Details for: CBR1

Gene ID: 873

Symbol: CBR1

Ensembl ID: ENSG00000159228

Description: carbonyl reductase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 248.9308
    Cell Significance Index: -38.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 139.1718
    Cell Significance Index: -35.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 86.3123
    Cell Significance Index: -40.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 75.1188
    Cell Significance Index: -38.6400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 61.0561
    Cell Significance Index: -40.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.3021
    Cell Significance Index: -41.0600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 29.8186
    Cell Significance Index: 226.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.0106
    Cell Significance Index: -36.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6766
    Cell Significance Index: -31.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.6208
    Cell Significance Index: -41.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.7999
    Cell Significance Index: 51.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.7534
    Cell Significance Index: 31.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 3.0353
    Cell Significance Index: 182.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.7395
    Cell Significance Index: 59.3500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 2.1424
    Cell Significance Index: 4.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9785
    Cell Significance Index: 139.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7183
    Cell Significance Index: 211.2800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.5577
    Cell Significance Index: 13.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4907
    Cell Significance Index: 40.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3302
    Cell Significance Index: 62.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2744
    Cell Significance Index: 563.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2687
    Cell Significance Index: 228.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2683
    Cell Significance Index: 1145.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1717
    Cell Significance Index: 136.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0428
    Cell Significance Index: 569.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7955
    Cell Significance Index: 109.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7483
    Cell Significance Index: 21.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7287
    Cell Significance Index: 21.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6969
    Cell Significance Index: 17.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6545
    Cell Significance Index: 18.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6179
    Cell Significance Index: 5.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6000
    Cell Significance Index: 27.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4948
    Cell Significance Index: 142.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4648
    Cell Significance Index: 59.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4568
    Cell Significance Index: 90.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3686
    Cell Significance Index: 19.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3511
    Cell Significance Index: 57.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3350
    Cell Significance Index: 8.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.3322
    Cell Significance Index: 26.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3264
    Cell Significance Index: 443.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3241
    Cell Significance Index: 61.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2774
    Cell Significance Index: 203.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2281
    Cell Significance Index: 351.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1907
    Cell Significance Index: 38.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1864
    Cell Significance Index: 12.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1524
    Cell Significance Index: 7.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1056
    Cell Significance Index: 194.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0608
    Cell Significance Index: 4.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0526
    Cell Significance Index: 5.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0400
    Cell Significance Index: 0.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0282
    Cell Significance Index: 10.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0223
    Cell Significance Index: 16.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0127
    Cell Significance Index: 0.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0071
    Cell Significance Index: -0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0082
    Cell Significance Index: -15.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0140
    Cell Significance Index: -1.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0230
    Cell Significance Index: -14.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0255
    Cell Significance Index: -3.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0394
    Cell Significance Index: -0.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0429
    Cell Significance Index: -5.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0444
    Cell Significance Index: -30.6800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0476
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0578
    Cell Significance Index: -42.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0688
    Cell Significance Index: -38.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0702
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0747
    Cell Significance Index: -46.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0789
    Cell Significance Index: -35.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0944
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1030
    Cell Significance Index: -17.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1039
    Cell Significance Index: -11.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1457
    Cell Significance Index: -2.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1717
    Cell Significance Index: -5.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1781
    Cell Significance Index: -13.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2202
    Cell Significance Index: -32.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2252
    Cell Significance Index: -47.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3112
    Cell Significance Index: -19.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3268
    Cell Significance Index: -17.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3435
    Cell Significance Index: -8.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3812
    Cell Significance Index: -29.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4069
    Cell Significance Index: -42.3700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4096
    Cell Significance Index: -3.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4366
    Cell Significance Index: -11.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4563
    Cell Significance Index: -27.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4701
    Cell Significance Index: -12.0100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4751
    Cell Significance Index: -6.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4833
    Cell Significance Index: -32.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4909
    Cell Significance Index: -13.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4912
    Cell Significance Index: -30.9600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4979
    Cell Significance Index: -4.0600
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: -0.5133
    Cell Significance Index: -2.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5439
    Cell Significance Index: -27.4900
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.5728
    Cell Significance Index: -3.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6011
    Cell Significance Index: -33.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6263
    Cell Significance Index: -13.1100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6286
    Cell Significance Index: -25.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6408
    Cell Significance Index: -7.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6661
    Cell Significance Index: -6.9000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.6986
    Cell Significance Index: -7.4900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7350
    Cell Significance Index: -16.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7553
    Cell Significance Index: -21.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CBR1 exhibits the following characteristics: 1. **NADPH-dependent activity**: CBR1 utilizes NADPH as a cofactor to reduce carbonyl compounds, indicating its role in maintaining the balance of redox reactions within cells. 2. **Wide substrate specificity**: CBR1 can reduce a variety of carbonyl compounds, including prostaglandin E2, arachidonic acid, and 15-hydroxyprostaglandin-D2, highlighting its versatility in metabolic pathways. 3. **Tissue-specific expression**: CBR1 is expressed in various cell types, including epithelial cells, kidney cells, and oligodendrocytes, suggesting its involvement in distinct physiological processes. 4. **Implication in metabolic pathways**: CBR1 is involved in the metabolism of lipids, fatty acids, and prostaglandins, highlighting its role in energy homeostasis and inflammation regulation. **Pathways and Functions** CBR1 is implicated in the following pathways and functions: 1. **Arachidonic acid metabolism**: CBR1 reduces arachidonic acid to eicosanoids, such as prostaglandins and leukotrienes, which play crucial roles in inflammation and immune responses. 2. **Prostaglandin synthesis**: CBR1 is involved in the reduction of prostaglandin E2, a key player in inflammation and immune responses. 3. **Vitamin K metabolism**: CBR1 reduces vitamin K, facilitating its recycling and ensuring the proper functioning of the coagulation cascade. 4. **Oxidative stress response**: CBR1 may play a role in regulating reactive oxygen species (ROS) production, which is essential for maintaining cellular homeostasis and preventing oxidative damage. 5. **Epithelial cell differentiation**: CBR1 may influence epithelial cell differentiation, particularly in the development and maintenance of epithelial tissues. **Clinical Significance** CBR1's involvement in various metabolic pathways and its tissue-specific expression make it a potential therapeutic target for the treatment of diseases characterized by impaired metabolic function, such as: 1. **Inflammatory disorders**: CBR1's role in prostaglandin synthesis and arachidonic acid metabolism makes it a potential target for the treatment of inflammatory diseases, such as arthritis and asthma. 2. **Metabolic disorders**: CBR1's involvement in lipid and fatty acid metabolism suggests its potential role in the treatment of metabolic disorders, such as obesity and type 2 diabetes. 3. **Neurological disorders**: CBR1's expression in oligodendrocytes and its potential involvement in ROS regulation make it a potential target for the treatment of neurological disorders, such as multiple sclerosis. In conclusion, CBR1 is a multifaceted enzyme that plays a crucial role in various cellular processes, including metabolism, differentiation, and response to oxidative stress. Its clinical significance lies in its potential as a therapeutic target for the treatment of inflammatory, metabolic, and neurological disorders.

