Details for: KYAT1

Gene ID: 883

Symbol: KYAT1

Ensembl ID: ENSG00000171097

Description: kynurenine aminotransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8192
    Cell Significance Index: -12.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2493
    Cell Significance Index: -9.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.4872
    Cell Significance Index: 152.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4151
    Cell Significance Index: 283.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.2925
    Cell Significance Index: 22.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.2547
    Cell Significance Index: 361.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1166
    Cell Significance Index: 221.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0521
    Cell Significance Index: 377.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9518
    Cell Significance Index: 20.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8366
    Cell Significance Index: 31.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8241
    Cell Significance Index: 36.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8177
    Cell Significance Index: 155.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7243
    Cell Significance Index: 55.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5803
    Cell Significance Index: 57.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4738
    Cell Significance Index: 13.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4253
    Cell Significance Index: 383.9900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3934
    Cell Significance Index: 4.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3742
    Cell Significance Index: 19.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3528
    Cell Significance Index: 8.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3011
    Cell Significance Index: 48.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2777
    Cell Significance Index: 17.0700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2744
    Cell Significance Index: 3.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2697
    Cell Significance Index: 29.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2449
    Cell Significance Index: 8.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1372
    Cell Significance Index: 6.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0991
    Cell Significance Index: 6.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0843
    Cell Significance Index: 9.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0797
    Cell Significance Index: 14.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0630
    Cell Significance Index: 3.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0620
    Cell Significance Index: 7.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0620
    Cell Significance Index: 1.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0292
    Cell Significance Index: 0.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0110
    Cell Significance Index: 6.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0029
    Cell Significance Index: 1.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0033
    Cell Significance Index: -0.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0054
    Cell Significance Index: -0.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0064
    Cell Significance Index: -0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0074
    Cell Significance Index: -13.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0083
    Cell Significance Index: -15.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0087
    Cell Significance Index: -1.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0101
    Cell Significance Index: -15.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0120
    Cell Significance Index: -16.3100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0133
    Cell Significance Index: -0.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0139
    Cell Significance Index: -10.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0153
    Cell Significance Index: -11.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0158
    Cell Significance Index: -11.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0191
    Cell Significance Index: -12.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0221
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0232
    Cell Significance Index: -14.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0238
    Cell Significance Index: -13.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0268
    Cell Significance Index: -0.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0303
    Cell Significance Index: -13.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0314
    Cell Significance Index: -0.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0315
    Cell Significance Index: -3.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0339
    Cell Significance Index: -0.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0586
    Cell Significance Index: -5.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0608
    Cell Significance Index: -10.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0688
    Cell Significance Index: -7.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0693
    Cell Significance Index: -14.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0742
    Cell Significance Index: -9.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0784
    Cell Significance Index: -1.6700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0808
    Cell Significance Index: -0.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0819
    Cell Significance Index: -11.9100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0833
    Cell Significance Index: -1.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0835
    Cell Significance Index: -10.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0904
    Cell Significance Index: -5.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1124
    Cell Significance Index: -3.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1184
    Cell Significance Index: -3.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1271
    Cell Significance Index: -9.4700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1300
    Cell Significance Index: -2.5700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1315
    Cell Significance Index: -2.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1337
    Cell Significance Index: -1.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1385
    Cell Significance Index: -14.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1393
    Cell Significance Index: -6.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1480
    Cell Significance Index: -4.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1491
    Cell Significance Index: -7.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1506
    Cell Significance Index: -10.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1548
    Cell Significance Index: -12.2600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1561
    Cell Significance Index: -1.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1696
    Cell Significance Index: -5.0000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1740
    Cell Significance Index: -2.1700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1752
    Cell Significance Index: -2.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1927
    Cell Significance Index: -5.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1943
    Cell Significance Index: -5.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2039
    Cell Significance Index: -5.0900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2051
    Cell Significance Index: -4.2800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2083
    Cell Significance Index: -5.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2083
    Cell Significance Index: -4.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2095
    Cell Significance Index: -7.3400
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.2130
    Cell Significance Index: -2.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2207
    Cell Significance Index: -10.2900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2282
    Cell Significance Index: -2.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2463
    Cell Significance Index: -8.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2630
    Cell Significance Index: -6.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2667
    Cell Significance Index: -7.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2802
    Cell Significance Index: -7.5000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3007
    Cell Significance Index: -2.8500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3127
    Cell Significance Index: -3.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3214
    Cell Significance Index: -11.8000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3295
    Cell Significance Index: -8.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KYAT1 is an enzyme that catalyzes the amination of kynurenine, a key intermediate in the kynurenine pathway of tryptophan metabolism. This pathway is crucial for the regulation of immune response, as it influences the production of various cytokines and neurotransmitters. KYAT1 is also involved in the metabolism of glutamate and glutamine, which are essential for neuronal function and synaptic plasticity. Furthermore, KYAT1 has been implicated in the response to bacterial infections, suggesting its role in modulating the host's immune response. **Pathways and Functions:** KYAT1 is involved in several key pathways, including: 1. **Kynurenine metabolic process:** KYAT1 is responsible for the amination of kynurenine, which is a critical step in the kynurenine pathway. This pathway is involved in the regulation of immune response, as it influences the production of various cytokines and neurotransmitters. 2. **Glutamate and glutamine metabolism:** KYAT1 is involved in the metabolism of glutamate and glutamine, which are essential for neuronal function and synaptic plasticity. 3. **Tryptophan catabolism:** KYAT1 is also involved in the catabolism of tryptophan, which is a precursor to serotonin and melatonin. 4. **Biosynthetic process:** KYAT1 is involved in the biosynthetic process of various compounds, including kynurenine and glutamate. **Clinical Significance:** The dysregulation of KYAT1 has been implicated in various diseases, including: 1. **Neurodegenerative diseases:** KYAT1 has been implicated in the regulation of immune response and metabolism, which are critical for the development of neurodegenerative diseases such as Alzheimer's and Parkinson's. 2. **Autoimmune diseases:** KYAT1 has been implicated in the regulation of immune response, which is critical for the development of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. 3. **Infectious diseases:** KYAT1 has been implicated in the response to bacterial infections, which is critical for the development of infectious diseases such as tuberculosis and sepsis. 4. **Cancer:** KYAT1 has been implicated in the regulation of immune response and metabolism, which are critical for the development of cancer. In conclusion, KYAT1 is a critical gene that plays a pivotal role in the regulation of immune response, metabolism, and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of KYAT1 and its potential therapeutic applications.

