Details for: CBR1
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 37.56rCSI 60.56%PRS 47.52
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CSI 33.29rCSI 35.68%PRS 35.21
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CSI 32.86rCSI 27.54%PRS 42.5
-
CSI 20.93rCSI 44.55%PRS 52.42
-
CSI 16.99rCSI 24.86%PRS 39.96
-
CSI 16.88rCSI 19.82%PRS 41.16
-
CSI 15.71rCSI 15.14%PRS 29.18
-
CSI 15.03rCSI 21.54%PRS 45.23
-
CSI 13.61rCSI 36.69%PRS 46.17
-
CSI 13.58rCSI 17.8%PRS 50.13
-
CSI 12.74rCSI 19.76%PRS 47.89
-
CSI 12.39rCSI 11.19%PRS 34.39
-
CSI 11.69rCSI 14.23%PRS 44.5
-
CSI 10.55rCSI 30.55%PRS 40.15
-
CSI 10.32rCSI 45.32%PRS 57.35
-
CSI 9.86rCSI 12.19%PRS 33.65
-
CSI 9.48rCSI 26.58%PRS 52.25
-
CSI 8.89rCSI 14.4%PRS 36.4
-
CSI 8.53rCSI 13.55%PRS 46.95
-
CSI 8.32rCSI 18.59%PRS 43.27
-
CSI 8.28rCSI 8.68%PRS 35.08
-
CSI 8.19rCSI 10.2%PRS 48.44
-
CSI 8.1rCSI 6%PRS 32.12
-
CSI 8.09rCSI 8.6%PRS 53.28
-
CSI 8.07rCSI 17.62%PRS 57.79
-
CSI 7.38rCSI 42.95%PRS 48.61
-
CSI 7.29rCSI 6.69%PRS 43.95
-
CSI 7.14rCSI 4.75%PRS 41.51
-
CSI 7.08rCSI 5.67%PRS 58.28
-
CSI 6.69rCSI 5.29%PRS 26.79
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CSI 6.51rCSI 16.53%PRS 34.74
-
CSI 6.38rCSI 55.15%PRS 41.01
-
CSI 6.27rCSI 8.04%PRS 35.7
-
CSI 6.18rCSI 4.76%PRS 35.83
-
CSI 5.89rCSI 9%PRS 53.73
-
CSI 5.77rCSI 7.99%PRS 43.54
-
CSI 5.68rCSI 8.97%PRS 38.21
-
CSI 5.54rCSI 8.87%PRS 67.42
-
CSI 5.44rCSI 12.77%PRS 47.05
-
CSI 5.24rCSI 6.08%PRS 48.25
-
CSI 5.15rCSI 12.74%PRS 35.58
-
CSI 5.12rCSI 5.6%PRS 41.2
-
CSI 5.02rCSI 6.86%PRS 41.75
-
CSI 4.79rCSI 7.36%PRS 41.54
-
CSI 4.79rCSI 8.39%PRS 30.62
-
CSI 4.72rCSI 10.59%PRS 24.6
-
CSI 4.51rCSI 6.02%PRS 39.15
-
CSI 4.48rCSI 12.74%PRS 38.08
-
CSI 4.47rCSI 3.93%PRS 28.08
-
CSI 4.41rCSI 6.45%PRS 38.07
-
CSI 4.38rCSI 30.92%PRS 64.4
-
CSI 4.32rCSI 7.71%PRS 53.46
-
CSI 4.32rCSI 5.18%PRS 35.78
-
CSI 4.25rCSI 3.93%PRS 38.46
-
CSI 4.22rCSI 65.27%PRS 65.63
-
CSI 4.14rCSI 3.98%PRS 38.12
-
CSI 4.1rCSI 4.28%PRS 37.98
-
CSI 4.04rCSI 4.67%PRS 28.77
-
CSI 3.99rCSI 6.57%PRS 42.32
-
CSI 3.98rCSI 3.54%PRS 36.9
-
CSI 3.93rCSI 3.09%PRS 43.3
-
CSI 3.92rCSI 5.8%PRS 41.78
-
CSI 3.9rCSI 20.95%PRS 53.79
-
CSI 3.88rCSI 5.69%PRS 47.73
-
CSI 3.86rCSI 8.51%PRS 51.87
-
CSI 3.84rCSI 5.24%PRS 40.21
-
CSI 3.79rCSI 14.73%PRS 46.78
-
CSI 3.72rCSI 2.88%PRS 37.31
