEHSKPPGSS SRPSSGQDLF LLPSDPFVDL 
ASGQVPLPPA RRLPGENVKT NRTSQDYDQL PSCSDGSQAP ARPPKPRPRR TAPEIHHRKP 
HGPEAALENV DAKIAKLMGE GYAFEEVKRA LEIAQNNVEV ARSILREFAF PPPVSPRLNL

Genular Protein ID: 1943509495

Symbol: B3KSS7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KSS7

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 DNASU 1 EC 1 EMBL 2 GO 5 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 405
  • Mass: 44242
  • Checksum: C1D94AF5EB185CF1
  • Sequence:
    • MAETLVVEEE IPEKVEFWVL LMLFRMQLDP LSKLPQIAKP GITASSNVNG RHSRVGSDPV 
LMRKHRRHDL PLEGAKVFSN GHLGSEEYDV PPRLSPPPPV TTLLPSIKCT GPLANSLSEK 
TRDPVEEDDD EYKIPSSHPV SLNSQPSHCH NVKPPVRSCD NGHCMLNGTH GPSSEKKSNI 
PDLSIYLKGD VFDSASDPVP LPPARPPTRD NPKHGSSLNR TPSDYDLLIP PLGEDAFDAL 
PPSLPPPPPP ARHSLIEHSK PPGSSSRPSS GQDLFLLPSD PFVDLASGQV PLPPARRLPG 
ENVKTNRTSQ DYDQLPSCSD GSQASARPPK PRPRRTAPEI HHRKPHGPEA ALENVDAKIA 
KLMGEGYAFE EVKRALEIAQ NNVEVARSIL REFAFPPPVS PRLNL

Genular Protein ID: 3583767040

Symbol: B7ZAG1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZAG1

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 DNASU 1 EC 1 EMBL 2 GO 6 Gene3D 5 GenomeRNAi 1 InterPro 14 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 4 UniPathway 1

Sequence Information:

  • Length: 960
  • Mass: 106994
  • Checksum: 14CF74D4DCABFE5B
  • Sequence:
    • MALAPGPDAH AHLPPLIELK FQMANSMNGR NPGGRGGNPR KGRILGIIDA IQDAVGPPKQ 
AAADRRTVEK TWKLMDKVVR LCQNPKLQLK NSPPYILDIL PDTYQHLRLI LSKYDDNQKL 
AQLSENEYFK IYIDSLMKKS KRAIRLFKEG KERMYEEQSQ DRRNLTKLSL IFSHMLAEIK 
AIFPNGQFQG DNFRITKADA AEFWRKFFGD KTIVPWKVFR QCLHEVHQIS SGLEAMALKS 
TIDLTCNDYI SVFEFDIFTR LFQPWGSILR NWNFLAVTHP GYMAFLTYDE VKARLQKYST 
KPGSYIFRLS CTRLGQWAIG YVTGDGNILQ TIPHNKPLFQ ALIDGSREGF YLYPDGRSYN 
PDLTGLCEPT PHDHIKVTQE QYELYCEMGS TFQLCKICAE NDKDVKIEPC GHLMCTSCLT 
AWQESDGQGC PFCRCEIKGT EPIIVDPFDP RDEGSRCCSI IDPFGMPMLD LDDDDDREES 
LMMNRLANVR KCTDRQNSPV TSPGSSPLAQ RRKPQPDPLQ IPHLSLPPVP PRLDLIQKGI 
VRSPCGSPTG SPKSSPCMVR KQDKPLPAPP PPLGDPPPPP PERPPPIPPD NRLSRHIHHV 
ESVPSRDPPM PLEAWCPRDV FGTNQLVGCR LLGEGSPKPG ITASSNVNGR HSRVGSDPVL 
MRKHRRHDLP LEGAKVFSNG HLGSEEYDVP PRLSPPPPVT TLLPSIKCTG PLANSLSEKT 
RDPVEEDDDE YKIPSSHPVS LNSQPSHCHN VKPPVRSCDN GHCMLNGTHG PSSEKKSNIP 
DLSIYLKGED AFDALPPSLP PPPPPARHSL IEHSKPPGSS SRPSSGQDLF LLPSDPFVDL 
ASGQVPLPPA RRLPGENVKT NRTSQDYDQL PSCSDGSQAP ARPPKPRPRR TAPEIHHRKP 
HGPEAALENV DAKIAKLMGE GYAFEEVKRA LEIAQNNVEV ARSILREFAF PPPVSPRLNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.