Details for: ACTN2

Gene ID: 88

Symbol: ACTN2

Ensembl ID: ENSG00000077522

Description: actinin alpha 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.9300
    Cell Significance Index: -17.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.1071
    Cell Significance Index: -13.4500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 11.2302
    Cell Significance Index: 274.0100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 8.6724
    Cell Significance Index: 139.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 7.4938
    Cell Significance Index: 575.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 7.3601
    Cell Significance Index: 189.1900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.8809
    Cell Significance Index: 72.0600
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.6814
    Cell Significance Index: 10.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.7356
    Cell Significance Index: 121.0000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.5423
    Cell Significance Index: 96.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7603
    Cell Significance Index: 152.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6878
    Cell Significance Index: 46.2500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5083
    Cell Significance Index: 7.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.4852
    Cell Significance Index: 50.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3560
    Cell Significance Index: 4.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2110
    Cell Significance Index: 145.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1348
    Cell Significance Index: 61.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1290
    Cell Significance Index: 46.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1012
    Cell Significance Index: 6.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0936
    Cell Significance Index: 2.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0906
    Cell Significance Index: 170.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0365
    Cell Significance Index: 56.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0033
    Cell Significance Index: 6.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0160
    Cell Significance Index: -10.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0194
    Cell Significance Index: -3.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0196
    Cell Significance Index: -14.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0241
    Cell Significance Index: -17.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0241
    Cell Significance Index: -18.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0291
    Cell Significance Index: -18.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0299
    Cell Significance Index: -16.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0317
    Cell Significance Index: -17.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0358
    Cell Significance Index: -5.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0408
    Cell Significance Index: -6.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0505
    Cell Significance Index: -14.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0626
    Cell Significance Index: -12.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0865
    Cell Significance Index: -18.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0958
    Cell Significance Index: -13.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1012
    Cell Significance Index: -11.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1034
    Cell Significance Index: -12.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1097
    Cell Significance Index: -12.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1176
    Cell Significance Index: -12.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1207
    Cell Significance Index: -15.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1385
    Cell Significance Index: -4.4100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1392
    Cell Significance Index: -1.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1395
    Cell Significance Index: -17.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1495
    Cell Significance Index: -17.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1729
    Cell Significance Index: -5.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1876
    Cell Significance Index: -14.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2093
    Cell Significance Index: -10.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2117
    Cell Significance Index: -15.7800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2139
    Cell Significance Index: -3.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2214
    Cell Significance Index: -10.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2314
    Cell Significance Index: -5.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2436
    Cell Significance Index: -12.6900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.2504
    Cell Significance Index: -3.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2674
    Cell Significance Index: -3.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2723
    Cell Significance Index: -7.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2759
    Cell Significance Index: -5.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2782
    Cell Significance Index: -15.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2900
    Cell Significance Index: -18.2800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2924
    Cell Significance Index: -3.8300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2989
    Cell Significance Index: -4.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3009
    Cell Significance Index: -10.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3122
    Cell Significance Index: -14.6800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3165
    Cell Significance Index: -3.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3711
    Cell Significance Index: -19.2800
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: -0.3733
    Cell Significance Index: -2.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3822
    Cell Significance Index: -17.8200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3961
    Cell Significance Index: -9.8800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3974
    Cell Significance Index: -4.3300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4106
    Cell Significance Index: -4.7900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4124
    Cell Significance Index: -8.9100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4269
    Cell Significance Index: -9.0600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4302
    Cell Significance Index: -5.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4325
    Cell Significance Index: -15.0300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4371
    Cell Significance Index: -5.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4388
    Cell Significance Index: -7.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4587
    Cell Significance Index: -16.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4751
    Cell Significance Index: -13.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4923
    Cell Significance Index: -7.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4936
    Cell Significance Index: -14.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4991
    Cell Significance Index: -14.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5017
    Cell Significance Index: -17.6300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5020
    Cell Significance Index: -10.7300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.5107
    Cell Significance Index: -5.3200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.5207
    Cell Significance Index: -16.4700
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.5233
    Cell Significance Index: -5.3800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5285
    Cell Significance Index: -10.4500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5349
    Cell Significance Index: -13.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5351
    Cell Significance Index: -14.0700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.5466
    Cell Significance Index: -7.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5503
    Cell Significance Index: -12.0500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5512
    Cell Significance Index: -9.5300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5523
    Cell Significance Index: -16.2200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5620
    Cell Significance Index: -11.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5686
    Cell Significance Index: -15.2100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5708
    Cell Significance Index: -6.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5908
    Cell Significance Index: -5.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5977
    Cell Significance Index: -15.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cytoskeletal binding**: ACTN2 binds to actin filaments, influencing their organization and dynamics. 2. **Cell adhesion**: ACTN2 is involved in cell-cell adhesion, particularly in skeletal muscle and cardiac muscle cells. 3. **Signaling pathways**: ACTN2 is a key regulator of various signaling pathways, including those involved in muscle contraction, neuronal transmission, and immune responses. 4. **Cellular localization**: ACTN2 is localized to the plasma membrane, cytosol, and cytoskeleton, highlighting its involvement in multiple cellular processes. 5. **Regulatory functions**: ACTN2 has been shown to regulate various cellular processes, including cell signaling, apoptosis, and membrane potential. **Pathways and Functions** 1. **Muscle contraction**: ACTN2 is involved in muscle contraction, particularly in skeletal muscle and cardiac muscle cells. 2. **Neuronal transmission**: ACTN2 is a key regulator of neuronal transmission, influencing postsynaptic density and glutamatergic synapse formation. 3. **Immune responses**: ACTN2 has been implicated in immune responses, particularly in the regulation of neutrophil activation and platelet aggregation. 4. **Signaling cascades**: ACTN2 is involved in various signaling cascades, including those mediated by NMDA receptors, MAPK family signaling, and Ras activation. 5. **Cell adhesion and migration**: ACTN2 regulates cell adhesion and migration, particularly in skeletal muscle and cardiac muscle cells. **Clinical Significance** 1. **Muscular dystrophy**: ACTN2 mutations have been associated with muscular dystrophy, particularly in Duchenne muscular dystrophy and Becker muscular dystrophy. 2. **Cardiac disease**: ACTN2 has been implicated in cardiac disease, particularly in hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy. 3. **Neurological disorders**: ACTN2 has been associated with various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Cancer**: ACTN2 has been implicated in cancer, particularly in the regulation of cell adhesion and migration. 5. **Immunological disorders**: ACTN2 has been associated with immunological disorders, particularly in the regulation of neutrophil activation and platelet aggregation. In conclusion, ACTN2 is a multifunctional protein that plays a crucial role in various cellular processes, including muscle contraction, neuronal transmission, and immune responses. Its dysregulation has been implicated in various diseases, including muscular dystrophy, cardiac disease, neurological disorders, cancer, and immunological disorders. Further research is necessary to fully understand the significance of ACTN2 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1547637273

