Details for: CBS

Gene ID: 875

Symbol: CBS

Ensembl ID: ENSG00000160200

Description: cystathionine beta-synthase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.4184
    Cell Significance Index: 57.5000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4202
    Cell Significance Index: 34.4000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.1352
    Cell Significance Index: 18.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7457
    Cell Significance Index: 214.5700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3860
    Cell Significance Index: 6.3600
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.3054
    Cell Significance Index: 2.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2692
    Cell Significance Index: 5.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1393
    Cell Significance Index: 76.0700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1249
    Cell Significance Index: 14.2600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1221
    Cell Significance Index: 1.7500
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.0991
    Cell Significance Index: 1.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0931
    Cell Significance Index: 1.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0375
    Cell Significance Index: 1.0800
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.0321
    Cell Significance Index: 0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0279
    Cell Significance Index: 3.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0201
    Cell Significance Index: 7.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0084
    Cell Significance Index: 0.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0060
    Cell Significance Index: 1.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0025
    Cell Significance Index: 4.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0010
    Cell Significance Index: 1.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0002
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0007
    Cell Significance Index: -0.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0021
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0028
    Cell Significance Index: -0.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0031
    Cell Significance Index: -1.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0034
    Cell Significance Index: -2.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0036
    Cell Significance Index: -0.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0042
    Cell Significance Index: -0.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0045
    Cell Significance Index: -0.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0056
    Cell Significance Index: -1.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0065
    Cell Significance Index: -2.9500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0076
    Cell Significance Index: -0.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0097
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0108
    Cell Significance Index: -1.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0112
    Cell Significance Index: -0.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0123
    Cell Significance Index: -0.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0154
    Cell Significance Index: -1.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0156
    Cell Significance Index: -0.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0158
    Cell Significance Index: -2.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0186
    Cell Significance Index: -2.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0197
    Cell Significance Index: -0.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0212
    Cell Significance Index: -2.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0231
    Cell Significance Index: -2.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0321
    Cell Significance Index: -3.3400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0329
    Cell Significance Index: -0.8200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0382
    Cell Significance Index: -0.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0384
    Cell Significance Index: -2.9500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0398
    Cell Significance Index: -0.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0415
    Cell Significance Index: -3.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0457
    Cell Significance Index: -2.1500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0472
    Cell Significance Index: -0.6300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0475
    Cell Significance Index: -0.4700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0477
    Cell Significance Index: -0.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0485
    Cell Significance Index: -2.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0498
    Cell Significance Index: -3.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0522
    Cell Significance Index: -3.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0525
    Cell Significance Index: -3.2200
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0549
    Cell Significance Index: -0.6100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0553
    Cell Significance Index: -0.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0564
    Cell Significance Index: -3.1700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0567
    Cell Significance Index: -0.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0574
    Cell Significance Index: -3.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0583
    Cell Significance Index: -1.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0590
    Cell Significance Index: -2.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0592
    Cell Significance Index: -2.0800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0618
    Cell Significance Index: -0.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0628
    Cell Significance Index: -3.3000
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0640
    Cell Significance Index: -0.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0661
    Cell Significance Index: -1.7700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0662
    Cell Significance Index: -1.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0677
    Cell Significance Index: -1.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0691
    Cell Significance Index: -1.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0708
    Cell Significance Index: -2.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0723
    Cell Significance Index: -3.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0744
    Cell Significance Index: -2.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0800
    Cell Significance Index: -2.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0802
    Cell Significance Index: -2.8100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0805
    Cell Significance Index: -1.6700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0814
    Cell Significance Index: -0.9100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0821
    Cell Significance Index: -2.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0842
    Cell Significance Index: -3.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0895
    Cell Significance Index: -2.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0940
    Cell Significance Index: -2.7600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0945
    Cell Significance Index: -2.9900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0954
    Cell Significance Index: -2.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0988
    Cell Significance Index: -1.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0998
    Cell Significance Index: -2.6700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1009
    Cell Significance Index: -1.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1029
    Cell Significance Index: -2.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1073
    Cell Significance Index: -3.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1080
    Cell Significance Index: -2.2600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1126
    Cell Significance Index: -2.2600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1137
    Cell Significance Index: -1.1000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1143
    Cell Significance Index: -2.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1151
    Cell Significance Index: -2.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1152
    Cell Significance Index: -2.8800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1154
    Cell Significance Index: -2.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic activity:** CBS is a pyridoxal phosphate-dependent enzyme that catalyzes the conversion of homocysteine to cystathionine. 2. **Subcellular localization:** CBS is primarily found in the cytosol and nucleus of cells. 3. **Cellular expression:** CBS is significantly expressed in endothelial cells, retinal cells, and immune cells. 4. **Regulation:** CBS activity is regulated by various mechanisms, including allosteric inhibition by cystathionine and homocysteine. 5. **Protein structure:** CBS consists of two homodimeric subunits, each containing a catalytic domain. **Pathways and Functions:** CBS plays a critical role in various cellular pathways, including: 1. **Homocysteine metabolism:** CBS is essential for the conversion of homocysteine to cystathionine, which can then be converted to cysteine or oxidized to formic acid. 2. **Nitric oxide production:** CBS is involved in the regulation of nitric oxide production by endothelial cells, which is essential for vascular relaxation and blood pressure regulation. 3. **Vascular function:** CBS is critical for maintaining vascular function, including blood vessel diameter maintenance and remodeling. 4. **Neuronal health:** CBS is involved in the regulation of neuronal health, including the synthesis of cysteine, which is essential for maintaining glutathione levels. 5. **Immune system regulation:** CBS is expressed in immune cells and plays a role in regulating immune responses, including the production of nitric oxide and the regulation of inflammatory pathways. **Clinical Significance:** Dysregulation of CBS activity has been implicated in various diseases, including: 1. **Cardiovascular disease:** Elevated homocysteine levels have been associated with an increased risk of cardiovascular disease, including atherosclerosis and stroke. 2. **Neurological disorders:** CBS dysfunction has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. 3. **Cancer:** CBS has been shown to play a role in the regulation of cancer cell growth and survival. 4. **Pregnancy complications:** CBS dysfunction has been linked to pregnancy complications, including preeclampsia and fetal growth restriction. In conclusion, CBS is a critical enzyme involved in various cellular pathways, including homocysteine metabolism, nitric oxide production, and vascular function. Dysregulation of CBS activity has been implicated in various diseases, highlighting the importance of understanding the mechanisms of CBS function and its role in human health and disease.

