Details for: CCK

Gene ID: 885

Symbol: CCK

Ensembl ID: ENSG00000187094

Description: cholecystokinin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.6891
    Cell Significance Index: 1323.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.4769
    Cell Significance Index: 445.7200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 2.9701
    Cell Significance Index: 39.6200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 2.5439
    Cell Significance Index: 32.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3789
    Cell Significance Index: 477.2100
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 1.3041
    Cell Significance Index: 10.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1873
    Cell Significance Index: 117.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9795
    Cell Significance Index: 884.4100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9628
    Cell Significance Index: 27.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7393
    Cell Significance Index: 45.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5611
    Cell Significance Index: 91.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4139
    Cell Significance Index: 45.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3324
    Cell Significance Index: 63.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3058
    Cell Significance Index: 7.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2734
    Cell Significance Index: 14.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1674
    Cell Significance Index: 11.5800
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.1640
    Cell Significance Index: 1.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1430
    Cell Significance Index: 7.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1212
    Cell Significance Index: 14.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1092
    Cell Significance Index: 1.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0642
    Cell Significance Index: 1.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0547
    Cell Significance Index: 10.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0438
    Cell Significance Index: 1.5400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0400
    Cell Significance Index: 0.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0076
    Cell Significance Index: -0.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0111
    Cell Significance Index: -20.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0143
    Cell Significance Index: -0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0149
    Cell Significance Index: -27.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0184
    Cell Significance Index: -28.2600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0209
    Cell Significance Index: -0.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0211
    Cell Significance Index: -28.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0273
    Cell Significance Index: -1.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0285
    Cell Significance Index: -21.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0291
    Cell Significance Index: -21.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0298
    Cell Significance Index: -1.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0318
    Cell Significance Index: -20.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0333
    Cell Significance Index: -0.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0368
    Cell Significance Index: -6.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0388
    Cell Significance Index: -21.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0391
    Cell Significance Index: -22.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0402
    Cell Significance Index: -17.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0508
    Cell Significance Index: -23.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0551
    Cell Significance Index: -0.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0557
    Cell Significance Index: -16.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0597
    Cell Significance Index: -3.6600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0724
    Cell Significance Index: -3.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0745
    Cell Significance Index: -9.1600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0777
    Cell Significance Index: -1.6600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0807
    Cell Significance Index: -1.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0834
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1281
    Cell Significance Index: -21.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1315
    Cell Significance Index: -19.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1378
    Cell Significance Index: -29.0300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1478
    Cell Significance Index: -1.5300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1493
    Cell Significance Index: -2.3100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1560
    Cell Significance Index: -2.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1591
    Cell Significance Index: -21.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1875
    Cell Significance Index: -24.2300
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.1902
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1920
    Cell Significance Index: -22.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2091
    Cell Significance Index: -21.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2100
    Cell Significance Index: -21.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2168
    Cell Significance Index: -10.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2372
    Cell Significance Index: -14.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2796
    Cell Significance Index: -15.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2883
    Cell Significance Index: -21.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2928
    Cell Significance Index: -22.4700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3196
    Cell Significance Index: -6.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3421
    Cell Significance Index: -7.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3580
    Cell Significance Index: -12.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3694
    Cell Significance Index: -19.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3823
    Cell Significance Index: -17.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3855
    Cell Significance Index: -8.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3965
    Cell Significance Index: -10.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4107
    Cell Significance Index: -10.9700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4114
    Cell Significance Index: -4.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4123
    Cell Significance Index: -13.5000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4135
    Cell Significance Index: -3.9200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.4682
    Cell Significance Index: -4.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4685
    Cell Significance Index: -14.9200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4775
    Cell Significance Index: -5.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4825
    Cell Significance Index: -12.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4929
    Cell Significance Index: -5.3700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.5009
    Cell Significance Index: -5.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5033
    Cell Significance Index: -22.2600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.5045
    Cell Significance Index: -10.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5095
    Cell Significance Index: -17.8500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5401
    Cell Significance Index: -10.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5688
    Cell Significance Index: -21.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6176
    Cell Significance Index: -16.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6418
    Cell Significance Index: -23.5600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6746
    Cell Significance Index: -14.0800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.6847
    Cell Significance Index: -9.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6959
    Cell Significance Index: -20.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7104
    Cell Significance Index: -18.6800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7260
    Cell Significance Index: -18.1100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.7331
    Cell Significance Index: -9.6000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7467
    Cell Significance Index: -12.9100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.7515
    Cell Significance Index: -7.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7598
    Cell Significance Index: -20.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCK is a 28-amino acid peptide hormone, primarily produced in the duodenum and jejunum of the gastrointestinal tract. It is synthesized and secreted by the I-cells of the intestinal epithelium in response to nutrient uptake. CCK exhibits a unique dual function, acting as both a digestive enzyme stimulator and a neurotransmitter. Its primary ligand, the gastrin/CCK receptor, is a G-protein coupled receptor (GPCR) that activates various signaling pathways. **Pathways and Functions:** CCK's signaling pathways are complex and multifaceted, involving various GPCRs, ion channels, and second messenger systems. Upon binding to its receptor, CCK triggers a cascade of events that modulate digestion, appetite, and satiety. The primary pathways involved include: 1. **Gαq signaling**: CCK activates Gαq, leading to the activation of phospholipase C and the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). 2. **Extracellular signal-regulated kinase (ERK)**: CCK activates ERK, a key kinase involved in cellular proliferation, differentiation, and survival. 3. **Calcium signaling**: CCK increases intracellular calcium levels, modulating muscle contraction, neuronal activity, and immune responses. CCK's functions in the immune system are equally fascinating. It has been shown to: 1. **Regulate immune cell function**: CCK modulates the activity of immune cells, including T cells, B cells, and macrophages. 2. **Influence cytokine production**: CCK affects the production of pro-inflammatory and anti-inflammatory cytokines, thereby modulating immune responses. 3. **Maintain epithelial barrier function**: CCK helps to regulate the integrity of the epithelial barrier, preventing the translocation of pathogens and toxins. **Clinical Significance:** CCK's dysregulation has been implicated in various immune-related disorders, including: 1. **Inflammatory bowel disease (IBD)**: CCK's role in modulating immune responses has been linked to the development of IBD, such as Crohn's disease and ulcerative colitis. 2. **Cancer**: CCK has been shown to promote tumor growth and metastasis in certain cancers, highlighting its potential as a therapeutic target. 3. **Neurological disorders**: CCK's involvement in neuronal communication has led to its investigation as a potential therapeutic agent for neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, CCK is a multifaceted peptide hormone with far-reaching implications for immune homeostasis and disease. Further research is needed to fully elucidate the complexities of CCK, but its importance in maintaining immune balance and preventing immune-related disorders is undeniable.

