Details for: ACTN1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: skeletal muscle satellite stem cell (CL0008011)
CSI Score: 11.6 - Cell Name: myoepithelial cell (CL0000185)
CSI Score: 10.7 - Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
CSI Score: 7.7 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
CSI Score: 6.6 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
CSI Score: 4.9 - Cell Name: enteric smooth muscle cell (CL0002504)
CSI Score: 4.7 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
CSI Score: 4.7 - Cell Name: endothelial cell of vascular tree (CL0002139)
CSI Score: 4.2 - Cell Name: hepatic stellate cell (CL0000632)
CSI Score: 3.9 - Cell Name: blood vessel endothelial cell (CL0000071)
CSI Score: 3.7 - Cell Name: luminal cell of prostate epithelium (CL0002340)
CSI Score: 3.6 - Cell Name: glutamatergic neuron (CL0000679)
CSI Score: 3.6 - Cell Name: obsolete animal cell (CL0000548)
CSI Score: 3.6 - Cell Name: pancreatic ductal cell (CL0002079)
CSI Score: 3.5 - Cell Name: classical monocyte (CL0000860)
CSI Score: 3.4 - Cell Name: malignant cell (CL0001064)
CSI Score: 3.4 - Cell Name: placental villous trophoblast (CL2000060)
CSI Score: 3.3 - Cell Name: endothelial cell (CL0000115)
CSI Score: 3.2 - Cell Name: platelet (CL0000233)
CSI Score: 3.1 - Cell Name: extravillous trophoblast (CL0008036)
CSI Score: 3.1 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
CSI Score: 3.1 - Cell Name: forebrain radial glial cell (CL0013000)
CSI Score: 3.1 - Cell Name: cardiac endothelial cell (CL0010008)
CSI Score: 3.0 - Cell Name: renal interstitial pericyte (CL1001318)
CSI Score: 3.0 - Cell Name: ON-bipolar cell (CL0000749)
CSI Score: 2.9 - Cell Name: pancreatic acinar cell (CL0002064)
CSI Score: 2.9 - Cell Name: rod bipolar cell (CL0000751)
CSI Score: 2.9 - Cell Name: myeloid cell (CL0000763)
CSI Score: 2.9 - Cell Name: mesenchymal cell (CL0008019)
CSI Score: 2.9 - Cell Name: retinal cone cell (CL0000573)
CSI Score: 2.8 - Cell Name: ciliated epithelial cell (CL0000067)
CSI Score: 2.7 - Cell Name: retinal rod cell (CL0000604)
CSI Score: 2.7 - Cell Name: basal cell (CL0000646)
CSI Score: 2.7 - Cell Name: lung ciliated cell (CL1000271)
CSI Score: 2.6 - Cell Name: smooth muscle cell (CL0000192)
CSI Score: 2.6 - Cell Name: myeloid leukocyte (CL0000766)
CSI Score: 2.6 - Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
CSI Score: 2.6 - Cell Name: CD14-positive monocyte (CL0001054)
CSI Score: 2.5 - Cell Name: kidney epithelial cell (CL0002518)
CSI Score: 2.5 - Cell Name: myofibroblast cell (CL0000186)
CSI Score: 2.5 - Cell Name: stratified epithelial cell (CL0000079)
CSI Score: 2.5 - Cell Name: mononuclear phagocyte (CL0000113)
CSI Score: 2.4 - Cell Name: conjunctival epithelial cell (CL1000432)
CSI Score: 2.4 - Cell Name: fibroblast (CL0000057)
CSI Score: 2.4 - Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
CSI Score: 2.3 - Cell Name: GABAergic neuron (CL0000617)
CSI Score: 2.3 - Cell Name: secretory cell (CL0000151)
CSI Score: 2.2 - Cell Name: ciliated cell (CL0000064)
CSI Score: 2.2 - Cell Name: mesodermal cell (CL0000222)
CSI Score: 2.1 - Cell Name: muscle cell (CL0000187)
CSI Score: 2.1 - Cell Name: peripheral nervous system neuron (CL2000032)
CSI Score: 2.1 - Cell Name: cardiac muscle cell (CL0000746)
CSI Score: 2.1 - Cell Name: gut endothelial cell (CL0000131)
CSI Score: 2.0 - Cell Name: alveolar macrophage (CL0000583)
CSI Score: 2.0 - Cell Name: goblet cell (CL0000160)
CSI Score: 2.0 - Cell Name: hepatocyte (CL0000182)
CSI Score: 2.0 - Cell Name: epithelial cell of proximal tubule (CL0002306)
CSI Score: 2.0 - Cell Name: neuron (CL0000540)
CSI Score: 2.0 - Cell Name: fibroblast of lung (CL0002553)
CSI Score: 2.0 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
CSI Score: 1.9 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
CSI Score: 1.9 - Cell Name: regular atrial cardiac myocyte (CL0002129)
CSI Score: 1.9 - Cell Name: brush cell (CL0002204)
CSI Score: 1.8 - Cell Name: glioblast (CL0000030)
CSI Score: 1.7 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
CSI Score: 1.7 - Cell Name: mural cell (CL0008034)
CSI Score: 1.7 - Cell Name: mesenchymal stem cell (CL0000134)
CSI Score: 1.7 - Cell Name: keratinocyte (CL0000312)
CSI Score: 1.6 - Cell Name: contractile cell (CL0000183)
CSI Score: 1.6 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
CSI Score: 1.6 - Cell Name: elicited macrophage (CL0000861)
CSI Score: 1.6 - Cell Name: epithelial cell (CL0000066)
CSI Score: 1.6 - Cell Name: fibroblast of cardiac tissue (CL0002548)
CSI Score: 1.6 - Cell Name: pancreatic A cell (CL0000171)
CSI Score: 1.5 - Cell Name: intermediate monocyte (CL0002393)
CSI Score: 1.5 - Cell Name: macrophage (CL0000235)
CSI Score: 1.5 - Cell Name: vein endothelial cell (CL0002543)