Genular Protein ID: 2855275710

Symbol: KAT1_HUMAN

Name: Glutamine transaminase K

UniProtKB Accession Codes:

Q16773 Q5T275 Q8N191

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EC 3 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 10 Rhea 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7883047

Title: Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase.

PubMed ID: 7883047

DOI: 10.1016/0014-5793(95)00123-q

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15364907

Title: Crystal structure of human kynurenine aminotransferase I.

PubMed ID: 15364907

DOI: 10.1074/jbc.m409291200

PubMed ID: 19338303

Title: Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K.

PubMed ID: 19338303

DOI: 10.1021/jm9000874

PubMed ID: 28097769

Title: High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate.

PubMed ID: 28097769

DOI: 10.1002/pro.3119

Sequence Information:

  • Length: 422
  • Mass: 47875
  • Checksum: EAEF2F5E77A9B55A
  • Sequence:
    • MAKQLQARRL DGIDYNPWVE FVKLASEHDV VNLGQGFPDF PPPDFAVEAF QHAVSGDFML 
NQYTKTFGYP PLTKILASFF GELLGQEIDP LRNVLVTVGG YGALFTAFQA LVDEGDEVII 
IEPFFDCYEP MTMMAGGRPV FVSLKPGPIQ NGELGSSSNW QLDPMELAGK FTSRTKALVL 
NTPNNPLGKV FSREELELVA SLCQQHDVVC ITDEVYQWMV YDGHQHISIA SLPGMWERTL 
TIGSAGKTFS ATGWKVGWVL GPDHIMKHLR TVHQNSVFHC PTQSQAAVAE SFEREQLLFR 
QPSSYFVQFP QAMQRCRDHM IRSLQSVGLK PIIPQGSYFL ITDISDFKRK MPDLPGAVDE 
PYDRRFVKWM IKNKGLVAIP VSIFYSVPHQ KHFDHYIRFC FVKDEATLQA MDEKLRKWKV 
EL

Genular Protein ID: 1255162379

Symbol: B7Z4W5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z4W5

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 2 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 3 Rhea 4 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 516
  • Mass: 57668
  • Checksum: 4D325694F484E633
  • Sequence:
    • MFRTAAAISV HLVGPLQGRK AGAPLTWFLH QTQVAEKNVG SPAPRPTSHL GLANPQERKV 
PQGPQSPCEV PAAEGILRTG GAKLPIQGHP AKLAMAKQLQ ARRLDGIDYN PWVEFVKLAS 
EHDVVNLGQG FPDFPPPDFA VEAFQHAVSG DFMLNQYTKT FGYPPLTKIL ASFFGELLGQ 
EIDPLRNVLV TVGGYGALFT AFQALVDEGD EVIIIEPFFD CYEPMTMMAG GRPVFVSLKP 
GPIQNGELGS SSNWQLDPME LAGKFTSRTK ALVLNTPNNP LGKVFSREEL ELVASLCQQH 
DVVCITDEVY QWMVYDGHQH ISIASLPGMW ERTLTIGSAG KTFSATGWKV GWVLGPDHIM 
KHLRTVHQNS VFHCPTQSQA AVAESFEREQ LLFRQPSSYF VQFPQAMQRC RDHMIRSLQS 
VGLKPIIPQG SYFLITDISD FKRKMPDLPG AVDEPYDRRF VKWMIKNKGL VAIPVSIFYS 
VPHQKHFDHY IRFCFVKDEA TLQAMDEKLR KWKVEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.