Details for: CBLN1

Gene ID: 869

Symbol: CBLN1

Ensembl ID: ENSG00000102924

Description: cerebellin 1 precursor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 7.5690
    Cell Significance Index: 129.7100
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.9043
    Cell Significance Index: 44.4500
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.4660
    Cell Significance Index: 28.0100
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.1749
    Cell Significance Index: 24.1500
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.3656
    Cell Significance Index: 14.8200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.2512
    Cell Significance Index: 10.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.2139
    Cell Significance Index: 38.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6243
    Cell Significance Index: 13.6700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4035
    Cell Significance Index: 5.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4015
    Cell Significance Index: 8.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3786
    Cell Significance Index: 37.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3335
    Cell Significance Index: 301.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2640
    Cell Significance Index: 50.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2620
    Cell Significance Index: 15.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2502
    Cell Significance Index: 27.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2064
    Cell Significance Index: 33.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1312
    Cell Significance Index: 9.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1028
    Cell Significance Index: 4.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0916
    Cell Significance Index: 2.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0183
    Cell Significance Index: 12.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0057
    Cell Significance Index: 0.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0055
    Cell Significance Index: 1.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0036
    Cell Significance Index: 0.0900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.0031
    Cell Significance Index: 0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0011
    Cell Significance Index: 0.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0023
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0041
    Cell Significance Index: -3.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0057
    Cell Significance Index: -2.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0067
    Cell Significance Index: -3.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0085
    Cell Significance Index: -1.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0093
    Cell Significance Index: -5.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0096
    Cell Significance Index: -2.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0115
    Cell Significance Index: -0.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0120
    Cell Significance Index: -0.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0124
    Cell Significance Index: -1.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0137
    Cell Significance Index: -6.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0141
    Cell Significance Index: -0.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0226
    Cell Significance Index: -4.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0226
    Cell Significance Index: -4.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0266
    Cell Significance Index: -4.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0286
    Cell Significance Index: -4.8900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0299
    Cell Significance Index: -1.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0355
    Cell Significance Index: -4.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0392
    Cell Significance Index: -4.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0478
    Cell Significance Index: -4.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0481
    Cell Significance Index: -5.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0497
    Cell Significance Index: -1.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0528
    Cell Significance Index: -2.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0596
    Cell Significance Index: -6.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0610
    Cell Significance Index: -4.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0615
    Cell Significance Index: -3.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0635
    Cell Significance Index: -0.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0718
    Cell Significance Index: -4.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0748
    Cell Significance Index: -5.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0838
    Cell Significance Index: -4.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0916
    Cell Significance Index: -1.2500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0971
    Cell Significance Index: -0.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1006
    Cell Significance Index: -4.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1134
    Cell Significance Index: -5.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1162
    Cell Significance Index: -5.1400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1180
    Cell Significance Index: -2.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1212
    Cell Significance Index: -6.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1225
    Cell Significance Index: -4.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1237
    Cell Significance Index: -4.0500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1347
    Cell Significance Index: -2.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1347
    Cell Significance Index: -5.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1351
    Cell Significance Index: -3.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1360
    Cell Significance Index: -4.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1414
    Cell Significance Index: -3.7900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1422
    Cell Significance Index: -2.0200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1430
    Cell Significance Index: -1.7400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1547
    Cell Significance Index: -6.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1566
    Cell Significance Index: -4.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1621
    Cell Significance Index: -5.9500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1652
    Cell Significance Index: -2.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1657
    Cell Significance Index: -4.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1689
    Cell Significance Index: -4.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1723
    Cell Significance Index: -4.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1786
    Cell Significance Index: -4.7700
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1816
    Cell Significance Index: -2.4700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1877
    Cell Significance Index: -1.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1908
    Cell Significance Index: -4.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1925
    Cell Significance Index: -5.1500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2010
    Cell Significance Index: -4.0900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2017
    Cell Significance Index: -5.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2054
    Cell Significance Index: -5.5900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2089
    Cell Significance Index: -2.2800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2118
    Cell Significance Index: -5.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2138
    Cell Significance Index: -4.6200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2156
    Cell Significance Index: -3.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2203
    Cell Significance Index: -6.1600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.2211
    Cell Significance Index: -2.2900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2218
    Cell Significance Index: -5.5400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2268
    Cell Significance Index: -2.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2271
    Cell Significance Index: -4.8200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2282
    Cell Significance Index: -4.5500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2309
    Cell Significance Index: -4.8200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2322
    Cell Significance Index: -4.5700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2467
    Cell Significance Index: -2.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2477
    Cell Significance Index: -6.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Patterns:** CBLN1 is expressed in neuronal brush cells, granule cells, and macroglial cells, as well as in goblet cells of the colon, intestinal crypt stem cells, and B cells. 2. **Protein Structure:** CBLN1 is a precursor protein that undergoes proteolytic processing to generate a mature protein. 3. **Cellular Localization:** CBLN1 is primarily localized to the postsynaptic membrane, where it plays a crucial role in regulating synaptic transmission. **Pathways and Functions:** 1. **Synaptic Transmission:** CBLN1 regulates the assembly and maintenance of synapses, including the formation of glutamatergic synapses and the regulation of excitatory and inhibitory synaptic potentials. 2. **Neuronal Development:** CBLN1 is involved in the development and organization of the cerebellum, specifically in the formation of parallel fibers to Purkinje cells and the regulation of neuronal migration. 3. **Synaptic Plasticity:** CBLN1 modulates synaptic plasticity by regulating long-term synaptic depression and the assembly of synaptic complexes. 4. **Cell-Cell Adhesion:** CBLN1 participates in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, facilitating the formation of functional synapses. **Clinical Significance:** Dysregulation of CBLN1 has been implicated in various neurological disorders, including: 1. **Neurodevelopmental Disorders:** Mutations in CBLN1 have been associated with cerebellar hypoplasia and other neurodevelopmental disorders. 2. **Neurodegenerative Diseases:** Altered CBLN1 expression has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Mental Health Disorders:** Abnormal CBLN1 expression has been observed in individuals with mental health disorders, including depression and anxiety. In conclusion, the CBLN1 gene plays a critical role in regulating synaptic transmission, neuronal development, and synaptic plasticity. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the importance of further research into the molecular mechanisms underlying these conditions.

Genular Protein ID: 1518742336

Symbol: CBLN1_HUMAN

Name: Cerebellin-1

UniProtKB Accession Codes:

P23435 B2RAN9 P02682 Q52M09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1704129

Title: Precerebellin is a cerebellum-specific protein with similarity to the globular domain of complement C1q B chain.

PubMed ID: 1704129

DOI: 10.1073/pnas.88.3.1069

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2760624

Title: Purification and characterisation of cerebellins from human and porcine cerebellum.

PubMed ID: 2760624

DOI: 10.1111/j.1471-4159.1989.tb11787.x

PubMed ID: 27418511

Title: Structural basis for integration of GluD receptors within synaptic organizer complexes.

PubMed ID: 27418511

DOI: 10.1126/science.aae0104

Sequence Information:

  • Length: 193
  • Mass: 21097
  • Checksum: D542FC7987E401A5
  • Sequence:
    • MLGVLELLLL GAAWLAGPAR GQNETEPIVL EGKCLVVCDS NPTSDPTGTA LGISVRSGSA 
KVAFSAIRST NHEPSEMSNR TMIIYFDQVL VNIGNNFDSE RSTFIAPRKG IYSFNFHVVK 
VYNRQTIQVS LMLNGWPVIS AFAGDQDVTR EAASNGVLIQ MEKGDRAYLK LERGNLMGGW 
KYSTFSGFLV FPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.