Genular Protein ID: 900826943

Symbol: B7Z2D6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z2D6

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 4 Gene3D 2 InterPro 8 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 ProteomicsDB 1 RefSeq 1 Rhea 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 2 UniPathway 1

Sequence Information:

  • Length: 508
  • Mass: 55874
  • Checksum: E65E8B0DE9CE6056
  • Sequence:
    • MPSETPQAEV GPTGCPHRSG PHHHTAPAKS PKILPDILKK IGDTPMVRIN KIGKKFGLKC 
ELLAKCEFFN AGGSVKDRIS LRMIEDAERD GTLKPGDTII EPTSGNTGIG LALAAAVRGY 
RCIIVMPEKM SSEKVDVLRA LGAEIVRTPT NARFDSPESH VGVAWRLKNE IPNSHILDQY 
RNASNPLAHY DTTADEILQQ CDGKLDMLVA SVGTGGTITG IARKLKEKCP GCRIIGVDPE 
GSILAEPEEL NQTEQTTYEV EGIGYDFIPT VLDRTVVDKW FKSNDEEAFT FARMLIAQEG 
LLCGGSAGST VAVAVKAAQE LQEGQRCVVI LPDSVRNYMT KFLSDRWMLQ KGFLKEEDLT 
EKKPWWWHLR VQELGLSAPL TVLPTITCGH TIEILREKGF DQAPVVDEAG VILGMVTLGN 
MLSSLLAGKV QPSDQVGKVI YKQFKQIRLT DTLGRLSHIL EMDHFALVVH EQIQYHSTGK 
SSQRQMVFGV VTAIDLLNFV AAQERDQK

Genular Protein ID: 3308877615

Symbol: Q9NTF0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NTF0

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 4 Gene3D 2 InterPro 8 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 1 RuleBase 1 SMART 1 SUPFAM 2 UniPathway 1

Sequence Information:

  • Length: 475
  • Mass: 52487
  • Checksum: 3F5E2D613783A1EF
  • Sequence:
    • RPDILKKIGD TPMVRINKIG KKFGLKCELL AKCEFFNAGG SVKDRISLRM IEDAERDGTL 
KPGDTIIEPT SGNTGIGLAL AAAVRGYRCI IVMPEKMSSE KVDVLRALGA EIVRTPTNAR 
FDSPESHVGV AWRLKNEIPN SHILDQYRNA SNPLPHYDTT ADEILQQCDG KLDMLVASVG 
TGGTITGIAR KLKEKCPGCR IIGVDPEGSI LAEPEELNQT EQTTYEVEGI GYDFIPTVLD 
RTVVDKWFKS NDEEAFTLAR MLIAQEGLLC GGSAGSTVAV AVKAAQELQE GQRCVVILPD 
SVRNYMTKFL SDRWMLQKGF LKEEDLTEKK PWWWHLRVQE LGLSAPLTVL PTITCGHTIE 
ILREKGFDQA PVVDEAGVIL GMVTLGNMLS SLLAGKVQPS DQVGKVIYKQ FKQIRLTDTL 
GRLSHILEMD HFALVVHEQI QYHSTGKSSQ RQMVFGVVTA IDLLNFVAAQ ERDQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.