SERPINH1 | ENSG00000149257 | NCBI 871

Details for: SERPINH1

Gene ID: 871

Symbol: SERPINH1

Ensembl ID: ENSG00000149257

Description: serpin family H member 1

Associated with

Attenuation phase
(R-HSA-3371568)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Collagen biosynthesis and modifying enzymes
(R-HSA-1650814)
Collagen formation
(R-HSA-1474290)
Extracellular matrix organization
(R-HSA-1474244)
Hsf1 activation
(R-HSA-3371511)
Hsf1-dependent transactivation
(R-HSA-3371571)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Chondrocyte development involved in endochondral bone morphogenesis
(GO:0003433)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen binding
(GO:0005518)
Collagen biosynthetic process
(GO:0032964)
Collagen fibril organization
(GO:0030199)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum-golgi intermediate compartment
(GO:0005793)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular space
(GO:0005615)
Membrane raft
(GO:0045121)
Negative regulation of endopeptidase activity
(GO:0010951)
Protein binding
(GO:0005515)
Protein maturation
(GO:0051604)
Response to unfolded protein
(GO:0006986)
Rna binding
(GO:0003723)
Serine-type endopeptidase inhibitor activity
(GO:0004867)
Unfolded protein binding
(GO:0051082)

Other Information

Proteins

Serpin H1
A8K259_HUMAN

Genular Protein ID: 3308983884

Symbol: SERPH_HUMAN

Name: Serpin H1

UniProtKB Accession Codes:

P50454 B3KVJ3 P29043 Q5XPB4 Q6NSJ6 Q8IY96 Q9NP88

Database IDs:

Citations:

PubMed ID: 1309665

Title: Cloning of a human collagen-binding protein, and its homology with rat gp46, chick hsp47 and mouse J6 proteins.

PubMed ID: 1309665

DOI: 10.1016/0167-4781(92)90498-o

PubMed ID: 7656593

Title: Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2).

PubMed ID: 7656593

DOI: 10.1159/000134103

PubMed ID: 11052465

Title: Rheumatoid arthritis-related antigen 47kDa (RA-A47) is a product of colligin-2 and acts as a human HSP47.

PubMed ID: 11052465

DOI: 10.1007/s007740070004

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16938879

Title: A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans.

PubMed ID: 16938879

DOI: 10.1073/pnas.0603676103

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 20188343

Title: Homozygosity for a missense mutation in SERPINH1, which encodes the collagen chaperone protein HSP47, results in severe recessive osteogenesis imperfecta.

PubMed ID: 20188343

DOI: 10.1016/j.ajhg.2010.01.034

Sequence Information:

Length: 418
Mass: 46441
Checksum: B7719FCA13A55DEB
Sequence:

MRSLLLLSAF CLLEAALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL AFSLYQAMAK 
DQAVENILVS PVVVASSLGL VSLGGKATTA SQAKAVLSAE QLRDEEVHAG LGELLRSLSN 
STARNVTWKL GSRLYGPSSV SFADDFVRSS KQHYNCEHSK INFRDKRSAL QSINEWAAQT 
TDGKLPEVTK DVERTDGALL VNAMFFKPHW DEKFHHKMVD NRGFMVTRSY TVGVMMMHRT 
GLYNYYDDEK EKLQIVEMPL AHKLSSLIIL MPHHVEPLER LEKLLTKEQL KIWMGKMQKK 
AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS VFHATAFELD 
TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL LFIGRLVRPK GDKMRDEL

Genular Protein ID: 301164840

Symbol: A8K259_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K259

Database IDs:

Sequence Information:

Length: 418
Mass: 46483
Checksum: 1DDF2FC1AF14805A
Sequence:

MRSLLLLSAF CLLEAALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL AFSLYQAMAK 
DQAVENILVS PVVVASSLGL VSLGGKATTA SQAKAVLSAE QLRDEEVHAV LGELLRSLSN 
STARNVTWKL GSRLYGPSSV SFADDFVRSS KQHYNCEHSK INFRDKRSAL QSINEWAAQT 
TDGKLPEVTK DVERTDGALL VNAMFFKPHW DEKFHHKMVD NRGFMVTRSY TVGVMMMHRT 
GLYNYYDDEK EKLQIVEMPL AHKLSSLIIL MPHHVEPLER LEKLLTKEQL KIWMGKMQKK 
AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS VFHATAFELD 
TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL LFIGRLVRPK GDKMRDEL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SERPINH1

Associated with

Other Information

Cloning of a human collagen-binding protein, and its homology with rat gp46, chick hsp47 and mouse J6 proteins. PubMed ID: 1309665

Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2). PubMed ID: 7656593

Rheumatoid arthritis-related antigen 47kDa (RA-A47) is a product of colligin-2 and acts as a human HSP47. PubMed ID: 11052465

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans. PubMed ID: 16938879

Initial characterization of the human central proteome. PubMed ID: 21269460

Resveratrol-induced changes of the human adipocyte secretion profile. PubMed ID: 22905912

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Homozygosity for a missense mutation in SERPINH1, which encodes the collagen chaperone protein HSP47, results in severe recessive osteogenesis imperfecta. PubMed ID: 20188343