Details for: SERPINH1

Gene ID: 871

Symbol: SERPINH1

Ensembl ID: ENSG00000149257

Description: serpin family H member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 236.3300
    Cell Significance Index: -36.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 142.6412
    Cell Significance Index: -36.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 85.1929
    Cell Significance Index: -35.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 79.7886
    Cell Significance Index: -37.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.4879
    Cell Significance Index: -31.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.0770
    Cell Significance Index: -31.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.6661
    Cell Significance Index: -37.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.9836
    Cell Significance Index: -37.4600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 11.6022
    Cell Significance Index: 148.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.5357
    Cell Significance Index: -32.3600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 9.8913
    Cell Significance Index: 61.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5748
    Cell Significance Index: -37.7800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 9.2425
    Cell Significance Index: 54.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.0156
    Cell Significance Index: 167.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 7.5781
    Cell Significance Index: 394.7300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.8071
    Cell Significance Index: 54.3500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 5.5397
    Cell Significance Index: 29.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.0050
    Cell Significance Index: 43.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.6604
    Cell Significance Index: 96.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.2852
    Cell Significance Index: 114.1600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.4938
    Cell Significance Index: 17.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.3570
    Cell Significance Index: 448.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.0519
    Cell Significance Index: 36.2600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.0402
    Cell Significance Index: 9.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.0157
    Cell Significance Index: 276.8100
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.9640
    Cell Significance Index: 7.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.8897
    Cell Significance Index: 242.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5773
    Cell Significance Index: 45.2200
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.4463
    Cell Significance Index: 6.6800
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.4147
    Cell Significance Index: 11.7000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 1.3441
    Cell Significance Index: 7.8900
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.3186
    Cell Significance Index: 7.7900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1505
    Cell Significance Index: 13.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8478
    Cell Significance Index: 765.4800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.7403
    Cell Significance Index: 4.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7291
    Cell Significance Index: 144.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6877
    Cell Significance Index: 18.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6854
    Cell Significance Index: 18.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6059
    Cell Significance Index: 98.5500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.6021
    Cell Significance Index: 2.7800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.5677
    Cell Significance Index: 3.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5512
    Cell Significance Index: 59.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4370
    Cell Significance Index: 26.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3880
    Cell Significance Index: 211.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3645
    Cell Significance Index: 6.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3474
    Cell Significance Index: 9.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3162
    Cell Significance Index: 139.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2837
    Cell Significance Index: 12.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2418
    Cell Significance Index: 17.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1974
    Cell Significance Index: 13.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1701
    Cell Significance Index: 30.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1542
    Cell Significance Index: 3.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1473
    Cell Significance Index: 4.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1200
    Cell Significance Index: 14.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1174
    Cell Significance Index: 6.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1035
    Cell Significance Index: 2.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0808
    Cell Significance Index: 2.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0719
    Cell Significance Index: 54.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0570
    Cell Significance Index: 5.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0091
    Cell Significance Index: -17.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0132
    Cell Significance Index: -0.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0252
    Cell Significance Index: -46.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0313
    Cell Significance Index: -48.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0325
    Cell Significance Index: -3.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0328
    Cell Significance Index: -44.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0339
    Cell Significance Index: -24.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0421
    Cell Significance Index: -26.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0551
    Cell Significance Index: -24.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0597
    Cell Significance Index: -44.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0697
    Cell Significance Index: -39.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0765
    Cell Significance Index: -22.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0769
    Cell Significance Index: -9.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0833
    Cell Significance Index: -52.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1022
    Cell Significance Index: -36.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1145
    Cell Significance Index: -13.3400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1359
    Cell Significance Index: -6.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1539
    Cell Significance Index: -2.1000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1672
    Cell Significance Index: -0.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1684
    Cell Significance Index: -24.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1779
    Cell Significance Index: -35.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1865
    Cell Significance Index: -31.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2047
    Cell Significance Index: -15.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2162
    Cell Significance Index: -45.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2393
    Cell Significance Index: -27.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2395
    Cell Significance Index: -5.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2901
    Cell Significance Index: -21.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3035
    Cell Significance Index: -35.8000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3188
    Cell Significance Index: -2.6000
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.3254
    Cell Significance Index: -1.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3460
    Cell Significance Index: -9.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3564
    Cell Significance Index: -37.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3756
    Cell Significance Index: -12.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4002
    Cell Significance Index: -26.9100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4059
    Cell Significance Index: -16.6300
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.4184
    Cell Significance Index: -2.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4271
    Cell Significance Index: -33.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4495
    Cell Significance Index: -20.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4744
    Cell Significance Index: -30.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4798
    Cell Significance Index: -29.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4837
    Cell Significance Index: -27.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SERPINH1 shares several key characteristics with other serpin genes, including: 1. **Serine protease inhibition**: SERPINH1 encodes a serpin protein that inhibits serine proteases, which are involved in various cellular processes, including collagen degradation and protein maturation. 2. **Collagen biosynthesis**: SERPINH1 is involved in the regulation of collagen biosynthesis, a process critical for maintaining tissue integrity and structure. 3. **Stress response**: SERPINH1 plays a role in the cellular response to stress, including heat shock and unfolded protein responses. 4. **Cellular regulation**: SERPINH1 is involved in the regulation of cellular processes, including protein maturation, protein binding, and regulation of endopeptidase activity. **Pathways and Functions:** SERPINH1 is involved in several cellular pathways, including: 1. **Collagen biosynthesis**: SERPINH1 regulates collagen biosynthesis by inhibiting serine proteases that degrade collagen. 2. **Stress response**: SERPINH1 plays a role in the cellular response to stress, including heat shock and unfolded protein responses. 3. **Regulation of endopeptidase activity**: SERPINH1 regulates endopeptidase activity, which is involved in protein maturation and degradation. 4. **Negative regulation of endopeptidase activity**: SERPINH1 inhibits endopeptidase activity, which is involved in protein maturation and degradation. **Clinical Significance:** SERPINH1 has been implicated in various diseases, including: 1. **Cardiovascular disorders**: SERPINH1 has been associated with cardiovascular disorders, including atherosclerosis and cardiovascular disease. 2. **Respiratory disorders**: SERPINH1 has been implicated in respiratory disorders, including chronic obstructive pulmonary disease (COPD) and asthma. 3. **Ovarian disorders**: SERPINH1 has been associated with ovarian disorders, including endometriosis and ovarian cancer. 4. **Bone disorders**: SERPINH1 has been implicated in bone disorders, including osteoporosis and bone metastasis. In conclusion, SERPINH1 is a gene that plays critical roles in collagen biosynthesis, stress response, and cellular regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of SERPINH1.

