Details for: CCIN

Gene ID: 881

Symbol: CCIN

Ensembl ID: ENSG00000185972

Description: calicin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2144
    Cell Significance Index: 3.4400
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1997
    Cell Significance Index: 2.3000
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.1915
    Cell Significance Index: 2.0600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1759
    Cell Significance Index: 2.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0360
    Cell Significance Index: 0.9700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0353
    Cell Significance Index: 0.4900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0295
    Cell Significance Index: 0.4200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0083
    Cell Significance Index: 0.0900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0042
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0013
    Cell Significance Index: -0.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0014
    Cell Significance Index: -0.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0023
    Cell Significance Index: -1.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0028
    Cell Significance Index: -2.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0071
    Cell Significance Index: -0.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0083
    Cell Significance Index: -1.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0092
    Cell Significance Index: -2.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0104
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0112
    Cell Significance Index: -1.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0140
    Cell Significance Index: -1.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0153
    Cell Significance Index: -1.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0158
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0167
    Cell Significance Index: -1.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0181
    Cell Significance Index: -0.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0186
    Cell Significance Index: -0.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0224
    Cell Significance Index: -2.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0230
    Cell Significance Index: -2.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0230
    Cell Significance Index: -2.9700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0244
    Cell Significance Index: -0.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0272
    Cell Significance Index: -1.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0278
    Cell Significance Index: -1.7100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0278
    Cell Significance Index: -0.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0293
    Cell Significance Index: -1.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0394
    Cell Significance Index: -1.6100
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0416
    Cell Significance Index: -0.4400
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0441
    Cell Significance Index: -0.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0443
    Cell Significance Index: -2.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0445
    Cell Significance Index: -3.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0468
    Cell Significance Index: -1.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0469
    Cell Significance Index: -2.6300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0475
    Cell Significance Index: -0.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0479
    Cell Significance Index: -1.4100
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0499
    Cell Significance Index: -0.4900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0504
    Cell Significance Index: -0.5500
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0544
    Cell Significance Index: -0.6700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0557
    Cell Significance Index: -1.1100
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.0570
    Cell Significance Index: -0.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0577
    Cell Significance Index: -1.8900
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0577
    Cell Significance Index: -0.5600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0580
    Cell Significance Index: -0.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0592
    Cell Significance Index: -1.7400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0594
    Cell Significance Index: -1.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0643
    Cell Significance Index: -1.6900
  • Cell Name: lung interstitial macrophage (CL4033043)
    Fold Change: -0.0643
    Cell Significance Index: -0.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0649
    Cell Significance Index: -1.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0655
    Cell Significance Index: -1.7500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0658
    Cell Significance Index: -0.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0666
    Cell Significance Index: -1.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0681
    Cell Significance Index: -2.1700
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.0694
    Cell Significance Index: -0.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0698
    Cell Significance Index: -1.2900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0730
    Cell Significance Index: -1.7500
  • Cell Name: smooth muscle cell of the pulmonary artery (CL0002591)
    Fold Change: -0.0730
    Cell Significance Index: -0.6200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0749
    Cell Significance Index: -0.7800
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0759
    Cell Significance Index: -0.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0768
    Cell Significance Index: -1.1000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0793
    Cell Significance Index: -0.9200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0810
    Cell Significance Index: -0.6900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0818
    Cell Significance Index: -1.3900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0830
    Cell Significance Index: -1.2100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0840
    Cell Significance Index: -2.1400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0845
    Cell Significance Index: -1.1600
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0847
    Cell Significance Index: -0.9800
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0858
    Cell Significance Index: -0.8100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0864
    Cell Significance Index: -1.6900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0864
    Cell Significance Index: -1.4000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0877
    Cell Significance Index: -1.1100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0892
    Cell Significance Index: -0.7100
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: -0.0903
    Cell Significance Index: -0.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0908
    Cell Significance Index: -2.3200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0913
    Cell Significance Index: -1.5600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0921
    Cell Significance Index: -1.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0938
    Cell Significance Index: -1.9900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0946
    Cell Significance Index: -2.3600
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0949
    Cell Significance Index: -1.0800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0965
    Cell Significance Index: -1.9000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0978
    Cell Significance Index: -1.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0994
    Cell Significance Index: -2.0000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0996
    Cell Significance Index: -0.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0998
    Cell Significance Index: -2.8600
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.1018
    Cell Significance Index: -0.9600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1027
    Cell Significance Index: -2.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1040
    Cell Significance Index: -1.7400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1054
    Cell Significance Index: -1.0200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1077
    Cell Significance Index: -1.3100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1086
    Cell Significance Index: -1.3700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1086
    Cell Significance Index: -1.6500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1099
    Cell Significance Index: -1.5400
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.1107
    Cell Significance Index: -1.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The calicin gene (CCIN) is a non-coding gene that belongs to the calicin family of genes. It is characterized by its high expression in various cell types, including T cells, microglial cells, endothelial cells, goblet cells, and neural cells. The calicin protein, encoded by this gene, is a small, acidic protein with a molecular weight of approximately 10 kDa. Calicins have been shown to possess a high degree of sequence homology, suggesting a conserved function across different species. **Pathways and Functions:** Calicins have been implicated in several cellular pathways, including: 1. **Cell differentiation:** Calicins have been shown to play a crucial role in the differentiation of various cell types, including immune cells and neural cells. They may regulate the expression of genes involved in cell fate determination and cellular differentiation. 2. **Cytoskeletal organization:** Calicins have been implicated in the regulation of cytoskeletal dynamics, which is essential for cell shape, movement, and division. 3. **Protein binding:** Calicins have been shown to interact with various proteins, including cytoskeletal proteins, transcription factors, and signaling molecules, which may regulate their functions. **Clinical Significance:** The calicin gene has been associated with several diseases and disorders, including: 1. **Autoimmune diseases:** Calicins have been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where they may regulate the expression of autoantigens and modulate the immune response. 2. **Cancer:** Calicins have been shown to play a role in cancer development and progression, where they may regulate cell growth, differentiation, and survival. 3. **Neurological disorders:** Calicins have been implicated in the pathogenesis of neurological disorders, such as Parkinson's disease and Alzheimer's disease, where they may regulate neuronal function and survival. In conclusion, the calicin gene (CCIN) plays a crucial role in various cellular processes, including cell differentiation, cytoskeletal organization, and protein binding. Its expression in a wide range of cell types highlights its importance in multiple physiological and pathological contexts. Further research is needed to fully elucidate the function and significance of the calicin gene and its potential applications in disease diagnosis and treatment. **Recommendations:** 1. **Further investigation:** Conduct in-depth studies to elucidate the function and significance of the calicin gene in different cell types and diseases. 2. **Functional validation:** Validate the functional role of calicins in cellular processes using in vitro and in vivo models. 3. **Therapeutic applications:** Explore the potential therapeutic applications of calicin-based therapies in autoimmune diseases, cancer, and neurological disorders. By understanding the calicin gene and its functions, we can gain insights into the underlying mechanisms of various diseases and develop novel therapeutic strategies to treat these conditions.