Genular Protein ID: 3635699975

Symbol: CCKN_HUMAN

Name: Cholecystokinin

UniProtKB Accession Codes:

P06307

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 4 EMDB 8 Ensembl 3 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3856870

Title: Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine.

PubMed ID: 3856870

DOI: 10.1073/pnas.82.7.1931

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9371719

Title: Cleavage of arginyl-arginine and lysyl-arginine from the C-terminus of pro-hormone peptides by human germinal angiotensin I-converting enzyme (ACE) and the C-domain of human somatic ACE.

PubMed ID: 9371719

DOI: 10.1042/bj3280587

PubMed ID: 10336644

Title: Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin.

PubMed ID: 10336644

DOI: 10.1046/j.1432-1327.1999.00419.x

PubMed ID: 11076522

Title: Role of tyrosine sulfation and serine phosphorylation in the processing of procholecystokinin to amidated cholecystokinin and its secretion in transfected AtT-20 cells.

PubMed ID: 11076522

DOI: 10.1021/bi0011072

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

Sequence Information:

  • Length: 115
  • Mass: 12669
  • Checksum: 8A3EE6442FAEAF4B
  • Sequence:
    • MNSGVCLCVL MAVLAAGALT QPVPPADPAG SGLQRAEEAP RRQLRVSQRT DGESRAHLGA 
LLARYIQQAR KAPSGRMSIV KNLQNLDPSH RISDRDYMGW MDFGRRSAEE YEYPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.