Details for: SERPINH1

Gene ID: 871

Symbol: SERPINH1

Ensembl ID: ENSG00000149257

Description: serpin family H member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 3.82
    Marker Score: 4697
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.74
    Marker Score: 49350
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.69
    Marker Score: 32407
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.34
    Marker Score: 21737
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.19
    Marker Score: 4380
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.99
    Marker Score: 1692
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.79
    Marker Score: 4302
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7
    Marker Score: 30391
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.66
    Marker Score: 11462
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.52
    Marker Score: 2369
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.51
    Marker Score: 2142
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.4
    Marker Score: 5009
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.39
    Marker Score: 677
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.38
    Marker Score: 900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.35
    Marker Score: 1682
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.32
    Marker Score: 2465
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.28
    Marker Score: 6196
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.27
    Marker Score: 8404
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.17
    Marker Score: 698
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.16
    Marker Score: 5651
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.15
    Marker Score: 4301
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.07
    Marker Score: 1383
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.04
    Marker Score: 496
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.04
    Marker Score: 4791.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.03
    Marker Score: 7987
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.02
    Marker Score: 2174
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.01
    Marker Score: 2480
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2
    Marker Score: 833
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.99
    Marker Score: 20065.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.99
    Marker Score: 1097
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.97
    Marker Score: 3354
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.84
    Marker Score: 7656
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.78
    Marker Score: 690
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.74
    Marker Score: 3275
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.67
    Marker Score: 578
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.66
    Marker Score: 374
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.64
    Marker Score: 55732
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.61
    Marker Score: 2583
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.6
    Marker Score: 914
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.58
    Marker Score: 446
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.57
    Marker Score: 369
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.57
    Marker Score: 1419
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.54
    Marker Score: 2011
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.54
    Marker Score: 3917
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5
    Marker Score: 3674
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.49
    Marker Score: 943
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.47
    Marker Score: 1567
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.42
    Marker Score: 832
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.42
    Marker Score: 330
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.42
    Marker Score: 932
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.39
    Marker Score: 1303
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.37
    Marker Score: 753
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.36
    Marker Score: 7168
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.35
    Marker Score: 1456
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.35
    Marker Score: 2213
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.35
    Marker Score: 1959
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.34
    Marker Score: 343
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.34
    Marker Score: 1351
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.34
    Marker Score: 322
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.34
    Marker Score: 2267
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.34
    Marker Score: 1152
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.31
    Marker Score: 7765
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.31
    Marker Score: 325
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.29
    Marker Score: 325
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.29
    Marker Score: 1619
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.27
    Marker Score: 1833
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.27
    Marker Score: 1134
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.24
    Marker Score: 1319
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.23
    Marker Score: 275
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.22
    Marker Score: 240
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.22
    Marker Score: 19613
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.21
    Marker Score: 725
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.2
    Marker Score: 1163
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.19
    Marker Score: 382
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.18
    Marker Score: 3704
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.18
    Marker Score: 739
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.17
    Marker Score: 528.5
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.17
    Marker Score: 653
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.16
    Marker Score: 267
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.15
    Marker Score: 592
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.15
    Marker Score: 17959
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.14
    Marker Score: 417
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.13
    Marker Score: 5547
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.11
    Marker Score: 695
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.1
    Marker Score: 749
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.1
    Marker Score: 1745
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.1
    Marker Score: 546
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.09
    Marker Score: 253
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.07
    Marker Score: 431
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.06
    Marker Score: 271
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.06
    Marker Score: 702
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.02
    Marker Score: 1172
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71709
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47934
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.98
    Marker Score: 242
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30395
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.98
    Marker Score: 1703
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.98
    Marker Score: 420
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.96
    Marker Score: 6289
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.96
    Marker Score: 255

