CBR1 | ENSG00000159228 | NCBI 873

Details for: CBR1

Gene ID: 873

Symbol: CBR1

Ensembl ID: ENSG00000159228

Description: carbonyl reductase 1

Associated with

Arachidonic acid metabolism
(R-HSA-2142753)
Fatty acid metabolism
(R-HSA-8978868)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Synthesis of prostaglandins (pg) and thromboxanes (tx)
(R-HSA-2162123)
15-hydroxyprostaglandin-d dehydrogenase (nadp+) activity
(GO:0047020)
15-hydroxyprostaglandin dehydrogenase (nadp+) activity
(GO:0047021)
Alcohol dehydrogenase (nadp+) activity
(GO:0008106)
Carbonyl reductase (nadph) activity
(GO:0004090)
Cyclooxygenase pathway
(GO:0019371)
Cytosol
(GO:0005829)
Epithelial cell differentiation
(GO:0030855)
Extracellular exosome
(GO:0070062)
Extracellular vesicle
(GO:1903561)
Glucocorticoid metabolic process
(GO:0008211)
Oxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor
(GO:0016655)
Oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
(GO:0016616)
Positive regulation of reactive oxygen species metabolic process
(GO:2000379)
Prostaglandin-e2 9-reductase activity
(GO:0050221)
Vitamin k metabolic process
(GO:0042373)
Xenobiotic metabolic process
(GO:0006805)

Other Information

Proteins

15-hydroxyprostaglandin dehydrogenase [NADP(+)]

Genular Protein ID: 2940824565

Symbol: CBR1_HUMAN

Name: 15-hydroxyprostaglandin dehydrogenase [NADP(+)]

UniProtKB Accession Codes:

P16152 B2RBZ7 B4DFK7 Q3LHW8

Database IDs:

Citations:

PubMed ID: 3141401

Title: Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.

PubMed ID: 3141401

DOI: 10.1016/s0021-9258(18)37576-8

PubMed ID: 2182121

Title: Induction of a human carbonyl reductase gene located on chromosome 21.

PubMed ID: 2182121

DOI: 10.1016/0167-4781(90)90050-c

PubMed ID: 1921984

Title: Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity.

PubMed ID: 1921984

PubMed ID: 9740676

Title: Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2.

PubMed ID: 9740676

DOI: 10.1006/geno.1998.5380

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8421682

Title: Carboxyethyllysine in a protein: native carbonyl reductase/NADP(+)-dependent prostaglandin dehydrogenase.

PubMed ID: 8421682

DOI: 10.1073/pnas.90.2.502

PubMed ID: 7005231

Title: Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase.

PubMed ID: 7005231

DOI: 10.1016/s0021-9258(19)69950-3

PubMed ID: 1597188

Title: Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase.

PubMed ID: 1597188

DOI: 10.1111/j.1432-1033.1992.tb16952.x

PubMed ID: 18449627

Title: Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER).

PubMed ID: 18449627

DOI: 10.1007/s11095-008-9592-5

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28878267

Title: Carbonyl reductase 1 catalyzes 20beta-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.

PubMed ID: 28878267

DOI: 10.1038/s41598-017-10410-1

PubMed ID: 15799708

Title: An unbiased cell morphology-based screen for new, biologically active small molecules.

PubMed ID: 15799708

DOI: 10.1371/journal.pbio.0030128

PubMed ID: 17912391

Title: Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct.

PubMed ID: 17912391

DOI: 10.1039/b707602a

PubMed ID: 18826943

Title: Human carbonyl reductase 1 is an S-nitrosoglutathione reductase.

PubMed ID: 18826943

DOI: 10.1074/jbc.m807125200

PubMed ID: 17344335

Title: A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity.

PubMed ID: 17344335

DOI: 10.1124/dmd.107.014779

Sequence Information:

Length: 277
Mass: 30375
Checksum: 51A5A495EB4F4EC3
Sequence:

MSSGIHVALV TGGNKGIGLA IVRDLCRLFS GDVVLTARDV TRGQAAVQQL QAEGLSPRFH 
QLDIDDLQSI RALRDFLRKE YGGLDVLVNN AGIAFKVADP TPFHIQAEVT MKTNFFGTRD 
VCTELLPLIK PQGRVVNVSS IMSVRALKSC SPELQQKFRS ETITEEELVG LMNKFVEDTK 
KGVHQKEGWP SSAYGVTKIG VTVLSRIHAR KLSEQRKGDK ILLNACCPGW VRTDMAGPKA 
TKSPEEGAET PVYLALLPPD AEGPHGQFVS EKRVEQW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CBR1

Associated with

Other Information

Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein. PubMed ID: 3141401

Induction of a human carbonyl reductase gene located on chromosome 21. PubMed ID: 2182121

Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity. PubMed ID: 1921984

Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2. PubMed ID: 9740676

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 21. PubMed ID: 10830953

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Carboxyethyllysine in a protein: native carbonyl reductase/NADP(+)-dependent prostaglandin dehydrogenase. PubMed ID: 8421682

Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase. PubMed ID: 7005231

Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase. PubMed ID: 1597188

Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER). PubMed ID: 18449627

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

Carbonyl reductase 1 catalyzes 20beta-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity. PubMed ID: 28878267

An unbiased cell morphology-based screen for new, biologically active small molecules. PubMed ID: 15799708

Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct. PubMed ID: 17912391

Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. PubMed ID: 18826943

A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity. PubMed ID: 17344335