CSI Score: 1.5 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
CSI Score: 1.5 - Cell Name: OFF-bipolar cell (CL0000750)
CSI Score: 1.4 - Cell Name: intestinal epithelial cell (CL0002563)
CSI Score: 1.4 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
CSI Score: 1.4 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
CSI Score: 1.3 - Cell Name: squamous epithelial cell (CL0000076)
CSI Score: 1.3 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
CSI Score: 1.3 - Cell Name: transit amplifying cell (CL0009010)
CSI Score: 1.3 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
CSI Score: 1.2 - Cell Name: endothelial cell of artery (CL1000413)
CSI Score: 1.2 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
CSI Score: 1.1 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
CSI Score: 1.1 - Cell Name: stromal cell (CL0000499)
CSI Score: 1.1 - Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
CSI Score: 1.1 - Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
CSI Score: 1.0 - Cell Name: neural progenitor cell (CL0011020)
CSI Score: 1.0 - Cell Name: capillary endothelial cell (CL0002144)
CSI Score: 1.0 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
CSI Score: 1.0 - Cell Name: duct epithelial cell (CL0000068)
CSI Score: 1.0 - Cell Name: stem cell (CL0000034)
CSI Score: 0.9 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
CSI Score: 0.9 - Cell Name: exhausted T cell (CL0011025)
CSI Score: 0.9 - Cell Name: promonocyte (CL0000559)
CSI Score: 0.9
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1668419499
Symbol: ACTN1_HUMAN
Name: Alpha-actinin-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2780298
Title: The cDNA sequence of a human placental alpha-actinin.
PubMed ID: 2780298
PubMed ID: 2349951
Title: Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene.
PubMed ID: 2349951
PubMed ID: 18353764
Title: Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis.
PubMed ID: 18353764
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2169343
Title: Expression of human alpha-actinin in human hepatocellular carcinoma.
PubMed ID: 2169343
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 8713105
Title: Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes.
PubMed ID: 8713105
PubMed ID: 7750553
Title: Identification of the cytoskeletal protein alpha-actinin as a platelet thrombospondin-binding protein.
PubMed ID: 7750553
PubMed ID: 10369880
Title: Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy.
PubMed ID: 10369880
DOI: 10.1093/hmg/8.7.1329
PubMed ID: 11114196
Title: Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.
PubMed ID: 11114196
PubMed ID: 11369769
Title: The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase.
PubMed ID: 11369769
PubMed ID: 12615977
Title: The lipoma preferred partner LPP interacts with alpha-actinin.
PubMed ID: 12615977
DOI: 10.1242/jcs.00309
PubMed ID: 16464232
Title: Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring.
PubMed ID: 16464232
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22689882
Title: EWI-2 association with alpha-actinin regulates T cell immune synapses and HIV viral infection.
PubMed ID: 22689882
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 16698282
Title: Crystal structure of the actin-binding domain of alpha-actinin 1: evaluating two competing actin-binding models.
PubMed ID: 16698282
PubMed ID: 23434115
Title: ACTN1 mutations cause congenital macrothrombocytopenia.
PubMed ID: 23434115
PubMed ID: 24069336
Title: A missense mutation in the alpha-actinin 1 gene (ACTN1) is the cause of autosomal dominant macrothrombocytopenia in a large French family.
PubMed ID: 24069336
Sequence Information:
- Length: 892
- Mass: 103058
- Checksum: 6DA3E4D1A0289519
- Sequence:
MDHYDSQQTN DYMQPEEDWD RDLLLDPAWE KQQRKTFTAW CNSHLRKAGT QIENIEEDFR DGLKLMLLLE VISGERLAKP ERGKMRVHKI SNVNKALDFI ASKGVKLVSI GAEEIVDGNV KMTLGMIWTI ILRFAIQDIS VEETSAKEGL LLWCQRKTAP YKNVNIQNFH ISWKDGLGFC ALIHRHRPEL IDYGKLRKDD PLTNLNTAFD VAEKYLDIPK MLDAEDIVGT ARPDEKAIMT YVSSFYHAFS GAQKAETAAN RICKVLAVNQ ENEQLMEDYE KLASDLLEWI RRTIPWLENR VPENTMHAMQ QKLEDFRDYR RLHKPPKVQE KCQLEINFNT LQTKLRLSNR PAFMPSEGRM VSDINNAWGC LEQVEKGYEE WLLNEIRRLE RLDHLAEKFR QKASIHEAWT DGKEAMLRQK DYETATLSEI KALLKKHEAF ESDLAAHQDR VEQIAAIAQE LNELDYYDSP SVNARCQKIC DQWDNLGALT QKRREALERT EKLLETIDQL YLEYAKRAAP FNNWMEGAME DLQDTFIVHT IEEIQGLTTA HEQFKATLPD ADKERLAILG IHNEVSKIVQ TYHVNMAGTN PYTTITPQEI NGKWDHVRQL VPRRDQALTE EHARQQHNER LRKQFGAQAN VIGPWIQTKM EEIGRISIEM HGTLEDQLSH LRQYEKSIVN YKPKIDQLEG DHQLIQEALI FDNKHTNYTM EHIRVGWEQL LTTIARTINE VENQILTRDA KGISQEQMNE FRASFNHFDR DHSGTLGPEE FKACLISLGY DIGNDPQGEA EFARIMSIVD PNRLGVVTFQ AFIDFMSRET ADTDTADQVM ASFKILAGDK NYITMDELRR ELPPDQAEYC IARMAPYTGP DSVPGALDYM SFSTALYGES DL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.