Genular Protein ID: 3308983884

Symbol: SERPH_HUMAN

Name: Serpin H1

UniProtKB Accession Codes:

P50454 B3KVJ3 P29043 Q5XPB4 Q6NSJ6 Q8IY96 Q9NP88

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 3 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 2 MIM 4 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1309665

Title: Cloning of a human collagen-binding protein, and its homology with rat gp46, chick hsp47 and mouse J6 proteins.

PubMed ID: 1309665

DOI: 10.1016/0167-4781(92)90498-o

PubMed ID: 7656593

Title: Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2).

PubMed ID: 7656593

DOI: 10.1159/000134103

PubMed ID: 11052465

Title: Rheumatoid arthritis-related antigen 47kDa (RA-A47) is a product of colligin-2 and acts as a human HSP47.

PubMed ID: 11052465

DOI: 10.1007/s007740070004

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16938879

Title: A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans.

PubMed ID: 16938879

DOI: 10.1073/pnas.0603676103

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20188343

Title: Homozygosity for a missense mutation in SERPINH1, which encodes the collagen chaperone protein HSP47, results in severe recessive osteogenesis imperfecta.

PubMed ID: 20188343

DOI: 10.1016/j.ajhg.2010.01.034

Sequence Information:

  • Length: 418
  • Mass: 46441
  • Checksum: B7719FCA13A55DEB
  • Sequence:
    • MRSLLLLSAF CLLEAALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL AFSLYQAMAK 
DQAVENILVS PVVVASSLGL VSLGGKATTA SQAKAVLSAE QLRDEEVHAG LGELLRSLSN 
STARNVTWKL GSRLYGPSSV SFADDFVRSS KQHYNCEHSK INFRDKRSAL QSINEWAAQT 
TDGKLPEVTK DVERTDGALL VNAMFFKPHW DEKFHHKMVD NRGFMVTRSY TVGVMMMHRT 
GLYNYYDDEK EKLQIVEMPL AHKLSSLIIL MPHHVEPLER LEKLLTKEQL KIWMGKMQKK 
AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS VFHATAFELD 
TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL LFIGRLVRPK GDKMRDEL

Genular Protein ID: 301164840

Symbol: A8K259_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K259

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 7 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 418
  • Mass: 46483
  • Checksum: 1DDF2FC1AF14805A
  • Sequence:
    • MRSLLLLSAF CLLEAALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL AFSLYQAMAK 
DQAVENILVS PVVVASSLGL VSLGGKATTA SQAKAVLSAE QLRDEEVHAV LGELLRSLSN 
STARNVTWKL GSRLYGPSSV SFADDFVRSS KQHYNCEHSK INFRDKRSAL QSINEWAAQT 
TDGKLPEVTK DVERTDGALL VNAMFFKPHW DEKFHHKMVD NRGFMVTRSY TVGVMMMHRT 
GLYNYYDDEK EKLQIVEMPL AHKLSSLIIL MPHHVEPLER LEKLLTKEQL KIWMGKMQKK 
AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS VFHATAFELD 
TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL LFIGRLVRPK GDKMRDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.