Details for: ALKBH1

Gene ID: 8846

Symbol: ALKBH1

Ensembl ID: ENSG00000100601

Description: alkB homolog 1, histone H2A dioxygenase

Associated with

Other Information

Genular Protein ID: 1692414032

Symbol: ALKB1_HUMAN

Name: DNA oxidative demethylase ALKBH1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8600462

Title: Molecular cloning and functional analysis of a human cDNA encoding an Escherichia coli AlkB homolog, a protein involved in DNA alkylation damage repair.

PubMed ID: 8600462

DOI: 10.1093/nar/24.5.931

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17979886

Title: Expression and sub-cellular localization of human ABH family molecules.

PubMed ID: 17979886

DOI: 10.1111/j.1582-4934.2007.00094.x

PubMed ID: 18603530

Title: Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA.

PubMed ID: 18603530

DOI: 10.1074/jbc.m803776200

PubMed ID: 19959401

Title: Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites.

PubMed ID: 19959401

DOI: 10.1016/j.dnarep.2009.10.011

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22961808

Title: ALKBH1 is a histone H2A dioxygenase involved in neural differentiation.

PubMed ID: 22961808

DOI: 10.1002/stem.1228

PubMed ID: 23577621

Title: A covalent protein-DNA 5'-product adduct is generated following AP lyase activity of human ALKBH1 (AlkB homologue 1).

PubMed ID: 23577621

DOI: 10.1042/bj20121908

PubMed ID: 25459764

Title: Homology modeling, molecular dynamics, and site-directed mutagenesis study of AlkB human homolog 1 (ALKBH1).

PubMed ID: 25459764

DOI: 10.1016/j.jmgm.2014.10.013

PubMed ID: 27745969

Title: ALKBH1-mediated tRNA demethylation regulates translation.

PubMed ID: 27745969

DOI: 10.1016/j.cell.2016.09.038

PubMed ID: 27497299

Title: NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation.

PubMed ID: 27497299

DOI: 10.15252/embj.201694885

PubMed ID: 30392959

Title: N6-methyladenine DNA modification in glioblastoma.

PubMed ID: 30392959

DOI: 10.1016/j.cell.2018.10.006

PubMed ID: 30017583

Title: N6-methyladenine DNA modification in the human genome.

PubMed ID: 30017583

DOI: 10.1016/j.molcel.2018.06.015

PubMed ID: 31188562

Title: AlkB homologue 1 demethylates N3-methylcytidine in mRNA of mammals.

PubMed ID: 31188562

DOI: 10.1021/acschembio.8b01001

Sequence Information:

  • Length: 389
  • Mass: 43832
  • Checksum: 539C4CE41D2D8AEC
  • Sequence:
  • MGKMAAAVGS VATLATEPGE DAFRKLFRFY RQSRPGTADL EGVIDFSAAH AARGKGPGAQ 
    KVIKSQLNVS SVSEQNAYRA GLQPVSKWQA YGLKGYPGFI FIPNPFLPGY QWHWVKQCLK 
    LYSQKPNVCN LDKHMSKEET QDLWEQSKEF LRYKEATKRR PRSLLEKLRW VTVGYHYNWD 
    SKKYSADHYT PFPSDLGFLS EQVAAACGFE DFRAEAGILN YYRLDSTLGI HVDRSELDHS 
    KPLLSFSFGQ SAIFLLGGLQ RDEAPTAMFM HSGDIMIMSG FSRLLNHAVP RVLPNPEGEG 
    LPHCLEAPLP AVLPRDSMVE PCSMEDWQVC ASYLKTARVN MTVRQVLATD QNFPLEPIED 
    EKRDISTEGF CHLDDQNSEV KRARINPDS

Genular Protein ID: 4048476898

Symbol: Q5XKL0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 380
  • Mass: 42997
  • Checksum: 30D461B61A1BB2CA
  • Sequence:
  • SVATLATEPG EDAFRKLFRF YRQSRPGTAD LEGVIDFSAA HAARGKGPGA QKVIKSQLNV 
    SSVSEQNAYR AGLQPVSKWQ AYGLKGYPGF IFIPNPFLPG YQWHWVKQCL KLYSQKPNVC 
    NLDKHMSKEE TQDLWEQSKE FLRYKEATKR RPRSLLEKLR WVTVGYHYNW DSKKYSADHY 
    TPFPSDLGFL SEQVAAACGF EDFRAEAGIL NYYRLDSTLG IHVDRSELDH SKPLLSFSFG 
    QSAIFLLGGL QRDEAPTAMF MHSGDIMIMS GFSRLLNHAV PRVLPNPEGE GLPHCLEAPL 
    PAVLPRDSMV EPCSLEDWQV CASYLKTARV NMTVRQVLAT DQNFPLEPIE DEKRDISTEG 
    FCHLDDQNSE VKRARINPDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.