-
CSI 3.67rCSI 8.07%PRS 41.24
-
CSI 3.65rCSI 8.91%PRS 34.57
-
CSI 3.5rCSI 3.62%PRS 42.83
-
CSI 3.49rCSI 3.01%PRS 47.03
-
CSI 3.47rCSI 2.64%PRS 47.52
-
CSI 3.47rCSI 36.75%PRS 40.28
-
CSI 3.42rCSI 4.35%PRS 42.19
-
CSI 3.4rCSI 4.36%PRS 41.86
-
CSI 3.31rCSI 4.51%PRS 32.15
-
CSI 3.29rCSI 2.29%PRS 49.37
-
CSI 3.19rCSI 31.48%PRS 67.23
-
CSI 3.06rCSI 2.48%PRS 38.32
-
CSI 3.03rCSI 4.88%PRS 29.43
-
CSI 3.01rCSI 3.15%PRS 37.46
-
CSI 3.01rCSI 3%PRS 32.29
-
CSI 2.97rCSI 7.15%PRS 54.21
-
CSI 2.96rCSI 2.8%PRS 38.56
-
CSI 2.82rCSI 6.77%PRS 54.47
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CSI 2.82rCSI 4.49%PRS 32.24
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CSI 2.81rCSI 7.11%PRS 45.03
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CSI 2.8rCSI 5.56%PRS 37.47
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CSI 2.77rCSI 4.9%PRS 23.22
-
CSI 2.75rCSI 2.28%PRS 35.94
-
CSI 2.71rCSI 3.37%PRS 22.77
-
CSI 2.62rCSI 3.63%PRS 37.38
-
CSI 2.58rCSI 6.16%PRS 40.14
-
CSI 2.54rCSI 3.61%PRS 34.95
-
CSI 2.47rCSI 3.53%PRS 40.16
-
CSI 2.44rCSI 3.24%PRS 41.43
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CSI 2.43rCSI 5.56%PRS 36.82
-
CSI 2.43rCSI 3.61%PRS 40.74
-
CSI 2.41rCSI 4.33%PRS 31.75
-
CSI 0.1rCSI 1.1%PRS 60.7%
-
CSI 0.3rCSI 2.7%PRS 54.8%
-
CSI 0.3rCSI 2.9%PRS 58.5%
-
CSI 0.6rCSI 2.6%PRS 60.9%
-
CSI 0.6rCSI 2.4%PRS 59.7%
-
CSI 0.6rCSI 5.3%PRS 78.7%
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CSI 0.7rCSI 1.6%PRS 27.6%
-
CSI 0.7rCSI 3.1%PRS 54.6%
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CSI 0.8rCSI 4.3%PRS 61.5%
-
CSI 0.8rCSI 18.4%PRS 90.5%
-
CSI 0.8rCSI 1.6%PRS 55.0%
-
CSI 0.8rCSI 1.4%PRS 24.1%
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CSI 0.9rCSI 3.0%PRS 48.4%
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CSI 0.9rCSI 4.8%PRS 47.5%
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CSI 0.9rCSI 3.3%PRS 51.2%
-
CSI 1.0rCSI 9.7%PRS 65.0%
-
CSI 1.0rCSI 2.5%PRS 48.3%
-
CSI 1.0rCSI 6.0%PRS 48.4%
-
CSI 1.1rCSI 2.7%PRS 29.4%
-
CSI 1.1rCSI 1.9%PRS 24.4%
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CSI 1.1rCSI 3.5%PRS 45.8%
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CSI 1.1rCSI 3.0%PRS 44.1%
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CSI 1.1rCSI 4.0%PRS 53.5%
