Details for: CDK5R1

Gene ID: 8851

Symbol: CDK5R1

Ensembl ID: ENSG00000176749

Description: cyclin dependent kinase 5 regulatory subunit 1

Associated with

Other Information

Genular Protein ID: 556515881

Symbol: CD5R1_HUMAN

Name: Cyclin-dependent kinase 5 activator 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8090221

Title: p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.

PubMed ID: 8090221

DOI: 10.1038/371419a0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10604467

Title: Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration.

PubMed ID: 10604467

DOI: 10.1038/45159

PubMed ID: 12393264

Title: Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35.

PubMed ID: 12393264

DOI: 10.1016/s0169-328x(02)00409-6

PubMed ID: 15128856

Title: p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent extracellular signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons.

PubMed ID: 15128856

DOI: 10.1523/jneurosci.0690-04.2004

PubMed ID: 17121855

Title: Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation.

PubMed ID: 17121855

DOI: 10.1074/jbc.m610541200

PubMed ID: 17671990

Title: Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35.

PubMed ID: 17671990

DOI: 10.1002/jnr.21438

PubMed ID: 18507738

Title: Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes.

PubMed ID: 18507738

DOI: 10.1111/j.1471-4159.2008.05500.x

PubMed ID: 20213681

Title: Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.

PubMed ID: 20213681

DOI: 10.1002/pmic.200900783

PubMed ID: 24235147

Title: Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation.

PubMed ID: 24235147

DOI: 10.1074/jbc.m113.494856

PubMed ID: 33398170

Title: Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron.

PubMed ID: 33398170

DOI: 10.1038/s41589-020-00703-4

PubMed ID: 16039528

Title: Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.

PubMed ID: 16039528

DOI: 10.1016/j.chembiol.2005.05.011

PubMed ID: 15689152

Title: Mechanism of CDK5/p25 binding by CDK inhibitors.

PubMed ID: 15689152

DOI: 10.1021/jm049323m

PubMed ID: 33398168

Title: Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase.

PubMed ID: 33398168

DOI: 10.1038/s41589-020-00704-3

Sequence Information:

  • Length: 307
  • Mass: 34060
  • Checksum: D1C29A07AFF1B644
  • Sequence:
  • MGTVLSLSPS YRKATLFEDG AATVGHYTAV QNSKNAKDKN LKRHSIISVL PWKRIVAVSA 
    KKKNSKKVQP NSSYQNNITH LNNENLKKSL SCANLSTFAQ PPPAQPPAPP ASQLSGSQTG 
    GSSSVKKAPH PAVTSAGTPK RVIVQASTSE LLRCLGEFLC RRCYRLKHLS PTDPVLWLRS 
    VDRSLLLQGW QDQGFITPAN VVFLYMLCRD VISSEVGSDH ELQAVLLTCL YLSYSYMGNE 
    ISYPLKPFLV ESCKEAFWDR CLSVINLMSS KMLQINADPH YFTQVFSDLK NESGQEDKKR 
    LLLGLDR

Genular Protein ID: 946926938

Symbol: Q8N619_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 307
  • Mass: 34060
  • Checksum: 3BC291C0A2476D29
  • Sequence:
  • MGTVLSLSPS YRKATLFEDG AATVGHYTAV QNSKNAKDKN LKRHSIISVL PWKRIVAVSA 
    KKKNSKKVQP NSSYQNNITH LNNENLKKSL SCANLSTFAQ PPPAQPPAPP ASQLSGSQTG 
    GSSSVKKAPH PAVTSAGTPK RVIVQASTSE LLRCLGEFLC RRCYRLKHLS PTDPVLWLRS 
    VDRSLLLQGW QDKGFITPAN VVFLYMLCRD VISSEVGSDH ELQAVLLTCL YLSYSYMGNE 
    ISYPLKPFLV ESCKEAFWDR CLSVINLMSS KMLQINADPH YFTQVFSDLK NESGQEDKKR 
    LLLGLDR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.