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Other Information

**Key characteristics:** - SerpinH1 is a secreted protein that is expressed in various cell types. - It is a protease that is involved in the regulation of cell growth, differentiation, and apoptosis. - It is a key regulator of chondrocyte development and differentiation. - It is involved in the regulation of collagen biosynthesis and modifying enzymes. - It is involved in the organization of the extracellular matrix. **Pathways and functions:** - SERPINH1 is involved in the attenuation phase of the inflammatory response. - It is involved in the cellular responses to stimuli, including inflammation and tissue damage. - It is involved in the cellular responses to stress, such as heat stress. - It is involved in the regulation of chondrocyte development and differentiation. - It is involved in the regulation of collagen biosynthesis and modifying enzymes. - It is involved in the organization of the extracellular matrix. **Clinical significance:** - Mutations in SERPINH1 have been linked to several diseases, including cancer, cardiovascular disease, and diabetes. - SERPINH1 inhibitors are being investigated as potential therapeutic agents for these diseases. - Therefore, understanding the role of SERPINH1 in health and disease is important for the development of new therapeutic strategies.

Genular Protein ID: 3308983884

Symbol: SERPH_HUMAN

Name: Serpin H1

UniProtKB Accession Codes:

P50454 B3KVJ3 P29043 Q5XPB4 Q6NSJ6 Q8IY96 Q9NP88

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 2 MIM 4 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1309665

Title: Cloning of a human collagen-binding protein, and its homology with rat gp46, chick hsp47 and mouse J6 proteins.

PubMed ID: 1309665

DOI: 10.1016/0167-4781(92)90498-o

PubMed ID: 7656593

Title: Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2).

PubMed ID: 7656593

DOI: 10.1159/000134103

PubMed ID: 11052465

Title: Rheumatoid arthritis-related antigen 47kDa (RA-A47) is a product of colligin-2 and acts as a human HSP47.

PubMed ID: 11052465

DOI: 10.1007/s007740070004

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16938879

Title: A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans.

PubMed ID: 16938879

DOI: 10.1073/pnas.0603676103

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20188343

Title: Homozygosity for a missense mutation in SERPINH1, which encodes the collagen chaperone protein HSP47, results in severe recessive osteogenesis imperfecta.

PubMed ID: 20188343

DOI: 10.1016/j.ajhg.2010.01.034

Sequence Information:

  • Length: 418
  • Mass: 46441
  • Checksum: B7719FCA13A55DEB
  • Sequence:
    • MRSLLLLSAF CLLEAALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL AFSLYQAMAK 
DQAVENILVS PVVVASSLGL VSLGGKATTA SQAKAVLSAE QLRDEEVHAG LGELLRSLSN 
STARNVTWKL GSRLYGPSSV SFADDFVRSS KQHYNCEHSK INFRDKRSAL QSINEWAAQT 
TDGKLPEVTK DVERTDGALL VNAMFFKPHW DEKFHHKMVD NRGFMVTRSY TVGVMMMHRT 
GLYNYYDDEK EKLQIVEMPL AHKLSSLIIL MPHHVEPLER LEKLLTKEQL KIWMGKMQKK 
AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS VFHATAFELD 
TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL LFIGRLVRPK GDKMRDEL

Genular Protein ID: 301164840

Symbol: A8K259_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K259

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 7 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 418
  • Mass: 46483
  • Checksum: 1DDF2FC1AF14805A
  • Sequence:
    • MRSLLLLSAF CLLEAALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL AFSLYQAMAK 
DQAVENILVS PVVVASSLGL VSLGGKATTA SQAKAVLSAE QLRDEEVHAV LGELLRSLSN 
STARNVTWKL GSRLYGPSSV SFADDFVRSS KQHYNCEHSK INFRDKRSAL QSINEWAAQT 
TDGKLPEVTK DVERTDGALL VNAMFFKPHW DEKFHHKMVD NRGFMVTRSY TVGVMMMHRT 
GLYNYYDDEK EKLQIVEMPL AHKLSSLIIL MPHHVEPLER LEKLLTKEQL KIWMGKMQKK 
AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS VFHATAFELD 
TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL LFIGRLVRPK GDKMRDEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.