Details for: CBR3

Gene ID: 874

Symbol: CBR3

Ensembl ID: ENSG00000159231

Description: carbonyl reductase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 104.3426
    Cell Significance Index: -16.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.4930
    Cell Significance Index: -15.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.3749
    Cell Significance Index: -12.3400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.7804
    Cell Significance Index: -14.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.2122
    Cell Significance Index: -16.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.0087
    Cell Significance Index: -12.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4799
    Cell Significance Index: -14.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.3407
    Cell Significance Index: -9.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1256
    Cell Significance Index: -16.2800
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 3.5477
    Cell Significance Index: 4.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8972
    Cell Significance Index: 88.4600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.3675
    Cell Significance Index: 21.9400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.2853
    Cell Significance Index: 7.9300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.9354
    Cell Significance Index: 16.5300
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.8930
    Cell Significance Index: 5.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7727
    Cell Significance Index: 15.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7640
    Cell Significance Index: 21.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6708
    Cell Significance Index: 127.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6701
    Cell Significance Index: 31.5000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5810
    Cell Significance Index: 4.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4891
    Cell Significance Index: 48.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4740
    Cell Significance Index: 13.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4618
    Cell Significance Index: 6.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4566
    Cell Significance Index: 6.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4438
    Cell Significance Index: 31.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4299
    Cell Significance Index: 25.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3855
    Cell Significance Index: 29.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3769
    Cell Significance Index: 166.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3738
    Cell Significance Index: 40.6600
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.3629
    Cell Significance Index: 2.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3583
    Cell Significance Index: 18.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3368
    Cell Significance Index: 43.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3272
    Cell Significance Index: 8.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3168
    Cell Significance Index: 51.5300
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: 0.3033
    Cell Significance Index: 2.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2586
    Cell Significance Index: 7.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2500
    Cell Significance Index: 6.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2375
    Cell Significance Index: 12.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2153
    Cell Significance Index: 3.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2143
    Cell Significance Index: 26.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2006
    Cell Significance Index: 40.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1906
    Cell Significance Index: 172.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1857
    Cell Significance Index: 33.4800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1817
    Cell Significance Index: 1.8800
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.1719
    Cell Significance Index: 1.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1654
    Cell Significance Index: 22.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1594
    Cell Significance Index: 31.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1593
    Cell Significance Index: 4.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1119
    Cell Significance Index: 7.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0994
    Cell Significance Index: 2.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0315
    Cell Significance Index: 4.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0162
    Cell Significance Index: 0.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0153
    Cell Significance Index: 28.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0149
    Cell Significance Index: 5.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0148
    Cell Significance Index: 8.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0143
    Cell Significance Index: 22.0100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0110
    Cell Significance Index: 0.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0108
    Cell Significance Index: 19.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0094
    Cell Significance Index: 0.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0074
    Cell Significance Index: 0.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0040
    Cell Significance Index: 0.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0018
    Cell Significance Index: 0.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0041
    Cell Significance Index: -0.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0082
    Cell Significance Index: -5.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0090
    Cell Significance Index: -12.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0142
    Cell Significance Index: -1.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0144
    Cell Significance Index: -6.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0170
    Cell Significance Index: -12.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0184
    Cell Significance Index: -13.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0206
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0210
    Cell Significance Index: -15.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0212
    Cell Significance Index: -1.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0231
    Cell Significance Index: -2.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0255
    Cell Significance Index: -15.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0277
    Cell Significance Index: -4.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0292
    Cell Significance Index: -16.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0330
    Cell Significance Index: -2.4600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0352
    Cell Significance Index: -0.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0448
    Cell Significance Index: -1.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0456
    Cell Significance Index: -7.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0482
    Cell Significance Index: -13.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0768
    Cell Significance Index: -16.1900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0790
    Cell Significance Index: -1.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0800
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1260
    Cell Significance Index: -14.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1264
    Cell Significance Index: -14.9100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1330
    Cell Significance Index: -2.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1402
    Cell Significance Index: -2.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1462
    Cell Significance Index: -15.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1642
    Cell Significance Index: -5.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1663
    Cell Significance Index: -13.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1679
    Cell Significance Index: -11.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1757
    Cell Significance Index: -3.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2135
    Cell Significance Index: -13.1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2522
    Cell Significance Index: -3.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2530
    Cell Significance Index: -2.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2704
    Cell Significance Index: -9.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2759
    Cell Significance Index: -15.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2937
    Cell Significance Index: -15.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2962
    Cell Significance Index: -3.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **NADPH-dependent**: CBR3 relies on NADPH as a cofactor to catalyze its enzymatic activity, which is a crucial aspect of its function in reducing carbonyl compounds. 2. **Broad substrate specificity**: CBR3 has been shown to reduce a wide range of carbonyl compounds, including steroids, fatty acids, and xenobiotics, making it a versatile enzyme in metabolic and detoxification processes. 3. **Tissue-specific expression**: CBR3 is expressed in various cell types, suggesting its involvement in different biological processes and tissue functions. **Pathways and Functions:** 1. **3-Keto Sterol Reductase Activity**: CBR3 participates in the reduction of 3-keto sterols, which are essential for cholesterol homeostasis and lipid metabolism. 2. **Carbonyl Reductase (NADPH) Activity**: This enzyme is involved in the reduction of carbonyl compounds, including steroids, fatty acids, and xenobiotics, which is crucial for detoxification and metabolic processes. 3. **Biological Oxidations**: CBR3 is involved in the reduction of oxidized compounds, which is essential for maintaining cellular redox balance. 4. **Cytosol and Extracellular Space**: CBR3 is expressed in both cytosolic and extracellular compartments, suggesting its involvement in both intracellular and intercellular processes. **Clinical Significance:** 1. **Xenobiotic Metabolism**: CBR3 plays a crucial role in the detoxification of xenobiotics, which is essential for maintaining cellular homeostasis and preventing toxicity. 2. **Metabolic Disorders**: Alterations in CBR3 expression or activity have been linked to metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes. 3. **Neurological Disorders**: CBR3 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia, where its dysregulation may contribute to disease pathogenesis. 4. **Cancer**: CBR3 has been shown to play a role in cancer development and progression, where its dysregulation may contribute to tumor growth and metastasis. In conclusion, CBR3 is a multifunctional enzyme that plays a crucial role in various biological processes, including metabolism, immune regulation, and xenobiotic detoxification. Its dysregulation has been linked to various diseases, highlighting the importance of understanding its function and regulation. Further research is necessary to elucidate the mechanisms underlying CBR3's functions and its clinical significance.