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CSI 1.1rCSI 1.7%PRS 34.6%
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CSI 1.2rCSI 3.5%PRS 39.6%
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CSI 1.2rCSI 1.9%PRS 38.8%
-
CSI 1.3rCSI 21.5%PRS 72.7%
-
CSI 1.3rCSI 3.2%PRS 50.0%
-
CSI 1.4rCSI 2.1%PRS 43.7%
-
CSI 1.4rCSI 3.0%PRS 47.2%
-
CSI 1.4rCSI 6.0%PRS 32.4%
-
CSI 1.4rCSI 5.0%PRS 23.1%
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CSI 1.5rCSI 3.3%PRS 34.8%
-
CSI 1.5rCSI 26.5%PRS 75.3%
-
CSI 1.6rCSI 2.1%PRS 35.1%
-
CSI 1.6rCSI 4.0%PRS 34.2%
-
CSI 1.6rCSI 4.3%PRS 47.0%
-
CSI 1.7rCSI 2.5%PRS 54.9%
-
CSI 1.7rCSI 3.5%PRS 60.1%
-
CSI 1.8rCSI 3.2%PRS 35.8%
-
CSI 1.8rCSI 2.3%PRS 50.5%
-
CSI 1.9rCSI 4.2%PRS 36.6%
-
CSI 1.9rCSI 2.9%PRS 35.6%
-
CSI 1.9rCSI 1.5%PRS 37.8%
-
CSI 1.9rCSI 40.9%PRS 84.7%
-
CSI 2.0rCSI 2.5%PRS 24.9%
-
CSI 2.0rCSI 3.7%PRS 58.2%
-
CSI 2.0rCSI 2.5%PRS 39.9%
-
CSI 2.1rCSI 6.7%PRS 41.0%
-
CSI 2.1rCSI 3.0%PRS 51.2%
-
CSI 2.1rCSI 3.2%PRS 37.8%
-
CSI 2.1rCSI 6.9%PRS 34.3%
-
CSI 2.2rCSI 2.6%PRS 44.0%
-
CSI 2.2rCSI 5.7%PRS 50.8%
-
CSI 2.2rCSI 5.2%PRS 43.2%
-
CSI 2.2rCSI 3.6%PRS 29.5%
-
CSI 2.3rCSI 4.0%PRS 45.8%
-
CSI 2.3rCSI 2.6%PRS 53.1%
-
CSI 2.3rCSI 3.1%PRS 45.2%
-
CSI 2.3rCSI 4.6%PRS 28.7%
-
CSI 2.3rCSI 2.4%PRS 56.1%
-
CSI 2.4rCSI 4.3%PRS 31.8%
-
CSI 2.4rCSI 3.6%PRS 40.7%
-
CSI 2.4rCSI 5.6%PRS 36.8%
-
CSI 2.4rCSI 3.2%PRS 41.4%
-
CSI 2.5rCSI 3.5%PRS 40.2%
-
CSI 2.5rCSI 3.6%PRS 35.0%
-
CSI 2.6rCSI 6.2%PRS 40.1%
-
CSI 2.6rCSI 3.6%PRS 37.4%
-
CSI 2.7rCSI 3.4%PRS 22.8%
-
CSI 2.8rCSI 2.3%PRS 35.9%
-
CSI 2.8rCSI 4.9%PRS 23.2%
-
CSI 2.8rCSI 5.6%PRS 37.5%
-
CSI 2.8rCSI 7.1%PRS 45.0%
-
CSI 2.8rCSI 4.5%PRS 32.2%
-
CSI 2.8rCSI 6.8%PRS 54.5%
-
CSI 3.0rCSI 2.8%PRS 38.6%
-
CSI 3.0rCSI 7.2%PRS 54.2%
-
CSI 3.0rCSI 3.0%PRS 32.3%
-
CSI 3.0rCSI 3.2%PRS 37.5%
-
CSI 3.0rCSI 4.9%PRS 29.4%
-
CSI 3.1rCSI 2.5%PRS 38.3%
-
CSI 3.2rCSI 31.5%PRS 67.2%
-
CSI 3.3rCSI 2.3%PRS 49.4%
-
CSI 3.3rCSI 4.5%PRS 32.2%
-
CSI 3.4rCSI 4.4%PRS 41.9%
-
CSI 3.4rCSI 4.4%PRS 42.2%
-
CSI 3.5rCSI 36.8%PRS 40.3%
-
CSI 3.5rCSI 2.6%PRS 47.5%
-
CSI 3.5rCSI 3.0%PRS 47.0%
-
CSI 3.5rCSI 3.6%PRS 42.8%
-
CSI 3.7rCSI 8.9%PRS 34.6%
-
CSI 3.7rCSI 8.1%PRS 41.2%
-
CSI 3.7rCSI 2.9%PRS 37.3%
-
CSI 3.8rCSI 14.7%PRS 46.8%
-
CSI 3.8rCSI 5.2%PRS 40.2%
-
CSI 3.9rCSI 8.5%PRS 51.9%
-
CSI 3.9rCSI 5.7%PRS 47.7%