Symbol: ACTN2_HUMAN

Name: Alpha-actinin-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1339456

Title: Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11.

PubMed ID: 1339456

DOI: 10.1016/s0021-9258(19)50420-3

PubMed ID: 10548523

Title: Fine mapping and genomic structure of ACTN2, the human gene coding for the sarcomeric isoform of alpha-actinin-2, expressed in skeletal and cardiac muscle.

PubMed ID: 10548523

DOI: 10.1006/bbrc.1999.1661

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10427098

Title: ZASP: a new Z-band alternatively spliced PDZ-motif protein.

PubMed ID: 10427098

DOI: 10.1083/jcb.146.2.465

PubMed ID: 10984498

Title: FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle.

PubMed ID: 10984498

DOI: 10.1074/jbc.m007493200

PubMed ID: 11114196

Title: Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.

PubMed ID: 11114196

DOI: 10.1073/pnas.260501097

PubMed ID: 11171996

Title: Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines.

PubMed ID: 11171996

DOI: 10.1073/pnas.98.4.1595

PubMed ID: 11842093

Title: Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.

PubMed ID: 11842093

DOI: 10.1074/jbc.m200712200

PubMed ID: 15159419

Title: Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction.

PubMed ID: 15159419

DOI: 10.1083/jcb.200308141

PubMed ID: 17046827

Title: Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein.

PubMed ID: 17046827

DOI: 10.1074/jbc.m603244200

PubMed ID: 20554076

Title: The sarcomeric Z-disc component myopodin is a multiadapter protein that interacts with filamin and alpha-actinin.

PubMed ID: 20554076

DOI: 10.1016/j.ejcb.2010.04.004

PubMed ID: 19932097

Title: BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin.

PubMed ID: 19932097

DOI: 10.1016/j.yexcr.2009.11.010

PubMed ID: 22972877

Title: F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo.