Genular Protein ID: 2940824565

Symbol: CBR1_HUMAN

Name: 15-hydroxyprostaglandin dehydrogenase [NADP(+)]

UniProtKB Accession Codes:

P16152 B2RBZ7 B4DFK7 Q3LHW8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChEBI 68 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 20 DrugCentral 1 EC 5 EMBL 15 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 20 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3141401

Title: Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.

PubMed ID: 3141401

DOI: 10.1016/s0021-9258(18)37576-8

PubMed ID: 2182121

Title: Induction of a human carbonyl reductase gene located on chromosome 21.

PubMed ID: 2182121

DOI: 10.1016/0167-4781(90)90050-c

PubMed ID: 1921984

Title: Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity.

PubMed ID: 1921984

PubMed ID: 9740676

Title: Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2.

PubMed ID: 9740676

DOI: 10.1006/geno.1998.5380

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8421682

Title: Carboxyethyllysine in a protein: native carbonyl reductase/NADP(+)-dependent prostaglandin dehydrogenase.

PubMed ID: 8421682

DOI: 10.1073/pnas.90.2.502

PubMed ID: 7005231

Title: Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase.

PubMed ID: 7005231

DOI: 10.1016/s0021-9258(19)69950-3

PubMed ID: 1597188

Title: Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase.

PubMed ID: 1597188

DOI: 10.1111/j.1432-1033.1992.tb16952.x

PubMed ID: 18449627

Title: Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER).

PubMed ID: 18449627

DOI: 10.1007/s11095-008-9592-5

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28878267

Title: Carbonyl reductase 1 catalyzes 20beta-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.

PubMed ID: 28878267

DOI: 10.1038/s41598-017-10410-1

PubMed ID: 15799708

Title: An unbiased cell morphology-based screen for new, biologically active small molecules.

PubMed ID: 15799708

DOI: 10.1371/journal.pbio.0030128

PubMed ID: 17912391

Title: Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct.

PubMed ID: 17912391

DOI: 10.1039/b707602a

PubMed ID: 18826943

Title: Human carbonyl reductase 1 is an S-nitrosoglutathione reductase.

PubMed ID: 18826943

DOI: 10.1074/jbc.m807125200

PubMed ID: 17344335

Title: A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity.

PubMed ID: 17344335

DOI: 10.1124/dmd.107.014779

Sequence Information:

  • Length: 277
  • Mass: 30375
  • Checksum: 51A5A495EB4F4EC3
  • Sequence:
    • MSSGIHVALV TGGNKGIGLA IVRDLCRLFS GDVVLTARDV TRGQAAVQQL QAEGLSPRFH 
QLDIDDLQSI RALRDFLRKE YGGLDVLVNN AGIAFKVADP TPFHIQAEVT MKTNFFGTRD 
VCTELLPLIK PQGRVVNVSS IMSVRALKSC SPELQQKFRS ETITEEELVG LMNKFVEDTK 
KGVHQKEGWP SSAYGVTKIG VTVLSRIHAR KLSEQRKGDK ILLNACCPGW VRTDMAGPKA 
TKSPEEGAET PVYLALLPPD AEGPHGQFVS EKRVEQW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.