-
CSI 3.9rCSI 21.0%PRS 53.8%
-
CSI 3.9rCSI 5.8%PRS 41.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2940824565
Symbol: CBR1_HUMAN
Name: 15-hydroxyprostaglandin dehydrogenase [NADP(+)]
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3141401
Title: Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.
PubMed ID: 3141401
PubMed ID: 2182121
Title: Induction of a human carbonyl reductase gene located on chromosome 21.
PubMed ID: 2182121
PubMed ID: 1921984
Title: Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity.
PubMed ID: 1921984
PubMed ID: 9740676
Title: Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2.
PubMed ID: 9740676
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10830953
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8421682
Title: Carboxyethyllysine in a protein: native carbonyl reductase/NADP(+)-dependent prostaglandin dehydrogenase.
PubMed ID: 8421682
PubMed ID: 7005231
Title: Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase.
PubMed ID: 7005231
PubMed ID: 1597188
Title: Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase.
PubMed ID: 1597188
PubMed ID: 18449627
Title: Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER).
PubMed ID: 18449627
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 28878267
Title: Carbonyl reductase 1 catalyzes 20beta-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.
PubMed ID: 28878267
PubMed ID: 15799708
Title: An unbiased cell morphology-based screen for new, biologically active small molecules.
PubMed ID: 15799708
PubMed ID: 17912391
Title: Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct.
PubMed ID: 17912391
DOI: 10.1039/b707602a
PubMed ID: 18826943
Title: Human carbonyl reductase 1 is an S-nitrosoglutathione reductase.
PubMed ID: 18826943
PubMed ID: 17344335
Title: A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity.
PubMed ID: 17344335
Sequence Information:
- Length: 277
- Mass: 30375
- Checksum: 51A5A495EB4F4EC3
- Sequence:
MSSGIHVALV TGGNKGIGLA IVRDLCRLFS GDVVLTARDV TRGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLDVLVNN AGIAFKVADP TPFHIQAEVT MKTNFFGTRD VCTELLPLIK PQGRVVNVSS IMSVRALKSC SPELQQKFRS ETITEEELVG LMNKFVEDTK KGVHQKEGWP SSAYGVTKIG VTVLSRIHAR KLSEQRKGDK ILLNACCPGW VRTDMAGPKA TKSPEEGAET PVYLALLPPD AEGPHGQFVS EKRVEQW