KSR1 | ENSG00000141068 | NCBI 8844

Details for: KSR1

Gene ID: 8844

Symbol: KSR1

Ensembl ID: ENSG00000141068

Description: kinase suppressor of ras 1

Associated with

Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Map2k and mapk activation
(R-HSA-5674135)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of mapk pathway
(R-HSA-5675221)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling downstream of ras mutants
(R-HSA-9649948)
Signal transduction
(R-HSA-162582)
14-3-3 protein binding
(GO:0071889)
Atp binding
(GO:0005524)
Camp-mediated signaling
(GO:0019933)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Intracellular membrane-bounded organelle
(GO:0043231)
Map-kinase scaffold activity
(GO:0005078)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Phosphorylation
(GO:0016310)
Positive regulation of mapk cascade
(GO:0043410)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Ras protein signal transduction
(GO:0007265)
Regulation of cell population proliferation
(GO:0042127)
Regulation of map kinase activity
(GO:0043405)
Ruffle membrane
(GO:0032587)

Other Information

Proteins

Kinase suppressor of Ras 1

Genular Protein ID: 4262625955

Symbol: KSR1_HUMAN

Name: Kinase suppressor of Ras 1

UniProtKB Accession Codes:

Q8IVT5 F8WEA9 H7BYU0 Q13476

Database IDs:

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8521512

Title: KSR, a novel protein kinase required for RAS signal transduction.

PubMed ID: 8521512

DOI: 10.1016/0092-8674(95)90204-x

PubMed ID: 10409742

Title: Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.

PubMed ID: 10409742

DOI: 10.1128/mcb.19.8.5523

PubMed ID: 12007434

Title: MAP kinase module: the Ksr connection.

PubMed ID: 12007434

DOI: 10.1016/s0960-9822(02)00831-x

PubMed ID: 12941695

Title: Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.

PubMed ID: 12941695

DOI: 10.1093/emboj/cdg426

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20679487

Title: VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer.

PubMed ID: 20679487

DOI: 10.1128/mcb.01581-09

PubMed ID: 21102438

Title: AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.

PubMed ID: 21102438

DOI: 10.1038/ncb2130

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29433126

Title: MEK drives BRAF activation through allosteric control of KSR proteins.

PubMed ID: 29433126

DOI: 10.1038/nature25478

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 923
Mass: 102160
Checksum: 61BF0F1598349540
Sequence:

MDRAALRAAA MGEKKEGGGG GDAAAAEGGA GAAASRALQQ CGQLQKLIDI SIGSLRGLRT 
KCAVSNDLTQ QEIRTLEAKL VRYICKQRQC KLSVAPGERT PELNSYPRFS DWLYTFNVRP 
EVVQEIPRDL TLDALLEMNE AKVKETLRRC GASGDECGRL QYALTCLRKV TGLGGEHKED 
SSWSSLDARR ESGSGPSTDT LSAASLPWPP GSSQLGRAGN SAQGPRSISV SALPASDSPT 
PSFSEGLSDT CIPLHASGRL TPRALHSFIT PPTTPQLRRH TKLKPPRTPP PPSRKVFQLL 
PSFPTLTRSK SHESQLGNRI DDVSSMRFDL SHGSPQMVRR DIGLSVTHRF STKSWLSQVC 
HVCQKSMIFG VKCKHCRLKC HNKCTKEAPA CRISFLPLTR LRRTESVPSD INNPVDRAAE 
PHFGTLPKAL TKKEHPPAMN HLDSSSNPSS TTSSTPSSPA PFPTSSNPSS ATTPPNPSPG 
QRDSRFNFPA AYFIHHRQQF IFPVPSAGHC WKCLLIAESL KENAFNISAF AHAAPLPEAA 
DGTRLDDQPK ADVLEAHEAE AEEPEAGKSE AEDDEDEVDD LPSSRRPWRG PISRKASQTS 
VYLQEWDIPF EQVELGEPIG QGRWGRVHRG RWHGEVAIRL LEMDGHNQDH LKLFKKEVMN 
YRQTRHENVV LFMGACMNPP HLAIITSFCK GRTLHSFVRD PKTSLDINKT RQIAQEIIKG 
MGYLHAKGIV HKDLKSKNVF YDNGKVVITD FGLFGISGVV REGRRENQLK LSHDWLCYLA 
PEIVREMTPG KDEDQLPFSK AADVYAFGTV WYELQARDWP LKNQAAEASI WQIGSGEGMK 
RVLTSVSLGK EVSEILSACW AFDLQERPSF SLLMDMLEKL PKLNRRLSHP GHFWKSADIN 
SSKVVPRFER FGLGVLESSN PKM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: KSR1

Associated with

Other Information

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

KSR, a novel protein kinase required for RAS signal transduction. PubMed ID: 8521512

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. PubMed ID: 10409742

MAP kinase module: the Ksr connection. PubMed ID: 12007434

Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. PubMed ID: 12941695

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

Phosphoproteome of resting human platelets. PubMed ID: 18088087

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer. PubMed ID: 20679487

AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. PubMed ID: 21102438

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

MEK drives BRAF activation through allosteric control of KSR proteins. PubMed ID: 29433126

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846