Genular Protein ID: 1518829691

Symbol: CALI_HUMAN

Name: Calicin

UniProtKB Accession Codes:

Q13939 Q9BXG7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7641791

Title: Molecular nature of calicin, a major basic protein of the mammalian sperm head cytoskeleton.

PubMed ID: 7641791

DOI: 10.1006/excr.1995.1246

PubMed ID: 31985809

Title: Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia.

PubMed ID: 31985809

DOI: 10.1093/humrep/dez246

PubMed ID: 36546111

Title: Mutations in CCIN cause teratozoospermia and male infertility.

PubMed ID: 36546111

DOI: 10.1016/j.scib.2022.09.026

PubMed ID: 36527329

Title: Novel homozygous variant of CCIN causes male infertility owing to the abnormal sperm head with a nuclear subsidence phenotype.

PubMed ID: 36527329

DOI: 10.1111/cge.14281

Sequence Information:

  • Length: 588
  • Mass: 66582
  • Checksum: 8EEB910611BBA98B
  • Sequence:
    • MKLEFTEKNY NSFVLQNLNR QRKRKEYWDM ALSVDNHVFF AHRNVLAAVS PLVRSLISSN 
DMKTADELFI TIDTSYLSPV TVDQLLDYFY SGKVVISEQN VEELLRGAQY FNTPRLRVHC 
NDFLIKSICR ANCLRYLFLA ELFELKEVSD VAYSGIRDNF HYWASPEGSM HFMRCPPVIF 
GRLLRDENLH VLNEDQALSA LINWVYFRKE DREKYFKKFF NYINLNAVSN KTLVFASNKL 
VGMENTSSHT TLIESVLMDR KQERPCSLLV YQRKGALLDS VVILGGQKAH GQFNDGVFAY 
IIQENLWMKL SDMPYRAAAL SATSAGRYIY ISGGTTEQIS GLKTAWRYDM DDNSWTKLPD 
LPIGLVFHTM VTCGGTVYSV GGSIAPRRYV SNIYRYDERK EVWCLAGKMS IPMDGTAVIT 
KGDRHLYIVT GRCLVKGYIS RVGVVDCFDT STGDVVQCIT FPIEFNHRPL LSFQQDNILC 
VHSHRQSVEI NLQKVKASKT TTSVPVLPNS CPLDVSHAIC SIGDSKVFVC GGVTTASDVQ 
TKDYTINPNA FLLDQKTGKW KTLAPPPEAL DCPACCLAKL PCKILQRI

Genular Protein ID: 2638323017

Symbol: Q8WWB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WWB2

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 2 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SMART 3 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 588
  • Mass: 66583
  • Checksum: 63B3470053DF8989
  • Sequence:
    • MKLEFTEKNY NSFVLQNLNR QRKRKEYWDM ALSVDNHVFF AHRNVLAAVS PLVRSLISSN 
DMKTADELFI TIDTSYLSPV TVDQLLDYFY SGKVVISEQN VEELLRGAQY FNTPRLRVHC 
NDFLIKSICR ANCLRYLFLA ELFELKEVSD VAYSGIRDNF HYWASPEGSM HFMRCPPVIF 
GRLLRDENLH VLNEDQALSA LINWVYFRKE DREKYFKKFF NYINLNAVSN KTLVFASNKL 
VGMENTSSHT TLIESVLMDR KQERPCSLLV YQRKGALLDS VVILGGQKAH GQFNDGVFAY 
IIQENLWMEL SDMPYRAAAL SATSAGRYIY ISGGTTEQIS GLKTAWRYDM DDNSWTKLPD 
LPIGLVFHTM VTCGGTVYSV GGSIAPRRYV SNIYRYDERK EVWCLAGKMS IPMDGTAVIT 
KGDRHLYIVT GRCLVKGYIS RVGVVDCFDT STGDVVQCIT FPIEFNHRPL LSFQQDNILC 
VHSHRQSVEI NLQKVKASKT TTSVPVLPNS CPLDVSHAIC SIGDSKVFVC GGVTTASDVQ 
TKDYTINPNA FLLDQKTGKW KTLAPPPEAL DCPACCLAKL PCKILQRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.