Genular Protein ID: 1178602429

Symbol: CBR3_HUMAN

Name: NADPH-dependent carbonyl reductase 3

UniProtKB Accession Codes:

O75828 Q6FHP2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 4 EC 2 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 4 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9740676

Title: Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2.

PubMed ID: 9740676

DOI: 10.1006/geno.1998.5380

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15537833

Title: Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3).

PubMed ID: 15537833

DOI: 10.1124/dmd.104.002006

PubMed ID: 18493841

Title: Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1.

PubMed ID: 18493841

DOI: 10.1007/s11010-008-9794-5

PubMed ID: 19841672

Title: Structural basis for substrate specificity in human monomeric carbonyl reductases.

PubMed ID: 19841672

DOI: 10.1371/journal.pone.0007113

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 277
  • Mass: 30850
  • Checksum: 8D39D6B99CFE5389
  • Sequence:
    • MSSCSRVALV TGANRGIGLA IARELCRQFS GDVVLTARDV ARGQAAVQQL QAEGLSPRFH 
QLDIDDLQSI RALRDFLRKE YGGLNVLVNN AAVAFKSDDP MPFDIKAEMT LKTNFFATRN 
MCNELLPIMK PHGRVVNISS LQCLRAFENC SEDLQERFHS ETLTEGDLVD LMKKFVEDTK 
NEVHEREGWP NSPYGVSKLG VTVLSRILAR RLDEKRKADR ILVNACCPGP VKTDMDGKDS 
IRTVEEGAET PVYLALLPPD ATEPQGQLVH DKVVQNW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.