PubMed ID: 22972877

DOI: 10.1161/circresaha.112.271007

PubMed ID: 10481917

Title: Structure of the alpha-actinin rod: molecular basis for cross-linking of actin filaments.

PubMed ID: 10481917

DOI: 10.1016/s0092-8674(00)81981-9

PubMed ID: 11573089

Title: Ca2+-independent binding of an EF-hand domain to a novel motif in the alpha-actinin-titin complex.

PubMed ID: 11573089

DOI: 10.1038/nsb1001-853

PubMed ID: 11470434

Title: Crystal structure of the alpha-actinin rod reveals an extensive torsional twist.

PubMed ID: 11470434

DOI: 10.1016/s0969-2126(01)00619-0

PubMed ID: 14567970

Title: Mutations in the muscle LIM protein and alpha-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis.

PubMed ID: 14567970

DOI: 10.1016/s1096-7192(03)00142-2

PubMed ID: 20022194

Title: Mutations in alpha-actinin-2 cause hypertrophic cardiomyopathy: a genome-wide analysis.

PubMed ID: 20022194

DOI: 10.1016/j.jacc.2009.11.016

PubMed ID: 25224718

Title: Exome sequencing identifies a mutation in the ACTN2 gene in a family with idiopathic ventricular fibrillation, left ventricular noncompaction, and sudden death.

PubMed ID: 25224718

DOI: 10.1186/s12881-014-0099-0

PubMed ID: 25173926

Title: Novel alpha-actinin 2 variant associated with familial hypertrophic cardiomyopathy and juvenile atrial arrhythmias: a massively parallel sequencing study.

PubMed ID: 25173926

DOI: 10.1161/circgenetics.113.000486

PubMed ID: 30701273

Title: ACTN2 mutations cause 'Multiple structured Core Disease' (MsCD).

PubMed ID: 30701273

DOI: 10.1007/s00401-019-01963-8

PubMed ID: 30900782

Title: Actininopathy: A new muscular dystrophy caused by ACTN2 dominant mutations.

PubMed ID: 30900782

DOI: 10.1002/ana.25470

Sequence Information:

  • Length: 894
  • Mass: 103854
  • Checksum: 7F612C1C3B3E2299
  • Sequence:
  • MNQIEPGVQY NYVYDEDEYM IQEEEWDRDL LLDPAWEKQQ RKTFTAWCNS HLRKAGTQIE 
    NIEEDFRNGL KLMLLLEVIS GERLPKPDRG KMRFHKIANV NKALDYIASK GVKLVSIGAE 
    EIVDGNVKMT LGMIWTIILR FAIQDISVEE TSAKEGLLLW CQRKTAPYRN VNIQNFHTSW 
    KDGLGLCALI HRHRPDLIDY SKLNKDDPIG NINLAMEIAE KHLDIPKMLD AEDIVNTPKP 
    DERAIMTYVS CFYHAFAGAE QAETAANRIC KVLAVNQENE RLMEEYERLA SELLEWIRRT 
    IPWLENRTPE KTMQAMQKKL EDFRDYRRKH KPPKVQEKCQ LEINFNTLQT KLRISNRPAF 
    MPSEGKMVSD IAGAWQRLEQ AEKGYEEWLL NEIRRLERLE HLAEKFRQKA STHETWAYGK 
    EQILLQKDYE SASLTEVRAL LRKHEAFESD LAAHQDRVEQ IAAIAQELNE LDYHDAVNVN 
    DRCQKICDQW DRLGTLTQKR REALERMEKL LETIDQLHLE FAKRAAPFNN WMEGAMEDLQ 
    DMFIVHSIEE IQSLITAHEQ FKATLPEADG ERQSIMAIQN EVEKVIQSYN IRISSSNPYS 
    TVTMDELRTK WDKVKQLVPI RDQSLQEELA RQHANERLRR QFAAQANAIG PWIQNKMEEI 
    ARSSIQITGA LEDQMNQLKQ YEHNIINYKN NIDKLEGDHQ LIQEALVFDN KHTNYTMEHI 
    RVGWELLLTT IARTINEVET QILTRDAKGI TQEQMNEFRA SFNHFDRRKN GLMDHEDFRA 
    CLISMGYDLG EAEFARIMTL VDPNGQGTVT FQSFIDFMTR ETADTDTAEQ VIASFRILAS 
    DKPYILAEEL RRELPPDQAQ YCIKRMPAYS GPGSVPGALD YAAFSSALYG ESDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.